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Gap Distance (gap + distance)
Selected AbstractsMechanisms of transjunctional transport of NaCl and water in proximal tubules of mammalian kidneysACTA PHYSIOLOGICA, Issue 1 2002F. KIILArticle first published online: 30 APR 200 ABSTRACT Tight junctions and the intercellular space of proximal tubules are not accessible to direct measurements of fluid composition and transport rates, but morphological and functional data permit analysis of diffusion and osmosis causing transjunctional NaCl and water transport. In the S2 segment NaCl diffuses through tight junctions along a chloride gradient, but against a sodium gradient. Calculation in terms of modified Nernst,Fick diffusion equation after eliminating electrical terms shows that transport rates (300,500 pmol min,1 mm,1 tubule length) and transepithelial voltage of +2 mV are in agreement with observations. Diffusion coefficients are Dtj=1500 ,m2 s,1 in the S1 segment, and Dtj=90,100 ,m2 s,1 in the S2 segment where apical intercellular NaCl concentration is 132 mM, 1 mM below complete stop (Dtj=0 and Donnan equilibrium). Tight junctions with gap distance 6 Å are impermeable to mannitol (effective molecular radius 4 Å); reflection coefficients are ,=0.92 for NaHCO3 and ,=0.28 for NaCl, because of difference in anion size. The osmotic force is provided by a difference in effective transjunctional osmolality of 10 mOsm kg,1 in the S1 segment and 30 mOsm kg,1 in the S2 segment, where differences in transjunctional concentration contribute with 21 mOsm kg,1 for NaHCO3 and ,4 mOsm kg,1 for NaCl. Transjunctional difference of 30 mOsm kg,1 causes a volume flow of 2 nL min,1 mm,1 tubule length. Luminal mannitol concentration of 30 mM stops all volume flow and diffusive and convective transport of NaCl. In conclusion, transjunctional diffusion and osmosis along gradients generated by transcellular transport of other solutes account for all NaCl transport in proximal tubules. [source] Mechanisms of intercellular hypertonicity and isotonic fluid absorption in proximal tubules of mammalian kidneysACTA PHYSIOLOGICA, Issue 1 2002F. KIILArticle first published online: 30 APR 200 ABSTRACT The main purpose of this theoretical analysis (second of two articles) is to examine whether transjunctional diffusion of NaCl causes intercellular hypertonicity, which permits transcellular water transport across solute-impermeable lateral cell membranes until osmotic equilibration. In the S2 segment with tubular NaCl concentration 140 mM, the calculated apical intercellular NaCl concentration is c0 , 132 mM, which exceeds peritubular NaCl concentration by 12 mM or 22 mOsm kg,1. Variations in volume flow, junctional reflection coefficient (,NaCl=0.25,0.50), gap distance (g=6,8 Å), junctional depth (d=18,100 Å), intercellular diffusion coefficient (DLIS=500,1500 ,m2 s,1) and hypothetical active NaCl transport alter c0 only by a fraction of 1 mM. However, dilution and back-leakage of NaHCO3 lower apical intercellular hyperosmolality to ,18 mOsm kg,1. Water transport through solute-impermeable lateral cell membranes continues until intercellular and cellular osmolalities are equal. Transcellular and transjunctional volume flow are of similar magnitude (2 nL min,1 mm,1 tubule length) in the S2 segment. Thus, diffusion ensures isotonic absorption of NaCl. Two-thirds of NaHCO3 and other actively transported sodium salts are extruded into the last third of the exponentially widening intercellular space where the exposure time is only 0.9 s. Osmotic equilibration is dependent on aquaporins in the cell membranes. If permeability to water is low, transcellular water transport stops; tubular fluid becomes hypotonic; NaCl diffusion diminishes, but transjunctional water transport remains unaltered as long as transcellular transport of NaHCO3 and other solutes provides the osmotic force. [source] Robust stability of iterative learning control schemesINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 10 2008Mark French Abstract A notion of robust stability is developed for iterative learning control in the context of disturbance attenuation. The size of the unmodelled dynamics is captured via a gap distance, which in turn is related to the standard ,2 gap metric, and the resulting robustness certificate is qualitatively equivalent to that obtained in classical robust ,, theory. A bound on the robust stability margin for a specific adaptive ILC design is established. Copyright © 2007 John Wiley & Sons, Ltd. [source] Tip enhanced Raman spectroscopy on azobenzene thiol self-assembled monolayers on Au(111)JOURNAL OF RAMAN SPECTROSCOPY, Issue 10 2009Gennaro Picardi Abstract Tip enhanced Raman spectroscopy (TERS) and imaging experiments in tunnelling (gap) mode were performed on a 2 nm thick azobenzene thiol monolayer grafted on Au(111). A strong dependence on the tunnelling parameters, regulating the gold tip,gold surface gap distance, was observed for the intensity of the enhanced Raman signal. The influence of the incident light polarization is also discussed. Copyright © 2009 John Wiley & Sons, Ltd. [source] Design of dual-band SIR bandpass filter with a broad upper rejection band for WLANsMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 4 2009Yu-Chi Chang Abstract In this letter, we proposed the design of novel dual-band bandpass filter (BPF) with a broad upper rejection band using only two asymmetric stepped impedance resonators (SIRs), which has a smaller circuit size in comparison of previous works. The feature of the asymmetric SIR is only one-step discontinuity, which is different from the conventional SIR with two-step discontinuities. By selecting properly the impedance ratio (R) and physical length ratio (,) of the proposed asymmetric SIRs, the low loss dual-band BPF centered at 2.4/5.2 GHz with a wide upper rejection band from 6 to 14 GHz can be implemented perfectly. The bandwidths and the coupling coefficients of the two passbands can be tunable by adjusting the coupling gap distance between the resonators, which are calculated by using full-wave simulator IE3D. Good agreement between the electromagnetic (EM) simulation and measurement is reported. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1143,1146, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24227 [source] Depinning field from notches on Co/Pd multilayer nanowires with perpendicular magnetic anisotropyPHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 12 2007Sug-Bong Choe Abstract Domain-wall pinning and depinning mechanisms of ferromagnetc nanowires with perpendicular magnetic anisotropy were investigated. Micromagnetic simulation results revealed that the depinning field from notches were determined solely by the gap distance between the notches, irrespective to the wire width and the notch size. The double-notch wires exhibited two-fold décalcomanie domain patterns and one half patterns were identical to those of single-notch wires. Therefore, the double-notch wires showed the same depinning field compared to single-notch wires with half width. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] A Passive Magnetically and Hydrodynamically Suspended Rotary Blood PumpARTIFICIAL ORGANS, Issue 3 2009Martin Stoiber Abstract A combined hydrodynamic,magnetic bearing allows the design of rotary blood pumps that are not encumbered with mechanical bearings and magnets requiring sensors or electrical power. However, such pumps have so far needed very small and accurately manufactured gaps between rotor and housing to assure effective hydromagnetic bearing behavior. In order to use this concept in disposable pump heads, a design that allows larger rotor-housing gaps, and thus larger manufacturing tolerances, is needed. A pump with passive magnetic bearings and a gap between rotor and housing in the range of 0.5 mm was designed. Numerical simulations were performed to optimize the rotor geometry at low levels of shear stress. An experimental test stand was used to find a range of speeds and gap settings that resulted in low levels of vibration and useful pressure,flow relationships. Three different rotor geometries were tested using a viscosity-adjusted test fluid. Blood damage tests were conducted within the desirable range of speeds and gap settings. In this study stable pump performance was demonstrated at total gap widths between 0.3 and 0.7 mm at flows of 0,10 L/min, with afterloads up to 230 mm Hg. Best performance was achieved with rotors sliding on a fluid pillow between the rotor and the outer housing at a gap distance of 50 to 250 µm. The inner gap distance, between the rotor and the inner housing, could be as great as 500 µm. Hemolysis tests on the prototype within the chosen operating range showed lower values (NIH = 0.0029 ± 0.0012 g/100 L) than the Biomedicus BP-80 pump (NIH = 0.0033 ± 0.0011 g/100 L). In conclusion, it is possible to build rotary blood pumps with passive hydromagnetic bearings that have large gaps between their rotors and housings. Rotor behavior is sensitive to the position of the permanent magnetic drive unit. To minimize vibration and blood damage, the fluid gaps and the rotational speed have to be adjusted according to the desired operating point of the pump. Further study is needed to optimize the magnetic drive unit and to ascertain its ability to withstand inertial loads imposed by sudden movements and external shock. [source] Gap-crossing decisions of forest birds in a fragmented landscapeAUSTRAL ECOLOGY, Issue 4 2009OLIVER J. ROBERTSON Abstract Habitat loss and fragmentation are recognized as primary drivers of biodiversity loss worldwide. To understand the functional effects of habitat fragmentation on bird populations, data on movement across gaps in habitat cover are necessary, although rarely available. In this study, we used call playback to simulate a conspecific territorial intruder to entice birds to move through the landscape in a predictable and directional manner. We then quantified the probability of movement in continuous forest and across cleared gaps for two forest-dependent species, the grey shrike-thrush (Colluricincla harmonica) and the white-throated treecreeper (Cormobates leucophaeus). Fifty-four playback trials were conducted for each species across distances ranging from 25 to 480 m in continuous forest and 15,260 m across gaps in a forest-agricultural landscape in southern Victoria, Australia. The probability of movement was significantly reduced by gaps in forest cover for both species. Shrike-thrushes were six times more likely to move 170 m in continuous forest than to cross 170-m gaps. The mean probability that treecreepers would cross any gap at all was less than 0.5, and they were three times less likely to move 50 m across a gap than through continuous forest. Both species displayed non-linear responses to increasing gap distance: we identified a gap-tolerance threshold of 85 m for the shrike-thrush and 65 m for the treecreeper beyond which individuals were most unlikely to cross. The presence of scattered paddock trees increased functional connectivity for the shrike-thrush, with individuals crossing up to 260 m when scattered trees were present. We conclude that gaps in habitat cover are barriers to movement, and that characteristics of the intervening matrix influence landscape permeability. [source] |