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Eyelid Basal Cell Carcinomas (eyelid + basal_cell_carcinoma)

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Medical Sciences100%

Selected Abstracts

Mohs' micrographic surgery for basal cell carcinomas on the eyelids and medial canthal areaI

ACTA OPHTHALMOLOGICA, Issue 4 2000
I. Characteristics of the tumours, details of the procedure
ABSTRACT. Purpose: To analyse the characteristics of eyelid basal cell carcinomas excised using Mohs' micrographic technique. Methods: Sixty-six eyelid basal cell carcinomas were excised using Mohs' micrographic technique. The tumours were classified into four subtypes; morpheiform, intermediate, nodular/micronodular and superficial. Data on previous treatment of the tumours were retrieved. Results: Thirty-two tumours (48%) were primary, 8 tumours (12%) were incompletely excised using conventional excision surgery and 26 tumours (39%) were recurrent. Nineteen of the 26 (73%) recurrent tumours and 14 of the 32 (44%) primary tumours were nodular/micronodular. To achieve radical excision, superficial tumours needed an average of 2.0, nodular/micronodular 2.5, intermediate 2.0 and morpheiform tumours 2.9 excisions. Conclusions: Eyelid basal cell carcinomas with ill-defined borders or recurrent tumours are well suited for Mohs' micrographic surgery. The extensions of the tumours are difficult to determine even in some less aggressive subtypes such as superficial and nodular/micronodular basal cell carcinomas. [source]

Imiquimod in the treatment of eyelid basal cell carcinoma

ACTA OPHTHALMOLOGICA, Issue 5 2007
Jari Leppälä
ABSTRACT. Purpose:, To assess the efficacy and safety of topical imiquimod 5% cream in the treatment of eyelid basal cell carcinoma. Methods:, Four patients with eyelid basal cell carcinoma were treated with imiquimod once daily, 5 days per week, for 6 weeks. Tissue biopsy was taken and clinical examination with slit-lamp microscopy was performed at the beginning of the study and after a follow-up of 12 weeks. Photographic follow-up was performed from the baseline visit to 6, 12 and 26 weeks. Results:, In the 12-week follow-up after imiquimod treatment, histopathological tissue sample analysis showed no signs of basal cell carcinoma in any of the patients. Conclusions:, The results indicate that 5% imiquimod cream with topical administration may represent a new therapy option for eyelid basal cell carcinoma. [source]

High incidence of demodicidosis in eyelid basal cell carcinomas

INTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 7 2003
Zülal Erbagci MD
Background Although UV radiation is the major cause of basal cell carcinoma (BCC), local factors, such as chronic trauma, irritation, or inflammation, may also have some role in its etiopathogenesis. The pilosebaceous follicle mites, Demodex folliculorum and D. brevis, inhabit most commonly and densely certain facial skin areas, including the nose and periorbital regions, where BCC also develops most frequently. Aim To investigate, in a retrospective histopathologic study, whether a possible etiopathogenetic relationship exists between demodicidosis and eyelid BCCs. Methods We examined 32 eyelid BCC specimens that contained at least five eyelashes or five hair follicles with respect to the presence and density of Demodex mites. As controls, we evaluated 34 matched specimens consisting of benign eyelid skin lesions. Results Twenty-one of 32 BCC cases (65.6%) and eight of 34 control cases (23.33%) had demodicidosis. Mean mite counts were 1.31 ± 1.57 and 0.47 ± 0.99 in BCC cases and controls, respectively. The differences were significant for both prevalence (P < 0.001) and density (P = 0.0052). Although there was a significant positive correlation between increasing mite number and patient age in the control group (r = 0.47, P < 0.05), no significant correlation was found between these two factors in BCC cases (r = ,0.102, P > 0.05). Conclusions Demodicidosis may be one of the triggering factors of carcinogenesis in eyelid BCCs in otherwise predisposed people due to its traumatic/irritating effect or chronic inflammation. [source]

Mohs' micrographic surgery for basal cell carcinomas on the eyelids and medial canthal areaI

ACTA OPHTHALMOLOGICA, Issue 4 2000
I. Characteristics of the tumours, details of the procedure
ABSTRACT. Purpose: To analyse the characteristics of eyelid basal cell carcinomas excised using Mohs' micrographic technique. Methods: Sixty-six eyelid basal cell carcinomas were excised using Mohs' micrographic technique. The tumours were classified into four subtypes; morpheiform, intermediate, nodular/micronodular and superficial. Data on previous treatment of the tumours were retrieved. Results: Thirty-two tumours (48%) were primary, 8 tumours (12%) were incompletely excised using conventional excision surgery and 26 tumours (39%) were recurrent. Nineteen of the 26 (73%) recurrent tumours and 14 of the 32 (44%) primary tumours were nodular/micronodular. To achieve radical excision, superficial tumours needed an average of 2.0, nodular/micronodular 2.5, intermediate 2.0 and morpheiform tumours 2.9 excisions. Conclusions: Eyelid basal cell carcinomas with ill-defined borders or recurrent tumours are well suited for Mohs' micrographic surgery. The extensions of the tumours are difficult to determine even in some less aggressive subtypes such as superficial and nodular/micronodular basal cell carcinomas. [source]

Mohs' micrographic surgery for basal cell carcinomas on the eyelids and medial canthal area.

ACTA OPHTHALMOLOGICA, Issue 4 2000

ABSTRACT. Purpose: To report our experience of reconstruction and follow-up of eyelid basal cell carcinomas treated with Mohs' micrographic technique. Methods: Sixty-four periocular basal cell carcinomas, with a high risk of recurrence in one or more aspects with regard to location, size, morphology or prior treatment, were excised using Mohs' micrographic technique. All ensuing defects were repaired. The cases were followed prospectively for up to ten years. All complications and interventions were documented during the follow-up period. Results: The average size of the defect before repair was 21 mm (range 5,45 mm). The mean follow-up time was 49 months (range 3,120). The recurrence rate was 5% (3 of 64 cases). The three recurrences occurred after one, four and six years, respectively. Conclusions: The recurrence rate of high risk tumours reported in this study was less than reported with other modes of treatment and comparable with that in other studies using Mohs' micrographic technique. [source]