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Alzheimer's Disease Pathology (alzheimer + disease_pathology)
Selected AbstractsCorticobasal syndrome with Alzheimer's disease pathologyMOVEMENT DISORDERS, Issue 1 2009Akiko Imamura MD [source] Reply: Corticobasal syndrome with Alzheimer's disease pathologyMOVEMENT DISORDERS, Issue 1 2009Pratap Chand DM [source] Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in miceTHE JOURNAL OF COMPARATIVE NEUROLOGY, Issue 4 2007Chiye Aoki Abstract Mice with knock-in of two mutations that affect beta amyloid processing and levels (2xKI) exhibit impaired spatial memory by 9,12 months of age, together with synaptic plasticity dysfunction in the hippocampus. The goal of this study was to identify changes in the molecular and structural characteristics of synapses that precede and thus could exert constraints upon cellular mechanisms underlying synaptic plasticity. Drebrin A is one protein reported to modulate spine sizes and trafficking of proteins to and from excitatory synapses. Thus, we examined levels of drebrin A within postsynaptic spines in the hippocampus and entorhinal cortex. Our electron microscopic immunocytochemical analyses reveal that, by 6 months, the proportion of hippocampal spines containing drebrin A is reduced and this change is accompanied by an increase in the mean size of spines and decreased density of spines. In the entorhinal cortex of 2xKI brains, we detected no decrement in the proportion of spines labeled for drebrin A and no significant change in spine density at 6 months, but rather a highly significant reduction in the level of drebrin A immunoreactivity within each spine. These changes are unlike those observed for the somatosensory cortex of 2xKI mice, in which synapse density and drebrin A immunoreactivity levels remain unchanged at 6 months and older. These results indicate that brains of 2xKI mice, like those of humans, exhibit regional differences of vulnerability, with the hippocampus exhibiting the first signatures of structural changes that, in turn, may underlie the emergent inability to update spatial memory in later months. J. Comp. Neurol. 505:352,362, 2007. © 2007 Wiley-Liss, Inc. [source] Lack of association between an estrogen receptor 1 gene polymorphism and Parkinson's disease with dementiaACTA NEUROLOGICA SCANDINAVICA, Issue 3 2002K. M. Mattila Objective, To test for an association between an estrogen receptor 1 (ESR1) gene polymorphism and Parkinson's disease with dementia (PDD) in Finnish subjects. Subjects and methods, Forty-one clinically demented and pathologically confirmed PDD patients and 59 cognitively intact aged individuals with normal neuropathology were genotyped for the ESR1 PvuII polymorphism. Results, We found no significant differences in the genotype or allele frequencies when the PDD patients were compared with the controls. Nor were there any significant differences in these frequencies when the PDD patients with coexisting Alzheimer's disease pathology were compared with the control group. Conclusion, We failed to demonstrate an association between dementia-associated PD and the ESR1 PvuII polymorphism in Finnish subjects. [source] | ||||||||||