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Alcohol Research (alcohol + research)
Selected AbstractsTHINKING OUTSIDE THE BOX: A NECESSARY COURSE FOR THE FUTURE OF ALCOHOL RESEARCHADDICTION, Issue 5 2010ROGER E. MEYER No abstract is available for this article. [source] Signal Transduction in Alcohol-Related DiseasesALCOHOLISM, Issue 7 2005Minoti V. Apte This article summarizes the proceedings of a symposium presented at the 12th World Congress on Biomedical Alcohol Research, organized by the International Society for Biomedical Research on Alcoholism, held at the University of Heidelberg in Mannheim, Germany, in September and October 2004. The organizers and chairpersons were Manfred V. Singer and Stephen J. Pandol. The presentations were (1) Ethanol-induced acinar cell injury, by Minoti V. Apte; (2) Oxidants and antioxidants: signal transduction and alcohol, by Thomá Zima; (3) Anti,TGF-, strategies for the treatment of chronic liver disease, by Steven Dooley; (4) Immune mechanisms in alcohol-induced liver disease, by Sören V. Siegmund; and (5) Alcoholic pancreatitis: insights from animal models, by Steven J. Pandol. [source] Recent Advances in Alcohol-Induced Adduct FormationALCOHOLISM, Issue 7 2005Thomas L. Freeman This article presents the proceedings of a symposium presented at the ISBRA 12th World Congress on Biomedical Alcohol Research, held in Heidelberg/Mannheim, Germany, September 29 through October 2, 2004. The organizers of the symposium were Simon Worrall and Victor Preedy, and the symposium was chaired by Onni Niemelä and Geoffrey Thiele. The presentations scheduled for this symposium were (1) Adduct chemistry and mechanisms of adduct formation, by Thomas L. Freeman; (2) Malondialdehyde-acetaldehyde adducts: the 2004 update, by Geoffrey Thiele; (3) Adduct formation in the liver, by Simon Worrall; (4) Protein adducts in alcoholic cardiomyopathy, by Onni Niemelä; and (5) Alcoholic skeletal muscle myopathy: a role for protein adducts, by Victor R. Preedy. [source] How Important Are Brain Banks for Alcohol Research?ALCOHOLISM, Issue 2 2003Clive Harper This article contains the proceedings of a symposium at the 2002 RSA/ISBRA Meeting in San Francisco, organized and chaired by Clive Harper and co-chaired by Izuru Matsumoto. The presentations were (1) Introduction, by Clive Harper; (2) The quality of tissue,a critical issue, by Therese Garrick; (3) The first systematic brain tissue donor program in Japan, by Izuru Matsumoto; (4) Brain scans after death,really! by Adolf Pfefferbaum, Elfar Adalsteinsson, and Edith Sullivan; (5) Capture that (genial) expression, by Joanne Lewohl and Peter Dodd; and (6) Neurochemical/pharmacological studies: experimental design and limitations, by Roger Butterworth. [source] Alcohol research and the alcoholic beverage industry: issues, concerns and conflicts of interestADDICTION, Issue 2009Thomas F. Babor ABSTRACT Aims Using terms of justification such as ,corporate social responsibility' and ,partnerships with the public health community', the alcoholic beverage industry (mainly large producers, trade associations and ,social aspects' organizations) funds a variety of scientific activities that involve or overlap with the work of independent scientists. The aim of this paper is to evaluate the ethical, professional and scientific challenges that have emerged from industry involvement in alcohol science. Method Source material came from an extensive review of organizational websites, newspaper articles, journal papers, letters to the editor, editorials, books, book chapters and unpublished documents. Results Industry involvement in alcohol science was identified in seven areas: (i) sponsorship of research funding organizations; (ii) direct financing of university-based scientists and centers; (iii) studies conducted through contract research organizations; (iv) research conducted by trade organizations and social aspects/public relations organizations; (v) efforts to influence public perceptions of research, research findings and alcohol policies; (vi) publication of scientific documents and support of scientific journals; and (vii) sponsorship of scientific conferences and presentations at conferences. Conclusion While industry involvement in research activities is increasing, it constitutes currently a rather small direct investment in scientific research, one that is unlikely to contribute to alcohol science, lead to scientific breakthroughs or reduce the burden of alcohol-related illness. At best, the scientific activities funded by the alcoholic beverage industry provide financial support and small consulting fees for basic and behavioral scientists engaged in alcohol research; at worst, the industry's scientific activities confuse public discussion of health issues and policy options, raise questions about the objectivity of industry-supported alcohol scientists and provide industry with a convenient way to demonstrate ,corporate responsibility' in its attempts to avoid taxation and regulation. [source] Forming a national multicentre collaboration to conduct clinical trials: Increasing high-quality research in the drug and alcohol fieldDRUG AND ALCOHOL REVIEW, Issue 5 2010ROB SANSON-FISHER Abstract Issues. There is a shortage of high-quality intervention-based evidence in the drug and alcohol misuse field. That is, evidence based on replicated effects using rigorous methodology, to establish a causal knowledge base around ethical, cost-effective methods relevant to clinical practice. The knowledge base in this field is limited participant recruitment challenges; difficulty generalising results from single-centre studies; lack of research culture; issues in managing research teams; incentives for descriptive research; and limited expertise in research design and working in multidisciplinary teams. Approach. An Australian national multicentre collaboration is proposed to overcome these barriers, and reduce the burden of drug and alcohol misuse by increasing the number of high-quality clinical trials in this field. It would involve: selecting a representative sample of centres nation-wide with expertise in specific drug and alcohol issues; creating an expert multidisciplinary team to facilitate clinical trials; simultaneous recruitment and implementation of clinical trials across centres; establishing a virtual infrastructure; forming an independent data-integrity and methodology review panel; and attracting and allocating funding for clinical trials. Implications. The ability to allocate funding, the involvement of multidisciplinary experts in drug and alcohol research, and the establishment of infrastructure and procedures are likely to result in the national multicentre group's capacity to prescribe the type of research conducted under its auspices. Conclusion. The proposed initiative is likely to increase the volume of high-quality clinical trials in the Australian drug and alcohol field, a key step towards reducing the burden of drug and alcohol misuse.[Sanson-Fisher R, Brand M, Shakeshaft A, Haber P, Day C, Conigrave K, Mattick R, Lintzeris N, Teesson M. Forming a national multicentre collaboration to conduct clinical trials: Increasing high-quality research in the drug and alcohol field. Drug Alcohol Rev 2010;29;469,474] [source] Alcohol research and the alcoholic beverage industry: issues, concerns and conflicts of interestADDICTION, Issue 2009Thomas F. Babor ABSTRACT Aims Using terms of justification such as ,corporate social responsibility' and ,partnerships with the public health community', the alcoholic beverage industry (mainly large producers, trade associations and ,social aspects' organizations) funds a variety of scientific activities that involve or overlap with the work of independent scientists. The aim of this paper is to evaluate the ethical, professional and scientific challenges that have emerged from industry involvement in alcohol science. Method Source material came from an extensive review of organizational websites, newspaper articles, journal papers, letters to the editor, editorials, books, book chapters and unpublished documents. Results Industry involvement in alcohol science was identified in seven areas: (i) sponsorship of research funding organizations; (ii) direct financing of university-based scientists and centers; (iii) studies conducted through contract research organizations; (iv) research conducted by trade organizations and social aspects/public relations organizations; (v) efforts to influence public perceptions of research, research findings and alcohol policies; (vi) publication of scientific documents and support of scientific journals; and (vii) sponsorship of scientific conferences and presentations at conferences. Conclusion While industry involvement in research activities is increasing, it constitutes currently a rather small direct investment in scientific research, one that is unlikely to contribute to alcohol science, lead to scientific breakthroughs or reduce the burden of alcohol-related illness. At best, the scientific activities funded by the alcoholic beverage industry provide financial support and small consulting fees for basic and behavioral scientists engaged in alcohol research; at worst, the industry's scientific activities confuse public discussion of health issues and policy options, raise questions about the objectivity of industry-supported alcohol scientists and provide industry with a convenient way to demonstrate ,corporate responsibility' in its attempts to avoid taxation and regulation. [source] Safety in drug and alcohol researchADDICTION, Issue 12 2003CAROLYN DAY No abstract is available for this article. [source] Alcohol consumption and liver cirrhosis mortality with and without mention of alcohol,the case of CanadaADDICTION, Issue 9 2003Mats Ramstedt ABSTRACT Aims, To analyse post-war variations in per capita alcohol consumption in relation to gender-specific liver cirrhosis mortality in Canadian provinces and to assess the extent to which alcohol bears a different relation to cirrhosis deaths with mention of alcohol (alcoholic cirrhosis) compared to cirrhosis deaths without mention of alcohol (non-alcoholic cirrhosis). Data and method, Annual liver cirrhosis mortality rates by 5-year age groups were converted into gender-specific and age-adjusted mortality rates. Outcome measures included total cirrhosis,the conventional measure of liver cirrhosis,alcoholic cirrhosis and non-alcoholic cirrhosis. Per capita alcohol consumption was measured by alcohol sales and weighted with a 10-year distributed lag model. A graphical analysis was used to examine the regional relationship and the Box,Jenkins technique for time-series analysis was used to estimate the temporal relationship. Findings, Geographical variations in alcohol consumption corresponded to variations in total liver cirrhosis and particularly alcoholic cirrhosis, whereas non-alcoholic cirrhosis rates were not associated geographically with alcohol consumption. In general, for all provinces, time-series analyses revealed positive and statistically significant effects of changes in alcohol consumption on cirrhosis mortality. In Canada at large, a 1-litre increase in per capita consumption was associated with a 17% increase in male total cirrhosis rates and a 13% increase in female total cirrhosis rates. Alcohol consumption had a stronger impact on alcoholic cirrhosis, which increased by fully 30% per litre increase in alcohol per capita for men and women. Although the effect on the non-alcoholic cirrhosis rate was weaker (12% for men and 7% for women) it was nevertheless statistically significant and suggests that a large proportion of these deaths may actually be alcohol-related. Conclusions, Some well-established findings in alcohol research were confirmed by the Canadian experience: per capita alcohol consumption is related closely to death rates from liver cirrhosis and alcohol-related deaths tend to be under-reported in mortality statistics. [source] Conversation with Klaus MäkeläADDICTION, Issue 10 2001Article first published online: 1 SEP 200 In this occasional series we record the views and personal experiences of people who have specially contributed to the evolution of ideas in the Journal's field of interest. Klaus Mäkelä is a Finnish sociologist who has exerted a wide international influence in thinking on alcohol research and policy analysis. [source] REVIEW: Consilient research approaches in studying gene × environment interactions in alcohol researchADDICTION BIOLOGY, Issue 2 2010Kenneth J. Sher ABSTRACT This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of environmental exposures, many key human environmental risk factors for alcohol dependence have no clear equivalents in other species, much of the genetic variance of alcohol dependence in human is not ,alcohol specific', and the potential range of gene-environment interactions that could be considered is so vast that maintaining statistical control of Type 1 errors is a daunting task. Despite these and other challenges, there appears to be a number of promising approaches that could be taken in order to achieve consilience and ecologically valid translation between human alcohol dependence and animal models. Foremost among these is to distinguish environmental exposures that are thought to have enduring effects on alcohol use motivation (and self-regulation) from situational environmental exposures that facilitate the expression of such motivations but do not, by themselves, have enduring effects. In order to enhance consilience, various domains of human approach motivation should be considered so that relevant environmental exposures can be sampled, as well as the appropriate species to study them in (i.e. where such motivations are ecologically relevant). Foremost among these are social environments, which are central to the initiation and escalation of human alcohol consumption. The value of twin studies, human laboratory studies and pharmacogenetic studies is also highlighted. [source] REVIEW: Alcohol-related genes: contributions from studies with genetically engineered miceADDICTION BIOLOGY, Issue 3-4 2006John C. Crabbe ABSTRACT Since 1996, nearly 100 genes have been studied for their effects related to ethanol in mice using genetic modifications including gene deletion, gene overexpression, gene knock-in, and occasionally by studying existing mutants. Nearly all such studies have concentrated on genes expressed in brain, and the targeted genes range widely in their function, including most of the principal neurotransmitter systems, several neurohormones, and a number of signaling molecules. We review 141 published reports of effects (or lack thereof) of 93 genes on responses to ethanol. While most studies have focused on ethanol self-administration and reward, and/or sedative effects, other responses studied include locomotor stimulation, anxiolytic effects, and neuroadaptation (tolerance, sensitization, withdrawal). About 1/4 of the engineered mutations increase self-administration, 1/3 decrease it, and about 40% have no significant effect. In many cases, the effects on self-administration are rather modest and/or depend on the specific experimental procedures. In some cases, genes in the background strains on which the mutant is placed are important for results. Not surprisingly, review of the systems affected further supports roles for serotonin, ,-aminobutyric acid, opioids and dopamine, all of which have long been foci of alcohol research. Novel modulatory effects of protein kinase C and G protein-activated inwardly rectifying K+ (GIRK) channels are also suggested. Some newer research with cannabinoid systems is promising, and has led to ongoing clinical trials. [source] The feasibility of providing community pharmacy-based services for alcohol misuse: A literature reviewINTERNATIONAL JOURNAL OF PHARMACY PRACTICE, Issue 4 2009Dr Margaret C. Watson Abstract Objectives Excessive consumption of alcohol is a major public health concern. The use of community pharmacies and pharmacists as sources of public health information and services is gaining greater recognition. The objective of this review was to provide an overview of the evidence on the feasibility, effectiveness and acceptability of providing community pharmacy-based services to address the excessive consumption of alcohol. Methods Electronic databases were searched for the period 1996,2007 to identify relevant evidence. Searches were also conducted of relevant pharmacy and addiction journals. Information was sought from key contacts in pharmacy and alcohol research. Studies were included if they were conducted in a community pharmacy setting. Key findings The review comprised three feasibility studies which included 14 pharmacies and 500 customers. Non-significant reductions in alcohol consumption were reported with two studies following brief interventions by pharmacists. Between 30% and 53% of pharmacy customers were identified as having hazardous or harmful drinking behaviour. Customer opinion of the pharmacy-based alcohol services was not reported. Conclusions There has been little empirical evaluation of the effectiveness of community pharmacy-based services for alcohol misuse. The evidence presented in this review suggests that community pharmacy-based screening is feasible. Organisations and individuals involved with tackling excessive alcohol consumption should consider the inclusion of community pharmacies and pharmacists as part of their strategies to address this problem. Large-scale studies are needed to evaluate the short- and long-term effects and cost-effectiveness of community pharmacy-based interventions to reduce excessive alcohol consumption, as well as to explore the acceptability of the service to users. [source] Characterizing and Reaching High-Risk Drinkers Using Audience SegmentationALCOHOLISM, Issue 8 2009Howard B. Moss Background:, Market or audience segmentation is widely used in social marketing efforts to help planners identify segments of a population to target for tailored program interventions. Market-based segments are typically defined by behaviors, attitudes, knowledge, opinions, or lifestyles. They are more helpful to health communication and marketing planning than epidemiologically defined groups because market-based segments are similar in respect to how they behave or might react to marketing and communication efforts. However, market segmentation has rarely been used in alcohol research. As an illustration of its utility, we employed commercial data that describes the sociodemographic characteristics of high-risk drinkers as an audience segment, including where they tend to live, lifestyles, interests, consumer behaviors, alcohol consumption behaviors, other health-related behaviors, and cultural values. Such information can be extremely valuable in targeting and planning public health campaigns, targeted mailings, prevention interventions, and research efforts. Methods:, We described the results of a segmentation analysis of those individuals who self-reported to consume 5 or more drinks per drinking episode at least twice in the last 30 days. The study used the proprietary PRIZMÔ (Claritas, Inc., San Diego, CA) audience segmentation database merged with the Center for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS) database. The top 10 of the 66 PRIZMÔ audience segments for this risky drinking pattern are described. For five of these segments we provided additional in-depth details about consumer behavior and the estimates of the market areas where these risky drinkers resided. Results:, The top 10 audience segments (PRIZM clusters) most likely to engage in high-risk drinking are described. The cluster with the highest concentration of binge-drinking behavior is referred to as the "Cyber Millenials." This cluster is characterized as "the nation's tech-savvy singles and couples living in fashionable neighborhoods on the urban fringe." Almost 65% of Cyber Millenials households are found in the Pacific and Middle Atlantic regions of the United States. Additional consumer behaviors of the Cyber Millenials and other segments are also described. Conclusions:, Audience segmentation can assist in identifying and describing target audience segments, as well as identifying places where segments congregate on- or offline. This information can be helpful for recruiting subjects for alcohol prevention research as well as planning health promotion campaigns. Through commercial data about high-risk drinkers as "consumers," planners can develop interventions that have heightened salience in terms of opportunities, perceptions, and motivations, and have better media channel identification. [source] Changes in the self-regulation guidelines of the US Beer Code reduce the number of content violations reported in TV advertisementsJOURNAL OF PUBLIC AFFAIRS, Issue 1-2 2010Thomas F. Babor From a public health perspective, alcohol advertising should not be directed at vulnerable groups, nor should it portray excessive drinking or other objectionable content such as illegal activity. To promote the responsible advertising of alcoholic beverages, alcohol industry groups have developed self-regulation guidelines that describe which types of content (and exposure markets) are unacceptable. In 2006 the US Beer Institute revised the content guidelines of the 1997 Beer Code. This study was designed to determine whether these changes made the revised Code more or less likely for expert judges to report guideline violations, and for alcohol advertisements to include otherwise inappropriate content from a public health perspective. Six alcohol advertisements known or suspected to have multiple content violations were rated by 139 experts selected on the basis of their expertise in public health, mental health, alcohol research and marketing. The ads were rated on two occasions with feedback about other viewers' ratings provided at the second rating. The data were collected by means of a computer-based rating program that used multiple items to evaluate the eight major content guidelines of the US Beer Code. The ratings were scored according to both the 1997 and the 2006 versions of the Beer Code. According to the 1997 criteria, raters identified an average of 26 guideline violations across the six ads; the number of violations was reduced to 18 when the 2006 criteria were applied. The difference was statistically significant and was primarily attributable to changes in guidelines dealing with the portrayal of illegal activity, humorous situations and the act of drinking. By removing or revising commonly violated guidelines, the 2006 Beer Code revision permits portrayal of previously objectionable ad content and increases the likelihood that risky drinking behaviours will be portrayed in US beer advertisements. Copyright © 2009 John Wiley & Sons, Ltd. [source] The Language of Intoxication: Preliminary InvestigationsALCOHOLISM, Issue 3 2009Ash Levitt Background:, The extensive vocabulary individuals use to describe alcohol's subjective effects has largely gone unexamined in contemporary alcohol research. The present study examined the language drinkers use to describe their own intoxication. It is argued that this language can provide a more complete characterization of alcohol's subjective effects than is available from existing objective and subjective measures of alcohol use and can inform future self-report research. Method:, Toward this goal, a preliminary, cross-sectional, web-based study of the familiarity and usage of current intoxication-related words was conducted in 2 different samples (n = 290 and 146, respectively) of university undergraduates. Results:, Exploratory factor analyses using data from the first sample and confirmatory factor analyses using data from the second sample similarly showed that commonly used terms loaded onto 2 factors, which directly reflected the number of drinks required to be considered moderately or heavily intoxicated, respectively. Gender differences were also found in the familiarity and self-use of some terms across both samples. Conclusions:, The findings suggest that alcohol researchers include multiple intoxication-related terms in future self-report research, and to periodically assess current intoxication-related vocabulary considering demographic, generational, and socio-cultural differences. [source] | ||||||||||