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Helical Coil (helical + coil)
Selected AbstractsConfiguration Studies on the Heliotron Fusion Energy Reactor with Split-Type Helical CoilsCONTRIBUTIONS TO PLASMA PHYSICS, Issue 6-7 2010N. Yanagi Abstract Configuration optimization is examined for the heliotron fusion energy reactor FFHR in order to find sufficient clearances between the ergodic region outside the nested magnetic surfaces and blankets at the inboard side of the torus. The standard configuration of FFHR, which is similar to that of LHD, has a relatively large major radius of the helical coils in order to satisfy this requirement. It has been found, as an alternative design, that equivalent clearances are obtained with a shorter major radius both by employing a lower helical pitch parameter and splitting the helical coils in the poloidal cross-section at the outboard side. Splitting the helical coils also provides another configuration that ensures magnetic well formation in the fairly large nested magnetic surfaces with outward shifted configurations. Optimization is being carried out for these configurations by adjusting the pitch modulation parameter to improve the particle confinement (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Solution structure of the matrix attachment region-binding domain of chicken MeCP2FEBS JOURNAL, Issue 15 2003Björn Heitmann Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional protein involved in chromatin organization and silencing of methylated DNA. MAR-BD, a 125-amino-acid residue domain of chicken MeCP2 (cMeCP2, originally named ARBP), is the minimal protein fragment required to recognize MAR elements and mouse satellite DNA. Here we report the solution structure of MAR-BD as determined by multidimensional heteronuclear NMR spectroscopy. The global fold of this domain is very similar to that of rat MeCP2 MBD and MBD1 MBD (the methyl-CpG-binding domains of rat MeCP2 and methyl-CpG-binding domain protein 1, respectively), exhibiting a three-stranded antiparallel ,-sheet and an ,-helix ,1. We show that the C-terminal portion of MAR-BD also contains an amphipathic helical coil, ,2/,3. The hydrophilic residues of this coil form a surface opposite the DNA interface, available for interactions with other domains of MeCP2 or other proteins. Spectroscopic studies of the complex formed by MAR-BD and a 15-bp fragment of a high-affinity binding site from mouse satellite DNA indicates that the coil is also involved in protein·DNA interactions. These studies provide a basis for discussion of the consequences of six missense mutations within the helical coil found in Rett syndrome cases. [source] Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelinationJOURNAL OF NEUROSCIENCE RESEARCH, Issue 15 2009Liliana Pedraza Abstract Neurofascin-155 (NF155) and caspr are transmembrane proteins found at discrete locations early during development of the nervous system. NF155 is present in the oligodendrocyte cell body and processes, whereas caspr is on the axonal surface. In mature nerves, these proteins are clustered at paranodes, flanking the node of Ranvier. To understand how NF155 and caspr become localized to the paranodal regions of myelinated nerves, we have studied their distribution over time in myelinating cultures. Our observations indicate that these two proteins are recruited to the cell surface at the contact zone between axons and oligodendrocytes, where they trans-interact. This association explains the early pattern of caspr distribution, a helical coil that winds around the axon, resembling the turns of the myelin sheath. Caspr, an axonal membrane protein, therefore seems to move in register with the overlying myelinating cell via its interactions with myelin proteins. We suggest that NF155 is the glial cell membrane protein responsible for caspr distribution. The pair act as interacting partners on either side of the axoglial contact area. Most likely, there are other proteins on the axonal surface whose distribution is equally influenced by interaction with the nascent myelin sheath. The fact that caspr follows the movement of the spiraling membrane has a direct affect on the interpretation of the way in which myelin is formed. © 2009 Wiley-Liss, Inc. [source] Configuration Studies on the Heliotron Fusion Energy Reactor with Split-Type Helical CoilsCONTRIBUTIONS TO PLASMA PHYSICS, Issue 6-7 2010N. Yanagi Abstract Configuration optimization is examined for the heliotron fusion energy reactor FFHR in order to find sufficient clearances between the ergodic region outside the nested magnetic surfaces and blankets at the inboard side of the torus. The standard configuration of FFHR, which is similar to that of LHD, has a relatively large major radius of the helical coils in order to satisfy this requirement. It has been found, as an alternative design, that equivalent clearances are obtained with a shorter major radius both by employing a lower helical pitch parameter and splitting the helical coils in the poloidal cross-section at the outboard side. Splitting the helical coils also provides another configuration that ensures magnetic well formation in the fairly large nested magnetic surfaces with outward shifted configurations. Optimization is being carried out for these configurations by adjusting the pitch modulation parameter to improve the particle confinement (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Taking shape: control of bacterial cell wall biosynthesisMOLECULAR MICROBIOLOGY, Issue 5 2005George C. Stewart Summary The characteristic shape of a bacterial cell is a function of the three dimensional architectures of the cell envelope and is determined by the balance between lateral wall extension and synthesis of peptidoglycan at the division septum. The three dimensional patterns of cell wall synthesis in the bacterium Bacillus subtilis is influenced by actin-like proteins that form helical coils in the cell and by the MreCD membrane proteins that link the cytoskeletal elements with the penicillin-binding proteins that carry out peptidoglycan synthesis. Recent genetic studies have provided important clues as to how these proteins are arranged in the cell and how they function to regulate cell shape. [source] Enantioseparation of extended metal atom chain complexes: Unique compounds of extraordinarily high specific rotationCHIRALITY, Issue 3 2007Molly M. Warnke Abstract Extended metal atom chains (EMACs) contain a linear metal chain wrapped by various ligands. Most complexes are of the form M3(dpa)4X2, where M = metal, dpa = 2,2,-dipyridylamide, and X = various anions. The ligands form helical coils about the metal chain, which results in chiral EMAC complexes. The EMACs containing the metals Co and Cu were partially separated in polar organic mode using a vancomycin-based chiral stationary phase. Under similar conditions, two EMACs with Ni metal and varying anions could be baseline separated. The polar organic mode was used because of the instability of the compounds in aqueous mobile phases. Also, these conditions are more conducive to preparative separations. Polarimetric measurements on the resolved enantiomers of Ni3(dpa)4Cl2 indicate that they have extraordinarily high specific rotations (on the order of 5000 deg cc/g dm). Chirality, 2007. © 2006 Wiley-Liss, Inc. [source] | |||||||||||||