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Kinds of Harbor Terms modified by Harbor Selected AbstractsBankrupting the enemy: the US financial siege of Japan before Pearl Harbor , By Edward S. MillerECONOMIC HISTORY REVIEW, Issue 1 2009EUGENE N. WHITE No abstract is available for this article. [source] Assessing human germ-cell mutagenesis in the Postgenome Era: A celebration of the legacy of William Lawson (Bill) Russell,ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 2 2007Andrew J. Wyrobek Abstract Birth defects, de novo genetic diseases, and chromosomal abnormality syndromes occur in ,5% of all live births, and affected children suffer from a broad range of lifelong health consequences. Despite the social and medical impact of these defects, and the 8 decades of research in animal systems that have identified numerous germ-cell mutagens, no human germ-cell mutagen has been confirmed to date. There is now a growing consensus that the inability to detect human germ-cell mutagens is due to technological limitations in the detection of random mutations rather than biological differences between animal and human susceptibility. A multidisciplinary workshop responding to this challenge convened at The Jackson Laboratory in Bar Harbor, Maine. The purpose of the workshop was to assess the applicability of an emerging repertoire of genomic technologies to studies of human germ-cell mutagenesis. Workshop participants recommended large-scale human germ-cell mutation studies be conducted using samples from donors with high-dose exposures, such as cancer survivors. Within this high-risk cohort, parents and children could be evaluated for heritable changes in (a) DNA sequence and chromosomal structure, (b) repeat sequences and minisatellites, and (c) global gene expression profiles and pathways. Participants also advocated the establishment of a bio-bank of human tissue samples from donors with well-characterized exposure, including medical and reproductive histories. This mutational resource could support large-scale, multiple-endpoint studies. Additional studies could involve the examination of transgenerational effects associated with changes in imprinting and methylation patterns, nucleotide repeats, and mitochondrial DNA mutations. The further development of animal models and the integration of these with human studies are necessary to provide molecular insights into the mechanisms of germ-cell mutations and to identify prevention strategies. Furthermore, scientific specialty groups should be convened to review and prioritize the evidence for germ-cell mutagenicity from common environmental, occupational, medical, and lifestyle exposures. Workshop attendees agreed on the need for a full-scale assault to address key fundamental questions in human germ-cell environmental mutagenesis. These include, but are not limited to, the following: Do human germ-cell mutagens exist? What are the risks to future generations? Are some parents at higher risk than others for acquiring and transmitting germ-cell mutations? Obtaining answers to these, and other critical questions, will require strong support from relevant funding agencies, in addition to the engagement of scientists outside the fields of genomics and germ-cell mutagenesis. Environ. Mol. Mutagen., 2007. Published 2007 Wiley-Liss, Inc. [source] Chemical amplification in an invaded food web: Seasonality and ontogeny in a high-biomass, low-diversity ecosystem,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2008Carla A. Ng Abstract The global spread of invasive species is changing the structure of aquatic food webs worldwide. The North American Great Lakes have proved particularly vulnerable to this threat. In nearshore areas, invasive benthic species such as dreissenid mussels and round gobies (Neogobius melanostomus) have gained dominance in recent years. Such species are driving the flow of energy and material from the water column to the benthic zone, with dramatic effect on nutrient and contaminant cycling. Here, we develop a stage-structured model of a benthified food web in Lake Michigan with seasonal resolution and show how its bioaccumulation patterns differ from expected ones. Our model suggests that contaminant recycling through the consumption of lipid-rich fish eggs and mussel detritus is responsible for these differences. In southern Lake Michigan's Calumet Harbor (Chicago, IL, USA), round gobies have nitrogen isotope signatures with considerable spread, with some values higher than their predators and others lower than their prey. Contrary to patterns observed in linear pelagic systems, we predict that polychlorinated biphenyl (PCB) concentrations in these fish decrease with increasing size due to the lipid- and benthos-enriched diets of smaller fish. We also present here round goby PCB concentrations measured in 2005 after an invasional succession in Calumet Harbor and demonstrate how the change from one invasive mussel species to another may have led to a decrease in round goby PCB accumulation. Our results suggest that benthic-dominated systems differ from pelagic ones chiefly due to the influence of detritus and that these effects are exacerbated in systems with low species diversity and high biomass. [source] Water-column concentrations and partitioning of polybrominated diphenyl ethers in the New York/New Jersey Harbor, USAENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 8 2008Archil Zarnadze Abstract Despite the emerging concern regarding polybrominated diphenyl ethers (BDEs), very few measurements of BDE concentrations in ambient water have been published. In the present study, BDEs were measured in water samples from the New York/New Jersey Harbor (USA). Samples were taken in Raritan Bay west of Sandy Hook during four intensive sampling campaigns in 2000 and 2001. Congeners 17, 47, 99, 100, 153, 154, 183, and 209 were detected. Total BDE (,BDE) concentrations (average ± standard deviation) were 175 ± 75 ng/g in the particle phase and 110 ± 72 pg/L in the apparent dissolved phase. The deca-congener, BDE 209, constituted 85 and 9% of ,BDEs in the particle and apparent dissolved phases, respectively. The ,BDE levels are significantly higher than those measured in Lake Ontario, USA, and in The Netherlands, but they are similar to concentrations measured in Lake Michigan and San Francisco Bay (both USA). Calculated values of the organic carbon-water partition coefficient (KOC) were strongly correlated with literature values of the octanol-water partition coefficient (KOW). The data suggest that sorption of BDEs to colloids is important in this system, although quantifying the extent of colloid sorption is difficult. [source] Field testing of equilibrium passive samplers to determine freely dissolved native polycyclic aromatic hydrocarbon concentrationsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 3 2008Gerard Cornelissen Abstract Equilibrium passive samplers are promising tools to determine freely dissolved aqueous concentrations (CW,free) of hydrophobic organic compounds. Their use in the field, however, remains a challenge. In the present study on native polycyclic aromatic hydrocarbons (PAHs) in Oslo Harbor, Norway, two different passive sampler materials, polyoxymethylene (POM; thickness, 55 ,m [POM-55] and 500 ,m [POM-500]) and polydimethylsiloxane (PDMS; thickness, 200 ,m), were used to determine in the laboratory CW,free in sediment pore water (CPW,free), and the suitability of five passive samplers for determination of CW,free in overlying surface water was tested under field conditions. For laboratory determinations of CPW,free, both POM-55 and PDMS turned out to be suitable. In the field, the shortest equilibrium times (approximately one month) were observed for POM-55 and PDMS (thickness, 28 ,m) coatings on solid-phase microextraction fibers, with PDMS tubing as a good alternative. Low-density polyethylene (thickness, 100 ,m) and POM-500 did not reach equilibrium within 119 d in the field. Realistic values were obtained for dissolved organic carbon,water partition coefficients in the field (approximately one log unit under log KOW), which strengthened the conclusion that equilibrium was established in field-exposed passive samplers. At all four stations, chemical activity ratios between pore water and overlying water were greater than one for all PAHs, indicating that the sediment was a PAH diffusion source and that sediment remediation may be an appropriate treatment for PAH contamination in Oslo Harbor. [source] Studies on bioremediation of polycyclic aromatic hydrocarbon-contaminated sediments: Bioavailability, biodegradability, and toxicity issuesENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 3 2003Henry H. Tabak Abstract The widespread contamination by polycyclic aromatic hydrocarbons (PAHs) has created a need for cost-effective bioremediation processes. This research studied a chronically PAH-contaminated estuarine sediment from the East River (ER; NY, USA) characterized by high concentrations of PAHs (,4,190 ppm), sulfide, and metals and a marine sediment from New York/New Jersey Harbor (NY/NJH; USA) with only trace quantities of PAHs (0.1,0.6 ppm). The focus was to examine the relationship between bioavailability of PAHs and their biological removal in a slurry system. Freshwater and marine sediment toxicity tests were conducted to measure baseline toxicity of both sediments to amphipods, aquatic worms, fathead and sheepshead minnow larvae, and a vascular plant; to determine the cause of toxicity; and to evaluate the effectiveness of the biotreatment strategies in reducing toxicity. Results showed the ER sediment was acutely toxic to all freshwater and marine organisms tested and that the toxicity was mainly caused by sulfide, PAHs, and metals present in the sediment. In spite of the high toxicity, most of the PAH compounds showed significant degradation in the aerobic sediment/water slurry system if the initial high oxygen demand due to the high sulfide content of the sediment was overcome. The removal of PAHs by biodegradation was closely related to their desorbed amount in 90% isopropanol solution during 24 h of contact, while the desorption of model PAH compounds from freshly spiked NY/NJH sediment did not describe the bioavailability of PAHs in the East River sediment well. The research improves our understanding of bioavailability as a controlling factor in bioremediation of PAHs and the potential of aerobic biodegradation for PAH removal and ecotoxicity reduction. [source] The Geologic Basis for a Reconstruction of a Grounded Ice Sheet in McMurdo Sound, Antarctica, at the Last Glacial MaximumGEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 2-3 2000George H. Denton A grounded ice sheet fed from the Ross Embayment filled McMurdo Sound at the last glacial maximum (LGM). This sheet deposited the little-weathered Ross Sea drift sheet, with far-traveled Transantarctic Mountains (TAM) erratics, on lower slopes of volcanic islands and peninsulas in the Sound, as well as on coastal forelands along the TAM front. The mapped upper limit of this drift, commonly marked by a distinctive moraine ridge, shows that the ice-sheet surface sloped landward across McMurdo Sound from 710 m elevation at Cape Crozier to 250 m in the eastern foothills of the Royal Society Range. Ice from the Ross Embayment flowed westward into the sound from both north and south of Ross Island. The northern flowlines were dominant, deflecting the southern flowlines toward the foothills of the southern Royal Society Range. Ice of the northern flowlines distributed distinctive kenyte erratics, derived from western Ross Island, in Ross Sea drift along the TAM front between Taylor and Miers Valleys. Lobes from grounded ice in McMurdo Sound blocked the mouths of TAM ice-free valleys, damming extensive proglacial lakes. A floating ice cover on each lake formed a conveyor that transported glacial debris from the grounded ice lobes deep into the valleys to deposit a unique glaciolacustrine facies of Ross Sea drift. The ice sheet in McMurdo Sound became grounded after 26,860 14C yr bp. It remained near its LGM position between 23,800 14C yr bp and 12,700 14C yr bp. Recession was then slow until sometime after 10,794 14C yr bp. Grounded ice lingered in New Harbor in the mouth of Taylor Valley until 8340 14C yr bp. The southward-retreating ice-sheet grounding line had penetrated deep into McMurdo Sound by 6500 14C yr bp. The existence of a thick ice sheet in McMurdo Sound is strong evidence for widespread grounding across the Ross Embayment at the LGM. Otherwise, the ice-sheet surface would not have sloped landward, nor could TAM erratics have been glacially transported westward into McMurdo Sound from farther offshore in the Ross Embayment. [source] Movements and foraging effort of Steller's Eiders and Harlequin Ducks wintering near Dutch Harbor, AlaskaJOURNAL OF FIELD ORNITHOLOGY, Issue 2 2007John A. Reed ABSTRACT We studied the movements and foraging effort of radio-marked Steller's Eiders (Polysticta stelleri) and Harlequin Ducks (Histrionicus histrionicus) to evaluate habitat quality in an area impacted by industrial activity near Dutch Harbor, Alaska. Foraging effort was relatively low, with Steller's Eiders foraging only 2.7 ± 0.6 (SE) hours per day and Harlequin Ducks 4.1 ± 0.5 hours per day. Low-foraging effort during periods of high-energetic demand generally suggests high food availability, and high food availability frequently corresponds with reductions in home range size. However, the winter ranges of Harlequin Ducks did not appear to be smaller than usual, with the mean range size in our study (5.5 ± 1.1 km2) similar to that reported by previous investigators. The mean size of the winter ranges of Steller's Eiders was similar (5.1 ± 1.3 km2), but no comparable estimates are available. Eutrophication of the waters near Dutch Harbor caused by seafood processing and municipal sewage effluent may have increased populations of the invertebrate prey of these sea ducks and contributed to their low-foraging effort. The threat of predation by Bald Eagles (Haliaeetus leucocephalus) that winter near Dutch Harbor may cause Steller's Eiders and Harlequin Ducks to move further offshore when not foraging, contributing to an increase in range sizes. Thus, the movement patterns and foraging behavior of these ducks likely represent a balance between the cost and benefits of wintering in a human-influenced environment. SINOPSIS Estudiamos los movimientos y esfuerzo de forrajeo de individuos de eidero (Polusticta stelleri) y el pato arlequín (Histrionicus histrionicus)(ambos con radiotransmisores) para evaluar la calidad del habitat en un área impactada por actividad industrial localizada en Dutch Harbor, Alaska. El esfuerzo de forrajeo (en horas/dia) fue bajo en el eidero con 2.7 ± 0.6 y en el arlequín 4.1 ± 0.5. Un bajo esfuerzo de forrajeo durante periodos de alta demanda energética por lo general sugieren una buena cantidad y calidad de alimentos. Alimentos en abundancia por lo general dan origen a una reducción en el ambiente ocupado (home range). Sin embargo, el ambiente ocupado del arlequín fue de 5.5 ± 1.1 km cuadrados, similar al informado en otros estudios, por lo que no parece haberse reducido. En el eidero el tamaño del área ocupada fue de 5.1 ± 1.3 km cuadrados y no hay otros estudios que nos permitieran hacer comparaciones. La eutroficación de las aguas en los alrededores de Dutch Harbor, causado por el procesamiento de pescado y las aguas usadas municipales, pueden haber incrementado los invertebrados de los cuales se alimentan ambas especies de aves estudiadas, y haber contrubuido al bajo esfuerzo de forrajeo observado en estas. El peligro de ser depredados por individuos de Haliaeetus leucocephalus, que pasan el invierno en el área de la bahía, puede haber sido el responsable del movimiento de las aves tierra adentro, cuando no se estaban alimentando, contribuyendo al tamaño del área ocupada por ambas especies. Por ende los movimientos y patrones de forrajeo de ambas especies probablemente no representa un balance entre el costo y los beneficios de pasar el invierno en un ambiente influenciado por la presencia de humanos. [source] The Seventh Messenger and Australia 1904,1980: Benjamin Purnell and the House of DavidJOURNAL OF RELIGIOUS HISTORY, Issue 3 2005GUY FEATHERSTONE The Southcottian tradition of the Seven Angelic Messengers of Rev. 10:7 has a long association with millennial belief in Australia. Brought hither by Christian Israelite missionaries in the 1840s, the final three Messengers (Wroe, Jezreel, and Purnell) all journeyed to Australia to win converts. After describing the origins and beliefs of the sects established by these Messengers, this article outlines the impact of Benjamin Purnell's House of David on local Christian Israelites and others. His visit to Melbourne in December 1904 to "ingather" over seventy converts from the Fitzroy congregation is outlined; a comparison is made with J. A. Dowie's missionary tour of the same year. A description of the life the Australians led in Michigan and their attempts to leave the colony and expose Purnell's sexual misconduct are outlined. Despite unfavourable press reports, continuing missionary activity in Melbourne and then in Sydney resulted in further converts leaving for America, and the establishment of a branch community at North Ryde. A comparison of its ethos and that prevailing at Benton Harbor is included. Details of the eventual demise of the North Ryde community are followed by a brief analysis of its place in Australia's religious life. This essay is published to mark the centenary of the departure of the Christian Israelites in February 1905. [source] Military Curfew, Race-Based Internment, and Mr. Justice RutledgeJOURNAL OF SUPREME COURT HISTORY, Issue 3 2003John M. Ferren The story is well known. A few months after Pearl Harbor, a curfew was imposed on West Coast residents of Japanese ancestry, including American citizens. Then they were confined at internment camps around the country. This tragic episode continues to generate scrutiny, including three new books last year.1 But there is at least one story, as yet untold, that will be of particular interest to students of the Supreme Court. Why did Justice Wiley Rutledge, the Court's newest member, who was known for his unyielding allegiance to civil liberties, join the majority in allowing internment? [source] National subjects: September 11 and Pearl HarborAMERICAN ETHNOLOGIST, Issue 3 2004Geoffrey M. White ABSTRACT Despite a long tradition of writing on collective representations of the past, anthropology has contributed relatively little to the expanding literature on national memory. Yet ethnographic approaches have the facility to delineate practices that create historical narrative and give it emotive power while keeping in view longer-term political forces that underwrite dominant imaginaries. In this article I inquire into the discursive origins of emotional involvement in national history by juxtaposing two events of spectacular violence, September 11 and Pearl Harbor. Focusing on the representation of these events in public culture and at memorial sites, I argue that personal narratives play a central role in formations of national subjectivity, at times emotionalizing dominant memories and at other times opening possibilities for alternative visions. [source] Group Threat, Collective Angst, and Ingroup Forgiveness for the War in IraqPOLITICAL PSYCHOLOGY, Issue 2 2009Michael J. A. Wohl We examine the consequences of threat to the ingroup for emotional reactions to ingroup harm doing. It was hypothesized that reminders of a past threat to the ingroup would induce collective angst, and this emotional reaction would increase forgiveness of the ingroup for its harmful actions toward another group. In Experiment 1, Americans read an article about the war in Iraq that implied Americans would soon experience another attack or one where such implied future threat to the ingroup was absent. When the ingroup's future was threatened, forgiveness for the harm Americans have committed in Iraq was increased, to the extent that collective angst was induced. In Experiment 2, Americans experienced more collective angst and were more willing to forgive their ingroup for their group's present harm doing in Iraq following reminders of either the terrorist attacks on September 11, 2001, or the 1941 Japanese attack on Pearl Harbor compared to when the victimization reminder was irrelevant to the ingroup. We discuss why ingroup threat encourages ingroup forgiveness for current harm doing. [source] Fish consumption and body burden of organochlorines among lower hudson urban anglersAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 8 2008Kimberly Morland PhD Abstract Background Polychlorinated biphenyls and other organochlorines have contaminated the Hudson River and New York/New Jersey Harbor for many decades. Although body burdens and health effects resulting from exposure to these pollutants have been measured in other populations, little is known about anglers from the lower Hudson area. Methods Anglers were recruited from fishing clubs and along piers on the lower Hudson River. One hundred twenty-five participants provided blood samples and questionnaire information. Serum was analyzed at Mount Sinai School of Medicine for organochlorines. Results Mean concentration of total PCB congeners was 4.78 µg/L. A non-significant adjusted mean difference of ,0.59 µg/L was observed between local fish eaters and non-eaters with higher levels among the non-eaters. Similar negative, but non-significant associations were observed for p,p'-DDT, HCB, and ,-BHC. For pp'-DDE, and several chlordane residues, levels were higher among anglers reporting local fish consumption, but the difference was statistically significant only for TN. Conclusions These findings suggest eating fish from the lower Hudson River and NY/NJ harbor is not associated with an increased body burden of PCBs or most other organochlorines. Am. J. Ind. Med. 51:587,594, 2008. © 2008 Wiley-Liss, Inc. [source] Reducing salinity and organic contaminants in the Pearl Harbor dredged material using soil amendments and plantsREMEDIATION, Issue 4 2002N. V. Hue Phytoremediation is an emerging technique that can be used to economically remediate sites contaminated with trace elements and/or man-made organic contaminants. This technique was used on Pearl Harbor (Oahu, Hawaii) dredged material (PHDM) containing polycyclic aromatic hydrocarbons (PAHs) and some heavy metals. The dredged material was first amended with a high-calcium soil (Waialua Mollisol) and a biosolids-based compost at different proportions to yield varying salinity levels. A mixture that yielded an electrical conductivity (EC, a measure of salinity) of the saturated paste extract of 15 to 20 dS/m was identified and used to evaluate the salt tolerance of five plant species. Relative germination and one-month-old biomass indicated that common bermuda grass (Cynodon dactylon), seashore paspalum (Paspalum vaginatum), beach pea (Vigna marina), and cow pea (Vigna unguiculata) can produce at least 40 percent of biomass of the control at an EC of approximately 18 dS/m, suggesting the four plants are relatively salt tolerant. In contrast, Desmodium intortum either did not germinate or died within two weeks after germination at the same salinity level. A subsequent greenhouse experiment, using mixtures of the PHDM (0 or 25 percent dry weight), organic amendments (10 percent leucaena green manure or biosolids-based compost), and a Mollisol (65 or 90 percent dry weight) in 6-liter pots containing 4 kilograms of material yielded the following results: (1) A combination of transplanted seashore paspalum, seeded bermuda grass, and seeded beach pea was effective in taking up sodium (Na), thereby reducing salinity and making the medium more amenable to diversified microbes and plants, which may be effective PAH degraders; (2) total PAH concentration was reduced by about 30 percent after three months of active plant growth, but degradation of individual PAH members varied significantly, however; (3) leguminous green manure, as a soil amendment, was more effective than compost for use in bio- and/or phytoremediations; and (4) soil amendments, when applicable, could supplement living plants in reducing organic contaminants, such as PAHs. © 200 Wiley Periodicals, Inc. [source] Structural analyses of Phycodnaviridae and IridoviridaeACTA CRYSTALLOGRAPHICA SECTION D, Issue 12 2003Alan A. Simpson The Phycodnaviridae, Iridoviridae and related viruses, with diameters of 1500,2000,Å, are formed from large trigonal arrays of hexagonally close-packed capsomers forming the faces of icosahedra [Yan et al. (2000), Nature Struct. Biol.7, 101,103; Nandhagopal et al. (2002), Proc. Natl Acad. Sci. USA, 99, 14758,14763]. Caspar and Klug predicted that such structures could be assembled from hexameric capsomers [Caspar & Klug (1962), Cold Spring Harbor. Symp. Quant. Biol.27, 1,24], as was subsequently found in numerous icosahedral viruses. During the course of evolution, some viruses, including the virus families mentioned above, replaced hexameric capsomers with pseudo-hexameric trimers by gene duplication. In large dsDNA icosahedral viruses, the capsomers are organized into `pentasymmetrons' and `trisymmetrons'. The interactions between the trimeric capsomers can be divided into three groups, one between similarly oriented trimers and two between oppositely oriented trimers (trimers related by an approximately sixfold rotation). The interactions within a trisymmetron belong to the first class, whereas those between trisymmetrons and within the pentasymmetron are of the other two types. Knowledge of these distances permits a more accurate fitting of the atomic structure of the capsomer into the cryo-electron microscopy (cryoEM) reconstruction of the whole virus. The adoption of pseudo-hexagonal capsomers places these viruses into a subset of the Caspar and Klug surface lattices. [source] Molecular Characterization of Anaerobic Microbial Communities from Benzene-Degrading Sediments under Methanogenic ConditionsBIOTECHNOLOGY PROGRESS, Issue 6 2005Wook Chang Anaerobic benzene degradation was confirmed in microbial communities enriched from Baltimore Harbor (Baltimore, MD) sediments under methanogenic conditions. Molecular characterization based on 16S rDNA gene sequences revealed that the strains in the communities were diversely affiliated with such phylogenetic branches as the Bacteroidetes, Euryarchaeota, Firmicutes, and Thermotogaephyla. Of interest was that the majority of the microbial populations detected in these cultures were closely related to the members of dechlorinating microbial communities. Further, some of those species were previously found in naphthalene- or phenanthrene-degrading methanogenic communities. Finally, this result could be used to design targeted isolation strategies for anaerobic benzene-degrading strains under methanogenic conditions. [source] Safe Harbors or Free Frontiers?JOURNAL OF SOCIAL ISSUES, Issue 2 2003Privacy, Transborder Data Flows This article explores the issues surrounding the harmonization of privacy or data protection during the last 30 years. It begins with a history of the conflict over transborder data flows and then proceeds to analyze current national and regional policy debates about the feasibility of policy solutions to address problems that are integral to global communications and economic networks. Ongoing discussions between the European Union and the United States over Safe Harbor Principles provide data for exploring these issues. The article concludes with an analysis of whether harmonization of privacy and data protection policies is likely to evolve through existing processes and institutions. [source] Multimarker approach in transplanted mussels for evaluating water quality in Charentes, France, coast areas exposed to different anthropogenic conditionsENVIRONMENTAL TOXICOLOGY, Issue 5 2003M. Roméo Abstract An active biomonitoring experiment was performed using mussels collected at a clean site, Fier d'Ars, and transplanted to two locations, outside the harbor of La Rochelle and in the Baie de L'Aiguillon along the coast of Charentes (French Atlantic coast) beginning in April for several months. Mussels were collected in June and October. The cadmium, copper, and zinc concentrations of all resident and transplanted mussel samples and the polycyclic aromatic hydrocarbon and polychlorinated biphenyl concentrations in some mussel samples and in the sediment samples were determined. Mussel response was evaluated for several biochemical biomarkers: concentrations of metallothionein, activities of glutathione S-transferase and acetylcholinesterase (AChE) and levels of thiobarbituric reactive substance (TBARS). The physiological status of the animals was assessed using the condition index. A principal component analysis performed with the chemical and biochemical results of the evaluations of the resident and transplanted mussels collected in June allowed them to be separated into three groups: resident mussels from la Rochelle with high metal and TBARS levels, resident mussels from Baie de L'Aiguillon with a very high condition index, and resident mussels from Fier d'Ars and transplanted mussels at La Rochelle and Baie de L'Aiguillon with low TBARS and AChE activities. Strong seasonal variation from June to October of all parameters was noted. Mussels transplanted to La Rochelle appeared to be the most "polluted" in their pollutant concentrations and biochemical responses; moreover, the La Rochelle site had the highest concentration of organics in sediments of all the sites. The choice of Fier d'Ars as a reference site may be questionable because some of the biomarker responses of the mussels were higher than expected there, although these pollutants in mussels and sediment were present at the lowest concentrations measured. © 2003 Wiley Periodicals, Inc. Environ Toxicol 18: 295,305, 2003. [source] Butyltin compounds in sediments from the commercial harbor of Alexandria City, EgyptENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 12 2001Assem O. Barakat Abstract Tributyltin (TBT), dibutyltin (DBT), and monobutyltin (MBT) compounds were quantitatively determined in surface-sediment samples collected from 23 sites in the commercial harbor of Alexandria City, Egypt. Butyltin concentrations in sediments varied widely depending on the sample location, ranging from less than 0.1 to 186 ng g,1 of Sn for MBT, less than 0.1 to 379 ng g,1 of Sn for DBT, and 1 to 2,067 ng g,1 of Sn for TBT. Elevated TBT concentrations, ranging from 727 to 2,067 ng g,1 of Sn were observed in harbors, marinas, and near ship-repair facilities, indicating that the butyltin-containing, antifouling paints of boats and vessels are the major source of butyltin contamination. The TBT concentration decreased rapidly away from potential source areas of boat docking and repair facilities. The high relative concentrations of TBT in the sediments indicated that degradation processes in the sediments are minor, probably due to the anoxic sedimentary conditions at the sampling sites and/or relatively fresh input of TBT to these sites. [source] Genetic reductions of ,-site amyloid precursor protein-cleaving enzyme 1 and amyloid-, ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model miceEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 1 2010Latha Devi Abstract Although transgenic mouse models of Alzheimer's disease (AD) recapitulate amyloid-, (A,)-related pathologies and cognitive impairments, previous studies have mainly evaluated their hippocampus-dependent memory dysfunctions using behavioral tasks such as the water maze and fear conditioning. However, multiple memory systems become impaired in AD as the disease progresses and it is important to test whether other forms of memory are affected in AD models. This study was designed to use conditioned taste aversion (CTA) and contextual fear conditioning paradigms to compare the phenotypes of hippocampus-independent and -dependent memory functions, respectively, in 5XFAD amyloid precursor protein/presenilin-1 transgenic mice that harbor five familial AD mutations. Although both types of memory were significantly impaired in 5XFAD mice, the onset of CTA memory deficits (,9 months of age) was delayed compared with that of contextual memory deficits (,6 months of age). Furthermore, 5XFAD mice that were genetically engineered to have reduced levels of ,-site amyloid precursor protein-cleaving enzyme 1 (BACE1) (BACE1+/,·5XFAD) exhibited improved CTA memory, which was equivalent to the performance of wild-type controls. Importantly, elevated levels of cerebral ,-secretase-cleaved C-terminal fragment (C99) and A, peptides in 5XFAD mice were significantly reduced in BACE1+/,·5XFAD mice. Furthermore, A, deposition in the insular cortex and basolateral amygdala, two brain regions that are critically involved in CTA performance, was also reduced in BACE1+/,·5XFAD compared with 5XFAD mice. Our findings indicate that the CTA paradigm is useful for evaluating a hippocampus-independent form of memory defect in AD model mice, which is sensitive to rescue by partial reductions of the ,-secretase BACE1 and consequently of cerebral A,. [source] EVOLUTION OF INCOMPATIBILITY-INDUCING MICROBES IN SUBDIVIDED HOST POPULATIONSEVOLUTION, Issue 2 2009Ralph Haygood Many insects, other arthropods, and nematodes harbor maternally inherited bacteria inducing "cytoplasmic incompatibility" (CI), reduced egg hatch when infected males mate with uninfected females. Although CI drives the spread of these microbes, selection on alternative, mutually compatible strains in panmictic host populations does not act directly on CI intensity but favors higher "effective fecundity," the number of infected progeny an infected female produces. We analyze the consequences of host population subdivision using deterministic and stochastic models. In subdivided populations, effective fecundity remains the primary target of selection. For strains of equal effective fecundity, if population density is regulated locally (i.e., "soft selection"), variation among patches in infection frequencies may induce change in the relative frequencies of the strains. However, whether this change favors stronger incompatibility depends on initial frequencies. Demographic fluctuations maintain frequency variation that tends to favor stronger incompatibility. However, this effect is weak; even with small patches, minute increases in effective fecundity can offset substantial decreases in CI intensity. These results are insensitive to many details of host life cycle and migration and to systematic outbreeding or inbreeding within patches. Selection acting through transfer between host species may be required to explain the prevalence of CI. [source] A CASE FOR REFORM OF THE CHILD WELFARE SYSTEMFAMILY COURT REVIEW, Issue 4 2007Miriam Aroni Krinsky There are more than half a million children in our nation's foster care system. While foster care is intended to provide a temporary safe harbor for abused and neglected children, too many of these youth spend years in foster care limbo,experiencing a turbulent life in motion as they move from placement to placement, community to community, and school to school. Youth in foster care commonly fail to receive basic health and psychological care, and nearly 20,000 youth age out of foster care every year to an adult path of homelessness, unemployment, and despair. Our entire community must work together to more responsibly parent these youth. This article will address how lawyers and child advocates can advocate for new approaches and enhanced support on behalf of the voiceless and most vulnerable members of our community. It will address existing hurdles and systemic challenges that have helped to create the current disheartening status quo. The article will then discuss strategies that advocates can employ to turn the corner on behalf of these youth at risk. [source] Physicochemical properties and distinct DNA binding capacity of the repressor of temperate Staphylococcus aureus phage ,11FEBS JOURNAL, Issue 7 2009Tridib Ganguly The repressor protein and cognate operator DNA of any temperate Staphylococcus aureus phage have not been investigated in depth, despite having the potential to enrich the molecular biology of the staphylococcal system. In the present study, using the extremely pure repressor of temperate Staphylococcus aureus phage ,11 (CI), we demonstrate that CI is composed of ,-helix and ,-sheet to a substantial extent at room temperature, possesses two domains, unfolds at temperatures above 39 °C and binds to two sites in the ,11 cI - cro intergenic region with variable affinity. The above CI binding sites harbor two homologous 15 bp inverted repeats (O1 and O2), which are spaced 18 bp apart. Several guanine bases located in and around O1 and O2 demonstrate interaction with CI, indicating that these 15 bp sites are used as operators for repressor binding. CI interacted with O1 and O2 in a cooperative manner and was found to bind to operator DNA as a homodimer. Interestingly, CI did not show appreciable binding to another homologous 15 bp site (O3) that was located in the same primary immunity region as O1 and O2. Taken together, these results suggest that ,11 CI and the ,11 CI,operator complex resemble significantly those of the lambdoid phages at the structural level. The mode of action of ,11 CI, however, may be distinct from that of the repressor proteins of , and related phages. [source] Survival rate, abundance, and residency of long-finned pilot whales in the Strait of GibraltarMARINE MAMMAL SCIENCE, Issue 3 2009P. Verborgh Abstract Long-finned pilot whales in the Strait of Gibraltar are distributed over the main shipping routes. This exposes them to risks of collisions and probable acoustic and physical disturbance. This species is also the target of whale-watching operations. The aim of this study was to estimate the annual population size, survival rate, and population growth rate of pilot whales occurring in the Strait and their inter-annual variation using photo-identification. A robust design was used to estimate all three parameters. A total of 10,784 individual pilot whale fins were photographed and analyzed. The population size estimation in summer ranged from a low of 147 individuals in 1999 to a high of 265 individuals in 2003. The annual population growth rate was estimated from mark recapture models to be 5.5%. The survival rate of adults was estimated at 0.982 (95% CI: 0.955,0.993). The same individuals have been observed between years. This suggests that this population is resident in the Strait, at least during summer. This study provides baseline knowledge prior to a predicted increase in shipping traffic throughout the main foraging area due to the opening in 2007 of a major shipping harbor along the Moroccan coast of the Strait. [source] HAUL-OUT SELECTION BY PACIFIC HARBOR SEALS (PHOCA VITULINA RICHARDII): ISOLATION AND PERCEIVED PREDATION RISKMARINE MAMMAL SCIENCE, Issue 1 2002Chad A. Nordstrom Abstract The potential for non-aquatic predators to influence habitat use by harbor seals (Phoca vitulina) in a nearshore marine environment was studied by examining haul-out site use and through an experimental approach. Distance from shore, distance to possible foraging depths, peripheral water depth, and haul-out areas were quantified for each haul-out. There was a positive relationship between the number of seals hauled out and the distance from shore for eight known haul-out sites. The hypothesis that harbor seals increasingly hauled out farther offshore to reduce predation risk was tested experimentally by measuring their response to a model of a potential terrestrial predator in comparison to a control object, and to disturbance by a human at one of the study sites. Harbor seals abandoned the haul-out in the presence of the predator model, but showed little response to the controls, suggesting they possess a threat image for terrestrial predators and avoid hauling out when it is perceived. These results support the hypothesis that harbor seals select isolated sites to reduce exposure to terrestrial carnivores. [source] How an investigator resolved the Vasa warship disasterALTERNATIVES TO THE HIGH COST OF LITIGATION, Issue 10 2006David Bristow David Bristow, Q.C., of Toronto, provides a current practice lesson by detailing an old story of how a creative mediator diffused the effects of a national tragedy, the sinking of the Vasa in Stockholm's harbor in 1628 [source] Fish consumption and body burden of organochlorines among lower hudson urban anglersAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 8 2008Kimberly Morland PhD Abstract Background Polychlorinated biphenyls and other organochlorines have contaminated the Hudson River and New York/New Jersey Harbor for many decades. Although body burdens and health effects resulting from exposure to these pollutants have been measured in other populations, little is known about anglers from the lower Hudson area. Methods Anglers were recruited from fishing clubs and along piers on the lower Hudson River. One hundred twenty-five participants provided blood samples and questionnaire information. Serum was analyzed at Mount Sinai School of Medicine for organochlorines. Results Mean concentration of total PCB congeners was 4.78 µg/L. A non-significant adjusted mean difference of ,0.59 µg/L was observed between local fish eaters and non-eaters with higher levels among the non-eaters. Similar negative, but non-significant associations were observed for p,p'-DDT, HCB, and ,-BHC. For pp'-DDE, and several chlordane residues, levels were higher among anglers reporting local fish consumption, but the difference was statistically significant only for TN. Conclusions These findings suggest eating fish from the lower Hudson River and NY/NJ harbor is not associated with an increased body burden of PCBs or most other organochlorines. Am. J. Ind. Med. 51:587,594, 2008. © 2008 Wiley-Liss, Inc. [source] The Specialized Religions of Ancient Mediterranean SeafarersRELIGION COMPASS (ELECTRONIC), Issue 4 2008Aaron J. Brody Ancient seafarers faced dangers and fears posed by the sea and sailing. Specialized religious beliefs and practices developed accordingly. Sailors honored deities whose attributes could benefit or devastate a voyage. Divine patrons were worshipped in harbor and at promontory shrines. Ships were considered imbued with a protective spirit and contained sacred spaces. Mariners performed religious ceremonies on land and at sea to protect their voyages. Specialized features are found in funerary practices and mortuary rituals of seafarers. Maritime religions were subsets of ancient religions, generated by unique uncertainties and perils at sea. [source] ,United We Stand': American Attitudes toward (Muslim) Immigration Post-September 11thTHE MUSLIM WORLD, Issue 1-2 2002Kathleen M. Moore Listen here, professor. You're the one that needs an American history lesson! You don't know nothing about Lady Liberty standing there in the harbor with her torch on high, saying ,Give me your poor, your dead-beats, your filthy.' -Archie Bunker All in the Family [source] Molecular cloning and sequence analysis of an ascidian egg ,-N-acetylhexosaminidase with a potential role in fertilizationDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 3 2003Ryo Koyanagi ,-N-Acetylhexosaminidase, which is found almost ubiquitously in sperm of invertebrates and vertebrates, supposedly mediates a carbohydrate-based transient sperm,egg coat binding. In ascidians and mammals, ,-hexosaminidase released at fertilization from eggs has been proposed to modify sperm receptor glycoproteins of the egg envelope, thus setting up a block to polyspermy. Previously, it was shown that in potential sperm receptor glycoproteins of the ascidian Phallusia mammillata, N-acetylglucosamine is the prevailing glycoside residue and that the egg harbors three active molecular forms of ,-hexosaminidase. In the present study, P. mammillata,-hexosaminidase cDNA was isolated from an ovarian cDNA library and characterized. The deduced amino acid sequence showed a high similarity with other known ,-hexosaminidases; however, P. mammillata,-hexosaminidase had a unique potential N-glycosylation site. A phylogenetic analysis suggested that P. mammillata,-hexosaminidase developed independently after having branched off from the common ancestor gene of the chordate enzyme before two isoforms of the mammalian enzyme appeared. In situ hybridization revealed stage-specific expression of ,-hexosaminidase mRNA during oogenesis in the oocyte and in the accessory test and follicle cells. This suggests that the three egg ,-hexosaminidase forms are specific for the oocyte, test cells and follicle cells. [source] | ||||||||||||||||||||||||||||||||||||||||