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Excessive
Terms modified by Excessive Selected AbstractsIS INJURY COMPENSATION EXCESSIVE?ECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 2 2004Peter Abelson In Australia, excessive awards in personal damage cases are widely perceived to have created a public liability crisis and cuts in valued services. This paper analyses whether awards for damages are excessive. The paper starts by setting out a normative basis for awards based on welfare economic principles and amounts that individuals are willing to pay to avoid injuries. It then provides estimates of appropriate compensation sums for 27 typical injuries ranging from broken arms to quadriplegia and severe brain damage. There follows an analysis of 192 court awards for injuries greater than $250 000 in New South Wales between 1991 and 2002, including awards for 101 traffic accidents, 64 workers compensation cases, and 27 personal injury cases. The paper concludes that these court awards are broadly consistent with economic estimates for damages and that the awards are generally not excessive. [source] Excessive belching and aerophagia: two different disordersDISEASES OF THE ESOPHAGUS, Issue 4 2010Albert J. Bredenoord SUMMARY Belching is physiological venting of excessive gastric air. Excessive and bothersome belching is a common symptom, which is often seen in patients with functional dyspepsia and gastroesophageal reflux disease. Other symptoms are usually predominant. However, a small group of patients complain of isolated excessive belching, with a frequency of several belches per minute. In these patients, the eructated air does not originate from the stomach but is sucked or injected in the esophagus from the pharynx and expelled immediately afterward in oral direction. This behavior is called supragastric belching because the air does not originate from the stomach and does not reach the stomach either. Excessive belching can be treated by speech therapy or behavior therapy. The term aerophagia should be reserved for those patients where there is evidence that they swallow air too frequently and in too large quantities. These patients have excessive amounts of intestinal gas visualized on a plain abdominal radiogram and their primary symptoms are bloating and abdominal distension and they belch only to a lesser degree. Aerophagia and excessive supragastric belching are thus two distinct disorders. [source] The developmental change in strategies parents employ to settle young children to sleep, and their relationship to infant sleeping problems, as assessed by a new questionnaire: the Parental Interactive Bedtime Behaviour ScaleINFANT AND CHILD DEVELOPMENT, Issue 1 2002Julian Morrell Abstract The development of a new parental self-report questionnaire, the Parental Interactive Bedtime Behaviour Scale (PIBBS) is described. The PIBBS was designed to capture a wide range of parental behaviours used to settle infants off to sleep. The commonest behaviours employed were giving a feed, talking softly to the child, cuddling in the arms, and stroking. A factor analysis revealed five settling strategies; ,active physical comforting' (e.g. cuddling in arms); ,encouraging infant autonomy' (e.g. leaving to cry); ,movement' (e.g. car rides), ,passive physical comforting' (e.g. standing next to the cot without picking the infant up), and ,social comforting' (e.g. reading a story). Excessive ,active physical comforting' and reduced ,encourage autonomy' strategy use was associated with infant sleeping problems. Regarding developmental change in strategy between 1 and 2 years, the later the onset at which ,encourage autonomy' became the principal strategy used, the more likely that persistent infant sleeping problems would be present. Factors accounting for the change in strategy use over time were: (i) parental adaptation to infant developmental maturation; (ii) the interaction between maternal cognition and strategy, and, to a lesser extent; (iii) the interaction between infant temperament and parental strategy. Copyright © 2002 John Wiley & Sons, Ltd. [source] Excessive, optimal, and insufficient fundraising among the Nonprofit Times 100INTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 2 2006Fred A. Jacobs Using a six-factor model of donations, we estimate the effect on net donations; i.e., donations less fundraising expenditures, of a one percent marginal increase in fundraising expenditures, for each sample nonprofit organization (NPO) from the Nonprofit Times 100 from 2000 to 2002. No prior study of U.S. NPOs estimates the effect of fundraising expense on net donations. We then use these estimates and what we argue is the correct benchmark, the ratio of fundraising expense to donations, to provide evidence, for each NPO, on whether the NPO's level of fundraising is ,excessive,' ,optimal,' or ,insufficient,' relative to the level that maximizes net donations. All prior studies using log-log models use what we suggest is an incorrect benchmark for evaluating NPO fundraising behavior. The estimated effect of a 1% increase in fundraising on net donations varies widely across NPOs in our sample,from an increase in net donations of 0.18% of gross donations to a decrease of 0.66% of gross donations. Of the 76 Nonprofit Times 100 NPOs with usable data in 2002, we estimate that 24 engaged in ,excessive' fundraising, 18 engaged in ,insufficient' fundraising, and 34 did not engage in ,excessive' or ,insufficient' fundraising; i.e., we could not reject the null hypothesis of ,optimal' levels of fundraising. Copyright © 2006 John Wiley & Sons, Ltd. [source] CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytesJOURNAL OF NEUROCHEMISTRY, Issue 2 2003Cathyryne K. Manner Abstract We have previously demonstrated that genetic ablation of cationic amino acid transporter 2 (Cat2) significantly inhibits nitric oxide (NO) production by inducible nitric oxide synthase (iNOS) in activated macrophages. Here we report that iNOS activity is impaired by 84% in activated Cat2 -deficient astrocytes. Cat2 ablation appears to reduce astrocyte NO synthesis by decreasing the uptake of the sole precursor, arginine, as well as by reducing the expression of iNOS following activation. Excessive or dysregulated NO production by activated astrocytes and other CNS cell types has been implicated in the pathogenesis of neurological disorders. Our results support the idea that manipulation of CAT2 transporter function might be useful for the therapeutic modulation of iNOS activity. [source] Mechanisms of Postural Control in Alcoholic Men and Women: Biomechanical Analysis of Musculoskeletal Coordination During Quiet StandingALCOHOLISM, Issue 3 2010Edith V. Sullivan Background:, Excessive sway during quiet standing is a common sequela of chronic alcoholism even with prolonged sobriety. Whether alcoholic men and women who have remained abstinent from alcohol for weeks to months differ from each other in the degree of residual postural instability and biomechanical control mechanisms has not been directly tested. Method:, We used a force platform to characterize center-of-pressure biomechanical features of postural sway, with and without stabilizing conditions from touch, vision, and stance, in 34 alcoholic men, 15 alcoholic women, 22 control men, and 29 control women. Groups were matched in age (49.4 years), general intelligence, socioeconomic status, and handedness. Each alcoholic group was sober for an average of 75 days. Results:, Analysis of postural sway when using all 3 stabilizing conditions versus none revealed diagnosis and sex differences in ability to balance. Alcoholics had significantly longer sway paths, especially in the anterior,posterior direction, than controls when maintaining erect posture without balance aids. With stabilizing conditions the sway paths of all groups shortened significantly, especially those of alcoholic men, who demonstrated a 3.1-fold improvement in sway path difference between the easiest and most challenging conditions; the remaining 3 groups, each showed a ,2.4-fold improvement. Application of a mechanical model to partition sway paths into open-loop and closed-loop postural control systems revealed that the sway paths of the alcoholic men but not alcoholic women were characterized by greater short-term (open-loop) diffusion coefficients without aids, often associated with muscle stiffening response. With stabilizing factors, all 4 groups showed similar long-term (closed loop) postural control. Correlations between cognitive abilities and closed-loop sway indices were more robust in alcoholic men than alcoholic women. Conclusions:, Reduction in sway and closed-loop activity during quiet standing with stabilizing factors shows some differential expression in men and women with histories of alcohol dependence. Nonetheless, enduring deficits in postural instability of both alcoholic men and alcoholic women suggest persisting liability for falling. [source] 6.,No More Hiroshimas and Sharp WeaponsAMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY, Issue 1 2009Keping Wang When it comes to rethinking the Hiroshima A-bombing and its historical impact, there arise a number of approaches to be exercised from different perspectives related to the human condition and the current situation today. This essay presents two of them: a poetical reflection and a philosophical pondering that are characterized by either factual inquiry or empirical wisdom. The former is deplorably sentimental and unforgettable with regard to the deadliest mode of warfare that has ever occurred in human history. The philosophical pondering from a Taoist viewpoint is thought-provoking and instructive with ongoing relevance to the problematic globe. Hence when the poet calls out "No More Hiroshimas," we shall go ahead and appeal for "No More Wars,""No More Sharp Weapons," or "No More Excessive Forces." However, what haunts the world all the time is constant warfare at varied scales here and there; and what worries us right now is the hard fact that some nations are presumably taking the risk of developing nuclear weapons on a starvation budget, for they think that they are under the threat and pressure of other countries armed with plenty of such mass-destructive devices. They all seem to have neglected or obliterated the historical memory of Hiroshima as a symbol of the worst violence ever known to humankind. [source] Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammationARTHRITIS & RHEUMATISM, Issue 2 2010Leo A. B. Joosten No abstract is available for this article. [source] Eco-psychological profiling: an oil company exampleCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 3 2004Tarja Ketola When organizational image is being challenged, use of psychological defences may become excessive. In this paper 18 defences that appeared in an oil company during an oil spill are studied. All defences except sublimation contributed to the deterioration of corporate image. Sublimation allowed the company to take responsibility. Other defences simply put off facing the truth. The selection of defences used during crises reveals organizations' true personalities. Twelve different organizational personality types are discussed. Use of certain defences leads to the development of a neurotic personality. The case company turned out to be normally and neurotically demanding, paranoid, narcissistic and attention seeking, and normally depressive. Organizations constantly using primitive defences are borderline personalities. Excessively defensive organizations may turn psychotic. The case company's reactions to the incident were psychologically revealing. Finding defences characteristic of the company allowed us to build its eco-psychological profile. Based on this case study an eco-psychological profiling model is proposed. Copyright © 2004 John Wiley & Sons, Ltd and ERP Environment. [source] Obsessive,compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V,DEPRESSION AND ANXIETY, Issue 6 2010James F. Leckman M.D. Abstract Background: Since the publication of the DSM-IV in 1994, research on obsessive,compulsive disorder (OCD) has continued to expand. It is timely to reconsider the nosology of this disorder, assessing whether changes to diagnostic criteria as well as subtypes and specifiers may improve diagnostic validity and clinical utility. Methods: The existing criteria were evaluated. Key issues were identified. Electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies. Results: This review presents a number of options and preliminary recommendations to be considered for DSM-V. These include: (1) clarifying and simplifying the definition of obsessions and compulsions (criterion A); (2) possibly deleting the requirement that people recognize that their obsessions or compulsions are excessive or unreasonable (criterion B); (3) rethinking the clinical significance criterion (criterion C) and, in the interim, possibly adjusting what is considered "time-consuming" for OCD; (4) listing additional disorders to help with the differential diagnosis (criterion D); (5) rethinking the medical exclusion criterion (criterion E) and clarifying what is meant by a "general medical condition"; (6) revising the specifiers (i.e., clarifying that OCD can involve a range of insight, in addition to "poor insight," and adding "tic-related OCD"); and (7) highlighting in the DSM-V text important clinical features of OCD that are not currently mentioned in the criteria (e.g., the major symptom dimensions). Conclusions: A number of changes to the existing diagnostic criteria for OCD are proposed. These proposed criteria may change as the DSM-V process progresses. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source] Managing Development for Results: A Role for Results-oriented Public Expenditure ManagementDEVELOPMENT POLICY REVIEW, Issue 6 2004John Roberts Can results-oriented approaches to public expenditure management function in low-income countries? Do they have a role in securing the implementation of poverty reduction strategies? And can they assist donors in ,managing aid for results'? Findings from seven countries suggest that they can work in environments with mediocre discipline in budget and public finance management and a degree of uncertainty caused by macroeconomic instability, but not when there is excessive ,informality' and instability. With political will and a strong finance ministry, they have proved valuable tools in ensuring the coherent expansion of pro-poor programmes and their delivery through autonomous local governments. However, they have yet to become effective in improving public administrations' accountability to parliament and to non-governmental stakeholders. [source] Epigenetic control of translation regulation: Alterations in histone H3 lysine 9 post-translation modifications are correlated with the expression of the translation initiation factor 2B (Eif2b5) during thermal control establishmentDEVELOPMENTAL NEUROBIOLOGY, Issue 2 2010Tatiana Kisliouk Abstract Thermal control set point is regulated by thermosensitive neurons of the preoptic anterior hypothalamus (PO/AH) and completes its development during postnatal critical sensory period. External stimuli, like increase in environmental temperature, influence the neuronal protein repertoire and, ultimately, cell properties via activation or silencing of gene transcription, both of which are regulated by the "histone code."" Here, we demonstrated an increase in global histone H3 lysine 9 (H3K9) acetylation as well as H3K9 dimethylation in chick PO/AH during heat conditioning at the critical period of sensory development. In contrast to the global profile of H3K9 modifications, acetylation and dimethylation patterns of H3K9 at the promoter of the catalytic subunit of eukaryotic translation initiation factor 2B (Eif2b5) were opposite to each other. During heat conditioning, there was an increase in H3K9 acetylation at the Eif2b5 promoter, simultaneously with decrease in H3K9 dimethylation. These alterations coincided with Eif2b5 mRNA induction. Moreover, exposure to excessive heat during the critical period resulted in long-term effect on both H3K9 tagging at the Eif2b5 promoter and Eif2b5 mRNA expression. These data suggest a role for dynamic H3K9 post-translational modifications in global translation regulation during the thermal control establishment. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2010 [source] Pathological gambling: an increasing public health problemACTA PSYCHIATRICA SCANDINAVICA, Issue 4 2001Article first published online: 7 JUL 200 Gambling has always existed, but only recently has it taken on the endlessly variable and accessible forms we know today. Gambling takes place when something valuable , usually money , is staked on the outcome of an event that is entirely unpredictable. It was only two decades ago that pathological gambling was formally recognized as a mental disorder, when it was included in the DSM-III in 1980. For most people, gambling is a relaxing activity with no negative consequences. For others, however, gambling becomes excessive. Pathological gambling is a disorder that manifests itself through the irrepressible urge to wager money. This disorder ultimately dominates the gambler's life, and has a multitude of negative consequences for both the gambler and the people they interact with, i.e. friends, family members, employers. In many ways, gambling might seem a harmless activity. In fact, it is not the act of gambling itself that is harmful, but the vicious cycle that can begin when a gambler wagers money they cannot afford to lose, and then continues to gamble in order to recuperate their losses. The gambler's ,tragic flaw' of logic lies in their failure to understand that gambling is governed solely by random, chance events. Gamblers fail to recognize this and continue to gamble, attempting to control outcomes by concocting strategies to ,beat the game'. Most, if not all, gamblers try in some way to predict the outcome of a game when they are gambling. A detailed analysis of gamblers' selfverbalizations reveals that most of them behave as though the outcome of the game relied on their personal ,skills'. From the gambler's perspective, skill can influence chance , but in reality, the random nature of chance events is the only determinant of the outcome of the game. The gambler, however, either ignores or simply denies this fundamental rule (1). Experts agree that the social costs of pathological gambling are enormous. Changes in gaming legislation have led to a substantial expansion of gambling opportunities in most industrialized countries around the world, mainly in Europe, America and Australia. Figures for the United States' leisure economy in 1996 show gross gambling revenues of $47.6 billion, which was greater than the combined revenue of $40.8 billion from film box offices, recorded music, cruise ships, spectator sports and live entertainment (2). Several factors appear to be motivating this growth: the desire of governments to identify new sources of revenue without invoking new or higher taxes; tourism entrepreneurs developing new destinations for entertainment and leisure; and the rise of new technologies and forms of gambling (3). As a consequence, prevalence studies have shown increased gambling rates among adults. It is currently estimated that 1,2% of the adult population gambles excessively (4, 5). Given that the prevalence of gambling is related to the accessibility of gambling activities, and that new forms of gambling are constantly being legalized throughout most western countries, this figure is expected to rise. Consequently, physicians and mental health professionals will need to know more about the diagnosis and treatment of pathological gamblers. This disorder may be under-diagnosed because, clinically, pathological gamblers usually seek help for the problems associated with gambling such as depression, anxiety or substance abuse, rather than for the excessive gambling itself. This issue of Acta Psychiatrica Scandinavica includes the first national survey of problem gambling completed in Sweden, conducted by Volberg et al. (6). This paper is based on a large sample (N=9917) with an impressively high response rate (89%). Two instruments were used to assess gambling activities: the South Oaks Gambling Screen-Revised (SOGS-R) and an instrument derived from the DSM-IV criteria for pathological gambling. Current (1 year) and lifetime prevalence rates were collected. Results show that 0.6% of the respondents were classified as probable pathological gamblers, and 1.4% as problem gamblers. These data reveal that the prevalence of pathological gamblers in Sweden is significantly less than what has been observed in many western countries. The authors have pooled the rates of problem (1.4%) and probable pathological gamblers (0.6%), to provide a total of 2.0% for the current prevalence. This 2% should be interpreted with caution, however, as we do not have information on the long-term evolution of these subgroups of gamblers; for example, we do not know how many of each subgroup will become pathological gamblers, and how many will decrease their gambling or stop gambling altogether. Until this information is known, it would be preferable to keep in mind that only 0.6% of the Swedish population has been identified as pathological gamblers. In addition, recent studies show that the SOGS-R may be producing inflated estimates of pathological gambling (7). Thus, future research in this area might benefit from the use of an instrument based on DSM criteria for pathological gambling, rather than the SOGS-R only. Finally, the authors suggest in their discussion that the lower rate of pathological gamblers obtained in Sweden compared to many other jurisdictions may be explained by the greater availability of games based on chance rather than games based on skill or a mix of skill and luck. Before accepting this interpretation, researchers will need to demonstrate that the outcomes of all games are determined by other factor than chance and randomness. Many studies have shown that the notion of randomness is the only determinant of gambling (1). Inferring that skill is an important issue in gambling may be misleading. While these are important issues to consider, the Volberg et al. survey nevertheless provides crucial information about gambling in a Scandinavian country. Gambling will be an important issue over the next few years in Sweden, and the publication of the Volberg et al. study is a landmark for the Swedish community (scientists, industry, policy makers, etc.). This paper should stimulate interesting discussions and inspire new, much-needed scientific investigations of pathological gambling. Acta Psychiatrica Scandinavica Guido Bondolfi and Robert Ladouceur Invited Guest Editors References 1.,LadouceurR & WalkerM. The cognitive approach to understanding and treating pathological gambling. In: BellackAS, HersenM, eds. Comprehensive clinical psychology. New York: Pergamon, 1998:588 , 601. 2.,ChristiansenEM. Gambling and the American economy. In: FreyJH, ed. Gambling: socioeconomic impacts and public policy. Thousand Oaks, CA: Sage, 1998:556:36 , 52. 3.,KornDA & ShafferHJ. Gambling and the health of the public: adopting a public health perspective. J Gambling Stud2000;15:289 , 365. 4.,VolbergRA. Problem gambling in the United States. J Gambling Stud1996;12:111 , 128. 5.,BondolfiG, OsiekC, FerreroF. Prevalence estimates of pathological gambling in Switzerland. Acta Psychiatr Scand2000;101:473 , 475. 6.,VolbergRA, AbbottMW, RönnbergS, MunckIM. Prev-alence and risks of pathological gambling in Sweden. Acta Psychiatr Scand2001;104:250 , 256. 7.,LadouceurR, BouchardC, RhéaumeNet al. Is the SOGS an accurate measure of pathological gambling among children, adolescents and adults?J Gambling Stud2000;16:1 , 24. [source] THE POLITICAL ECONOMY OF OVERLAPPING JURISDICTIONS AND THE FRENCH/DUTCH REJECTION OF THE EU CONSTITUTIONECONOMIC AFFAIRS, Issue 1 2006Jean-Luc Migué In seeking to protect their failed social model by rejecting the EU constitution, French and Dutch voters ironically contributed to promoting the very ,liberal' order they misunderstand and despise. When, as in federalist politics, functions overlap, two levels of government compete for the same votes in the same territory in the supply of similar services. Not unlike the tragedy of the commons in oil extraction, it is in the interest of both political authorities to seek to gain votes in implementing the programme first. The overall equilibrium supply of public services is excessive and both levels of government have a tendency to invade every field. Short of effective constitutional limits on the powers of the central government, a more decentralised EU offers an opportunity to overcome the common-pool problem of multi-level government. [source] IS INJURY COMPENSATION EXCESSIVE?ECONOMIC PAPERS: A JOURNAL OF APPLIED ECONOMICS AND POLICY, Issue 2 2004Peter Abelson In Australia, excessive awards in personal damage cases are widely perceived to have created a public liability crisis and cuts in valued services. This paper analyses whether awards for damages are excessive. The paper starts by setting out a normative basis for awards based on welfare economic principles and amounts that individuals are willing to pay to avoid injuries. It then provides estimates of appropriate compensation sums for 27 typical injuries ranging from broken arms to quadriplegia and severe brain damage. There follows an analysis of 192 court awards for injuries greater than $250 000 in New South Wales between 1991 and 2002, including awards for 101 traffic accidents, 64 workers compensation cases, and 27 personal injury cases. The paper concludes that these court awards are broadly consistent with economic estimates for damages and that the awards are generally not excessive. [source] Adsorbing colloid flotation for removal of metal ions in waters from base metal minesENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 1 2002H. Sabti Adsorbing Colloid Flotation (ACF) has been shown in laboratory experiments to be effective for the removal of heavy metals (Zn, Cu, Cd and Pb) from dilute solutions. Sodium dodecyl sulphate (SDS) and sodium oleate (NaOl) were used as surfactants in single or mixed form, with Fe(OH)3 as a flocculant for colloid formation. These reagents worked best for zinc and copper ions for a feed concentration of 50 parts per million (ppm). The removal of lead improved significantly by the use of Fe(OH)3 and NaLS (Sodium lauryl sulphate), while the best removal of cadmium was achieved by the use of Al(OH)3 and HTMABr (hexadecyltrimethylammonium bromide). Flotation experiments were conducted with feed concentrations of 50 and 500 parts per billion (ppb) and 50 ppm (parts per million). The experimental results showed that the residual concentration of metal ions decreased significantly with the decrease in the feed concentration. This could be the effect of excessive (much more than stoichiometric ratio) amounts of surfactant and flocculant, compared to the feed concentrations, required in the effective flotation of dilute feed solutions. The surfactant concentration and feed pH had the largest effects on the process, as observed in the case of cadmium removal. This can be attributed to the flocformation and flotation tendencies of the colloid-metal complexes at various solution pH and surfactant concentrations. The ACF method was applied to a number of natural drainage solutions from the metal mines at Te Aroha, New Zealand, and the experimental results demonstrate that significant removal is achieved for most of the heavy metals. [source] Impact of Mandatory Physician Reporting on Accident Risk in EpilepsyEPILEPSIA, Issue 8 2007Richard S McLachlan Summary:,Background: In some jurisdictions, physicians are required by law to report patients with seizures to the department of motor vehicles. We assessed the hypothesis that mandatory reporting reduces the risk of automobile accidents in people with epilepsy. Methods: A retrospective survey of driving and accident rates was done by mailed questionnaire to two groups of subjects with epilepsy in Canada, one living in Ontario where reporting is mandatory and the other in Alberta where it is not. Responses were obtained from a control group without epilepsy for comparison. Results: The epilepsy (n = 425) and control (n = 375) groups were comparable in age and sex. Seventy-three percent of the epilepsy group were or had been licensed drivers compared to 94% of the controls (rr 0.77, 95% CI 0.73,0.83, p < 0.001). Lifetime accident rate of licensed drivers was 58% in epilepsy and 60% in controls (rr 0.99, 95%CI 0.82,1.19, ns) while 9% of the epilepsy group and 9% of the controls had an accident in the previous year (rr 1.00, 95%CI 0.95,1.06, ns). All those with epilepsy in Ontario (n = 202) and Alberta (n = 223), also comparable in age and sex, had equal lifetime accident rates of 45 and 46% (rr 0.99, 95%CI 0.67,1.47, ns) and 1-year rates of 11 and 8% (rr 1.38, 95%CI 0.59,3.27, ns). In Ontario, 20% of drivers were unlicensed compared to 9% in Alberta (rr 2.39, 95%CI 1.17,4.89, p = 0.01) Conclusion: Although it is clearly dangerous for many people with ongoing seizures to drive, the findings provide no support for the hypothesis that mandatory reporting of patients by physicians reduces accident risk and suggest that concerns about the impact of epilepsy on driving compared to other medical and nonmedical risk factors may be excessive. [source] The Effects of Ascorbic Acid on Penicillin-induced Epileptiform Activity in RatsEPILEPSIA, Issue 7 2007Mustafa Ayyildiz Summary:,Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as ,-tocopherol or ascorbic acid (vitamin C). In the present study, we examined the effects of ascorbic acid, at the six different doses, on penicillin-induced epileptiform activity. Methods: A single microinjection of penicillin (2.5 ,l, 500 units, intracortically) into the left sensorimotor cortex induced epileptiform activity within 2,5 min, progressing to full seizure activity lasting ,3,5 h. In the first set of experiments, 30 min after penicillin injection, six different doses of ascorbic acid (25, 50, 100, 200, 400, or 800 mg/kg) were administered intraperitoneally (IP). The other group of animals received the effective dose of ascorbic acid (100 mg/kg, IP) for 7 days. Ascorbic acid administration was stopped 24 h before penicillin treatment. Another group of rats received the effective dose of ascorbic acid (100 mg/kg, IP) 30 min before penicillin treatment. In the second set of experiments, the lipid peroxidation (MDA) and reduced glutathione (GSH) levels of brain were measured in the control, control + ascorbic acid, penicillin, and penicillin + ascorbic acid groups. Results: Ascorbic acid, at the low dose (50, 100 mg/kg, 30 min after penicillin injection), decreased both the frequency and amplitude of penicillin-induced epileptiform activity in rats. Ascorbic acid, at intermediate doses (200, 400 mg/kg, 30 min after penicillin injection), decreased the frequency of epileptiform activity without changing the amplitude. Ascorbic acid, at the lowest dose (25 mg/kg) and highest dose (800 mg/kg) (30 min after penicillin injection), did not change either the frequency or amplitude of epileptiform activity. Ascorbic acid, at the low dose (100 mg/kg) was the most effective dose in changing the frequency and amplitude of penicillin-induced epileptiform activity. Pretreatment with ascorbic acid (100 mg/kg) 30 min before penicillin treatment caused a significant delay in the onset of penicillin-induced epileptiform activity. Pretreatment with ascorbic acid (100 mg/kg) for 7 days did not change the latency of epileptiform activity. The most effective dose of ascorbic acid (100 mg/kg) prevented both the decrease in GSH level and the increase in lipid peroxidation level (MDA) occurring after penicillin-induced epileptiform activity. Conclusions: These data indicate that ascorbic acid has neuroprotective activity against penicillin-induced epileptiform electrocorticogram activity. [source] Long-term survey of laryngoplasty and ventriculocordectomy in an older, mixed-breed population of 200 horses.EQUINE VETERINARY JOURNAL, Issue 4 2003Part 1: Maintenance of surgical arytenoid abduction, complications of surgery Summary Reasons for performing study: Laryngoplasty (LP) is currently the most common surgical treatment for equine laryngeal paralysis, however, there have been no reports quantifying the degree of retention of arytenoid abduction following L P. ADitionally, the complications of LP have been poorly documented. Objectives: To record the degree of arytenoid abduction retention following LP and to accurately document all complications of surgery. Methods: A study (1986,1998) of 200 horses of mixed breed and workload, median age 6 years (prospective 136 cases and retrospective 64 cases) undergoing LP (using 2 stainless steel wires) and combined ventriculocordectomy was undertaken; 198 owners completed questionnaires, a median of 19 months following surgery. The degree of arytenoid abduction achieved was endoscopically, semi-quantitatively evaluated using a 5-grade system, at 1 day, 7 days, and 6 weeks after surgery. Results: On the day following LP, 62% of horses had good (median grade 2) arytenoid abduction, 10% had excessive (grade 1), and 5% had minimal (grade 4) abduction (overall - median grade 2). Due to progressive loss of abduction, moderate (median grade 3, range 1,5) abduction was present overall at 1 and 6 weeks after LP. Further surgery was required to re-tighten prostheses in 10% of cases with excessive loss of abduction, or to loosen prostheses in 7% of horses which had continuing high levels of LP abduction and significant post operative dysphagia. LP wound problems (mainly seromas and suture abscesses) were reported to last <2 weeks in 9% of cases, <4 weeks in 4% and >4 weeks in 4%. The (partially sutured) laryngotomy wounds discharged post operatively for <2 weeks in 22% of cases, <4 weeks in 7% and for >4 weeks in 2%. Coughing occurred at some stage post operatively in 43% of cases and its presence correlated significantly with the degree of surgical arytenoid abduction. This coughing occurred during eating in 24% of cases and was not associated with eating (or dysphagia) in the other 19% of cases. Chronic (>6 months duration) coughing occurred in 14% of cases, but appeared to be due to intercurrent pulmonary disease in half of these horses. Conclusions: Suturing the cricotracheal membrane allows most laryngotomy wounds to heal quickly. Laryngoplasty wound problems were of little long-term consequence when stainless steel wire prostheses were used. Potential relevance: A significant loss of LP abduction occurs in most horses in the 6 weeks following surgery and efforts should be made to find ways to prevent such loss. However, excessive LP abduction is associated with post operative dysphagia and coughing. [source] An Evaluation of the Cod Fishing Policies of Denmark Iceland and NorwayEUROCHOICES, Issue 3 2004R. Arnason Summary An Evaluation of the Cod Fishing Policies of Denmark, Iceland and Norway Many ocean fisheries are subject to a fundamental economic problem generally referred to as the common property problem. This problem manifests itself as excessive fishing fleets and fishing effort, depressed fish stocks and little or no profitability of the fishing activity, irrespective of the richness of the underlying marine resources. European fisheries represent some of the most dramatic examples of the common property problem. This article employs simple empirical models and recently developed mathematical techniques to examine the economic efficiency of three European fisheries, namely the Danish, Icelandic and Norwegian cod fisheries, The optimal harvesting policies for each of these fisheries are calculated. Comparing these optimal policies with actual harvests provides a measure of the relative efficiency in these three cod fisheries. The comparison confirms the widely held impression that the cod harvesting policies of ail three countries have been hugely inefficient in the past. Moreover, it appears that the inefficiency has been increasing over time. Only during the last few years of our data are there indications that this negative trend may have been halted. Somewhat more surprisingly, in spite of radically different fisheries management systems, we find relatively little difference in the level of stock over-exploitation between these three countries. Politiques compareées de pêhe à la morue au Danemark, en Islande et en Norvège Beaucoup de pêcheries océaniques sont confrontées au problème nique fondamental de la "propriété collective". Celui-ci se manifeste par des flottes de taille excessive, au service d' efforts de péche exagérés, qui aboutissent à détruire les stocks de poisson et la rentabilité des pécheries, en dépit de la richesse des ressources marines sousjacentes. Les pêcheries européennes constituent actuellement l'un des exemples les plus dramatiques des problèmes associés a la propriété collective. On présente ici un modèle empirique assez simple mais associéà de nouvelles techniques mathématiques récemment développé es pour mesurer l' efficacitééconomique de trois types de politiques de pêche à la morue, au Danemark, en Norvège et en Islande. On commence par calculer le volume optimal des prises pour chacun de ces pays. La comparaison entre le niveau optimal et le niveau réel des prises permet de mesurer le degré d' efficacité des politiques suivies. Elle permet de confirmer l'opinion largement répandue selon laquelle les politiques passées ont été extrêmement peu efficaces. En outre, il apparaît que l'inefficacité est croissante avec le temps. C'est seulement dans les toutes dernières années des séries de données que l' on observe un infléchissement de cette tendance négative. Enfin, et c'est le plus surprenant, on trouve peu de differences entre les trois pays en ce qui conceme le degré de surexploitation du stock, et cela, bien que les principes de gestion des pêcheries y soient entiArement différents. Eine Bewertung der Kabeljaufischereipolitik in Dänemark, Island und Norwegen ahlreiche Hochseefischereien tehen einem grundlegenden ftliehen Problem gegenüber, das allgemein als Problem des kollektiven Eigentums bezeichnet wird. Dieses Problem zeigt sich in übermäßig großen Fangflotten und beträchtlichem Fischereiaufwand, geschrumpften Fischbeständen und geringer oder fehlender Rentabilität der Fischerei; dabei ist die Höhe der Fischressourcen unbedeutend für das Problem. Die europäischen Fischereien stellen einige der drastischsten Beispiele für das Problem des kollektiven Eigentums dar. In diesem Beitrag werden einfache empirische Modelle und kürzlich entwickelte mathematische Verfahren angewendet, um die wirtschaftliche Effizienz von drei europäischen Fischereien zu untersuchem der dänischen, der isländischen und der norwegischen Kabeljaufischerei. Für jede dieser Fischereien wird die optimale Nutzungsstrategie berechnet. Aus dem Vergleich dieser optimalen Nutzungsstrategie mit den tatsächlichen Erträgen ergibt sich ein Maß fur die relative Effizienz, die bei diesen drei Kabeljaufischereien vorliegt. Der Vergleich bestätigt den weit verbreiteten Eindruck, dass die Strategien zum Kabeljaufang in alien drei Ländern in der Vergangenheit enorm ineffizient waren. Darüber hinaus wird deutlich, dass die Ineffizienz im Laufe der Zeit zugenommen hat. Lediglich die Daten der letzten jahre enthalten Hinweise darauf, dass dieser negative Trend zum Stillstand gekommen sein könnte. Obwohl sich die Fischwirtschaft in jedem dieser drei Länder sehr stark unterscheidet, lassen sich erstaunlich wenige Unterschiede im Maß der Übernutzung des Fischbestandes finden. [source] Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivoEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 9 2003Séverine Guillaume Abstract The antigen dose conditions the functional properties of CD8+ T cells generated after priming. At relatively low antigen doses, efficient memory T cells may be generated, while high antigen doses lead to tolerance. To determine the mechanisms leading to such different functional outcomes, we compared the proximal TCR signal transduction of naive cells, to that of memory or high-dose tolerant cells generated in vivo. In vivo activation led to the constitutive phosphorylation of CD3,, recruiting Zap70, in both memory and tolerant cells. In tolerant cells, these phenomena were much more marked, the CD3, and , chains no longer associated, and the Src kinases p56Lck and p59Fyn were inactive. Therefore, when the antigen load overcomes the capacities of immune control, a new mechanism intervenes to block signal transduction: the recruitment of Zap70 to CD3, becomes excessive, leading to TCR complex destabilization, Src kinase dysfunction, and signal arrest. [source] Functional characterization of compound heterozygosity for GlyR,1 mutations in the startle disease hyperekplexiaEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 2 2002Ruth Rea Abstract The human disease hyperekplexia is characterized by excessive startle reactions to auditory and cutaneous stimuli. In its familial form, hyperekplexia has been associated with both dominant and recessive mutations of the GLRA1 gene encoding the glycine receptor ,1 subunit (GlyR,1), which mediates inhibitory transmission in the spinal cord and brainstem. Here we have examined the functional consequences of two amino acid substitutions found in a compound heterozygous family, R252H and R392H, to investigate the mechanisms determining this inheritance pattern. When expressed in Xenopus laevis oocytes, both mutations were non-functional. Neither mutant affected the electrophysiological properties of wild type GlyR,1 when co-expressed. We introduced a green fluorescent protein tag to mutant subunits and found that both mutant proteins were detectable. Evidence that subcellular localization differed from wild type was significant for one of the mutants. Thus, an effective loss of functional GlyR,1-mediated current underlies hyperekplexia in this family, whereas a partial loss is asymptomatic. [source] Enhanced survival of vascular smooth muscle cells accounts for heightened elastin deposition in arteries of neonatal spontaneously hypertensive ratsEXPERIMENTAL PHYSIOLOGY, Issue 4 2010Silvia M. Arribas Abnormal stiffening and narrowing of arteries are characteristic features of spontaneously hypertensive rats (SHR). In this strain, we have previously demonstrated an increased elastin content and abnormal organization of lamellae in conduit and resistance arteries from neonatal rats that preceded the impending inward remodelling, increased vascular stiffness and development of hypertension. The aim of this study was to assess the mechanism responsible for such excessive and aberrant elastin deposition in SHR vessels during perinatal development. We compared elastin, collagen and fibronectin production (inmunocytochemistry and quantitative assay of metabolically labelled insoluble elastin), DNA content as well as cell proliferation (proliferative cellular nuclear antigen, bromodeoxyuridine incorporation) and death rates (propidium iodide exclusion test, terminal transferase nick and labeling (TUNEL) assay) in cultures of vascular smooth muscle cells (VSMC) derived from neonatal SHR and Wistar,Kyoto (WKY) control rats. Cultures of VSMC derived from neonatal SHR exhibited hypertrophy, produced more elastin, collagen and fibronectin and contained more DNA than equally plated WKY counterparts. Further analysis revealed that the higher net DNA content in SHR-derived cultures was due to increased diploidy, but not to a heightened cell multiplication. The SHR-derived VSMC also exhibited lower rates of cell death and apoptosis, which were associated with increased levels of the anti-apoptotic protein, survivin. We therefore conclude that the peculiar heightened survival of matrix-producing VSMC in neonatal SHR is responsible for accumulation of hard-wearing elastin and other extracellular matrix elements in the growing arteries, thereby contributing to the subsequent development of systemic hypertension. [source] Responses of jawbone to pressure,GERODONTOLOGY, Issue 2 2004Gunnar E. Carlsson Objective:, To provide a literature review of bone resorption of edentulous jaws focusing on responses to pressure. Background:, After the extraction of all teeth in a jaw there is a continuous reduction of the residual ridge. The individual variation of bone resorption is great, and the aetiology is complex and not yet well understood. Materials and methods:, A search of the literature published up to May 2003 on bone resorption and pressure was performed using PubMed/Medline. Results:, Animal studies have demonstrated that excessive and constant pressure induces bone resorption. Recent experimental research has indicated that bone resorption is a pressure-regulated phenomenon with a lower threshold for continuous than for intermittent pressure. Clinical studies have suggested that residual ridge resorption is due more to the effects of denture wearing than to disuse atrophy. However, the results of leaving out dentures at night are not conclusive. Nor does the literature offer any strong evidence for the so-called combination syndrome, which has been described as a result of unfavourable loading. Clinical studies using multivariate analyses indicate that female gender and systemic factors may be of greater importance than oral and denture factors. Implant-supported prostheses have a bone preserving effect rather than the continuing resorption under complete dentures. Conclusions:, The best way to reduce bone resorption is to avoid total extraction, preserve a few teeth and fabricate overdentures. In edentulous jaws, placement of implant-supported prostheses will lead to less bone loss and may even promote bone growth. To increase our knowledge of residual ridge resorption extended experimental, clinical and statistical methods will be needed, preferably including collaboration between dental and medical researchers. [source] Numerical Modeling of Unsaturated Flow in Wastewater Soil Absorption SystemsGROUND WATER MONITORING & REMEDIATION, Issue 2 2003Deborah N. Huntzinger Beach It is common practice in the United States to use wastewater soil absorption systems (WSAS) to treat domestic wastewater. WSAS are expected to provide efficient, long-term removal of wastewater contaminants prior to ground water recharge. Soil clogging at the infiltrative surface of WSAS occurs due to the accumulation of suspended solids, organic matter, and chemical precipitates during continued wastewater infiltration. This clogging zone (CZ) creates an impedance to flow, restricting the hydraulic conductivity and rate of infiltration. A certain degree of clogging may improve the treatment of wastewater by enhancing purification processes, in part because unsaturated flow is induced and residence times are significantly increased. However, if clogging becomes excessive, the wastewater pond height at the infiltrative surface can rise to a level where system failure occurs. The numerical model HYDRUS-2D is used to simulate unsaturated flow within WSAS to better understand the effect of CZs on unsaturated flow behavior and hydraulic retention times in sandy and silty soil. The simulations indicate that sand-based WSAS with mature CZs are characterized by a more widely distributed flow regime and longer hydraulic retention times. The impact of clogging on water flow within the silt is not as substantial. For sand, increasing the hydraulic resistance of the CZ by a factor of three to four requires an increase in the pond height by as much as a factor of five to achieve the same wastewater loading. Because the degree of CZ resistance directly influences the pond height within a system, understanding the influence of the CZ on flow regimes in WSAS is critical in optimizing system design to achieve the desired pollutant-treatment efficiency and to prolong system life. [source] Demand for traditional medicine in Taiwan: a mixed Gaussian,Poisson model approachHEALTH ECONOMICS, Issue 3 2001Steven T. Yen Abstract Hurdle count models are used to examine the participation and consumption decisions in Chinese medicine use. Motivated by a household production model, a second censoring mechanism is introduced into existing single-hurdle models, and the resulting specification accommodates conscientious abstainers, as well as economic non-consumers, and admits excessive zeros in the sample. In contrast to previous studies that found few predictors, empirical results based on a Taiwanese national sample suggest that Western medicine is a gross substitute to Chinese medicine, and both time price and money price play more important roles than income. Insurance, lifestyle and demographics also determine the use of Chinese medicine. Copyright © 2001 John Wiley & Sons, Ltd. [source] Efficient contracting and accountingACCOUNTING & FINANCE, Issue 2 2003David Emanuel This paper examines the role of accounting in an efficient contracting perspective of the firm. The firm is an alternative to the market when the costs of using the market become excessive. When a firm replaces the market, authority substitutes for the price mechanism in determining how decisions are made. This paper examines accounting's role in controlling the firm to ensure resources are put to their highest-value use. Accounting, together with employment contracts, compensation arrangements, debt contracts, internal and external auditors, and the board of directors including its audit and compensation committees comprise a package of mechanisms that have evolved to govern the firm. These institutional devices become the firm's efficient contracting technology. As accounting is part of that contracting technology, the accounting controls and systems that evolve and get implemented are efficient and the accounting methods that are used in calculating the numbers that form part of the firm's contractual arrangements are, likewise, efficient. [source] Efficacy, safety and tolerability of lumiracoxib in patients with rheumatoid arthritisINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 11 2004P. Geusens Summary A randomised, double-blind study was performed to assess the efficacy and tolerability of lumiracoxib in patients with rheumatoid arthritis (RA). Patients received lumiracoxib 200 mg once daily (o.d.) (n = 280), lumiracoxib 400 mg o.d. (n = 281), naproxen 500 mg twice daily (n = 279) or placebo (n = 284) for 26 weeks. The primary efficacy variable was response to treatment according to ACR20 criteria (adjusted for prohibited concomitant or excessive rescue medication use and discontinuations due to unsatisfactory therapeutic response) at week 13. Safety and tolerability was also assessed. Significantly more patients receiving lumiracoxib than placebo were responders according to ACR20 criteria at week 13 (41.1 and 42.7% for lumiracoxib 200 and 400 mg o.d., respectively; 32.4% for placebo; both p < 0.05). The proportion responding to naproxen (39.1%) was not significantly different from placebo. Prespecified gastrointestinal adverse events were more frequent with naproxen than with either lumiracoxib dose or placebo. Lumiracoxib is therefore an effective and well-tolerated therapy for RA. [source] Three-dimensional MRI mapping of minimum temperatures achieved in microwave and conventional food processingINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 3 2001John R. Bows Microbiological assurance protocols for food preservation are based on the ,worst-case' slowest heating point within the food product. For conduction-limited processing, this leads to well-known overheating near surface regions of products, with resultant quality loss. For volumetric heating processes such as microwave heating, it is practically impossible to guarantee where the slowest heating point will be. Consequently, microwave heating regimes are generally excessive and product quality is often similar to conventional conduction-limited heating processes. It is well known that Magnetic Resonance Imaging (MRI) can provide three-dimensional (3D) images which quantify the spatial distribution of water in foods, and also that the MRI parameters of water are temperature dependent. The present study demonstrates that a combination of these two concepts has led to a new approach for the validation of thermal processing in food manufacture. The potential for on-line assurance of minimum and maximum temperatures for manufacture of microbiologically assured, minimally processed, high quality food is discussed. [source] Excessive, optimal, and insufficient fundraising among the Nonprofit Times 100INTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 2 2006Fred A. Jacobs Using a six-factor model of donations, we estimate the effect on net donations; i.e., donations less fundraising expenditures, of a one percent marginal increase in fundraising expenditures, for each sample nonprofit organization (NPO) from the Nonprofit Times 100 from 2000 to 2002. No prior study of U.S. NPOs estimates the effect of fundraising expense on net donations. We then use these estimates and what we argue is the correct benchmark, the ratio of fundraising expense to donations, to provide evidence, for each NPO, on whether the NPO's level of fundraising is ,excessive,' ,optimal,' or ,insufficient,' relative to the level that maximizes net donations. All prior studies using log-log models use what we suggest is an incorrect benchmark for evaluating NPO fundraising behavior. The estimated effect of a 1% increase in fundraising on net donations varies widely across NPOs in our sample,from an increase in net donations of 0.18% of gross donations to a decrease of 0.66% of gross donations. Of the 76 Nonprofit Times 100 NPOs with usable data in 2002, we estimate that 24 engaged in ,excessive' fundraising, 18 engaged in ,insufficient' fundraising, and 34 did not engage in ,excessive' or ,insufficient' fundraising; i.e., we could not reject the null hypothesis of ,optimal' levels of fundraising. Copyright © 2006 John Wiley & Sons, Ltd. 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