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Ageing
Kinds of Ageing Terms modified by Ageing Selected AbstractsTHE GROWTH OF SOCIAL EXPENDITURE AND POPULATION AGEINGECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 4 2000JOHN CREEDY First page of article [source] CROSS-SECTIONAL AND LONGITUDINAL ASSOCIATIONS BETWEEN ANEMIA AND DEPRESSIVE SYMPTOMS IN THE ENGLISH LONGITUDINAL STUDY OF AGEINGJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2009Mark Hamer PhD No abstract is available for this article. [source] ACCOUNTING FOR POPULATION AGEING IN TAX MICROSIMULATION MODELLING BY SURVEY REWEIGHTING,AUSTRALIAN ECONOMIC PAPERS, Issue 1 2006LIXIN CAI This paper investigates the use of sample reweighting, in a behavioural tax microsimulation model, to examine the implications for government taxes and expenditure of population ageing in Australia. First, a calibration approach to sample reweighting is described, producing new weights that achieve specified population totals for selected variables. Second, the performance of the Australian Bureau of Statistics' (ABS) weights provided with the 2000,2001 Survey of Income and Housing Cost (SIHC) was examined and it was found that reweighting does not improve the simulation outcomes for the 2001 situation, so the original ABS weights were retained for 2001. Third, the implications of changes in the age distribution of the population were examined, based on population projections to 2050. A ,pure' change in the age distribution was examined by keeping the aggregate population size fixed and changing only the relative frequencies in different age-gender groups. Finally, the effects of a policy change to benefit taper rates in Australia were compared for 2001 and 2050 population weights. It is suggested that this type of exercise provides an insight into the implications for government income tax revenue and social security expenditure of changes in the population, indicating likely pressures for policy changes. [source] COSTLY AGEING OR COSTLY DEATHS?AUSTRALIAN ECONOMIC PAPERS, Issue 1 2006UNDERSTANDING HEALTH CARE EXPENDITURE USING AUSTRALIAN MEDICARE PAYMENTS DATA In health economics and health care planning, the observation that age cohorts are generally positively correlated with per capita health expenditures is often cited as evidence that population ageing is the main driver of health care costs. Several recent studies, however, challenge this view. Zweifel et al. (1999) and Felder et al. (2000), for example, find that individuals incur the highest health care costs around the time before their death. Thus, they argue, it is proximity to death rather than ageing that is driving health care costs. This paper examines the issue by estimating a two-equation exact aggregation demand model using Australian Medicare payments data over an eight-year period (1994,2001). The results suggest that once proximity to death is accounted for, population ageing has either a negligible or even negative effect on health care demand. [source] EQUALITY AND THE DUTY TO RETARD HUMAN AGEINGBIOETHICS, Issue 8 2010COLIN FARRELLY ABSTRACT Where does the aspiration to retard human ageing fit in the ,big picture' of medical necessities and the requirements of just healthcare? Is there a duty to retard human ageing? And if so, how much should we invest in the basic science that studies the biology of ageing and could lead to interventions that modify the biological processes of human ageing? I consider two prominent accounts of equality and just healthcare , Norman Daniels's application of the principle of fair equality of opportunity and Ronald Dworkin's account of equality of resources , and conclude that, once suitably amended and revised, both actually support the conclusion that anti-ageing research is important and could lead to interventions that ought to be considered ,medical necessities'. [source] AGEING, OESTROGEN, PLATELETS AND THROMBOTIC RISKCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Issue 8 2007Virginia M Miller SUMMARY 1Adverse thrombotic cardiovascular events increase in women coincident with the onset of menopause. 2Age past menopause may be an important variable in defining the benefit/risk of hormone treatments. 3Few studies have examined hormonal status as a variable of ageing using a polygenomic approach of both humoral and cellular components of the coagulation system. 4Longitudinal studies of a global set of platelet functions that define procoagulant activity (i.e. adhesion, aggregation, secretion and thrombin production) in individuals with documented hormonal status are needed to better understand how hormonal changes associated with ageing impact thrombotic risk. [source] Comparison of Additional Costs for Several Replacement Strategies of Randomly Ageing Reinforced Concrete PipesCOMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 7 2009Franck Schoefs Some of them carry seawater and can deteriorate with time because of internal corrosion. Because of the low O2 content of aggressive water, slow corrosion is expected for such applications. If the RCPs are not periodically replaced, they will eventually fail. Replacement strategies for these pipes depend on (1) the risks associated with the failure of the water distribution network, and (2) the costs associated with replacing the pipes, including the removal of existing pipes, installation of new pipes, and associated production losses. Because of the lack of statistical data regarding RCP failure, the development of a risk-based replacement strategy is not an easy task. This article demonstrates how predictive models for the evolution of the failure of RCPs and the associated consequences of failure can be used to develop risk-based replacement strategies for RCPs. An application for the replacement strategies of a network modeled as a system consisting of 228 RCPs is presented as a case study. We focus on the assessment of the number of replaced components that governs the costs. The main objective of this article is to provide a theoretical approach for comparing replacement strategies, based on (1) the results of a reliability study, (2) the representation of the distributions of failed components (binomial distribution), and (3) the decision tree representation for replacement of RCPs. A focus on the scatter of the induced costs themselves is suggested to emphasize the financial risk. [source] Ageing, oxidative stress, and mitochondrial uncouplingACTA PHYSIOLOGICA, Issue 4 2004M.-E. Harper Abstract Mitochondria are a cell's single greatest source of reactive oxygen species. Reactive oxygen species are important for many life sustaining processes of cells and tissues, but they can also induce cell damage and death. If their production and levels within cells is not effectively controlled, then the detrimental effects of oxidative stress can accumulate. Oxidative stress is widely thought to underpin many ageing processes, and the oxidative stress theory of ageing is one of the most widely acknowledged theories of ageing. As well as being the major source of reactive oxygen species, mitochondria are also a major site of oxidative damage. The purpose of this review is a concise and current review of the effects of oxidative stress and ageing on mitochondrial function. Emphasis is placed upon the roles of mitochondrial proton leak, the uncoupling proteins, and the anti-ageing effects of caloric restriction. [source] Risk factors for incident mild cognitive impairment , results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)ACTA PSYCHIATRICA SCANDINAVICA, Issue 4 2010T. Luck Luck T, Riedel-Heller SG, Luppa M, Wiese B, Wollny A, Wagner M, Bickel H, Weyerer S, Pentzek M, Haller F, Moesch E, Werle J, Eisele M, Maier W, van den Bussche H, Kaduszkiewicz H for the AgeCoDe Study Group. Risk factors for incident mild cognitive impairment , results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Objectives:, To provide age- and gender-specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI. Method:, Data were derived from the longitudinal German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Incidence was calculated according to the ,person-years-at-risk' method. Risk factors were analysed using multivariate logistic regression models. Results:, During the 3-year follow-up period, 350 (15.0%) of the 2331 patients whose data were included in the calculation of incidence developed MCI [person-years (PY) = 6198.20]. The overall incidence of MCI was 56.5 (95% confidence interval = 50.7,62.7) per 1000 PY. Older age, vascular diseases, the apoE ,4 allele and subjective memory complaints were identified as significant risk factors for future MCI. Conclusion:, Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches. [source] Age-related anthropometric remodelling resulting in increased and redistributed adiposity is associated with increases in the prevalence of cardiovascular risk factors in Chinese subjectsDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 1 2006G. Neil Thomas Abstract Background Ageing promotes increases in the prevalence of components of the metabolic syndrome, which obesity often underlies. Methods We report the relationship between ageing, obesity and other cardiovascular risk factors in 694 community-based Chinese subjects in gender-specific groups of three age ranges: 20.0,39.9 (young), 40.0,59.9 (middle-aged) and 60.0,79.9 (old-aged) years. Results Body mass index (BMI) values were similar in males in each age group, but waist and percentage body fat increased (6.6, and 39.5%, both p < 0.001, respectively), from young to old-age groups, as did blood pressure and glycated haemoglobin levels (all p < 0.001). In the females, increases (all p < 0.001) in percentage body fat (29.3%) were accompanied by greater increases in BMI (10.3%) and waist (19.2%) than the males. Blood pressure, glycated haemoglobin, total and LDL-cholesterol and triglyceride levels increased linearly with age (all p < 0.001). Conclusion Age-related increases in central adiposity and percentage body fat were associated with increasingly adverse cardiovascular risk factor profiles. Copyright © 2005 John Wiley & Sons, Ltd. [source] Trends in morphine prescriptions, illicit morphine use and associated harms among regular injecting drug users in AustraliaDRUG AND ALCOHOL REVIEW, Issue 5 2006LOUISA DEGENHARDT Abstract This paper examines population trends in morphine prescriptions in Australia, and contrasts them with findings from annual surveys with regular injecting drug users (IDU). Data on morphine prescriptions from 1995 to 2003 were obtained from the Drug Monitoring System (DRUMS) run by the Australian Government Department of Health and Ageing. Data collected from regular IDU as part of the Australian Illicit Drug Reporting System (IDRS) were analysed (2001,2004). The rate of morphine prescription per person aged 15,54 years increased by 89% across Australia between 1995 and 2003 (from 46.3 to 85.9 mg per person). Almost half (46%) of IDU surveyed in 2004 reported illicit morphine use, with the highest rates in jurisdictions where heroin was less available. Recent morphine injectors were significantly more likely to be male, unemployed, out of treatment and homeless in comparison to IDU who had not injected morphine. They were also more likely to have injected other pharmaceutical drugs and to report injection related problems. Among those who had injected morphine recently, the most commonly reported injecting harms were morphine dependence (38%), difficulty finding veins into which to inject (36%) and scarring or bruising (27%). Morphine use and injection is a common practice among regular IDU in Australia. In some cases, morphine may be a substitute for illicit heroin; in others, it may be being used to treat heroin dependence where other pharmacotherapies, such as methadone and buprenorphine, are perceived as being unavailable or undesirable by IDU. Morphine injection appears to be associated with polydrug use, and with it, a range of problems related to drug injection. Further research is required to monitor and reduce morphine diversion and related harms by such polydrug injectors. [source] Ageing and unused capacity in Europe: is there an early retirement trap?ECONOMIC POLICY, Issue 59 2009Viola Angelini Summary We address the issue of how early retirement may interact with limited use of financial markets in producing financial hardship later in life, when some risks (such as long-term care) are not insured. We argue that the presence of financially attractive early retirement schemes in a world of imperfect financial and insurance markets can lead to an ,early retirement trap'. Indeed, Europe witnesses many (early) retired individuals in financial distress. In our analysis we use data on 10 European countries, which differ in their pension and welfare systems, in prevailing retirement age and in households' access to financial markets. We find evidence that an early retirement trap exists, particularly in some Southern and Central European countries: people who retired early in life are more likely to be in financial hardship in the long run. Our analysis implies that governments should stop making early retirement attractive, let retirees go back to work, improve access to financial markets and make sure long-term care problems are adequately insured. , Viola Angelini, Agar Brugiavini and Guglielmo Weber [source] Retirement Migration: Paradoxes of Ageing.ETHOS, Issue 1 2010Caroline Oliver. No abstract is available for this article. [source] Formation and Stability of Near Convoluted Structure Obtained in the Ti,46Al,8Ta Alloy Via Air Quenching and Ageing,ADVANCED ENGINEERING MATERIALS, Issue 1-2 2010Valery Imayev Abstract Microstructure evolution after air quenching and variable ageing treatment has been investigated in small-sized ingot bars of the Ti,46Al,8Ta alloy. It was found that air quenching and subsequent ageing at 1200,1260,°C led to the formation of a homogeneous refined near convoluted microstructure. To increase the stability of the near convoluted structure, very slow cooling after high-temperature ageing and final long-term ageing at around 900,°C can be recommended. [source] Population Ageing, Fiscal Pressure and Tax Smoothing: A CGE Application to Australia,FISCAL STUDIES, Issue 2 2006Ross Guest Abstract This paper analyses the fiscal pressure from population ageing using an intertemporal CGE model, applied to Australia, and compares the results with those of a recent government-commissioned study. The latter study uses an alternative modelling approach based on extrapolation rather than optimising behaviour of consumers and firms. The deadweight losses from the fiscal pressure caused by population ageing are equivalent to an annual loss of consumption of $260 per person per year in 2003 dollars in the balanced-budget scenario. A feasible degree of tax smoothing would reduce this welfare loss by an equivalent of $70 per person per year. Unlike the extrapolation-based model, the CGE approach takes account of feedback effects of ageing-induced tax increases on consumption and labour supply, which in turn impact on the ultimate magnitude of fiscal pressure and therefore tax increases. However, a counterfactual simulation suggests that the difference in terms of deadweight losses between the two modelling approaches is modest, at about $30 per person per year. [source] Ageing and the tax implied in public pension schemes: simulations for selected OECD countriesFISCAL STUDIES, Issue 2 2004Robert Fenge Abstract A key figure suited to measuring intergenerational imbalances in unfunded public pension schemes is given by the ,implicit tax rate' imposed on each generation's lifetime income. The implicit tax arises from the fact that, quite generally, pension benefits fall short of actuarial returns to contributions paid to these systems while actively working. Under current pension policies, implicit tax rates will increase sharply for younger generations in most industrialised countries. In this paper, this is illustrated for the cases of France, Germany, Italy, Japan, Sweden, the UK and the USA. Nevertheless, there are remarkable differences across countries regarding both the level of implicit taxes and their development over successive age cohorts, which can be attributed to differences in ageing processes and in the institutional features of national pension systems. In addition, we can demonstrate how effective different approaches to pension reform are in smoothing the intergenerational profile of implicit tax rates. [source] Model predicting dynamics of biomass, structure and digestibility of herbage in managed permanent pastures.GRASS & FORAGE SCIENCE, Issue 2 2006Abstract To investigate seasonal and annual interactions between management and grassland dynamics, a simple mechanistic model of the dynamics of production, structure and digestibility in permanent pastures was constructed. The model is designed to respond to various defoliation regimes, perform multiple-year simulations and produce simple outputs that are easy to use as inputs for a model of ruminant livestock production. Grassland communities are described using a set of average functional traits of their constituent grass groups. The sward is subdivided into four structural compartments: green leaves and sheath, dead leaves and sheath, green stems and flowers, and dead stems and flowers. Each compartment is characterized by its biomass, age and digestibility. Only above-ground growth is modelled, using a light-utilization efficiency approach modulated by a seasonal pattern of storage and mobilization of reserves. Ageing of plant parts is driven by cumulative thermal time from 1 January and by biomass flows. Age affects senescence, abscission and digestibility of green compartments and, therefore, the quality of green leaves and stems can increase or decrease over time in relation to net growth and defoliation dynamics. The functional traits having the greatest impact on model outputs are seasonal effects, period of reproductive growth and effects of temperature on photosynthetic efficiency. The functional traits of the grass groups were parameterized for temperate pastures of the Auvergne region in France. The other model inputs are few: proportion of functional groups, basic weather data (incident photosynthetically active radiation, mean daily temperature, precipitation and potential evapotranspiration) and site characteristics (nitrogen nutrition index, soil water-holding capacity). In the context of a whole-farm simulator, the model can be applied at a field scale. [source] Providing care for an elderly parent: interactions among siblings?HEALTH ECONOMICS, Issue 9 2009Roméo Fontaine Abstract This article is focused on children providing and financing long-term care for their elderly parent. The aim of this work is to highlight the interactions that may take place among siblings when deciding whether or not to become a caregiver. We look at families with two children using data from the Survey of Health, Ageing and Retirement in Europe; our sample contains 314 dependent elderly and their 628 adult children. In order to identify the interactions between siblings, we have specified a two-person discrete game model. To estimate this model, without invoking the ,coherency' condition, we have added an endogenous selection rule to solve the incompleteness problem arising from multiplicity or absence of equilibrium. Our empirical results suggest that the three classical effects identified by Manski could potentially explain the observed correlation between the siblings' caregiving behaviour. Correlated effects alone appear to be weak. Contextual interactions and endogenous interactions reveal cross-effects. The asymmetric character of the endogenous interactions is our most striking result. The younger child's involvement appears to increase the net benefit of caregiving for the elder one, whereas the elder child's involvement decreases the net benefit of caregiving for the younger child. Copyright © 2009 John Wiley & Sons, Ltd. [source] Ageing and the neutrophil: no appetite for killing?IMMUNOLOGY, Issue 4 2000S. Butcher Summary In the armoury of the immune system developed to combat the various micro-organisms that could invade the host, the neutrophil forms the first line of defence against rapidly dividing bacteria and fungi. However, as humans age they become more susceptible to infection with these microbes and this has been ascribed to a decline in immune status, termed immune senescence. Here we summarize the literature specifically concerning the attenuation of neutrophil function with age and the possible mechanisms underlying their reduced response to infectious agents. [source] Genome-wide analysis of gene expression in adult Anopheles gambiaeINSECT MOLECULAR BIOLOGY, Issue 1 2006O. Marinotti Abstract With their genome sequenced, Anopheles gambiae mosquitoes now serve as a powerful tool for basic research in comparative, evolutionary and developmental biology. The knowledge generated by these studies is expected to reveal molecular targets for novel vector control and pathogen transmission blocking strategies. Comparisons of gene-expression profiles between adult male and nonblood-fed female Anopheles gambiae mosquitoes revealed that roughly 22% of the genes showed sex-dependent regulation. Blood-fed females switch the majority of their metabolism to blood digestion and egg formation within 3 h after the meal is ingested, in detriment to other activities such as flight and response to environment stimuli. Changes in gene expression are most evident during the first, second and third days after a blood meal, when as many as 50% of all genes showed significant variation in transcript accumulation. After laying the first cluster of eggs (between 72 and 96 h after the blood meal), mosquitoes return to a nongonotrophic stage, similar but not identical to that of 3-day-old nonblood-fed females. Ageing and/or the nutritional state of mosquitoes at 15 days after a blood meal is reflected by the down-regulation of ,5% of all genes. A full description of the large number of genes regulated at each analysed time point and each biochemical pathway or biological processes in which they are involved is not possible within the scope of this contribution. Therefore, we present descriptions of groups of genes displaying major differences in transcript accumulation during the adult mosquito life. However, a publicly available searchable database (http://www.angagepuci.bio.uci.edu/) has been made available so that detailed analyses of specific groups of genes based on their descriptions, functions or levels of gene expression variation can be performed by interested investigators according to their needs. [source] Ageing and later life: growing old in modern society. edited by Lewis R. Aiken and Charles C. Thomas.INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 9 20022001. pages: 405. $89.9, Publishers Ltd No abstract is available for this article. [source] Selective non-response to clinical assessment in the longitudinal study of aging: implications for estimating population levels of cognitive function and dementiaINTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 8 2002Kaarin J. Anstey Abstract Objective To identify the cognitive outcome of interviewed participants who did not progress to partake in clinical assessments in a longitudinal aging study. Design A retrospective study was conducted on participants who were interviewed but who did not complete the clinical assessment (including an extended cognitive assessment) at either Wave 1 or both Wave 1 and Wave 3 of the Australian Longitudinal Study of Ageing. A total of 1947 participants aged 70 and older commenced the study, 246 participants without clinical data at either or both Waves 1 and 3 were identified for the sub-sample followed-up retrospectively. The Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) was administered to informants and medical records were reviewed. Results Participants who did not complete the clinical assessment at Wave 3 reported poorer health and had poorer cognitive function at Wave 1 independent of age and gender. Rates of possible dementia or cognitive decline were higher in the group who did not undertake the clinical assessment compared with both those who did the clinical assessment and with population data. Conclusion Selective non-response to clinical assessment in a longitudinal aging study is associated with higher risk of cognitive decline and probable dementia. Longitudinal aging studies may underestimate rates of dementia and population levels of cognitive decline. Copyright © 2002 John Wiley & Sons, Ltd. [source] Ascertaining late-life depressive symptoms in Europe: an evaluation of the survey version of the EURO-D scale in 10 nations.INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 1 2008The SHARE project Abstract The reported prevalence of late-life depressive symptoms varies widely between studies, a finding that might be attributed to cultural as well as methodological factors. The EURO-D scale was developed to allow valid comparison of prevalence and risk associations between European countries. This study used Confirmatory Factor Analysis (CFA) and Rasch models to assess whether the goal of measurement invariance had been achieved; using EURO-D scale data collected in 10 European countries as part of the Survey of Health, Ageing and Retirement in Europe (SHARE) (n = 22,777). The results suggested a two-factor solution (Affective Suffering and Motivation) after Principal Component Analysis (PCA) in 9 of the 10 countries. With CFA, in all countries, the two-factor solution had better overall goodness-of-fit than the one-factor solution. However, only the Affective Suffering subscale was equivalent across countries, while the Motivation subscale was not. The Rasch model indicated that the EURO-D was a hierarchical scale. While the calibration pattern was similar across countries, between countries agreement in item calibrations was stronger for the items loading on the affective suffering than the motivation factor. In conclusion, there is evidence to support the EURO-D as either a uni-dimensional or bi-dimensional scale measure of depressive symptoms in late-life across European countries. The Affective Suffering sub-component had more robust cross-cultural validity than the Motivation sub-component. Copyright © 2008 John Wiley & Sons, Ltd. [source] Modelling the burden of stroke in Finland until 2030INTERNATIONAL JOURNAL OF STROKE, Issue 5 2009J. Sivenius Background It is well known that increasing age is the strongest risk factor of stroke. Therefore, it has been a common belief in many countries including Finland that the numbers of stroke patients will increase considerably during the next two decades because the population is rapidly ageing. Methods The FINMONICA and FINSTROKE registers operated in Finland in the Kuopio area and city of Turku from 1983 to 1997. The results showed that the incidence, mortality and case fatality of stroke declined significantly during that period. Importantly, it was established that the trends in incidence and mortality were also declining among the elderly (>74 years). We used these results to create a model for the entire country. The model was based on the trends present in these registers from Turku and Kuopio area and age-specific population projections up to the year 2030 that were obtained from Statistics Finland. Results In the year 2000, the number of new first stroke cases was estimated to be 11 500. If the declining trend were to level off totally after the year 2000, the number of new strokes would be 20 100 in the year 2030 due to the ageing of the population. It would be 12 100 if the trend continued as favourable as during the years 1983,1997. Conclusions Ageing of the population will not inevitably increase the burden of stroke in Finland if the present declining trends are maintained, but the annual number of cases will almost double if the incidence remains at the level of the year 2000. [source] Social Dialogue: A Potential "Highroad" to Policies Addressing Ageing in The EU Member StatesINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 1 2006Hedva Sarfati The impact of demographic ageing on the sustainability of pensions has become the focus of heated debate in Europe, as governments try to reform their welfare systems. Among the most vocal opponents of the reforms are employers' organizations and managements, trade unions and individual workers. The article looks at the issues at stake and the relevance of social dialogue, despite difficulties, for reaching consensus among all stakeholders on acceptable labour market and pension reforms. These have to be comprehensive and free from ideological a priori assumptions. Specific examples of available options are mentioned, including Finland, Denmark, Spain and the United Kingdom. [source] Issues in pension system designINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 1 2002Maria Augusztinovics External conditions for pension system design and demographic and labour market trends are briefly considered and the latter found decisive. Basic concepts, e.g. social assistance and insurance, redistribution and actuarial fairness, are then introduced. Then it is argued that the "public PAYG versus private funded" dichotomy has attracted an unduly large share of attention in recent pension reform debates, as such institutional changes do not really address the basic problems, while quantitative aspects, the relationship between contribution and replacement rates, have been improperly neglected or shielded by the paradigmatic controversy. The next, crucial point is that traditional, employment-based, earnings-related forms of pension insurance are endangered by new trends on the labour market; hence, new solutions will have to be sought to ensure pension coverage for the entire population. A brief plea for more, relevant and comparative information on pension issues follows. The paper concludes with a concise summary and by contemplating what could and should be expected from the Second World Assembly on Ageing. [source] Ageing and the changing role of the family and the community: An African perspectiveINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 1 2002Nana Araba Apt Global ageing, the major social issue of the twenty-first century, will have greater social repercussions for developing countries. The fastest increase of older persons in terms of ratio in relation to younger people is happening in developing countries, and in Africa segregation of older people in rural areas will become manifest. While beneficial changes for women have accompanied modernization in many of the developing countries, the situation of older women appears to be particularly precarious. Social changes brought about by modernization are also profoundly affecting the traditional systems of care for older people. Even though most older people requiring care are still looked after within the informal structures of the family, this can no longer be taken for granted as we move into the new century. This paper critically reviews social protection systems and the resource constraints which characterize developing countries and warns against blind development of social security systems based on those of the industrialized countries. The paper argues for the design of intergenerational support back into mainstream social relations so that older persons are not marginalized and put at risk through social protection programmes which reinforce physical vulnerability stereotypes and stress welfare needs over and above older people's social and economic contributions to society [source] Understanding and Modulating AgeingIUBMB LIFE, Issue 4-5 2005Suresh IS Rattan Abstract Ageing is characterized by a progressive accumulation of molecular damage in nucleic acids, proteins and lipids. The inefficiency and failure of maintenance, repair and turnover pathways is the main cause of age-related accumulation of damage. Research in molecular gerontology is aimed at understanding the genetic and epigenetic regulation of survival and maintenance mechanisms at the levels of transcription, post-transcriptional processing, post-translational modifications, and interactions among various gene products. Concurrently, several approaches are being tried and tested to modulate ageing in a wide variety of organisms. The ultimate aim of such studies is to improve the quality of human life in old age and prolong the health-span. Various gerontomodulatory approaches include gene therapy, hormonal supplementation, nutritional modulation and intervention by free radical scavengers and other molecules. A recent approach is that of applying hormesis in ageing research and therapy, which is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress. A combination of molecular, physiological and psychological modulatory approaches can realize "healthy ageing" as an achievable goal in the not-so-distant future. IUBMB Life, 57: 297-304, 2005 [source] Neighborhood Deprivation, Individual Socioeconomic Status, and Cognitive Function in Older People: Analyses from the English Longitudinal Study of AgeingJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 2 2008Iain A. Lang PhD OBJECTIVES: To assess the relationship between cognitive function, socioeconomic status, and neighborhood deprivation (lack of local resources of all types, financial and otherwise). DESIGN: Nationally representative cross-section. SETTING: The English Longitudinal Study of Ageing (ELSA). PARTICIPANTS: Seven thousand one hundred twenty-six community-dwelling individuals aged 52 and older and resident in urban areas. MEASUREMENTS: Individual cognitive function score and index of multiple deprivation (IMD) at the Super Output Area level, adjusting for health, lifestyle, and sociodemographic confounders. Analyses were conducted separately according to sex and age group (52,69 and ,70). RESULTS: IMD affected cognitive function independent of the effects of education and socioeconomic status. For example, in fully adjusted models, women aged 70 and older had a standardized cognitive function score (z -score) that was 0.20 points (95% confidence interval (CI)=0.01,0.39) lower in the bottom 20% of wealth than the top 20%, 0.44 points (95% CI=0.20,0.69) lower in the least-educated group than in the most educated, and 0.31 points (95% CI 0.15,0.48) lower if resident lived in an area in the bottom 20% of IMD than in the top 20%. CONCLUSION: In community-based older people in urban neighborhoods, neighborhood deprivation,living in a neighborhood with high levels of deprivation, compared with national levels,is associated with cognitive function independent of individual socioeconomic circumstances. The mechanisms underlying this relationship are unclear and warrant further investigation. [source] KEYNOTE ADDRESS Ku80-deletion causes early ageing and suppresses cancerJOURNAL OF ANIMAL PHYSIOLOGY AND NUTRITION, Issue 2 2009P. Hasty Ageing is widespread cellular decline resulting in a loss of fitness that is both pleiotropic and stochastic and influenced by both genetics and environment. As a result the fundamental underling causes of ageing are diverse and controversial. One potential ageing target is nuclear DNA, as it is a permanent blueprint that controls cellular processes. Thus, DNA replication and genome maintenance are highly regulated events that ensure faithful reproduction and maintenance of the blueprint and these pathways assure sufficient longevity for reproduction and survival of the species. As a consequence, imperfections or defects in maintaining the genome may contribute to ageing. Therefore, genome maintenance pathways are longevity-assurance mechanisms that sustain an organism long enough to reproduce and propagate. Chief among these mechanisms are those that respond to damaged DNA. There are two basics responses to genomic damage: DNA repair and cell cycle checkpoints. Both are considered to be tumour suppressors and are categorized as either caretakers or gatekeepers, respectively. Interestingly, observations of human and mouse pre-mature ageing models suggest these anti-tumour pathways impact the ageing process. Caretakers suppress cancer by repairing DNA damage caused by defects in replication or by a variety of agents including endogenously produced reactive by-products of oxygen metabolism and exogenous agents naturally encountered in our environment. As a consequence DNA is subject to a variety of insults that cause a diverse range of lesions and phenotypic outcomes. There are many forms of DNA damage including base lesions and double-strand breaks (DSBs) with the latter being more toxic. Cancer-causing chromosomal rearrangements may result if DSBs are not repaired properly. Additionally, an accumulation of these rearrangements may contribute to ageing since they increase in some cell types as humans and mice age. Furthermore, early ageing models suggest that defects in repairing DSBs lead to early ageing in humans and mice. Non-homologous end joining (NHEJ) is an important pathway for repairing DNA DSBs and is considered a caretaker. The Ku heterodimer (composed of Ku70 and Ku80) binds to DNA ends to initiate NHEJ, and defects in either Ku70 or Ku80 lead to increased levels of DNA DSBs and chromosomal rearrangements, leading many to believe Ku is a caretaker. Ku-mutant mice display increased GCRs, but without increased cancer. Instead, these mice show early ageing and shortened life span. Thus, Ku's role as a caretaker is uncertain as the low cancer levels may be due to Ku80-deletion or, instead, the low cancer levels may simply be a consequence of the shortened life span that prohibits sufficient time for tumours to develop. Gatekeepers respond to DNA damage by halting the cell cycle long enough for the DNA to be repaired. If the damage is irreparable, gatekeepers induce either apoptosis or senescence. These responses are deleterious to the cell but protect the organism from cancer as one potential outcome of genetic mutations is uncontrolled proliferation. p53 is critical for checkpoints and is the best-known gatekeeper because it is mutated in over half of all cancers. In addition, p53 activity influences many aspects of the Ku-mutant phenotype suggesting that Ku-deletion leads to persistent p53-mediated responses and presenting the possibility that low cancer levels and early ageing are caused by elevated gatekeeper responses. Our hypothesis is that Ku-mutant mice exhibit low cancer levels and, perhaps, ageing due to persistent p53-mediated responses to inefficiently repaired DNA. To test this hypothesis, Ku80-mutant mice were crossed to cancer-prone mice with either non-functional or functional gatekeeper responses. Ku80-mutant mice were crossed to p53-mutant mice to determine if Ku80-deletion exacerbates oncogenesis when gatekeeper responses are diminished. Ku80-mutant mice deleted for p53 exhibit early onset and high levels of two forms of cancer: pro-B cell lymphoma and medulloblastoma, thus supporting the hypothesis. Ku80-mutant mice were also crossed to APCMIN mice to determine if Ku80-deletion ameliorates oncogenesis gatekeeper responses are intact. APCMIN mice exhibit high levels of intestinal adenomas and adenocarcinomas but have normal p53-mediated responses to DNA damage. APCMIN mice, deleted for Ku80, exhibit about 67% fewer tumours than APCMIN mice with Ku80. Thus, deletion of Ku80 suppresses tumour formation, again supporting the hypothesis. Ku80-mutant cells and tissues were tested for p53-mediated DNA damage responses, levels of DNA damage, and mutations. Ku80-mutant fibroblasts exhibit elevated levels of p53-mediated DNA damage responses that increase p21-mediated cellular senescence. In addition, there are elevated levels DNA damage as seen by increased 53BP1 foci and elevated levels of chromosomal rearrangements. Thus, these data support the hypothesis that Ku80-deletion reduces tumors by elevating DNA damage gatekeeper responses to inefficiently repaired DNA. These data also support the possibility that the Ku80-mutant ageing phenotype is also due to elevated gatekeeper responses. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||