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Expanding Application (expanding + application)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Impedance Spectroscopy: A Powerful Tool for Rapid Biomolecular Screening and Cell Culture Monitoring

ELECTROANALYSIS, Issue 23 2005
Isaac
Abstract Dielectric spectroscopy or Electrochemical impedance spectroscopy (EIS) is traditionally used in corrosion monitoring, coatings evaluation, batteries, and electrodeposition and semiconductor characterization. However, in recent years, it is gaining widespread application in biotechnology, tissue engineering, and characterization of biological cells, disease diagnosis and cell culture monitoring. This article discusses the principles and implementation of dielectric spectroscopy in these bioanalytical applications. It provides examples of EIS as label-free, mediator-free strategies for rapid screening of biocompatible surfaces, monitoring pathogenic bacteria, as well as the analysis of heterogeneous systems, especially biological cells and tissues. Descriptions are given of the application of nanoparticles to improve the analytical sensitivities in EIS. Specific examples are given of the detection of base pair mismatches in the DNA sequence of Hepatitis B disease, TaySach's disease and Microcystis spp. Others include the EIS detection of viable pathogenic bacteria and the influence of nanomaterials in enhancing biosensor performance. Expanding applications in tissue engineering such as adsorption of proteins onto thiolated hexa(ethylene glycol)-terminated (EG6) self-assembled monolayer (SAM) are discussed. [source]

Recent advances in permafrost modelling

PERMAFROST AND PERIGLACIAL PROCESSES, Issue 2 2008
Daniel Riseborough
Abstract This paper provides a review of permafrost modelling advances, primarily since the 2003 permafrost conference in Zürich, Switzerland, with an emphasis on spatial permafrost models, in both arctic and high mountain environments. Models are categorised according to temporal, thermal and spatial criteria, and their approach to defining the relationship between climate, site surface conditions and permafrost status. The most significant recent advances include the expanding application of permafrost thermal models within spatial models, application of transient numerical thermal models within spatial models and incorporation of permafrost directly within global circulation model (GCM) land surface schemes. Future challenges for permafrost modelling will include establishing the appropriate level of integration required for accurate simulation of permafrost-climate interaction within GCMs, the integration of environmental change such as treeline migration into permafrost response to climate change projections, and parameterising the effects of sub-grid scale variability in surface processes and properties on small-scale (large area) spatial models. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Malignant Tumors of the Maxilla: Virtual Planning and Real-Time Rehabilitation with Custom-Made R-zygoma Fixtures and Carbon,Graphite Fiber-Reinforced Polymer Prosthesis

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 1 2008
Karl Ekstrand LDS
ABSTRACT Background: Oral cancer is a mutilating disease. Because of the expanding application of computer technology in medicine, new methods are constantly evolving. This project leads into a new technology in maxillofacial reconstructive therapy using a redesigned zygoma fixture. Purpose: Previous development experiences showed that the procedure was time-consuming and painful for the patients. Frequent episodes of sedation or general anesthetics were required and the rehabilitation is costly. The aim of our new treatment goal was to allow the patients to wake up after tumor surgery with a functional rehabilitation in place. Materials and Methods: Stereolithographic models were introduced to produce a model from the three-dimensional computed tomography (CT). A guide with the proposed resection was fabricated, and the real-time maxillectomy was performed. From the postoperative CT, a second stereolithographic model was manufactured and in addition, a stent for the optimal position of the implants. Customized zygoma implants were installed (R-zygoma, Integration AB, Göteborg, Sweden). A fixed construction was fabricated by using a new material based on poly(methylacrylate) reinforced with carbon/graphite fibers and attached to the implants. On the same master cast, a separate obturator was fabricated in permanent soft silicon. Results: The result of this project showed that it was possible to create a virtual plan preoperatively to apply during surgery in order for the patient to wake up functionally rehabilitated. Conclusion: From a quality-of-life perspective, it is an advantage to be rehabilitated fast. By using new computer technology, pain and discomfort are less and the total rehabilitation is faster, which in turn reduces days in hospital and thereby total costs. [source]

Laparoscopic Donor Distal Pancreatectomy for Living Donor Pancreas and Pancreas,Kidney Transplantation

AMERICAN JOURNAL OF TRANSPLANTATION, Issue 8 2005
Miguel Tan
With the proliferation and expanding applications of laparoscopic techniques, we determined the applicability of the laparoscopic approach to living pancreas donation. We performed the first laparoscopic donor distal pancreatectomy in 1999. We herein present our initial experience with five hand-assisted laparoscopic donor pancreatectomies. Three donors underwent distal pancreatectomy alone; two underwent a simultaneous left nephrectomy. The mean donor age was 48.4 ± 8.7 years with a body mass index of 23.7 kg/m2. The donor and recipient survival rate was 100% at up to 3 years of follow-up. There were no episodes of pancreatitis, leaks, or pseudocysts. All donors returned to their preoperative state of health and to work. None of the donors have required oral anti-diabetic medications or insulin. We conclude that laparoscopic donor distal pancreatectomy is a safe and efficient procedure; hand-assisted laparoscopic distal pancreatectomy appears to be preferable, because of the added margin of safety from increased tactile feedback and ease of pancreatic dissection. The procedure can be accomplished with a single 6-cm periumbilical incision and only two 12-mm ports, resulting in excellent cosmesis and high donor satisfaction. [source]