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Functions Related (function + relate)
Selected AbstractsClinical assessment and management of spasticity: a reviewACTA NEUROLOGICA SCANDINAVICA, Issue 2010T. Rekand Rekand T. Clinical assessment and management of spasticity: a review. Acta Neurol Scand: 2010: 122 (Suppl. 190): 62,66. © 2010 John Wiley & Sons A/S. Spasticity is a sign of upper motor neurone lesion, which can be located in the cerebrum or the spinal cord, and be caused by stroke, multiple sclerosis, spinal cord injury, brain injury, cerebral paresis, or other neurological conditions. Management is dependent on clinical assessment. Positive and negative effects of spasticity should be considered. Ashworth score and the modified Ashworth score are the most used scales for assessment of spasticity. These and other spasticity scales are based on assessment of resistance during passive movement. The main goal of management is functional improvement. A novel 100-point score to assess disability, function related to spasticity (Rekand disability and spasticity score) is proposed. Management of spasticity should be multimodal and should always include physiotherapy or exercise. Oral medications such as baclofen and tizanidine have limited efficacy and considerable side effects, but are easiest to use. Botulinum toxin combined with physiotherapy and/or orthopaedic surgery is effective treatment of localized spasticity. Treatment with intrathecal baclofen via programmable implanted pump is effective in generalized spasticity, particularly in the lower extremities. Neurosurgical and orthopaedic procedures may be considered in intractable cases. [source] Neurocognitive functions in euthymic bipolar patientsACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2009K. Jamrozinski Objective:, Meta-analytic findings support the hypothesis of specific neurocognitive deficits for bipolar patients in the domains of attention, processing speed, memory and executive functions. This study aims to show neurocognitive impairment in euthymic patients with bipolar I disorder compared with healthy controls while detailing the impact of medication side-effects or illness characteristics on neuropsychological test performance. Method:, Forty euthymic patients with bipolar I disorder were compared with 40 healthy controls in a cross-sectional design. Clinical features and neuropsychological measures of IQ, psychomotor speed, verbal fluency, learning and memory, executive functions and attention were assessed. Results:, Patients without antipsychotic drug use did not differ significantly from healthy controls in any neuropsychological measure. Yet patients treated with antipsychotics showed significant underperformance in the domains of semantic fluency, verbal learning and recognition memory as well as executive functions related to planning abilities, even when clinical features were controlled for. Conclusion:, The impact of antipsychotic medication needs to be further clarified for euthymic bipolar patients and should be considered when neuropsychological test performance is interpreted. [source] Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving ratsEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2007Mauricio Valenzuela-Harrington Abstract The difference in the amounts of NR2 subunits contained in NMDA receptors of the hippocampus has been related to their different involvement in activity-dependent synaptic plasticity. Here, we show that Ro 25-6981, a high-affinity and selective blocker of NMDA receptors containing NR2B subunits, is able to block the acquisition of a trace conditioning paradigm in adult rats, a task that requires the active participation of hippocampal circuits. Reconditioning with the same trace paradigm was also prevented by Ro 25-6981. In addition, we show that the slope of monosynaptic field excitatory postsynaptic potentials evoked at the dentate gyrus by single pulses presented to the medial perforant pathway increases significantly across conditioning sessions and during reconditioning, in a linear relationship with the increase in the number of classically conditioned eyelid responses. Administration of Ro 25-6981 prevented these learning-related changes in synaptic strength at the perforant pathway,dentate granule cell synapse. The present results suggest the involvement of NR2B-containing NMDA receptors in hippocampal functions related to both associative learning and activity-dependent synaptic plasticity. [source] An exact sinusoidal beam finite elementPROCEEDINGS IN APPLIED MATHEMATICS & MECHANICS, Issue 1 2008Zdzislaw Pawlak The purpose of the paper is to derive an efficient sinusoidal thick beam finite element for the static analysis of 2D structures. A two,node, 6,DOF curved, sine,shape element of a constant cross,section is considered. Effects of flexural, axial and shear deformations are taken into account. Contrary to commonly used curvilinear co,ordinates, a rectangular co,ordinates system is used in the present analysis. First, an auxiliary problem is solved: a symmetric clamped,clamped sinusoidal arch subjected to unit nodal displacements of both supports is considered using the flexibility method. The exact stiffness matrix for the shear,flexible and compressible element is derived. Introduction of two parameters "n" and "t" enables the identification of shear and membrane influences in the element stiffness matrix. Basing on the principle of virtual work a full set of 18 shape functions related to unit support displacements is derived (total rotations of cross,sections, tangential and normal displacements along the element). The functions are found analytically in the closed form. They are functions of one linear dimensionless coordinate of x,axis and depend on one geometrical parameter of sinusoidal arch, height/span ratio "c" and on physical and geometrical properties of the element cross,section. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Carbon monoxide-induced axial skeletal dysmorphogenesis in the chick embryo,,BIRTH DEFECTS RESEARCH, Issue 4 2003Peter G. Alexander Abstract BACKGROUND Congenital axial skeletal defects affect two to three individuals per 1,000 live births. Without strong evidence for heritability, the cause is assumed to be multi-factorial. Carbon monoxide (CO), an increasingly prevalent environmental toxicant, is a potential environmental component in the etiology of these defects. The chick embryo is a useful model for the characterization and assessment of the mechanism(s) of action of basic developmental mechanisms. METHODS We have determined a critical period and dose for CO teratogenicity and established a model of CO-induced axial skeletal dysmorphogenesis in the chick embryo. The resulting phenotypes reveal a spectrum of axial skeletal defects ranging from minor defects of the vertebral canal and inter,vertebral discs, to thoraco,lumbar scoliosis, to a tailless phenotype reminiscent of caudal dysgenesis syndrome. These axial skeletal defects have been related to earlier developmental defects in somitogenesis, including errors in segmentation and epithelialization and the expression of the somitic epithelialization factor, Paraxis. We have examined patterns of cell death and apoptosis in CO exposed chick embryos to assess the target tissue(s) involved in the teratogenicity of CO. RESULTS With respect to the embryonic axis, the neural tube was found to be the most sensitive to CO-induced apoptosis, followed by the somitic mesoderm and Hensen's node. CONCLUSIONS We hypothesize that the somitic defects and the resulting axial skeletal dysmorphogenesis are caused by disrupted neural tube or ectoderm functions related to somite formation and maintenance. We also hypothesize that CO-induced dysmorphogenesis at this critical period of somitogenesis is caused by the overabundance of CO acting endogenously as a cellular signal, while coincidentally exerting its influence as a toxicant of oxygen delivery or utilization. Birth Defects Research (Part A) 67:219,230, 2003. Published 2003 Wiley-Liss, Inc. [source] |