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Allyl Cyanides (allyl + cyanide)

Distribution by Scientific Domains

Chemistry	80%

Selected Abstracts

ChemInform Abstract: Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones.

CHEMINFORM, Issue 27 2009
Ryo Yazaki
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides.

CHEMINFORM, Issue 52 2009
Yasuhiro Hirata
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides.

The Ototoxic Effects Induced in Rats by Treatment for 12 Weeks with 2-Butenenitrile, 3-Butenenitrile and cis-2-Pentenenitrile

BASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 3 2001
François Gagnaire
The rats were given, by gastric intubation, doses of 10, 20 and 40 mg ,· ,kg,1 3-butenenitrile (allyl cyanide) and 25, 50 and 100 mg ,· ,kg,1 of either cis/trans-2-butenenitrile (crotononitrile) or cis-2-pentenenitrile once a day, 5 days per week for 12 weeks. Oral administration of the three unsaturated nitriles produced deafness and absence of reaction when the animals were subject to droptest. Rats in the high dosage groups exhibited a complete disappearance of the five waves of the auditory evoked-potentials. There was a decrease in the amplitudes of the 2nd component of the auditory evoked-potentials. Those changes were not reversible at the 8th week of the recovery period. A dose-dependent effect on inner and outer hair cells was observed in the organ of Corti. The basal part of the cochlea was the most affected. Though no measurements were made of systemic exposure, a tentative ranking of decreasing ototoxicity of these three unsaturated nitriles might be proposed based on the electrophysiological deficiencies and histological losses observed: 3-butenenitrile >cis-2-pentenenitrile >cis/trans-2-butenenitrile. Moreover, rats treated with those nitriles showed a corneal opacity as well as a decrease in the amplitude and lengthening of the peak latencies of the visual evoked-potentials. These latter changes were reversible by the end of the 8th week of the recovery period and appeared to be related to the opacity of the cornea. [source]

Modular Chiral Bidentate Phosphonites: Design, Synthesis, and Application in Catalytic Asymmetric Hydroformylation Reactions

CHEMISTRY - A EUROPEAN JOURNAL, Issue 26 2008
Baoguo Zhao Dr.
Abstract A new class of C2 -symmetric chiral bidentate phosphonite ligands has been synthesized in moderate to good yields from readily available starting materials. Application of these air-stable chiral phosphonites in the RhI -catalyzed asymmetric hydroformylation of styrene derivatives, vinyl acetate, and allyl cyanide afforded the corresponding chiral aldehydes with high regio- and enantioselectivities under mild reaction conditions. The modular nature of the ligands allows fine-tuning of the selectivities through judicious modifications of the substituents on the ligand backbone. X-ray structural analysis of the catalyst precursor suggested that the steric hindrance caused by the protruding remote substituents of the ligands into the vicinity of the metal center might be an important factor for the enantio-control of the reaction, whereas the sense of asymmetric induction can be rationalized on the basis of a trigonal-bipyramidal transition state diagram. [source]