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General Synthetic Route (general + synthetic_route)

Distribution by Scientific Domains

Chemistry	100%

Distribution within Chemistry

Organic Chemistry	57%
General & Introductory Chemistry	42%

Selected Abstracts

A General Synthetic Route to Dibenzospiropyrans and Dinaphthospiropyrans from Dibenzofuran and Dinaphthofuran.

CHEMINFORM, Issue 41 2007
Bin Wang
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

A General Synthetic Route to Indenofluorene Derivatives as New Organic Semiconductors.

CHEMINFORM, Issue 29 2005
Tayebeh Hadizad
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

A General Synthetic Route to 1-Azabicyclo[m.n.0]alkenes via Cyclization Based on ,-Sulfinyl Carbanions.

CHEMINFORM, Issue 8 2004
Manat Pohmakotr
No abstract is available for this article. [source]

The Biosynthesis of 3-(trans -2-Nitrocyclopropyl)alanine, a Constituent of the Signal Metabolite Hormaomycin

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 1 2005
Melanie Brandl
Abstract Feeding experiments with Streptomyces griseoflavus using deuterium-labeled racemic 3,3-[D2]- (6b), 4,4-[D2]- (6c), 5,5-[D2]- (6d), and 6,6-[D2]-lysine (6e), and 3-amino-5-(2-amino-1,1-dideuterioethyl)-4,5-dihydrofuran-2-one dihydrochloride (34·2HCl) were carried out in order to obtain detailed information about the hitherto unknown biosynthetic pathway from lysine to the unusual amino acid 3-(trans -2,-nitrocyclopropyl)alanine [(3-Ncp)Ala] (2), which is a building block of hormaomycin 1a. The corresponding lysine dihydrochlorides were prepared in 33, 24, 19, and 30% overall yield, respectively, along a new efficient general synthetic route applying an alkylation of the lithium enolate of O,Donnel's glycine equivalent 7 as a key step. In the attempted preparation of 5,5-[D2]-4-hydroxylysine (29), the respective ,-lactone (34·2 HCl) was obtained in five steps with 10% overall yield. The distribution of isotope labels in hormaomycins 1b,d led to the formulation of a reasonable cyclization mechanism of 2-amino-4-hydroxy-6-(hydroxyimino)hexanoic acid, an ,-oxime analogue of 4-hydroxylysine. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

The Development of a Convergent and Efficient Enantioselective Synthesis of the Bengamides via a Common Polyol Intermediate

HELVETICA CHIMICA ACTA, Issue 12 2002
Robert
An efficient, general synthetic route to the bengamide family of antitumor agents from a common polyol thioester is described. Consecutive aldol condensations afford the protected polyol thioester side chain suitable for coupling to the bengamides. A novel chiral-phase-transfer-catalyzed enantioselective alkylation affords the properly functionalized caprolactams required for the synthesis of more-complex members of the bengamide family. Use of the methyl 2-naphthyl ether protecting group, compatible with the boron Lewis acids required for enantioselective aldol condensation, allows direct access to all the bengamides. [source]

Solid-Phase Synthesis of DOTA,Peptides

CHEMISTRY - A EUROPEAN JOURNAL, Issue 5 2004
Luis M. De León-Rodriguez Dr.
Abstract A general synthetic route to two DOTA-linked N -Fmoc amino acids (DOTA-F and DOTA-K) is described that allows insertion of DOTA at any endo -position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid-phase peptide synthesis. Both DOTA derivatives reacted smoothly by means of standard HBTU activation chemistry to the point of insertion of the DOTA amino acid, but extension of the peptide chain beyond the DOTA-amino acid insertion required the use of pre-activated C -pentafluorophenyl ester N - , -Fmoc amino acids. Three Gal-80 binding peptides (12-mers) were then prepared by using this methodology with DOTA positioned either at the N terminus or at one of two different internal positions;the binding of the resulting GdDOTA-12-mers to Gal-80 were compared. The methodology described here allows versatile, controlled introduction of DOTA into any location within a peptide sequence. This provides a potential method for the screening of libraries of DOTA-linked peptides for optimal targeting properties. [source]

Aqueous-Solution Growth of GaP and InP Nanowires: A General Route to Phosphide, Oxide, Sulfide, and Tungstate Nanowires

CHEMISTRY - A EUROPEAN JOURNAL, Issue 3 2004
Yujie Xiong Dr.
Abstract A general synthetic route has been developed for the growth of metal phosphide, oxide, sulfide, and tungstate nanowires in aqueous solution. In detail, cetyltrimethylammonium cations (CTA+) can be combined with anionic inorganic species along a co-condensation mechanism to form lamellar inorganic,surfactant intercalated mesostructures, which serve as both microreactors and reactants for the growth of nanowires. For example, GaP, InP, ,-MnO2, ZnO, SnS2, ZnS, CdWO4, and ZnWO4 nanowires have been grown by this route. To the best of our knowledge, this is the first time that the synthesis of GaP and InP nanowires in aqueous solution has been achieved. This strategy is expected to extend to grow nanowires of other materials in solution or by vapor transport routes, since the nanowire growth of any inorganic materials can be realized by selecting an appropriate reaction and its corresponding lamellar inorganic,surfactant precursors. [source]