Alkyl Ketones (alkyl + ketone)

Distribution by Scientific Domains
Distribution within Chemistry

Kinds of Alkyl Ketones

  • aryl alkyl ketone

  • Selected Abstracts

    SnCl4 -Mediated Reactions of Cyclopropyl Alkyl Ketones with ,-Keto Esters.

    CHEMINFORM, Issue 12 2007
    Yong-Hua Yang
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Ruthenium-Catalyzed Enantioselective Reduction of Electron-Rich Aryl Alkyl Ketones.

    CHEMINFORM, Issue 49 2006
    Jenny Wettergren
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    (E)-Selective Horner,Wadsworth,Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2-trifluoroethyl)phosphonacetic Acid.

    CHEMINFORM, Issue 10 2004
    Shigeki Sano
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    ChemInform Abstract: The Reaction of 2-(Tetrazol-5-yl)alkyl Ketones and of 2-(Tetrazol-5-yl)alkanoic Acid Derivatives with Lead Tetraacetate.

    CHEMINFORM, Issue 35 2001
    A Novel Method of Preparation of Alk-2-ynyl Ketones, Alk-2-ynoic Acid Derivatives.
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    Convenient Enantioselective Hydrosilylation of Ketones Catalyzed by Zinc-Macrocyclic Oligoamine Complexes

    Jadwiga Gajewy
    Abstract Chiral macrocyclic tetra- and hexamine macrocycles derived from trans -1,2-diaminocyclohexane (DACH) in complexes with diethylzinc efficiently catalyze the asymmetric hydrosilylation of aryl alkyl ketones with enantiomeric excess of the product up to 89%. The cyclic structure of the trianglamine ligand increases the enantioselectivity of the reaction, in comparison to the catalysis with the acyclic N,N, -dibenzyl-DACH ligand. Density functional theory (DFT) computations on the structures of ligand-zinc complexes and on the structures of these complexes with a coordinated acetophenone molecule allow us to rationalize the direction of the asymmetric induction of the hydrosilylation reaction as well as the superiority of the cyclic ligand compared to the acyclic one. This is the first example of asymmetric catalysis for the hydrosilylation reaction of ketones with the use of a readily available, inexpensive, and reusable macrocyclic trianglamine ligand. [source]

    Discrete versus In Situ -Generated Aluminum-Salen Catalysts in Enantioselective Cyanosilylation of Ketones: Role of Achiral Ligands

    Ali Alaaeddine
    Abstract The monometallic species {Salen}AlX (X=Me, 2a,b; X=Cl, 4a,b; O- i- Pr, 5a,b) and open bimetallic species {Salen}[AlMe2]2 (3a,b) that result from binary combinations between an aluminum precursor [trimethylaluminum, dimethylaluminum chloride, aluminum tris(isopropoxide)] and a diprotio {Salen}H2 pro-ligand 1a,b (a=1R,2R -cyclohexyl-salen; b=1R,2R -diphenylethylene-salen) have been isolated. The crystal structures of 3b, 4b and of ,-oxo species [{diphenylethylene-salen}Al]2O (6b) are reported. The discrete species 2,5a,b have been individually evaluated in the asymmetric cyanosilylation of acetophenone. It is shown that, in several cases, these discrete catalysts display dramatically different performances than the catalyst systems in situ -generated from the binary combinations. The influence of the achiral ligand X on both the enantioselectivity and activity of the cyanosilylation reaction has been investigated, resulting in the definition of a highly active and productive hexafluoro-2-propoxide-based catalyst for a variety of aryl alkyl ketones (TON up to 470, TOF up to 140,h,1 at ,20,°C for acetophenone). [source]

    Investigations into the C -deuteriation of silyl enol ethers derived from aryl alkyl ketones

    Svitlana Buksha
    Abstract Results are reported on the regioselective C -deuteriation of a series of silyl enol ethers derived from aryl alkyl ketones using deuterium (D2) gas as the deuterium source and palladium-on-barium sulfate as the mediator. These results highlight the numerous reaction pathways and different product types available from simple deuteriation of substituted enol precursors. Copyright © 2006 John Wiley & Sons, Ltd. [source]

    Highly Enantioselective Ruthenium-Catalyzed Reduction of Ketones Employing Readily Available Peptide Ligands

    Anders Bøgevig Dr.
    Abstract Highly efficient and selective catalysts for the asymmetric reduction of aryl alkyl ketones under hydrogen-transfer conditions (2-propanol) were obtained by combining a novel class of pseudo-dipeptide ligands with [{RuCl2(p- cymene)}2]. A library of 36 dipeptide-like ligands was prepared from N -Boc-protected ,-amino acids and the enantiomers of 2-amino-1-phenylethanol and 1-amino-2-propanol. The catalyst library was evaluated with the reduction of acetophenone and excellent enantioselectivity of 1-phenylethanol was obtained with several of the novel catalysts. A ligand based on the combination of N -Boc- L -alanine and (S)-1-amino-2-propanol (ligand A - (S)- 4) was found to be particular effective. When the situ formed ruthenium complex of this ligand was employed as the catalyst in the hydrogen-transfer reaction of various aryl alkyl ketones, the corresponding alcohol products were achieved in excellent enantioselectivity (up to 98,% ee). [source]

    Facile and Efficient Reduction of Ketones in the Presence of Zinc Catalysts Modified by Phenol Ligands

    Stephan Enthaler Dr.
    Abstract In the present study, the zinc-catalyzed hydrosilylation of various ketones to give their corresponding alcohols has been examined in detail. Diethyl zinc that can be modified by easily accessible phenol ligands allows the efficient reduction of various aryl and alkyl ketones. By using a practical in situ catalyst, excellent turnover frequencies up to 1000,h,1 and a broad functional group tolerance were achieved. Im Rahmen dieser Arbeit wird die Zink-katalysierte Hydrosilylierung von Ketonen zu den entsprechenden Silylethern mit anschließender Hydrolyse zu deren Alkoholen vorgestellt. Wobei exzellente Ausbeuten und Umsätze durch die Modifikation des katalytisch eingesetzten Diethylzink mit Phenolen erreicht werden konnten. Nach genauer Untersuchung verschiedenster Reaktionsparameter konnten turnover frequencies (TOF) von ca. 1000,h,1 erzielt werden. Die hervorragenden Eigenschaften des Katalysatorsystems konnte weiterhin in der Hydrosilylierung verschiedenster Ketone erfolgreich gezeigt werden. Zum besseren Verständnis der Reaktion wurden verschiedene mechanistische Experimente durchgeführt. [source]

    Palladium-Mediated 11C-Carbonylative Cross-Coupling of Alkyl/Aryl Iodides with Organostannanes: An Efficient Synthesis of Unsymmetrical Alkyl/Aryl [11C- carbonyl]Ketones

    Farhad Karimi
    Abstract [11C]Carbon monoxide in low concentration, palladium complexes, alkyl/aryl iodides, and organostannanes are utilized in the synthesis of twenty alkyl [carbonyl- 11C]ketones. The activated palladium(0) species [Pd{P(o -Tol)3}2] was generated in situ from tris(dibenzylideneacetone)palladium(0) [Pd2(dba)3] and a large excess of tri- o -tolylphosphane [P(o -Tol)3]. The Stille coupling reactions were performed in a micro-autoclave system. Radiochemical yields of 11C-labelled alkyl/aryl ketones were in the range of 37,98,% with specific radioactivity up to 300 GBq,,mol,1. Using this method, 4'-aminoacetophen[13C- arbonyl)one 6 was synthesised in order to confirm the position of labelling (, = 196.7 ppm, CDCl3). The presented approach is an efficient way for synthesising 11C-labelled alkyl/aryl ketones with acceptable radiochemical yield and is generally applicable in 13C-labelling syntheses. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]