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Aminocarbonylation Reactions (aminocarbonylation + reaction)

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Chemistry100%

Selected Abstracts

A Microfluidic Approach to the Rapid Screening of Palladium-Catalysed Aminocarbonylation Reactions

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 18 2009
Philip
Abstract The evaluation and selection of the most appropriate catalyst for a chemical transformation is an important process in many areas of synthetic chemistry. Conventional catalyst screening involving batch reactor systems can be both time-consuming and expensive, resulting in a large number of individual chemical reactions. Continuous flow microfluidic reactors are increasingly viewed as a powerful alternative format for reacting and processing larger numbers of small-scale reactions in a rapid, more controlled and safer fashion. In this study we demonstrate the use of a planar glass microfluidic reactor for performing the three-component palladium-catalysed aminocarbonylation reaction of iodobenzene, benzylamine and carbon monoxide to form N -benzylbenzamide, and screen a series of palladium catalysts over a range of temperatures. N -Benzylbenzamide product yields for this reaction were found to be highly dependent on the nature of the catalyst and reaction temperature. The majority of catalysts gave good to high yields under typical flow conditions at high temperatures (150,°C), however the palladium(II) chloride-Xantphos complex [PdCl2(Xantphos)] proved to be far superior as a catalyst at lower temperatures (75,120,°C). The utilised method was found to be an efficent and reliable way for screening a large number of palladium-catalysed carbonylation reactions and may prove useful in screening other gas/liquid phase reactions. [source]

Palladium bis(2,2,6,6-tetramethyl-3,5-heptanedionate) catalyzed alkoxycarbonylation and aminocarbonylation reactions

APPLIED ORGANOMETALLIC CHEMISTRY, Issue 6 2009
Pawan J. Tambade
Abstract Palladium bis(2,2,6,6-tetramethyl-3,5-heptanedionate), a structurally well defined O -containing transition metal complex, is reported to be an efficient catalyst for alkoxycarbonylation and aminocarbonylation reactions under milder operating conditions. The system tolerated the carbonylative coupling of various aryl halides with phenol/alcohol and amines, providing good to excellent yields of desired products under optimized reaction conditions. Copyright © 2009 John Wiley & Sons, Ltd. [source]