			Home About us Contact

HCl Titration (hcl + titration)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Clinical and laboratory studies of the antacid and raft-forming properties of Rennie alginate suspension

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 6 2006
G. N. TYTGAT
Summary Background Acid pockets at the gastro-oesophageal junction escape buffering from meals in the stomach. Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal reflux disease. Aim To characterize the antacid and raft-forming properties of Rennie alginate suspension (containing high-dose antacid and alginate; Bayer Consumer Care, Bladel, the Netherlands). Methods The in vitro acid-neutralizing capacity of Rennie algniate was compared with Gaviscon (Reckitt Benckiser, Slough, UK) by pH-recorded HCl titration. Alginate raft weight formed in vitro at different pH was used to evaluate the pH dependency of raft formation with each product. A double-blind, placebo-controlled, randomized crossover study also compared the antacid activity of Rennie alginate vs. placebo in vivo using continuous intragastric pH monitoring in 12 healthy fasting volunteers. Results Compared with Gaviscon, Rennie alginate had a higher acid-neutralizing capacity, greater maximum pH and longer duration of antacid activity in vitro. However, the two products produced comparable alginate rafts at each pH evaluated. In vivo, Rennie alginate provided rapid, effective and long-lasting acid neutralization, with an onset of action of <5 min, and duration of action of almost 90 min. Conclusions The dual mode of action of Rennie alginate offers an effective treatment option for mild symptomatic gastro-oesophageal reflux disease particularly considering recent findings regarding ,acid pockets'. [source]

Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential

AUSTRALIAN DENTAL JOURNAL, Issue 2 2008
H Aiuchi
Abstract Background:, The ion activity product for hydroxyapatite (IpHA) is a comprehensive parameter reflecting pH, calcium and phosphate ion concentration in saliva which govern the degree of saturation with respect to the dissolving tooth mineral. The aim of this study was to evaluate the relationship between quantitative assessments of salivary buffering capacity and IpHA in relation to cariogenic potential. Methods:, Stimulated whole saliva was collected from 33 patients, and the initial pH of samples was measured using a hand-held pH meter. Then samples were titrated with 0.1 N HCl to evaluate buffering capacities and divided into three groups (high, medium and low). After measuring concentrations of calcium and phosphate ions in the samples, IpHA was calculated using the values of the ion concentrations and pH. Differences in the mean pH values, the concentrations of calcium, phosphate ions and log[IpHA] among three groups were analysed using the Kruskal Wallis and the Mann-Whitney non-parametric test, p < 0.05. Results:, After HCl 50 ,L titration, there were statistical differences of the mean pH and IpHA among each buffering capacity group. Moreover, after 50 ,L HCl titration, there was an excellent correlation between the buffer capacity and log[IpHA]. Conclusions:, The pH change for saliva after HCl titration has a significant influence on the rate of IpHA. [source]

The pH change after HCl titration into resting and stimulated saliva for a buffering capacity test

AUSTRALIAN DENTAL JOURNAL, Issue 2 2006
M. Moritsuka
Abstract Background: Saliva collection can provide clinical information about individual patients. However, a correlation between ranking buffering capacity using resting and stimulated saliva is still unknown. The aim of this study was to evaluate the pH change after HCl titration into resting and stimulated saliva for a salivary buffering capacity test. Methods: Resting and stimulated saliva (by chewing paraffin wax) were collected from 80 patients. After the pH of both saliva samples was measured using a hand-held pH meter, the saliva samples were titrated with 0.1N HCl to evaluate the buffering capacity. Correlations of ranking buffering capacity (high, medium, low) between stimulated saliva and resting saliva with 30,L HCl titration and between stimulated saliva and resting saliva with 40,L HCl titration were statistically analysed by Spearman Rank Correlation Test (p < 0.05). Results: At 50,L HCl titration, stimulated saliva buffering capacities were ranked into high (above pH 5.5), medium (pH from 5.5 to 4.5) and low (below pH 4.5). At 30,40,L HCl titration, the resting saliva buffering capacities were ranked into the same categories. Spearman Rank Correlation indicated significant positive coefficients for the stimulated saliva and resting saliva buffering capacity at 30,L titration and the stimulated saliva and resting saliva at 40,L titration. Conclusion: Stimulated saliva is more resistant to variation in pH change during HCl titration than resting saliva. Stimulated saliva sampling is a good method to determine buffering capacity during a comprehensive oral health assessment. [source]