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Gerstmann Syndrome (gerstmann + syndrome)

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Medical Sciences100%

Selected Abstracts

A disconnection account of Gerstmann syndrome: Functional neuroanatomy evidence,

ANNALS OF NEUROLOGY, Issue 5 2009
Elena Rusconi PhD
Objective To examine the functional neuroanatomy that could account for pure Gerstmann syndrome, which is the selective association of acalculia, finger agnosia, left-right disorientation, and agraphia. Methods We used structural and functional neuroimaging at high spatial resolution in healthy subjects to seek a shared cortical substrate of the Grundstörung posited by Gerstmann, ie, a common functional denominator accounting for this clinical tetrad. We construed a functional activation paradigm that mirrors each of the four clinical deficits in Gerstmann syndrome and determined cortical activation patterns. We then applied fiber tracking to diffusion tensor images and used cortical activation foci in the four functional domains as seed regions. Results None of the subjects showed parietal overlap of cortical activation patterns from the four cognitive domains. In every subject, however, the parietal activation patterns across all four domains consistently connected to a small region of subcortical parietal white matter at a location that is congruent with the lesion in a well-documented case of pure Gerstmann syndrome. Interpretation Our functional neuroimaging findings are not in agreement with Gerstmann's postulate of damage to a common cognitive function underpinning clinical semiology. Our evidence from intact functional neuroanatomy suggests that pure forms of Gerstmann's tetrad do not arise from lesion to a shared cortical substrate but from intraparietal disconnection after damage to a focal region of subcortical white matter. Ann Neurol 2009;66:654,662 [source]

The ,Gerstmann's Syndrome' of transjugular intrahepatic portosystemic shunt: should it be the left or should it be the right

LIVER INTERNATIONAL, Issue 8 2009
Florence WongArticle first published online: 3 AUG 200
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