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Aldol Condensation Reaction (aldol + condensation_reaction)
Selected AbstractsChemInform Abstract: Efficient Synthesis of Dibenzo[a,c]cyclohepten-5-ones via a Sequential Suzuki,Miyaura Coupling and Aldol Condensation Reaction.CHEMINFORM, Issue 39 2009Young Lok Choi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] An Organocatalytic Domino Thia-Michael/Aldol Condensation Reaction: Highly Enantioselective Synthesis of Functionalized DihydrothiophenesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 13 2010Jie Tang Abstract An organocatalytic domino thia-Michael/aldol condensation reaction of ,, ,-unsaturated aldehydes with 1, 4-dithiane-2,5-diol catalyzed by chiral diphenylprolinol TMS ether has been developed, which provides a new practical and direct route to chiral dihydrothiophenes with high yields (up to 90%) and excellent enantioselectivities (up to>99% ee). The catalytic mechanism of the domino reaction was further confirmed through the APCI-MS detection of proposed reaction intermediates. [source] Convergent Approaches to Saudin IntermediatesHELVETICA CHIMICA ACTA, Issue 8 2003Raquel Different convergent approaches to the highly oxygenated sesquiterpene natural product saudin (1), has been investigated. Our strategy has included a Michael addition and aldol condensation reaction as key steps. During the synthetic development, we have found serious steric hindrance when an , -Me-substituted alkyl vinyl ketone was used. Such steric hindrance has been overcome by synthesizing the vinyl ketone 16 through an anionic fragmentation, which was carefully studied. Finally, the intermediate 18 has been synthesized in a one-pot reaction from the vinyl ketone 16 and has been cyclized to obtain the promising tricyclic intermediate 20. [source] Synthesis and Reactions of Halo-, Arylazo-substituted 3-(3-(1-naphthyl)acryloyl)tropolones.CHINESE JOURNAL OF CHEMISTRY, Issue 8 2010Formation of (Naphthalen-1-yl)vinyl)substituted Heterocycle-fused Troponoid Compounds Abstract The starting substrate 3-(3-(1-naphthyl)acryloyl)tropolone (3) was achieved by the aldol condensation reaction of 3-acetyltropolone with 1-naphthaldehyde. Compound 3 reacted with bromine to afford 7-bromo-3- (3-(1-naphthyl)acryloyl)tropolone (4), 5,7-dibromo-3-(3-(1-naphthyl)acryloyl)tropolone (5) according to the molar ratio of the reactants. Iodination of 3 gave 7-iodo-3-(3-(1-naphthyl)acryloyl)tropolone (6). Azo-coupling reactions of 3 gave the 5-arylazo-3-(3-(1-naphthyl)acryloyl)tropolones (7,8). Compounds 3, 4, 6 reacted respectively with hydroxyamine to give the corresponding 3-[2-(1-naphthyl)vinyl]-8H -cyclohepta[d]isoxazol-8-ones (9,11). The reactions of 3, 5 with phenylhydrazine and substituted phenylhydrazines gave 3-[2-(1-naphthyl)vinyl]-1-phenylcyclohepta[c]pyrazol-8(1H)-ones (12,18). [source] An Organocatalytic Domino Thia-Michael/Aldol Condensation Reaction: Highly Enantioselective Synthesis of Functionalized DihydrothiophenesADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 13 2010Jie Tang Abstract An organocatalytic domino thia-Michael/aldol condensation reaction of ,, ,-unsaturated aldehydes with 1, 4-dithiane-2,5-diol catalyzed by chiral diphenylprolinol TMS ether has been developed, which provides a new practical and direct route to chiral dihydrothiophenes with high yields (up to 90%) and excellent enantioselectivities (up to>99% ee). The catalytic mechanism of the domino reaction was further confirmed through the APCI-MS detection of proposed reaction intermediates. [source] | ||||||||||||||||||||||