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Better Visual Outcome (good + visual_outcome)
Selected AbstractsNeuroplasticity predicts outcome of optic neuritis independent of tissue damageANNALS OF NEUROLOGY, Issue 1 2010Thomas M. Jenkins MRCP Objectives To determine whether lateral occipital complex (LOC) activation with functional magnetic resonance imaging (fMRI) predicts visual outcome after clinically isolated optic neuritis (ON). To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage. Methods Patients with acute ON and healthy volunteers were studied longitudinally over 12 months. Structural MRI, visual evoked potentials (VEPs), and optical coherence tomography (OCT) were used to quantify acute inflammation, demyelination, conduction block, and later to estimate remyelination and neuroaxonal loss over the entire visual pathway. The role of neuroplasticity was investigated using fMRI. Multivariable linear regression analysis was used to study associations between vision, structure, and function. Results Greater baseline fMRI responses in the LOCs were associated with better visual outcome at 12 months. This was evident on stimulation of either eye (p = 0.007 affected; p = 0.020 fellow eye), and was independent of measures of demyelination and neuroaxonal loss. A negative fMRI response in the LOCs at baseline was associated with a relatively worse visual outcome. No acute electrophysiological or structural measures, in the anterior or posterior visual pathways, were associated with visual outcome. Interpretation Early neuroplasticity in higher visual areas appears to be an important determinant of recovery from ON, independent of tissue damage in the anterior or posterior visual pathway, including neuroaxonal loss (as measured by MRI, VEP, and OCT) and demyelination (as measured by VEP). ANN NEUROL 2010;67:99,113 [source] Manifestation of Coats' disease by age in TaiwanCLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 4 2007Chien-Hsiung Lai MD Abstract Background:, To compare the differences in clinical manifestation of Coats' disease between younger and older patients in the Far East. Methods:, Coats' disease cases diagnosed at one Taiwanese hospital from July 1986 to June 2004 were retrospectively reviewed (n = 30; 32 eyes). Patients were stratified into groups according to the initial diagnosis of Coats' disease at the age of <20 years (Group Y) or ,20 years (Group O). The clinical manifestations of Coats' disease in Group Y (19 eyes) and Group O (13 eyes) were compared. Results:, A higher proportion of female patients was noted in Group O (P = 0.046). Diseases were generally limited geographically, with 14 eyes (73.7%) manifesting involvement greater than 6 clock hours in Group Y and four eyes (30.8%) in Group O. The involved area including retinal telangiectasia and exudates was smaller in Group O (P = 0.016). Patients without posterior pole involvement were associated with better visual outcome (adjusted odds ratio, 6.5; 95% confidence interval, 1.1,40.1, P = 0.044). Conclusion:, Coats' disease manifestation was different between different age groups. Treatment is important to prevent disease progression. Visual prognosis is associated with posterior pole involvement. [source] The effect of treatment zone diameter in hyperopic orthokeratologyOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 6 2009Paul Gifford Abstract Purpose:, To investigate the time course of treatment zone (TZ) diameter changes in hyperopic orthokeratology (OK) lens wear from 1 h in the open eye through to seven nights in the closed eye. Methods:, Twelve subjects were fitted with rigid hyperopic OK lenses. Lenses were worn in the open eye for 1 h then one night in the closed eye, separated by a washout period of 4 days. Changes in best corrected visual acuity (BCVA) and corneal topography (Medmont E-300) were measured on lens removal. The TZ, comprising the central steepened zone (CSZ) and surrounding annular flattened zone (AFZ), was measured from corneal topography. Subsequently, ten subjects wore the same lens design overnight for seven nights, and measurements were taken on lens removal and 8 h later on Days 1 and 7. Results:, Both CSZ and AFZ were apparent after 1 h of hyperopic OK lens wear. CSZ decreased while AFZ increased with longer periods of lens wear. BCVA reduced with longer periods of lens wear and was associated with decreasing CSZ (r = ,0.866, p < 0.001) and increasing AFZ (r = 0.447, p < 0.05). Conclusions:, The association of changes of treatment zone size with reductions in BCVA suggests that increasing CSZ may lead to better visual outcomes in hyperopic OK. [source] Predictive factors of visual outcome in acute post-cataract endophthalmitisACTA OPHTHALMOLOGICA, Issue 2009A COMBEY-DE LAMBERT Purpose To study potential clinical and microbiological predictive factors of visual outcome in patients with acute endophthalmitis following cataract surgery. Methods A prospective study included 100 patients in 4 University hospital.Factors related to the cataract surgery, the initial clinical presentation and the microbiological identification were analyzed according to the final visual outcome using univariate and multivariate (logistic regression) analysis. Results 46% out of the patients had a final visual acuity less than or equal to 0.3 logMar (good visual outcome) at 6 months while 10% had only light perceptions. Patients with good visual outcome differed for the duration of cataract surgery, initial visual acuity, the visibility of fundus and the identification of a coagulase negative staphylococcus. In contrast, patients with a poor visual outcome were older, had more cornea oedema and a more important hypopion at the admission, more complications at the time of cataract surgery. Furthermore a bacterium was more frequently identified in this latter group. Multivariate analysis showed that age, complications at the time of cataract surgery, microbiological identification, pars plana vitrectomy were independent predictive factors. Conclusion Factors of visual outcome in acute postcataract endophthalmitis identified in this prospective study were similar to that reported during the Endophthalmitis Vitrectomy Study 10 years ago. As part of the treatment, pars plana vitrectomy is associated with predictive factors of poor visual outcome. Identification of these predictive factors at presentation should allow a better management of patients needed an aggressive treatment. [source] Traumatic intralenticular abscess: a case seriesCLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 3 2007Amjad Salman MS Abstract Purpose:, To report the clinical presentation, management and outcome of eyes with traumatic intralenticular abscess. Methods:, In this interventional case series, records of eight patients (eight eyes) with intralenticular abscess developing following trauma were reviewed. All patients underwent extracapsular cataract extraction with intracameral antibiotics with or without pars plana vitrectomy. Main outcome measures studied were resolution of infection and final visual outcome. Results:, Lens abscess developed in six eyes following penetrating injury and in two eyes following intraocular penetration of caterpillar hair. Gram positive cocci were cultured from the lens aspirate in five eyes and Staphylococcus epidermidis was the most common organism isolated. Cataract extraction resulted in control of the infection in all eyes and seven eyes (87.5%) had a favourable visual outcome. Conclusion:, Early lens extraction with intracameral antibiotics in eyes with intralenticular abscess allows control of infection with good visual outcome. [source] 1363: White dot syndromesACTA OPHTHALMOLOGICA, Issue 2010S ANDROUDI Purpose The white dot syndromes (WDS) are a group of distinct clinical entities characterized by one common underlying feature: the presence of multiple "spots" in the fundus, usually in the deep retina or choroid without any other systemic manifestations. Methods The disorders are relatively rare and include the following entities: acute posterior multifocal placoid pigment epitheliopathy (APMPPE), multiple evanescent white dot syndrome (MEWDS), birdshot retinochoroidopathy (BSRC), serpiginous choroidopathy (SC), multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), subretinal fibrosis and uveitis syndrome, and presumed ocular histoplasmosis syndrome (POHS). Results Despite the fact that many infectious and noninfectious inflammatory diseases may present with multifocal chorioretinal lesions, the entities included in the WDS share some features which make them a particular group of ocular disorders. In fact, the WDS would be better labeled as idiopathic inflammatory multifocal chorioretinopathies, since with the exception of diffuse unilateral subacute neuroretinitis, their causes are still unknown. Conclusion Because the specific diagnosis may have profound implications on therapy and prognosis, it is important to narrow the diagnosis to the greatest extent possible, even in patients with seemingly atypical findings. The correct diagnosis of WDS is important because the management is totally different from one another. Some of them are self-limited and have good visual outcomes without treatment, while others are associated with serious retinal and choroidal sequelae, which can result in severe visual loss even after adequate immunosuppressive therapy. [source] | ||||||||||