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Half

Distribution by Scientific Domains
Medical Sciences46%
Life Sciences18%
Humanities and Social Sciences7%
Chemistry6%
Earth and Environmental Science5%
Psychology4%
Business, Economics, Finance and Accounting4%
7 Other Domains10%

Kinds of Half

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    • Terms modified by Half

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  • half space
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    • Selected Abstracts

    HALF A CENTURY OF CROPLAND CHANGE,

    GEOGRAPHICAL REVIEW, Issue 3 2001
    JOHN FRASER HART
    ABSTRACT. The census concept of total cropland is a better measure of effective agricultural land than is total farmland, which includes extensive areas of woodland owned by farmers. The cropland area of the United States dropped from 478 million acres in 1949 to 431 million acres in 1997, for a net loss of less than 1 million acres, or roughly one-fifth of 1 percent, per year. In the midwestern agricultural heartland most counties changed less than 5 percent in the half-century, and more counties gained than lost. The West was a crazy quilt of change, and in the East most counties lost more than 10 percent. Major metropolitan counties lost a few percentage points more than did adjacent areas, but at a lower rate per capita than the nation as a whole. Most of the loss of cropland was in marginal agricultural counties with soils of low inherent fertility and topography unsuited to modern farm machinery. The loss of cropland to suburban encroachment may be cause for intense local concern, but attempts to thwart development cannot be justified on grounds of a net national loss of good cropland. [source]

    A GIFT HALF UNDERSTOOD: REDISCOVERING AN INCARNATIONAL VIEW OF POLITICAL AUTHORITY

    THE HEYTHROP JOURNAL, Issue 4 2010
    DAVID HENRECKSON
    First page of article [source]

    Pitfalls in the Diagnosis of Cerebellar Infarction

    ACADEMIC EMERGENCY MEDICINE, Issue 1 2007
    Sean I. Savitz MD
    Abstract Background Cerebellar infarctions are an important cause of neurologic disease. Failure to recognize and rapidly diagnose cerebellar infarction may lead to serious morbidity and mortality due to hydrocephalus and brain stem infarction. Objectives To identify sources of preventable medical errors, the authors obtained pilot data on cerebellar ischemic strokes that were initially misdiagnosed in the emergency department. Methods Fifteen cases of misdiagnosed cerebellar infarctions were collected, all seen, or reviewed by the authors during a five-year period. For each patient, they report the presenting symptoms, the findings on neurologic examination performed in the emergency department, specific areas of the examination not performed or documented, diagnostic testing, the follow-up course after misdiagnosis, and outcome. The different types of errors leading to misdiagnosis are categorized. Results Half of the patients were younger than 50 years and presented with headache and dizziness. All patients had either incomplete or poorly documented neurologic examinations. Almost all patients had a computed tomographic scan of the head interpreted as normal, and most of these patients underwent subsequent magnetic resonance imaging showing cerebellar infarction. The initial incorrect diagnoses included migraine, toxic encephalopathy, gastritis, meningitis, myocardial infarction, and polyneuropathy. The overall mortality in this patient cohort was 40%. Among the survivors, about 50% had disabling deficits. Pitfalls leading to misdiagnosis involved the clinical evaluation, diagnostic testing, and establishing a diagnosis and disposition. Conclusions This study demonstrates how the diagnosis of cerebellar infarction can be missed or delayed in patients presenting to the emergency department. [source]

    FC02.4 Meteorological factors and standard series patch test reactions

    CONTACT DERMATITIS, Issue 3 2004
    Janice Hegewald
    The existence of seasonal patterns to patch test reactions has been described, but with conflicting causal interpretations. The potential seasonality of patch tests may be due to irritation, changes to skin barrier or changes to immunological functions caused by meteorological fluctuations. For example, increased skin irritability due to cold winter weather and low humidity may cause an increase in irritative/doubtful and weak positive (false positive) reactions. To investigate the extent of the association between weather and patch test results, consecutive patients (N = 73691) patch tested with the standard series of the German Contact Dermatitis Research Group (DKG) at German or Austrian IVDK (http://www.ivdk.de) centres were matched with weather data collected at a nearby (30 km radius) weather station. Temperature and absolute humidity (AH) on the day of patch test application and the two preceding days were averaged to represent the environment most likely to have influenced the skin condition at the time of testing. The results of 24 standard series substances were analyzed with multivariate logistic regression. Half of the standard series substances examined, including fragrance mix, nickel sulphate, and formaldehyde, exhibited evidence of a relationship with meteorological conditions. Fragrance mix and p-Phenylene diamine exhibited the strongest evidence of an association to weather, with the odds of the reactions in all three reaction categories (ir/?, +, ++/+++) increasing during winter conditions. Due to the association between weather and patch test reactivity, the potential effect of meteorological conditions should be considered in the interpretation of patch test reactions. [source]

    Are psychiatrists affecting the legal process by answering legal questions?

    CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2008
    Timothy Hardie
    Background,Psychiatrists are often asked to answer legal questions. The extent to which they answer strictly legal rather than medical matters is not known. Aim,To investigate how strongly psychiatrists in England and Wales express opinions on one legal question , that of diminished responsibility in respect of a murder charge, and how this is related to outcome in court. Method,Our data were extracted from psychiatric reports and case files supplied by the then Department of Constitutional Affairs (now the Ministry of Justice) on cases heard in the Crown Courts between 1 January 1997 and 31 December 2001 in which the defence of diminished responsibility had been raised. The cases had been selected by the Law Commission in their earlier review of partial defences to murder. We devised a reliable system of rating the presence/absence and strength of expression of a legal opinion in the medical reports. We tested the data for relationship between nature and strength of opinion and progression to trial and verdict. Results,Psychiatric reports were available on 143 of 156 cases in which diminished responsibility was considered. They yielded 338 opinions on at least one aspect of diminished responsibility. In 110 (93%) of the 118 cases in which there was a diminished verdict, this was made without trial and, therefore, without reference to a jury. In only eight (27%) out of the 30 cases that went to trial, was a diminished responsibility verdict made. Half of the reports (169) gave a clear opinion on diminished responsibility, a third (121) invited the court to draw a particular conclusion and only 11% (36) provided relevant evidence without answering the legal questions. When there was an opinion or an invitation to make a finding on the legal question, a trial was less likely. A trial was also less likely if reports agreed on what the verdict should be. Conclusions,Psychiatrists frequently answer the legal question of diminished responsibility. The judiciary and medical experts should join in research to examine the consequences of different styles or approaches in presentation of essentially similar evidence in court. Copyright © 2008 John Wiley & Sons, Ltd. [source]

    Impact of assertive community treatment and client characteristics on criminal justice outcomes in dual disorder homeless individuals

    CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 4 2005
    Dr Robert J. Calsyn PhD
    Background People with severe mental illness and substance use disorders (dual disorder) often have considerable contact with the criminal justice system. Aims To test the effects of client characteristics on six criminal justice outcomes among homeless (at intake) people with mental illness and substance misuse disorders. Methods The sample was of participants in a randomized controlled trial comparing standard treatment, assertive community treatment (ACT) and integrated treatment (IT). Data were analysed using hierarchical logistic regression. Results Half the sample was arrested and a quarter incarcerated during the two-year follow-up period. The regression models explained between 22% and 35% of the variance of the following criminal justice measures: (1) major offences, (2) minor offences, (3) substance-use-related offences, (4) incarcerations, (5) arrests, and (6) summons. Prior criminal behaviour was the strongest predictor of all of the dependent variables; in general, demographic and diagnostic variables were not. Similarly, neither the type nor the amount of mental health treatment received predicted subsequent criminal behaviour. Conclusion Elsewhere the authors have shown that ACT and IT had advantages for health and stability of accommodation but these analyses suggest that more specialized interventions are needed to reduce criminal behaviour in dual disorder individuals. Copyright © 2005 John Wiley & Sons, Ltd. [source]

    Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure

    ACTA PHYSIOLOGICA, Issue 4 2007
    M. Torp
    Abstract Introduction:, Vasopressin (AVP) stimulates sodium reabsorption and Na,K,2Cl-cotransporter (NKCC2) protein level in the thick ascending limb (TAL) of Henle's loop in rats. Rats with congestive heart failure (CHF) have increased protein level of NKCC2, which can be normalized by angiotensin II receptor type-1 (AT1) blockade with losartan. Aim:, In this study, we investigated whether CHF rats displayed changes in AVP stimulated cAMP formation in the TAL and examined the role of AT1 receptor blockade on this system. Method:, CHF was induced by ligation of the left anterior descending coronary artery (LAD). SHAM-operated rats were used as controls. Half of the rats were treated with losartan (10 mg kg day,1 i.p.). Results:, CHF rats were characterized by increased left ventricular end diastolic pressure. Measurement of cAMP in isolated outer medullary TAL showed that both basal and AVP (10,6 m) stimulated cAMP levels were significantly increased in CHF rats (25.52 ± 4.49 pmol cAMP ,g,1 protein, P < 0.05) compared to Sham rats (8.13 ± 1.14 pmol cAMP ,g,1 protein), P < 0.05). Losartan significantly reduced the basal level of cAMP in CHF rats (CHF: 12.56 ± 1.93 fmol ,g,1 protein vs. Los-CHF: 7.49 ± 1.08, P < 0.05), but not in Sham rats (SHAM: 4.66 ± 0.59 vs. Los-SHAM: 4.75 ± 0.71). AVP-mediated cAMP accumulation was absent in both groups treated with losartan (Los-SHAM: 4.75 ± 0.71 and Los-CHF: 7.49 ± 1.08). Conclusion:, The results indicate that the increased NKCC2 protein level in the mTAL from CHF rats is associated with increased cAMP accumulation in this segment. Furthermore, the finding that AT1 receptor blockade prevents AVP-mediated cAMP accumulation in both SHAM and CHF rats suggests an interaction between angiotensin II and AVP in regulation of mTAL Na reabsorption. [source]

    The Effect of Full-Face Broadband Light Treatments Alone and in Combination With Bilateral Crow's Feet Botulinum Toxin Type A Chemodenervation

    DERMATOLOGIC SURGERY, Issue 3 2004
    Jean Carruthers MD
    Background. Broadband light (BBL; Intense Pulsed Light; Lumenis Ltd., Yokneam, Israel) is a powerful, nonablative, light-based technology that targets melanin and hemoglobin and stimulates the formation of collagen and elastin. Botulinum toxin type A (BTX-A; BOTOX; Allergan Inc., Irvine, CA) treatment of the lateral periocular region relaxes the vertical fibers of the orbicularis oculi and results in softening of the lateral orbital crow's feet rhytides and widening of the palpebral aperture. Objective. To compare the effects of full-face BBL in combination with BTX-A and BBL alone in female subjects with Fitzpatrick I,III skin types, Glogau II,III rhytides, and significant associated facial lentigines and telangiectasia. Methods. This was a prospective, randomized study of 30 women with moderate to severe crow's feet rhytides. Half of the subjects were treated with BTX-A and BBL and the other half with BBL alone. Their response was assessed clinically and photographically. Skin biopsies of the temporal skin were taken from two subjects in each group and were stained with Masson trichrome. Results. Patients treated with a combination of BTX-A and BBL experienced a better response to treatment, both at rest and on maximum smile, as well as a slightly improved response in associated lentigines, telangiectasia, pore size, and facial skin texture compared with patients who received BBL treatment alone. Skin biopsies showed an increase in dermal collagen in each group. Conclusions. The patients in this study benefited from both treatments. Although BBL led to a remarkable improvement in full-face telangiectasias, lentigines, and skin texture, the improvement increased in all categories with combination therapy. In addition, an added improvement in the full-face aesthetic with both BTX-A and BBL therapy combined was obvious. These results suggest that both treatments,although evidently complementary,may also act synergistically to produce optimal clinical effects, revolutionizing the treatment of facial aging. [source]

    Limited Opportunities for Paramedic Student Endotracheal Intubation Training in the Operating Room

    ACADEMIC EMERGENCY MEDICINE, Issue 10 2006
    Bradford D. Johnston MD
    Abstract Background Paramedics, who often are the first to provide emergency care to critically ill patients, must be proficient in endotracheal intubation (ETI). Training in the controlled operating room (OR) setting is a common method for learning basic ETI technique. Objectives To determine the quantity and nature of OR ETI training currently provided to paramedic students. Methods The authors surveyed directors of paramedic training programs accredited by the Commission on Accreditation of Allied Health Education Programs. An anonymous 12-question, structured, closed-response survey instrument was used that requested information regarding the duration and nature of OR training provided to paramedic students. The results were analyzed by using descriptive statistics. Results From 192 programs, 161 completed surveys were received (response rate, 85%). OR training was used at 156 programs (97%) but generally was limited (median, 17,32 hours per student). Half of the programs provided fewer than 16 OR hours per student. Students attempted a limited number of OR ETI (median, 6,10 ETI). Most respondents (61%) reported competition from other health care students for OR ETI. Other identified hindering factors included the increasing OR use of laryngeal mask airways and physicians' medicolegal concerns. Respondents from 52 (33%) programs reported a recent reduction in OR access, and 56 (36%) programs expected future OR opportunities to decrease. Conclusions Despite its key role in airway management education, the quantity and nature of OR ETI training that is available to paramedic students is limited in comparison to that available to other ETI providers. [source]

    Life expectancy among people with cerebral palsy in Western Australia

    DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 8 2001
    E Blair PhD
    This report describes trends, predictors, and causes of mortality in persons with cerebral palsy (CP)using individuals identified by the Western Australian Cerebral Palsy Register and born between 1958 and 1994. Two thousand and fourteen people were identified (1154 males, 860 females), of whom 225 had died by 1 June 1997. Using date-of-death data, crude and standardized mortality rates were estimated and predictors of mortality sought using survival analysis stratified by decade of birth, description of impairments, and demographic and perinatal variables. For those born after 1967, the cause of death profile was examined over time. Mortality exceeded 1% per annum in the first 5 years and declined to age 15 years after which it remained steady at about 0.35% for the next 20 years. The strongest single predictor was intellectual disability, but all forms of disability contributed to decreased life expectancy. Half of those with IQ/DQ score <20 survived to adulthood, increasing to 76% with IQ/DQ score 20,34, and exceeding 92% for higher scores. Severe motor impairment primarily increased the risk of early mortality. Despite there being 72 persons aged from 25 to 41 years with severe motor impairment in our data set, none had died after the age of 25 years. Infants born after more than 32 weeks'gestation were at significantly higher risk of mortality than very preterm infants, accounted for by their higher rates of intellectual disability. No improvements in survival of persons with CP were seen over the study period despite advances in medical care, improved community awareness, and the increasing proportion of very preterm births among people with CP. This may be the result of improved neonatal care enabling the survival of infants with increasingly severe disabilities. [source]

    Effects of neonatal novelty exposure on sexual behavior, fear, and stress-response in adult rats

    DEVELOPMENTAL PSYCHOBIOLOGY, Issue 3 2007
    Fernando Benetti
    Abstract Environmental stimuli in early life may result in permanent behavioral and physiological changes. Present study evaluated the effects of exposing pups to a novel environment on behaviors (open-field test and sexual behavior) and prolactin stress-responses in adult male rats. Half of a litter was daily removed outside (OUT) from the nest and stimulated by handling for 3 min, while the other half remained inside (IN) the nest and was also handled for the same period during the first 10 days postpartum. Maternal behavior after all the pups were returned to the nest was not different between IN and OUT littermates. In adulthood, OUT males showed increased general and central locomotion activity in the open-field test, reduced sexual behavior, and attenuated prolactin secretion in response to restraint stress compared with the IN littermates. The repeated exposition of rat pups to a novel environment is a causal factor for the long-lasting behavioral and endocrine changes. The premature exposition of the pup to unfamiliar environments decreases fear and stress-response, and also reduces sexual behavior. We suggest that the absence of the odor of the mother may be crucial to explain the effects detected in adulthood. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 258,264, 2007. [source]

    Cardiovascular responses to pacifier experience and feeding in newborn infants

    DEVELOPMENTAL PSYCHOBIOLOGY, Issue 1 2001
    Morris Cohen
    Abstract This study examined the effects of sucking on a pacifier immediately before feeding on cardiovascular responses to feeding. Twenty-eight bottle-feeding infants were studied at 12 to 40 hr of age. Blood pressure and heart rate measurements were made during three periods: Period 1,while infants rested in their cribs before a regularly scheduled feeding, Period 2,while being held by the feeder immediately before feeding, and Period 3,during the first 3 to 5 min of feeding. Half of the infants were given a pacifier during Period 2. Blood pressures and heart rates increased across the periods; however, increases in systolic blood pressure during feeding were reduced for the group of infants given a pacifier prior to feeding. We suggest that cardiovascular responses to feeding in infants are comprised of multiple elements. Most of the systolic blood pressure responses to feeding are elicited by sucking whereas the heart rate response is dependent on both sucking and nutrient intake. © 2001 John Wiley & Sons, Inc. Dev Psychobiol 39: 34,39, 2001 [source]

    Gastroesophageal reflux before and after Helicobacter pylori eradication.

    DISEASES OF THE ESOPHAGUS, Issue 4 2003
    A prospective study using ambulatory 24-h esophageal pH monitoring
    SUMMARY, The aim of this study was to assess prevalence of GERD before and after Helicobacter pylori (HP) eradication utilizing 24-h esophageal pH/manometry studies. Helicobacter pylori status was confirmed by the Campylobacter like organism test. Those testing positive underwent 24-h pH/manometry followed by HP eradication therapy and urea breath test. Patients were followed up at 6 months and then at 1 year when they underwent a repeat 24-h pH/manometry. Twenty patients, 10 with non-ulcer dyspepsia (NUD) and 10 with duodenal ulcer (DU) were enrolled, though only 10 patients attended for a repeat 24-h pH/manometry study. The patients were well matched, though patients with NUD had a significantly higher symptom score at entry compared with the DU group (8.5 vs 5.7, P < 0.05). The pH and esophageal manometry data were similar in the two groups. Overall nine patients (45%; DU = 5, NUD = 4) had evidence of GERD prior to HP eradication and it persisted one year after cure of the infection. The reflux disease occurred in the presence of normal LES pressure (mean 15.6 ± 3.3 mmHg). New onset GERD was uncommon after cure of HP infection, occurring in only one patient with NUD. Overall HP eradication had no impact on percentage of time pH < 4 (4.69 ± 3 vs 4.79 ± 3), episodes > 5 min (9.8 ± 16 vs 15.5 ± 25.3) and Johnson DeMeester Score (16.8 ± 7.5 vs 26.8 ± 18). In addition successful cure of HP produced no significant changes in LES pressure (17.9 ± 3.8 mmHg vs 19.3 ± 4.6 mmHg), and other esophageal manometry data. Half of HP-positive patients with NUD and DU have evidence of GERD before HP eradication. This persists after successful cure of the infection. New onset GERD occurs very uncommonly one year after HP eradication. [source]

    Simulation of the dissolution of weathered versus unweathered limestone in carbonic acid solutions of varying strength

    EARTH SURFACE PROCESSES AND LANDFORMS, Issue 6 2007
    M. J. Thornbush
    Abstract A simulation was undertaken within a climatic chamber to investigate limestone dissolution under varied carbonic acid (H2CO3) strengths as a possible analogue for future increases in atmospheric CO2 arising from global warming. Twenty-eight samples cut from a block of Bath (Box Hill) limestone from Somerville College, Oxford, which had been removed during restoration after 150 years in an urban environment, were weighed and placed in closed bottles of thin plastic containing varying concentrations of H2CO3. Half of the stone samples were derived from exposed surfaces of the stone block (weathered) while the others were obtained from the centre of the block on unexposed surfaces (unweathered). The purpose of this was to compare dissolution of previously weathered versus unweathered surfaces in strong (pH 4·73) versus weak (pH 6·43) solutions of H2CO3. A temperature of c. 19 °C was maintained within the chamber representing a plausible future temperature in Oxford for the year 2200 given current warming scenarios. The simulation lasted 25 days with a few stone samples being removed midway. Stone samples show reduced weight in all cases but one. There was greater dissolution of stone samples in a strong H2CO3 solution as conveyed by higher concentrations of total hardness and Ca2+ in the water samples as well as enhanced microscopic dissolution features identified using SEM. The simulation confirms that enhanced atmospheric CO2 under global warming, given adequate moisture, will accelerate dissolution rates particularly of newly replaced limestone building stones. However, previously weathered surfaces, such as those on historical stone exposed for a century or more, appear to be less susceptible to the effects of such increased rainfall acidity. Conservation techniques which remove weathered surfaces, such as stone cleaning, may accelerate future decay of historical limestone structures by increasing their susceptibility to dissolution. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    Mass regulation in response to predation risk can indicate population declines

    ECOLOGY LETTERS, Issue 10 2007
    Ross MacLeod
    Abstract In theory, survival rates and consequent population status might be predictable from instantaneous behavioural measures of how animals prioritize foraging vs. avoiding predation. We show, for the 30 most common small bird species ringed in the UK, that one quarter respond to higher predation risk as if it is mass-dependent and lose mass. Half respond to predation risk as if it only interrupts their foraging and gain mass thus avoiding consequent increased starvation risk from reduced foraging time. These mass responses to higher predation risk are correlated with population and conservation status both within and between species (and independently of foraging habitat, foraging guild, sociality index and size) over the last 30 years in Britain, with mass loss being associated with declining populations and mass gain with increasing populations. If individuals show an interrupted foraging response to higher predation risk, they are likely to be experiencing a high quality foraging environment that should lead to higher survival. Whereas individuals that show a mass-dependent foraging response are likely to be in lower quality foraging environments, leading to relatively lower survival. [source]

    Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy

    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 3 2003
    Stefania Pacini
    Abstract We evaluated the effects of urban air pollutants on human nasal mucosa over an 8-month period on 102 subjects living in Florence, Tuscany, Italy. A group of subjects living in a city with a lower level of pollution (Sassari, Sardinia, Italy) was also analyzed. Nasal mucosa cells were harvested by brushing, a noninvasive procedure. Half of the cells were used for genotoxicity studies using the alkaline comet assay, and half for morphological studies. The levels of DNA damage in the nasal mucosa were considerably higher (+73%) in the subjects living in Florence than in Sassari. High levels of atmospheric ozone in Florence air correlated with DNA damage, and to the prevalence of inflammatory pathologies of the upper respiratory tract, although the ozone concentrations were below the Italian recommended attention level. Furthermore, higher levels of DNA damage were correlated with a dysfunction in the ability to maintain a normal epithelial cell structure. These data suggest an association between ozone air levels and damage in the upper respiratory tract. It remains unclear whether ozone itself or other associated pollutants are responsible for the observed alterations. Environ. Mol. Mutagen. 42:127,135, 2003. © 2003 Wiley-Liss, Inc. [source]

    Reproduction and metabolism at , 10°C of bacteria isolated from Siberian permafrost

    ENVIRONMENTAL MICROBIOLOGY, Issue 4 2003
    Corien Bakermans
    Summary We report the isolation and properties of several species of bacteria from Siberian permafrost. Half of the isolates were spore-forming bacteria unable to grow or metabolize at subzero temperatures. Other Gram-positive isolates metabolized, but never exhibited any growth at , 10°C. One Gram-negative isolate metabolized and grew at , 10°C, with a measured doubling time of 39 days. Metabolic studies of several isolates suggested that as temperature decreased below + 4°C, the partitioning of energy changes with much more energy being used for cell maintenance as the temperature decreases. In addition, cells grown at , 10°C exhibited major morphological changes at the ultrastructural level. [source]

    Cadmium-regulated gene fusions in Pseudomonas fluorescens

    ENVIRONMENTAL MICROBIOLOGY, Issue 4 2000
    Silvia Rossbach
    To study the mechanisms soil bacteria use to cope with elevated concentrations of heavy metals in the environment, a mutagenesis with the lacZ -based reporter gene transposon Tn5 -B20 was performed. Random gene fusions in the genome of the common soil bacterium Pseudomonas fluorescens strain ATCC 13525 were used to create a bank of 5000 P. fluorescens mutants. This mutant bank was screened for differential gene expression in the presence of the toxic metal cadmium. Fourteen mutants were identified that responded with increased or reduced gene expression to the presence of cadmium. The mutants were characterized with respect to their metal-dependent gene expression and their metal tolerance. Half the identified mutants reacted with differential gene expression specifically to the metal cadmium, whereas some of the other mutants also responded to elevated concentrations of copper and zinc ions. One of the mutants, strain C8, also showed increased gene expression in the presence of the solvent ethanol, but otherwise no overlap between cadmium-induced gene expression and general stress response was detected. Molecular analysis of the corresponding genetic loci was performed using arbitrary polymerase chain reaction (PCR), DNA sequencing and comparison of the deduced protein products with sequences deposited in genetic databases. Some of the genetic loci targeted by the transposon did not show any similarities to any known genes; thus, they may represent ,novel' loci. The hypothesis that genes that are differentially expressed in the presence of heavy metals play a role in metal tolerance was verified for one of the mutants. This mutant, strain C11, was hypersensitive to cadmium and zinc ions. In mutant C11, the transposon had inserted into a genetic region displaying similarity to genes encoding the sensor/regulator protein pairs of two-component systems that regulate gene expression in metal-resistant bacteria, including czcRS of Ralstonia eutropha, czrRS of Pseudomonas aeruginosa and copRS of Pseudomonas syringae. Although the P. fluorescens strain used in this study had not been isolated from a metal-rich environment, it nevertheless contained at least one genetic region enabling it to cope with elevated concentrations of heavy metals. [source]

    Prevalence of HIV, hepatitis C and syphilis among injecting drug users in Russia: a multi-city study

    ADDICTION, Issue 2 2006
    Tim Rhodes
    ABSTRACT Objectives To estimate the prevalence of HIV, hepatitis C virus (HCV) and syphilis in injecting drug users (IDUs) in Russia. Methods Unlinked anonymous cross-sectional survey of 1473 IDUs recruited from non-treatment settings in Moscow, Volgograd and Barnaul (Siberia), with oral fluid sample collection for HIV, HCV antibody (anti-HIV, anti-HCV) and syphilis testing. Results Prevalence of antibody to HIV was 14% in Moscow, 3% in Volgograd and 9% in Barnaul. HCV prevalence was 67% in Moscow, 70% in Volgograd and 54% in Barnaul. Prevalence of positive syphilis serology was 8% in Moscow, 20% in Volgograd and 6% in Barnaul. Half of those HIV positive and a third of those HCV positive were unaware of their positive status. Common risk factors associated with HIV and HCV infection across the cities included both direct and indirect sharing of injecting equipment and injection of home-produced drugs. Among environmental risk factors, we found increased odds of anti-HIV associated with being in prison in Moscow, and some association between official registration as a drug user and anti-HIV and anti-HCV. No associations were found between sexual risk behaviours and anti-HIV in any city. Conclusions HIV prevalence among IDUs was markedly higher than city routine surveillance data suggests and at potentially critical levels in terms of HIV prevention in two cities. HCV prevalence was high in all cities. Syphilis prevalence highlights the potential for sexual risk and sexual HIV transmission. Despite large-scale testing programmes, knowledge of positive status was poor. The scaling-up of harm reduction for IDUs in Russia, including sexual risk reduction, is an urgent priority. [source]

    Metacognition in patients with anorexia nervosa, dieting and non-dieting women: a preliminary study

    EUROPEAN EATING DISORDERS REVIEW, Issue 1 2008
    Rachel A. Woolrich
    Abstract Objective To explore metacognition in women with anorexia nervosa (AN), dieting and non-dieting women. Method A cross-sectional study between groups design compared women with AN (n,=,15), normal dieters (n,=,17) and non-dieters (n,=,18). A semi-structured interview was used to explore presence and content of explicit metacognitions and use of metacognitive control strategies. Results Explicit metacognitions and metacognitive control strategies were present in all three groups of women. There were group differences in amount and function of metacognitive activity and trends in the qualitative data suggested participants with AN believed that their thoughts were abnormal and uncontrollable. They used six metacognitive strategies more than control groups and were less successful at using thought re-appraisal and attending to body and others. Half of participants with AN reported using these strategies to deliberately make themselves feel worse. Discussion It is suggested that metacognitive activity may play a role in the maintenance of AN, particularly in reinforcing negative self-evaluations. Copyright © 2007 John Wiley & Sons, Ltd and Eating Disorders Association. [source]

    Patient-orientated web sites on laryngectomy: is their information readable?

    EUROPEAN JOURNAL OF CANCER CARE, Issue 6 2009
    L. POTHIER m, language therapist , macmillan, speech
    POTHIER L. & POTHIER D.D. (2009) European Journal of Cancer Care Patient-orientated web sites on laryngectomy: is their information readable? The objective of the study was to determine levels of readability of commonly accessed websites containing patient information on laryngectomy. A Cross-sectional study of Internet websites was designed. The first 20 websites obtained from a Google® search of the word "laryngectomy" that contained a patient information section were selected. Primary outcome measures were the Flesch Readability Ease Score (FRE) and Flesch-Kincaid readability grade (FKRG) score; from these data UK reading age was calculated. The secondary outcome measure was whether or not a site was accredited by an online readability organisation. The reading ages of the 20 sites ranged from 7.8 to 14.7 years with a median of 11.7 years. Half of the Flesch Reading Ease scores were in the "Difficult" or "Fairly difficult" category with 30% falling into the "Standard" or "Fairly easy" categories. Only 20% sites fell into the "Easy" or "Very Easy" categories that are the recommended level for comprehension by the general UK population. Sites not accredited by an online healthcare quality and content control organisation had worse readability scores than those that were not (FRE: p = 0.007, FKRG: p = 0.012). The poor readability of many of the encountered sites about laryngectomy on the Internet may confuse patients who turn to the Internet for information. Methods to improve patient information websites are discussed. [source]

    Evolution of Academic Emergency Medicine over a Decade (1991-2001)

    ACADEMIC EMERGENCY MEDICINE, Issue 10 2002
    E. John Gallagher MD
    Abstract Objective: To test the hypothesis that emergency medicine (EM) has made significant, quantifiable progress within U.S. academic medicine over the past ten years, 1991-2001. Methods: Baseline (7/1/1991) and comparison (7/1/2001) data sets contained all Liaison Committee on Medical Education (LCME)-accredited schools, Association of Academic Chairs of Emergency Medicine (AACEM)-recognized academic departments of EM, Residency Review Committee (RRC)-accredited EM residencies, and Association of American Medical Colleges (AAMC)-designated academic medical centers. The increase over ten years in the two primary variables of academic departmental status, and EM residencies located at academic medical centers, was examined in the aggregate, then stratified by medical schools grouped by academic rank. Differences over time are expressed as simple proportions, bounded by 95% confidence intervals (95% CIs). Results: Between 1991 and 2001, the proportion of academic departments of EM at medical schools increased from 18% to 48% (95% CI for difference of 30%= 19% to 41%). The proportion of EM residencies at academic medical centers increased from 42% to 66% (95% CI for a difference of 24%= 11% to 36%). The largest increment of 37% (95% CI = 22% to 52%) in academic departments of EM, and of 36% (95% CI = 20% to 52%) in EM residencies located at academic medical centers, occurred within medical schools whose academic rank was above the median. Conclusions: A quantitatively and statistically significant increase in academic departments of EM within medical schools and EM residency programs at academic medical centers has occurred over the past decade. Half of all medical schools now have academic departments of EM, and two-thirds of academic medical centers house EM residency programs. This has taken place largely within institutions whose academic ranking places them among the top half of all U.S. medical schools. [source]

    Fc,RIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease

    EUROPEAN JOURNAL OF IMMUNOLOGY, Issue 4 2003
    Kaori Yajima
    Abstract MRL.Faslpr/lpr mice, a model for systemic lupus erythematosus (SLE) and arthritis in humans, have a Fas mutation that results in spontaneous development of systemic autoimmune diseases and a short life span. Half of them die by 5,6,months of age due to massive progression of systemic autoimmune diseases, such as lupus nephritis. However, C57BL/6 (B6).Faslpr/lpr strain does not develop such disorders within the normal life span, indicating that suppressor gene(s) in B6 mice may control the onset and exacerbation of disease. Here, we show that the gene for a unique inhibitory Fc receptor for IgG (Fc,RIIB) is a critical SLE suppressor. Fc,RIIB-deficient B6.Faslpr/lpr (B6.IIB,/,Faslpr/lpr) mice developed systemic autoimmune diseases, including anti-DNA and anti-type,II collagen autoantibodies and cryoglobulin production, immune complex glomerulonephritis and arthritis. They were short-lived, due to enhanced autoantibody production by B cells culminating in fatal lupus nephritis. Thus, Fc,RIIB deletion with Fas mutation is sufficient for the development of systemic autoimmunity in B6 mice. The inhibitory signaling cascade via Fc,RIIB may be critical for suppressing SLE in humans. [source]

    Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosis

    EUROPEAN JOURNAL OF NEUROLOGY, Issue 1 2010
    M. Witgert
    Background:, Cognitive impairment secondary to frontal lobe atrophy exists in 40,60% of Amyotrophic Lateral Sclerosis (ALS) cases. We aimed to determine the prevalence of frontal-lobe mediated behavioral impairment in (ALS) and to ascertain its relationship to cognitive impairment. Methods:, Two-hundred and twenty five patients diagnosed with sporadic ALS were evaluated for behavioral dysfunction using the Frontal Systems Behavior Scale (FrSBe), a validated measure used to examine frontal-lobe mediated behaviors, specifically apathy, executive dysfunction and disinhibition; a total behavior score is also provided. Additionally, a subset of patients also underwent a comprehensive neuropsychological evaluation. Results:, Changes in the total FrSBe scores were observed in 24.4% of the patients and 39.6% of the patients had impairment in at least one behavioral domain with symptoms of Apathy being the most common (31.1%). Cognitively impaired ALS patients had worse total (P = 0.05) and apathy scores (P < 0.01); however, behavioral dysfunction was also present in 16% of the cognitively intact patients. Half of the behaviorally intact patients exhibited cognitive impairment. Significant correlations were observed for performance on certain neuropsychological tests (Animal fluency, Block Design, Logical Memory I and Verbal Series Attention Test) and severity of behavioral dysfunction on certain FrSBe sub scores. Conclusions:, Frontal-lobe mediated behavioral dysfunction appears to be common in ALS. Cognitively impaired ALS patients had greater behavioral dysfunction. Recognition of behavioral and cognitive dysfunction may assist health-care providers and care-givers recognize changes in decision-making capacity and treatment compliance of patients with ALS. [source]

    Nigrostriatal lesion induces D2-modulated phase-locked activity in the basal ganglia of rats

    EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 7 2007
    Camila L. Zold
    Abstract There is a debate as to what modifications of neuronal activity underlie the clinical manifestations of Parkinson's disease and the efficacy of antiparkinsonian pharmacotherapy. Previous studies suggest that release of GABAergic striatopallidal neurons from D2 receptor-mediated inhibition allows spreading of cortical rhythms to the globus pallidus (GP) in rats with 6-hydroxydopamine-induced nigrostriatal lesions. Here this abnormal spreading was thoroughly investigated. In control urethane-anaesthetized rats most GP neurons were excited during the active part of cortical slow waves (,direct-phase' neurons). Two neuronal populations having opposite phase relationships with cortical and striatal activity coexisted in the GP of 6-hydroxydopamine-lesioned rats. ,Inverse-phase' GP units exhibited reduced firing coupled to striatal activation during slow waves, suggesting that this GP oscillation was driven by striatopallidal hyperactivity. Half of the pallidonigral neurons identified by antidromic stimulation exhibited inverse-phase activity. Therefore, spreading of inverse-phase oscillations through pallidonigral axons might contribute to the abnormal direct-phase cortical entrainment of basal ganglia output described previously. Systemic administration of the D2 agonist quinpirole to 6-hydroxydopamine-lesioned rats reduced GP inverse-phase coupling with slow waves, and this effect was reversed by the D2 antagonist eticlopride. Because striatopallidal hyperactivity was only slightly reduced by quinpirole, other mechanisms might have contributed to the effect of quinpirole on GP oscillations. These results suggest that antiparkinsonian efficacy may rely on other actions of D2 agonists on basal ganglia activity. However, abnormal slow rhythms may promote enduring changes in functional connectivity along the striatopallidal axis, contributing to D2 agonist-resistant clinical signs of parkinsonism. [source]

    Long-lasting hippocampal potentiation and contextual memory consolidation

    EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 12 2001
    Benedetto Sacchetti
    Abstract In order to ascertain whether there are hippocampal electrophysiological modifications specifically related to memory, exploratory activity and emotional stress, extracellular electrical activity was recorded in hippocampal slices prepared from the brains of male adult rats. Several groups of animals were employed: (i) rats which had freely explored the experimental apparatus (8 min exposure); (ii) rats which had been subjected, in the same apparatus, to a fear conditioning paradigm training entailing the administration of aversive electrical footshocks (8 min exposure); (iii) rats to which the same number of aversive shocks had been administered in the same apparatus, but temporally compressed so as to make difficult the association between painful stimuli and the apparatus (30 s exposure); (iv) naïve rats never placed in the apparatus. Half of the rats from each treatment group were used for retrieval testing and the other half for hippocampal excitability testing. The conditioned freezing response was exhibited for no less than 4 weeks. Hippocampal excitability was measured by means of input,output curves (IOC) and paired-pulse facilitation curves (PPF). Retrieval testing or brain slices preparation were performed at increasing delays after the training sessions: immediately afterwards or after 1, 7 or 28 days. Only the rats subjected to the fear conditioning training exhibited freezing when placed again in the apparatus (retrieval testing). It was found that IOCs, with respect to naïve rats, increased in the conditioned animals up to the 7-day delay. In free exploration animals the IOCs increased only immediately after the training session. In all other rats no modification of the curves was observed. IOC increases do not appear to imply presynaptic transmitter release modifications, because they were not accompanied by PPF modifications. In conclusion, a clear-cut correlation was found between the increase in excitability of the Schaffer collateral,CA1 dendrite synapses and freezing response consolidation. [source]

    Output of the Spanish Cortes (1979,2000): A case of adaptation to party government

    EUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 4 2006
    MANUEL SANCHEZ DE DIOS
    It mainly examines the output of the lower chamber due to the asymmetrical bicameralism and weak status of the Senate. In Spain, the legislative output has been dependent on different situations of party government. In general terms, the Cortes have been always very active in controlling the executive and its participation in law-making was highly relevant when there was a minority government. Because parties are central actors in parliament and due to the strong party discipline in the Spanish case, the author mainly studied parliament output from the viewpoint of strategies of opposition parties. Sometimes parties behaved in parliament procedures in a competitive way, while in others they behave cooperatively. There was a great variety of patterns of strategic behaviour on account of the different situations of party government and the diverse opposition parties. Half of the parliaments had minority governments in which minority parties played a very important role by supporting the government in parliament; however, the main opposition party was never the same since there were two changes of government. [source]

    Overcoming ego depletion: the influence of exemplar priming on self-control performance

    EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 2 2007
    Carolien Martijn
    Self-regulation research suggested that active self-control depends on a limited resource. Therefore the capacity for self-control is lower among people who already exercised control, a phenomenon labelled as ego depletion. This experiment examines whether priming of a persistent person exemplar may help to overcome ego depletion. Half of the participants engaged in a demanding self-control task (solving extremely difficult labyrinths) whereas the other half took part in a task that demanded little self-control (solving easy labyrinths). Then, half of the participants received a person exemplar prime related to persistence; the other half received a neutral prime. Finally, participants' persistence on a subsequent self-control task (squeezing a handgrip) was measured. The effect of a person exemplar prime on a subsequent self-control task depended on initial self-control demands. Participants who exercised high initial self-control and were then presented with a persistent exemplar prime showed assimilation. Their handgrip persistence was higher than the persistence of participants who received a neutral prime. Under conditions of low initial self-control the opposite pattern was found. A persistent person prime resulted in contrast and resulted in lower handgrip performance as compared to those who received a neutral prime. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    Picture this: emotional and political responses to photographs of the Kenneth Bigley kidnapping,

    EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 5 2006
    Aarti Iyer
    The use of photographs to augment media reports of kidnapping victims in Iraq has sparked debates over the effects of such images on the public and, ultimately, the politics surrounding the event. We considered the effects of such images in a sample of British university students during the 2004 kidnapping of British citizen Kenneth Bigley. Drawing on emotions theory, we examined the effects of graphic images on emotional reactions and attitudes towards negotiations. Half of the participants were exposed to photographs of the victim that had recently been published in a national newspaper. The other half were not shown any images. As predicted, the photographs increased fear reactions amongst participants compared to no photograph controls. Fear and sympathy, but not anger, predicted attitudes towards negotiation. The photographs used in this study thus indirectly increased participants' support for negotiating with and submitting to the demands of the captors. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    The anxiety buffering function of close relationships: mortality salience effects on the readiness to compromise mate selection standards

    EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 5 2002
    Gilad Hirschberger
    This research examines the utility of a terror management approach to understanding the motivations and emotional consequences of compromise in mate selection. One hundred and sixty-eight undergraduates completed a self-esteem scale and a scale tapping ideal mate characteristics, and were then assigned either to a mortality salience, physical pain salience, or neutral condition. Half of the participants rated their readiness to compromise ideal mate standards and the remaining half completed a neutral scale. Then, participants completed a scale tapping their emotional state. Mortality salience led participants to significantly compromise their mate requirements. This effect seemed to be most pronounced among high self-esteem participants who also experienced the greatest amount of guilt when compromising under mortality salient conditions. Low self-esteem participants who compromised under mortality salient conditions reacted with higher levels of shame. The results are discussed in terms of the anxiety buffering functions of close relationships. Copyright © 2002 John Wiley & Sons, Ltd. [source]