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Germ Cell Cancer (germ + cell_cancer)
Selected AbstractsProceedings of the 6th Copenhagen Workshop on Carcinoma in situ Testis and Germ Cell Cancer, 26,28 October 2006INTERNATIONAL JOURNAL OF ANDROLOGY, Issue 4 2007Ewa Rajpert-De Meyts No abstract is available for this article. [source] Sperm DNA integrity in cancer patients: the effect of disease and treatmentINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 6 2009O. Ståhl Summary As oncological treatment might impair the patients' fertility, male cancer patients are offered to cryopreserve semen prior to treatment. Impaired sperm DNA quality is associated with reduced fertility, and in case of assisted reproduction, sperm DNA integrity may have an impact on choice of method. Therefore, we have assessed sperm DNA integrity in cancer patients, comparing pre- and post-treatment quality. Sperm DNA integrity was investigated in cryopreserved semen from 121 cancer patients, the predominating diagnoses were germ cell cancer (GCC) and Hodgkin's lymphoma (HL). Post-treatment samples, with a median follow-up of 3 years, were analysed for 58 of the men, allowing a pre- and post-treatment analysis on an individual basis. Sperm DNA integrity was assessed using the Sperm Chromatin Structure Assay and expressed here as the DNA Fragmentation Index (DFI%). One hundred and thirty-seven fertile men served as controls. Before treatment, GCC (n = 84) and HL (n = 18) patients had higher DFI% than controls (n = 143) with a mean difference of 7.7 (95% CI 3.2,8.8) and 7.0 (95% CI 2,12), respectively. The same trend was observed for other cancer diagnoses, but without reaching statistical significance (mean difference 3.6, 95% CI ,1.2 to 8.4). No increase was seen in DFI% comparing pre- and post-treatment semen, regardless of treatment modality. A moderate elevation of DFI% was observed in cryopreserved semen from cancer patients. Oncological treatment, generally, did not induce any increase in DFI. These findings should be considered when discussing the utilization of pre-treatment cryopreserved semen vs. post-treatment fresh sperm in cancer patients undergoing assisted reproduction. [source] Recent advances and future directions in research on testicular germ cell cancerINTERNATIONAL JOURNAL OF ANDROLOGY, Issue 4 2007Ewa Rajpert-De Meyts First page of article [source] Risk factors for testicular cancer , differences between pure non-seminoma and mixed seminoma/non-seminoma?INTERNATIONAL JOURNAL OF ANDROLOGY, Issue 4 2006E. L. Aschim Summary The origin of testicular germ cell cancer (TGCC) is believed to be carcinoma in situ cells developed in utero. Clinically, TGCCs are divided into two major histological groups, seminomas and non-seminomas, where the latter group includes non-seminomatous TGCCs with seminomatous components (mixed S/NS TGCC). Recent studies, however, have suggested that non-seminomas and mixed S/NS TGCCs could have certain differences in aetiology, and in this study the TGCCs were divided into three, rather than the conventional two histological groups. A large case-control study was undertaken on data on all live-born boys registered in the Medical Birth Registry of Norway during the period 1967,1998 (n = 961 396). Among these were 1087 TGCC cases registered in the Cancer Registry of Norway until February 2004. We found several risk factors for TGCC, including low parity, low gestational age, epilepsy and retained placenta. Several of the variables studied seemed to be risk factors for specific histological groups, e.g. parity 0 vs. 2 and low gestational age being associated with increased risk of non-seminomas, but not of mixed S/NS TGCC, and low maternal age being associated with increased risk of mixed S/NS TGCC, but not of non-seminomatous TGCC. Therefore, our results might suggest that non-seminomas and mixed S/NS TGCCs have partially different risk factors, whose associations may be obscured by combining these two histological groups. The histological groups were not significantly different, however. Most of our findings on risk factors for TGCC are in agreement with at least some previous studies. An unexplainable exception is low birth weight being associated with reduced risk of TGCC in our study. [source] Modified expression of cytoplasmic isocitrate dehydrogenase electrophoretic isoforms in seminal plasma of men with sertoli-cell-only syndrome and seminomaMOLECULAR CARCINOGENESIS, Issue 6 2008Mireille Starita-Geribaldi Abstract Two isoforms of human cytoplasmic isocitrate dehydrogenase (IDPc) of close molecular weights and different isoelectric points were identified in human seminal plasma (SP) by two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (MS). These two isoforms were detected in the normospermic men SP and their expressions were markedly altered in patients with testicular seminoma, the most frequent testicular germ cell cancer (TGCC): increase of the more acidic spot and decrease of the more basic one. Since oligospermia has been considered as a high risk pathological condition for developing a testicular cancer, the two IDPc isoforms were analyzed in SP of a group of secretory azoospermic patients. In this group the two spots displayed similar variations of expression to those observed in testicular seminoma. These results propose IDPc as a promising SP biomarker of testicular seminoma. Whether IDPc alteration in secretory azoospermia is predictive of testicular seminoma remains to be elucidated. © 2007 Wiley-Liss, Inc. [source] Case,control study of male germ cell tumors nested in a cohort of car-manufacturing workers: Findings from the occupational historyAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 10 2010Ingo Langner PhD Abstract Background To examine whether the previously observed excess risk of male germ cell cancer in a cohort of car-manufacturing workers can be attributed to occupational activities inside and/or outside the car industry. Methods A nested case,control study among workers in six plants included 205 cases of germ cell cancer and 1,105 controls, individually matched by year of birth (±2 years). Job periods of the individual occupational histories were coded based on the International Standard Classification of Occupations (ISCO) and the industrial classification of economic activities (NACE). Odds ratios (ORs) and corresponding 95%-confidence intervals (CI) for ever-never and cumulative employment were calculated by conditional multivariate logistic regression adjusted for cryptorchidism. Results Significantly increased risks were observed for machinery fitters and assemblers (A) (OR,=,1.8, 95% CI 1.25,2.53) and "workers not elsewhere classified" (OR,=,2.10, 95% CI 1.27,3.54), but no trend was observed for employment duration in either occupational group. Stratification of job group A by metal-cutting and non-cutting jobs yielded ORs of 1.87 (95% CI 1.31,2.67) and of 1.24 (95% CI 0.68,2.28), respectively. Among "plumbers, welders, sheet & structural metal workers" (adjusted OR 1.4, 95% CI 0.99,1.95) only "structural metal preparers and erectors" showed a substantially increased risk (OR,=,2.30; 95% CI 1.27,4.27). Conclusions Our results do not fully explain the increased incidence of germ cell cancer in the cohort, but support previous findings showing increased risks among metal workers. These risks were most strongly pronounced in metal-cutting activities. Am. J. Ind. Med. 53:1006,1018, 2010. © 2010 Wiley-Liss, Inc. [source] High-dose chemotherapy in nonseminomatous germ cell cancerBJU INTERNATIONAL, Issue 9b 2009Christian Kollmannsberger First page of article [source] Bilateral germ cell cancer of the testis: a report of 11 patients with a long-term follow-upBJU INTERNATIONAL, Issue 3 2001A. Heidenreich First page of article [source] | ||||||||||