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Extensive Spectroscopic Analyses (extensive + spectroscopic_analysis)
Selected AbstractsNew Epoxy-Substituted Nitrogenous Bisabolene-Type Sesquiterpenes from a Hainan Sponge Axinyssa sp.HELVETICA CHIMICA ACTA, Issue 3 2010Ji-Zheng Sun Abstract Two new uncommon epoxy-substituted nitrogenous bisabolene-type sesquiterpenes, 3-formamido-7,8-epoxy- , -bisabolane (4), 3-isocyano-7,8-epoxy- , -bisabolane (5), together with three known related sesquiterpenes, 1,3, were isolated from the Hainan sponge Axinyssa sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their NMR data with those of structurally related compounds. [source] Daphnoldines A and B, Two New Yuzurine Alkaloids with a Four-Ring System, from the Fruits of Daphniphyllum oldhamiHELVETICA CHIMICA ACTA, Issue 5 2008Qiang Zhang Abstract Two new yuzurine alkaloids, daphnoldines A (1) and B (2), possessing a rare four-ring system, were isolated from the fruits of Daphniphyllum oldhami. Their structures were established on the basis of extensive spectroscopic analyses. Daphnoldine A (1) is the first example of Daphniphyllum alkaloids bearing a hydroxymethyl group at C(14). [source] Diarylheptanoids from the Rhizomes of Alpinia officinarumHELVETICA CHIMICA ACTA, Issue 1 2008Yi Sun Abstract A novel dimeric diarylheptanoid, (5R,5,R)-7,7,-(6,6,-dihydroxy-5,5,-dimethoxy[1,1,-biphenyl]-3,3,-diyl)bis[5-methoxy-1-phenylheptan-3-one] (1), and two new diarylheptanoids, (4E,6R)-6-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (2) and (4E,6R)-6-hydroxy-1,7-diphenylhept-4-en-3-one (3), together with seven known diarylheptanoids, were isolated from the rhizomes of Alpinia officinarum. Their structures were elucidated by application of extensive spectroscopic analyses and the modified Mosher method. [source] A Novel Atisane Diterpenoid from Spiraea japonica var. acutaHELVETICA CHIMICA ACTA, Issue 7 2007Hai-Yang Liu Abstract A novel ent -atisane lactone, spiramilactone E (1), was isolated from Spiraea japonica var. acutaYu. Its structure was elucidated by extensive spectroscopic analyses, and unequivocally confirmed by single-crystal X-ray diffraction (Fig.,2). Compound 1 contains a , -lactone moiety between the 6-OH function and C(20), and ,- configuration for the 7-OH group, in contrast to known related diterpenes previously isolated from the S. japonica complex. [source] Antioxidant polyphenols from the mycelial culture of the medicinal fungi Inonotus xeranticus and Phellinus linteusJOURNAL OF APPLIED MICROBIOLOGY, Issue 6 2008J.-Y. Jung Abstract Aims:, The medicinal fungi Inonotus xeranticus and Phellinus linteus in the family Hymenochaetaceae have been used as traditional medicines for the treatment of various diseases. However, the compound responsible for the antioxidant activity is still unknown. Therefore, this study was conducted to characterize the antioxidant substances present in cultured broths made from these fungi. Methods and Results:, Antioxidant fractions of the cultured broths obtained from I. xeranticus and P. linteus were analysed using reversed-phase HPLC, which revealed several peaks that exhibited a potent free radical scavenging activity. To identify these antioxidant peaks, an I. xeranticus strain was mass-cultured, and the cultured broth was separated using antioxidant activity-guided fractionation. Four major active substances were purified and identified as hispidin and its dimers, 3,14,-bihispidinyl, hypholomine B, and 1,1-distyrylpyrylethan based on spectroscopic analyses. All compounds exhibited a significant scavenging activity against these radical species in a concentration-dependent manner. Conclusions:, Antioxidant substances found in the cultured broths of the medicinal fungi I. xeranticus and P. linteus were identified as hispidin and its dimers, 3,14,-bihispidinyl, hypholomine B, and 1,1-distyrylpyrylethan. Significance and Impact of the Study:, Polyphenol antioxidants were isolated from the cultured broth of the medicinal fungi I. xeranticus and P. linteus and identified based on extensive spectroscopic analyses. These compounds exhibited a strong antioxidant activity. [source] Terpioside from the Marine Sponge Terpios sp., the First Glycosphingolipid Having an L -Fucofuranose Unit,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 12 2008Valeria Costantino Abstract The new diglycosylceramide terpioside (1a) has been isolated from the marine sponge Terpios sp. Terpioside is a diglycosylated glycosphingolipid which is the first example of a natural glycosphingolipid having an L -fucofuranose unit. The structure of terpioside was elucidated by extensive spectroscopic analysis, whereas chemical degradation was used to establish the nature of the alkyl chains and the absolute configuration of the sugars and of the ceramide stereogenic centers.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source] A New Tricyclo[6.3.1.02,5]dodecane Sesquiterpene from Cultures of the Basidiomycete Campanella junghuhniiHELVETICA CHIMICA ACTA, Issue 2 2009Rong Liu Abstract A new sesquiterpene with a tricyclo[6.3.1.02,5]dodecane skeleton, 2,3,6-trihydroxycaryol-5-en-7-one (1), was isolated from the culture of the basidiomycete Campanella junghuhnii. The structure of 1 was elucidated on the basis of extensive spectroscopic analysis including IR, UV, MS, 1D- and 2D-NMR experiments. [source] New Briaranes from the South China Sea Gorgonian Junceella fragilisHELVETICA CHIMICA ACTA, Issue 8 2005Shu-Hua Qi Three new briarane diterpenes, junceellonoids C,E (1,3), along with six known briaranes, junceellin A (4), praelolide (5), and junceellolides A-D (6,9), were isolated from the EtOH/CH2Cl2 extracts of the South China Sea gorgonian coral Junceella fragilis. The structures of 1,3 were established by extensive spectroscopic analysis, including 1D- and 2D-NMR data. Compounds 1 and 2 exhibited mild cytotoxicity against human galactophore carcinoma (MDA-mB-231 and MCF-7) cells at the concentration of 100,,M. [source] Polyprenylated Xanthones from Garcinia lancilimba Showing Apoptotic Effects against HeLa-C3 CellsCHEMISTRY & BIODIVERSITY, Issue 12 2008Quan-Bing Han Abstract Three new prenylated xanthones, 1,3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein. [source] Cytotoxic Prenylated Phenolic Compounds from the Twig Bark of Garcinia xanthochymusCHEMISTRY & BIODIVERSITY, Issue 5 2007Quan-Bin Han Abstract Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1,3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans. [source] | ||||||||||