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Age-matched Subjects (age-matched + subject)
Selected AbstractsTreatment of massive hypertriglyceridemia resistant to PUFA and fibrates: A possible role for the coenzyme Q10?BIOFACTORS, Issue 1 2005A.F.G. Cicero Abstract Objective: to describe the effect of CoQ10 (added to either a fibrate, or PUFA or association of both) in patients affected by massive hypertriglyceridemia (MHTG) resistant to fibrates and PUFA. Design: Open, sequential, comparative intervention study. Setting: Specialised centres for dyslipidemia management. Subjects: 15 subjects (mean age: 45.1 ± 12.5 years) affected by MHTG and hyporesponsive to either fibrates, or PUFA, or fibrates-PUFA association, and 15 age-matched subjects regularly responders to PUFA and fenofibrate treatment. Interventions: Treatment for periods of 6 weeks each with the following consecutive treatments: CoQ10 150 mg/day, PUFA 3000 mg/day, fenofibrate 200 mg/day, PUFA 3000 mg/day + fenofibrate 200 mg/day, PUFA 3000 mg/day + CoQ10 150 mg/day, fenofibrate 200 mg/day + CoQ10 150 mg/day, and finally, fenofibrate 200 mg/day + PUFA 3000 mg/day + CoQ10 150 mg/day. Results: CoQ10 supplementation improved, in the control group, systolic and diastolic blood pressure, creatinine and Lp(a) plasma levels, both during fenofibrate and/or PUFA treatment. In MHTG group, CoQ10 supplementation significantly improved TG, TC, Lp(a), uric acid and blood pressure during fenofibrate treatment, but only Lp(a) and blood pressure during PUFA treatment. Fenofibrate appeared to have better effect on hsCRP and ,-GT plasma levels than PUFA. No significant change was observed in any group and under any treatment in regards to homocysteinemia, PAI-1, or t-PA. Conclusion: Even though the mechanism of action through which the effects were obtained is yet to be elucidated, adding CoQ10 to fenofibrate could improve the drug's efficacy in MHTG patients not responding to fenofibrate alone. [source] What do patients with glaucoma do when they search and look at everyday scenes?ACTA OPHTHALMOLOGICA, Issue 2009ND SMITH Purpose To test the hypothesis that patients with bilateral glaucoma exhibit different eye movements compared to normally-sighted subjects when viewing computer displayed photographs, or searching for features or items within them. Methods Thirteen glaucoma patients and 17 age-matched subjects with normal vision viewed 28 randomised digital photographs of various everyday scenes displayed on a computer screen for 3 seconds each. Subjects were instructed to view the images as they would when looking at a slideshow. The subjects then viewed another set of images, but were timed to find a feature or item in the scene. Eye movements were simultaneously recorded using an Eyetracking system. Results In the passive viewing experiment, there was a significant reduction in the average number of saccades for glaucoma patients compared to controls (p<0.0001). In addition, average fixation duration was longer and the average area scanned was more restricted in patients compared to controls. In the search task glaucoma patients took, on average, longer to find the objects (p<0.0001) compared to controls. For this task, saccades were still reduced in number. In some cases, individual scanning patterns appeared related to the type and nature of the binocular visual field defect. Conclusion Eye movement behaviour in patients with glaucomatous defects in both eyes differ from normal-sighted subjects when viewing images and photographs. These patients with glaucoma find it more difficult to locate items within scenes compared to normally sighted subjects. Acknowledgements: This work is generously supported by an unrestricted grant from the Special Trustees of Moorfields Eye Hospital. [source] Tear functions in patients with pingueculaACTA OPHTHALMOLOGICA, Issue 3 2001Halit Oguz ABSTRACT. Purpose: To investigate the tear flow, tear film stability and condition of mucus in patients with pinguecula. Methods: The Schirmer I and ferning tests were performed and break-up time (BUT) was determined in 57 patients with pinguecula [random eyes; 34 males and 23 females, 18 to 70 years of age (mean±SD: 39.1±13.5 years)] and in 57 age-matched subjects (control) [random eyes; 35 males and 22 females, 11 to 70 years of age (mean±SD: 37.8±15.2 years)], and the test results were statistically analysed. Results: The mean Schirmer test value was 22.72±12 mm in the eyes with pinguecula and 22.7±8.5 mm in the control eyes. There was no statistically significant difference (t=0.01, p=0.99) between the groups. The mean BUTs were 11.42±6.89 s in the eyes with pinguecula and 15.46±5.85 s in the control eyes. Comparison of BUTs between the groups revealed a statistically significant difference (t=3.37, p=0.0010). Also, ferning types were found to be significantly abnormal in the eyes with pinguecula (p<0.01). Conclusion: The alteration in the mucin layer is a possible change inducing pinguecula formation, or it may reflect an already existing pathology in the cells on the ocular surface. [source] Immediate effect of benzalkonium chloride in decongestant nasal spray on the human nasal mucosal temperatureCLINICAL OTOLARYNGOLOGY, Issue 4 2004J. Lindemann Benzalkonium chloride is a preservative commonly used in nasal decongestant sprays. It has been suggested that benzalkonium chloride may be harmful to the nasal mucosa. Decongestion with the vasoconstrictor xylometazoline containing benzalkonium chloride has been shown to cause a significant reduction of the nasal mucosal temperature. The purpose of the present study was to determine the short-term influence of xylometazoline nasal spray with and without benzalkonium chloride on the nasal mucosal temperature. Healthy volunteers (30) were included in the study. Fifteen volunteers received xylometazoline nasal spray (1.0 mg/mL) containing benzalkonium chloride (0.1 mg/mL) and 15 age-matched subjects, received xylometazoline nasal spray without benzalkonium chloride. Using a miniaturized thermocouple the septal mucosal temperature was continuously measured at defined intranasal detection sites before and after application of the nasal spray. The mucosal temperature values did not significantly differ between the group receiving xylometazoline containing benzalkonium chloride and the group receiving xylometazoline spray without benzalkonium chloride before and after decongestion (P > 0.05). In both study groups septal mucosal temperatures significantly decreased after decongestion (P < 0.05) because of a reduction of the nasal mucosal blood flow following vasoconstriction. This study indicates that benzalkonium chloride itself does not seem to influence nasal blood flow and nasal mucosal temperature in topical nasal decongestants. [source] | ||||||||||