Home About us Contact
|
Home About us Contact | ||
|
|
||
Exceptional
Terms modified by Exceptional Selected AbstractsA Case of Multiple Keratoacanthoma Centrifugum MarginatumDERMATOLOGIC SURGERY, Issue 5 2004Cristina Mangas MD Background. Keratoacanthoma centrifugum marginatum is a rare variety of keratoacanthoma, usually presented and classified as solitary keratoacanthoma. Reported cases of multiple keratoacanthoma centrifugum marginatum are exceptional in the literature. Observations. A 21-year-old man presented for evaluation of erythematous papules and plaques on both legs that had had a peripheral growth over the past year. Clinical and histologic examination showed typical features of keratoacanthoma centrifugum marginatum. Owing to the multiplicity and size of the lesions, treatment with oral isotretinoin was started. It was ineffective. Subsequent treatment with methotrexate combined with oral prednisone led to the regression of all lesions. Conclusions. The exceptional case of a man with multiple keratoacanthoma centrifugum marginatum is reported. Treatment with methotrexate combined with oral prednisone was effective. This case illustrates how some variants of keratoacanthomas do not really fit into the current classification and how complex the treatment of these tumors is. [source] Outcome of severe unilateral cerebellar hypoplasiaDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 8 2010ANDREA PORETTI Aim, Complete or subtotal absence of one cerebellar hemisphere is exceptional; only single cases have been described. We aimed to assess the long-term outcome in children with severe unilateral cerebellar hypoplasia (UCH). Method, As part of a retrospective study we describe neuroimaging features, clinical findings, and cognitive outcomes of seven children with UCH (five males, two females; age at first magnetic resonance imaging [MRI]: median 1y 3mo, range 9d,8y 10mo; age at latest follow-up: median 6y 6mo, range 2y 3mo,14y 11mo). Results, One child had abnormalities on prenatal MRI at 21 weeks' gestation. The left cerebellar hemisphere was affected in five children, and the right hemisphere in two children. The vermis was involved in five children. The volume of the posterior fossa was variable. At the latest follow-up, neurological findings included truncal ataxia and muscular hypotonia in five children, limb ataxia in three patients, and head nodding in two patients. Three children had learning disability*, five had speech and language disorders, and one had a severe behavioural disorder. Interpretation, Severe UCH is a residual change after a disruptive prenatal cerebellar insult, most likely haemorrhagic. The outcome is variable, ranging from almost normal development to marked developmental impairment. Ataxia is a frequent but not a leading sign. It seems that involvement of the cerebellar vermis is often, but not consistently, associated with a poorer cognitive outcome, whereas an intact vermis is associated with normal outcome and no truncal ataxia. [source] The ,revolt of the early modernists' and the ,first modern economy': an assessmentECONOMIC HISTORY REVIEW, Issue 4 2002Jan Luiten Van Zanden Established views of the early modern economy have changed considerably. De Vries and Van der Woude maintain that the Dutch economy was exceptional in its process of ,modern economic growth' in 1500,1815. This article argues that economic growth in the Netherlands was probably not much faster than in England, as is clear from the development of real wages. The modernity of the Dutch economy in this period appears to be a product of economic and institutional changes in the middle ages. [source] Reading, Work, and Catholic Women's BiographiesENGLISH LITERARY RENAISSANCE, Issue 3 2003Frances E. Dolan This essay considers biographies of Catholic women written after their deaths, largely by priests who served as their confessors, and the saints' lives which these biographies took as their models. The purpose of this essay is twofold: to draw attention to a significant body of Catholic writing, and to use this material to shed new light on the one text of this group that has gained considerable critical attention, The Lady Falkland, Her Life, a biography of Elizabeth Cary by one of her daughters, a Benedictine nun. Considering the Life as a participant in a subgenre of Catholic biography reveals the tension between the conventions and precedents available to Cary's biographer, on the one hand, and her intractable subject, on the other. The Life, like other similar biographies, borrows from and verges on hagiography, but is particularly unsuccessful at transforming its subject into a saint. While criticism of Cary and her works continues to dwell on her as eccentric and exceptional, determined by the particularities of her own character and experience, she is as like other female subjects of Catholic biography and hagiography as she is unlike them. This can only be seen by attending to the kinds of texts that Cary and her daughter might well have read, and the parameters they set for writing an eminent Catholic woman's life. These texts figure reading and housework as the chief means by which Catholic women define and sustain their confessional identities in the hostile environment of post-reformation England. [source] Patterns of bacterial diversity across a range of Antarctic terrestrial habitatsENVIRONMENTAL MICROBIOLOGY, Issue 11 2007Etienne Yergeau Summary Although soil-borne bacteria represent the world's greatest source of biological diversity, it is not well understood whether extreme environmental conditions, such as those found in Antarctic habitats, result in reduced soil-borne microbial diversity. To address this issue, patterns of bacterial diversity were studied in soils sampled along a > 3200 km southern polar transect spanning a gradient of increased climate severity over 27° of latitude. Vegetated and fell-field plots were sampled at the Falkland (51°S), South Georgia (54°S), Signy (60°S) and Anchorage Islands (67°S), while bare frost-sorted soil polygons were examined at Fossil Bluff (71°S), Mars Oasis (72°S), Coal Nunatak (72°S) and the Ellsworth Mountains (78°S). Bacterial 16S rRNA gene sequences were recovered subsequent to direct DNA extraction from soil, polymerase chain reaction amplification and cloning. Although bacterial diversity was observed to decline with increased latitude, habitat-specific patterns appeared to also be important. Namely, a negative relationship was found between bacterial diversity and latitude for fell-field soils, but no such pattern was observed for vegetated sites. The Mars Oasis site, previously identified as a biodiversity hotspot within this region, proved exceptional within the study transect, with unusually high bacterial diversity. In independent analyses, geographical distance and vegetation cover were found to significantly influence bacterial community composition. These results provide insight into the factors shaping the composition of bacterial communities in Antarctic terrestrial habitats and support the notion that bacterial diversity declines with increased climatic severity. [source] A Study of 43 Patients with Panayiotopoulos Syndrome, a Common and Benign Childhood Seizure SusceptibilityEPILEPSIA, Issue 1 2003Christina Lada Summary: ,Purpose: To determine prevalence, clinical, EEG features, and prognosis of Panayiotopoulos syndrome and to examine the proposition that clinical manifestations are more important than EEG findings. Methods: We analyzed retrospectively the clinical and EEG records of 1,340 children with one or more focal seizures seen in the last 18 years, supplemented with a prospective study from 1998. Panayiotopoulos syndrome was defined by clinical criteria, mainly ictal emesis, irrespective of EEG findings. Results: We analyzed 43 of 90 patients with Panayiotopoulos syndrome who were seizure free >2 years. Girls predominated. Mean age at first seizure was 5 years. Seizures consisted mainly of autonomic manifestations; ictal emesis was often the first symptom, culminating in vomiting in 86%. Of nonautonomic manifestations, lateral eye deviation was the most common; visual symptoms were exceptional. Impairment of consciousness ensued in all seizures, half of which ended with hemi or generalized convulsions. Nearly 46.5% of cases had at least one seizure >30 min, constituting autonomic status epilepticus. Seizures during sleep (84%) were more common than those in wakefulness. EEG showed occipital spikes in 29 patients. Of the other 14 cases, five had extraoccipital abnormalities or brief generalized discharges, and nine had normal awake and sleep EEG. Prognosis was excellent. All 43 children have been free of seizures for ,2 years, 53% having a single seizure, and 47%, an average two to three seizures. Conclusions: Panayiotopoulos syndrome is common and needs wider recognition. EEG shows occipital or extraoccipital abnormalities, is normal in one third of patients, and does not determine clinical manifestations or prognosis, which is excellent despite the high prevalence of lengthy seizures. [source] Time course of striatal ,FosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatmentEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2003M. Andersson Abstract ,FosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/,FosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the drug-induced FosB/,FosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of ,FosB, paralleled the time-course of ,FosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that ,FosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy. [source] Aspects of stability and phenomenology in type IIA orientifolds with intersecting D6-branesFORTSCHRITTE DER PHYSIK/PROGRESS OF PHYSICS, Issue 1 2004T. OttArticle first published online: 14 JAN 200 Abstract Intersecting branes have been the subject of an elaborate string model building for several years. After a general introduction into string theory, this work introduces in detail the toroidal and -orientifolds. The picture involving D9-branes with B-fluxes is shortly reviewed, but the main discussion employs the T-dual picture of intersecting D6-branes. The derivation of the R-R and NS-NS tadpole cancellation conditions in the conformal field theory is shown in great detail. Various aspects of the open and closed chiral and non-chiral massless spectrum are discussed, involving spacetime anomalies and the generalized Green-Schwarz mechanism. An introduction into possible gauge breaking mechanisms is given, too. Afterwards, both ,, = 1 supersymmetric and non-supersymmetric approaches to low energy model building are treated. Firstly, the problem of complex structure instabilities in toroidal ,R -orientifolds is approached by a -orbifolded model. In particular, a stable non-supersymmetric standard-like model with three fermion generations is discussed. This model features the standard model gauge groups at the same time as having a massless hypercharge, but possessing an additional global B - L symmetry. The electroweak Higgs mechanism and the Yukawa couplings are not realized in the usual way. It is shown that this model descends naturally from a flipped SU(5) GUT model, where the string scale has to be at least of the order of the GUT scale. Secondly, supersymmetric models on the -orbifold are discussed, involving exceptional 3-cycles and the explicit construction of fractional D-branes. A three generation Pati-Salam model is constructed as a particular example, where several brane recombination mechanisms are used, yielding non-flat and non-factorizable branes. This model even can be broken down to a MSSM-like model with a massless hypercharge. Finally, the possibility that unstable closed and open string moduli could have played the role of the inflaton in the evolution of the universe is being explored. In the closed string sector, the important slow-rolling requirement can only be fulfilled for very specific cases, where some moduli are frozen and a special choice of coordinates is taken. In the open string sector, inflation does not seem to be possible at all. [source] Long-range foraging by the honey-bee, Apis mellifera L.FUNCTIONAL ECOLOGY, Issue 4 2000M. Beekman Abstract 1.,Waggle dances of honey-bees (Apis mellifera L.) were decoded to determine where and how far the bees foraged during the blooming of heather (Calluna vulgaris L.) in August 1996 using a hive located in Sheffield, UK, east of the heather moors. The median distance foraged was 6·1 km, and the mean 5·5 km. Only 10% of the bees foraged within 0·5 km of the hive whereas 50% went more than 6 km, 25% more than 7·5 km and 10% more than 9·5 km from the hive. 2.,These results are in sharp contrast with previous studies in which foraging distances were much closer to the hive. In May 1997 the mean foraging distance was 1 km, showing that long-range dancing is not the rule in Sheffield. 3.,The observed foraging distances described in this study may not be exceptional in a patchy environment where differences in patch size and patch quality are large. When travel distances to patches are large, distant patches can probably be utilized only by individuals that live in groups and recruit foragers to the patches found. Only then are the benefits of scouting for distant patches high enough to enable the exploitation of these patches. [source] Getting the biodiversity intactness index right: the importance of habitat degradation dataGLOBAL CHANGE BIOLOGY, Issue 11 2006MATHIEU ROUGET Abstract Given high-level commitments to reducing the rate of biodiversity loss by 2010, there is a pressing need to develop simple and practical indicators to monitor progress. In this context, a biodiversity intactness index (BII) was recently proposed, which provides an overall indicator suitable for policy makers. The index links data on land use with expert assessments of how this impacts the population densities of well-understood taxonomic groups to estimate current population sizes relative to premodern times. However, when calculated for southern Africa, the resulting BII of 84% suggests a far more positive picture of the state of wild nature than do other large-scale estimates. Here, we argue that this discrepancy is in part an artefact of the coarseness of the land degradation data used to calculate the BII, and that the overall BII for southern Africa is probably much lower than 84%. In particular, based on two relatively inexpensive, ground-truthed studies of areas not generally regarded as exceptional in terms of their degradation status, we demonstrate that Scholes and Biggs might have seriously underestimated the extent of land degradation. These differences have substantial bearing on BII scores. Urgent attention should be given to the further development of cost-effective ground-truthing methods for quantifying the extent of land degradation in order to provide reliable estimates of biodiversity loss, both in southern Africa and more widely. [source] The multiplicity of citizenship: transnational and local practices and identifications of middle-class migrantsGLOBAL NETWORKS, Issue 3 2010MARIANNE VAN BOCHOVE Abstract In this article we focus on local and transnational forms of active citizenship, understood as the sum of all political practices and processes of identification. Our study, conducted among middle-class immigrants in Rotterdam, the Netherlands, indicates that the importance of active transnational citizenship should not be overstated. Among these immigrants, political practices are primarily focused on the local level; political practices directed to the home country appear to be quite rare. However, although transnational activities in the public sphere are rather exceptional, many immigrants do participate in homeland-directed activities in the private sphere. If we look at processes of identification, we see that a majority of the middle-class immigrants have a strong local identity. Many of them combine this local identification with feelings of belonging to people in their home country. [source] Oral primary angiosarcoma of the lower lip mucosa: Report of a case in a 15-year-old boyHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 10 2008Ignacio Arribas-Garcia MD Abstract Background. Angiosarcomas are rare soft tissue malignant tumors with dismal prognosis. Head and neck involvement is uncommon (5%) and usually affects the scalp or facial skin. Methods and Results. We present the case of an inferior lip mucosal low-grade angiosarcoma in a 15-year-old boy treated exclusively with surgery. One and a half years after treatment, the patient was free of signs of recurrence. Prompt and accurate diagnosis with adequate imaging modalities and multidisciplinary treatment are crucial for optimal management of these neoplasms. Conclusion. Lip mucosal involvement is exceptional with only a few cases described in the literature, all in patients older than 60 years To our knowledge, this is the youngest patient ever reported. © 2008 Wiley Periodicals, Inc. Head Neck, 2008 [source] Fully Flexible Solution-Deposited ZnO Thin-Film TransistorsADVANCED MATERIALS, Issue 38 2010Keunkyu Song Solution-processed, fully flexible ZnO thin-film transistors (TFTs) on semitransparent substrates are demonstrated. Our devices show exceptional and unprecedented stablity against various bending stresses, i.e., bending, rolling, wearing, and folding, exhibiting no degradation at tensile strains up to 6.35%. [source] High-nickel insects and nickel hyperaccumulator plants: A reviewINSECT SCIENCE, Issue 1 2009Robert S. Boyd Abstract Insects can vary greatly in whole-body elemental concentrations. Recent investigations of insects associated with Ni hyperaccumulator plants have identified insects with relatively elevated whole-body Ni levels. Evaluation of the limited data available indicates that a whole-body Ni concentration of 500 ,g Ni/g is exceptional: I propose that an insect species with a mean value of 500 ,g Ni/g or greater, in either larval/nymphal or adult stages, be considered a "high-Ni insect". Using the 500 ,g Ni/g criterion, 15 species of high-Ni insects have been identified to date from studies in Mpumalanga (South Africa), New Caledonia and California (USA). The highest mean Ni concentration reported is 3 500 ,g Ni/g for nymphs of a South African Stenoscepa species (Orthoptera: Pyrgomorphidae). The majority of high-Ni insects (66%) are heteropteran herbivores. Studies of high-Ni insect host preference indicate they are monophagous (or nearly so) on a particular Ni hyperaccumulator plant species. Much of the Ni in bodies of these insects is in their guts (up to 66%,75%), but elevated levels have also been found in Malpighian tubules, suggesting efficient elimination as one strategy for dealing with a high-Ni diet. Tissue levels of Ni are generally much lower than gut concentrations, but up to 1200 ,g Ni/g has been reported from exuviae, suggesting that molting may be another pathway of Ni elimination. One ecological function of the high Ni concentration of these insects may be to defend them against natural enemies, but to date only one experimental test has supported this "elemental defense" hypothesis. Community-level studies indicate that high-Ni insects mobilize Ni into food webs but that bioaccumulation of Ni does not occur at either plant-herbivore or herbivore-predator steps. Unsurprisingly, Ni bioaccumulation indices are greater for high-Ni insects compared to other insect species that feed on Ni hyperaccumulator plants. There is some evidence of Ni mobilization into food webs by insect visitors to flowers of Ni hyperaccumulator plants, but no high-Ni insect floral visitors have been reported. [source] Presence of pores and vacuoles in set endodontic sealersINTERNATIONAL ENDODONTIC JOURNAL, Issue 10 2005L. Mutal Abstract Aim, To assess qualitatively the presence of pores and vacuoles in the structure of various endodontic sealers when set. Methodology, Eight specimens were prepared in keeping with Instituto Argentino de Racionalización de Materiales (IRAM) and ISO regulations for each of the 10 sealers assessed. Four specimens per sealer were examined to identify the presence of structural defects, termed pores, on the external surface. The remaining four specimens were used to examine the presence of defects on the surface exposed by cross-sectional fracture; these were termed vacuoles. The largest and smallest diameters of the pores and vacuoles were measured by scanning electron microscope on both surfaces. The structural defects were classified according to their frequency as abundant, frequent, scarce or exceptional. Results, Pores and vacuoles were consistently found in every specimen of each sealer. However, their frequency and dimensions were greater in zinc-eugenol-based sealers than in epoxy-resins and glass,ionomer sealers; they increased if the sealer contained calcium hydroxide. The diameter of the pores ranged from 5 to 320 ,m and the diameter of the vacuoles ranged from 80 to 500 ,m. The diameter of the vacuoles always exceeded that of the pores. Conclusions, Pores and vacuoles were a consistent finding in set sealers. Their frequency and size depended on the density of the sealer and increased when the sealers contained calcium hydroxide. [source] Meshfree point collocation method for elasticity and crack problemsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 1 2004Sang-Ho Lee Abstract A generalized diffuse derivative approximation is combined with a point collocation scheme for solid mechanics problems. The derivatives are obtained from a local approximation so their evaluation is computationally very efficient. This meshfree point collocation method has other advantages: it does not require special treatment for essential boundary condition nor the time-consuming integration of a weak form. Neither the connectivity of the mesh nor differentiability of the weight function is necessary. The accuracy of the solutions is exceptional and generally exceeds that of element-free Galerkin method with linear basis. The performance and robustness are demonstrated by several numerical examples, including crack problems. Copyright © 2004 John Wiley & Sons, Ltd. [source] The Ciempozuelos Necropolis skull: a case of double trepanation?INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 4 2003C. Liesau von Lettow-Vorbeck Abstract The focus of this study is the analysis of a trepanation performed on the skull of an adult male from the famous Bell Beaker necropolis of Ciempozuelos (Madrid) excavated at the end of the 19th century. The unusual characteristics of the pottery and other associated grave goods gave rise to the use of the name ,Ciempozuelos' to define the regional Bell Beaker style; this refers to similar finds from other sites on the Meseta of central Spain. Although trepanations from Chalcolithic contexts in the Iberian peninsula are not infrequent, they are unusual in Bell Beaker inhumations. Furthermore, this skull is exceptional not only for the type of trepanation performed, but also for the subsequent cranial deformation apparently resulting from the operation, as well as evidence of a second subsequent trepanation which indicates a very short post-surgical survival period for the individual. Copyright © 2003 John Wiley & Sons, Ltd. [source] Security, Law, Borders: Spaces of ExclusionINTERNATIONAL POLITICAL SOCIOLOGY, Issue 4 2008Tugba Basaran Politics of borders and the distinction between inside/outside have become an important security practice of liberal states. Borders are strategically used to change the balance between security and liberties. This article analyzes the legal constitution of border zones and argues that security is not exceptional in its constitution but results from ordinary law and practices. Illiberal practices at border zones are embedded in ordinary politics of the liberal state. [source] Authoritarianism and Islamic Movements in the Middle East: Research and Theory-building in the Twenty-first CenturyINTERNATIONAL STUDIES REVIEW, Issue 1 2009Oded Haklai In the previous decade, many scholars with expertise in the politics of the Middle East pointed to an intellectual gulf between Middle East studies and mainstream international and comparative political studies. Common perceptions that the Middle East experience was too exceptional to be theory-relevant and that area studies work was excessively a-theoretical were said to be responsible for the alleged chasm. If these concerns are taken at face value, a review of research published on authoritarianism and Islamic movements in the first years of the twenty-first century in top academic presses and scholarly journals indicates that a counter trend has emerged. Middle East area experts are increasingly making use of theoretical frameworks produced by non-Middle East specialists. There is, however, variation in how well disciplinary social science analytical tools are applied and in the significance of various works to theory-building. More emphasis on theory-testing and construction (rather than just theory application) as well as cross-regional and cross-cultural comparisons will increase the comparative value of works produced by Middle East area studies specialists and will add to their visibility in the discipline at large. [source] Paul Everett Meehl: The cumulative recordJOURNAL OF CLINICAL PSYCHOLOGY, Issue 10 2005Niels G. Waller In this brief biographical sketch of Paul Meehl, the authors examine the "cumulative record" of his scholarship and mentorship. This record sheds light on why Meehl is widely regarded as one of the most influential clinical psychologists of the 20th century, as well as on Meehl's remarkable intellectual life. Time has proven that Meehl's writings are exceptional in their quality, influence, breadth, and depth. In addition, Meehl's cumulative record raises important questions regarding the reinforcement contingencies in major research-oriented psychology departments. © 2005 Wiley Periodicals, Inc. J Clin Psychol 61: 1209,1229, 2005. [source] Intra-arterial angiolymphoid hyperplasia with eosinophiliaJOURNAL OF CUTANEOUS PATHOLOGY, Issue 5 2008Wafa Koubaa Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare skin disorder of unknown etiology. This paper describes the case of a 34-year-old man with a lesion located on the right part of his forehead. Microscopically, it displayed a typical morphology of ALHE. However, it was exceptional by its intra-arterial location and its prominent lymphocytic rim-like component. Differential diagnoses, with special emphasis to organized thrombosis and juvenile arteritis, are discussed here. [source] Squamous cell apocrine hidradenomaJOURNAL OF CUTANEOUS PATHOLOGY, Issue 10 2007Jorge Angulo Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation. The neoplasm is composed of four different types of epithelial cells, including pale or clear cells, polygonal cells, mucinous cells and squamous cells, with variable proportions of them from case to case. In most examples of this neoplasm, clear or the polygonal cells are predominant, whereas the other types of neoplastic cells are less abundant. We report two cases of apocrine hidradenoma mostly composed of squamous cells. Histopathologic examination showed that the neoplasms were composed of both solid and cystic areas. The solid aggregations of neoplastic cells were composed of a peripheral layer of basaloid polygonal cells, whereas squamous cells forming the bulk of the aggregations. These squamous cells showed large eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli. In one case, small foci of mucinous cells could also be seen in some aggregations of neoplastic cells, mostly around ductal structures. In both the cases, some of the tubular structures lined by epithelial cells showed evidence of decapitation secretion in their luminal border. The neoplastic stroma consisted of sclerotic collagen bundles when compared with adjacent normal dermis, and artefactual clefts separated the neoplasms from the surrounding tissue. The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms. [source] Defective human T-cell leukaemia virus type 1 (HTLV-1) genomes: No evidence in serologically indeterminate german blood donors but new type detected in established cell linesJOURNAL OF MEDICAL VIROLOGY, Issue 1 2002V.A. Morozov Abstract Individuals reactive in antibody screening tests (ELISA) and with one or more reactions to HTLV-1 proteins on Western blotting, but lacking the criteria of a confirmed HTLV infection, are not exceptional in regions with a low prevalence of HTLV-1/-2 infections. PCR analysis of these indeterminate samples, using "diagnostic" pol and tax sets of primers, give negative results. However, expression of HTLV-1 defective proviruses with internal deletions undetectable by PCR with diagnostic primers could have taken place. Seven German HTLV-1 ELISA-reactive blood donors, who showed reactivity also in Western blots against several viral proteins, and twenty haemophiliacs, were examined by nested PCR and/or PCR/Southern hybridisation with primers designed for detection of HTLV-1 defective proviruses. No HTLV-1-specific amplification products were obtained. However, HTLV-1 defective proviruses with large internal deletions were detected in four out of five cell lines established from symptomatic HTLV-1 cases and two in HUT-102 cells. In two amplicons, short inverted rRNA sequences between gag and env fragments of HTLV-1 defective proviruses were revealed. These results do not exclude the presence of defective HTLV-1 proviruses in individuals with indeterminate serology although this is unlikely. J. Med. Virol. 66:102,106, 2002. © 2002 Wiley-Liss, Inc. [source] Central Pontine Signal Changes in Wilson's Disease: Distinct MRI Morphology and Sequential Changes with De-Coppering TherapyJOURNAL OF NEUROIMAGING, Issue 4 2007Sanjib Sinha DM ABSTRACT BACKGROUND AND PURPOSE Reports of central pontine myelinolysis (CPM)-like changes in Wilson's disease (WD) and its sequential changes are exceptional. The aim was to study the MRI characteristics of CPM-like changes in WD and the serial changes. METHODS Among the 121 patients of WD, twenty (M:F:9:11, age at onset: 14.2 ± 4.6 years) had features similar to CPM. All had progressive neuropsychiatric form of WD. All except five were on de-coppering treatment. None had acute deterioration or hepatic failure. Ten patients underwent repeat studies. RESULTS Twenty patients with CPM-like changes manifested with characteristic phenotype of WD. Three distinct patterns of CPM-like changes were observed: (a) characteristic round shape -7, (b) "bisected" -9, and (c) "trisected" -4. Only one had signal changes suggesting extra-pontine myelinolysis. All patients had contiguous involvement of midbrain. Serial MRI evaluation in 10 patients, at mean interval period of 17.4 ± 13.2 months, revealed complete reversal in one, partial improvement in five, and no change in three. Clinical and MRI improvement occurred pari passu, except in one. CONCLUSIONS CPM-like changes in WD are perhaps under-recognized and are distinct from the commonly known "osmotic demyelination." It is potentially reversible similar to other MRI features of WD. [source] Mosaicism in men in hemophilia: is it exceptional?JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 2 2009Impact on genetic counselling [source] An agency analysis of church,pastor relationsMANAGERIAL AND DECISION ECONOMICS, Issue 6 2001Charles Zech Incentives are critical to the study of economics. But do they work in non-traditional economic settings, such as religious organizations, in a manner consistent with economic theory? This study considers the agency relationship between churches and their clergy. This paper contends that pastor compensation is not typically tied directly to performance, but rather indirectly through promotion tournaments. Pastors whose performance is recognized as being exceptional are rewarded by being called to larger, more prestigious congregations. Given the difficulty of observing and measuring pastor performance this represents a sensible solution to the church,pastor principal,agent problem. Copyright © 2001 John Wiley & Sons, Ltd. [source] Geophysical survey of the proposed Tsenkher impact structure, Gobi Altai, MongoliaMETEORITICS & PLANETARY SCIENCE, Issue 3 2010Jens ORMÖ Extensive occurrences of brecciated rocks, mainly in the form of an ejecta blanket outside the elevated rim of the structure, support an explosive origin (e.g., cosmic impact, explosive volcanism). The host rocks in the area are mainly weakly magnetic, silica-rich sandstones, and siltstones. A near absence of surface exposures of volcanic rocks makes any major volcanic structures (e.g., caldera) unlikely. Likewise, the magnetic models exclude any large, subsurface, intrusive body. This is supported by an 8 mGal gravity low over the structure indicating a subsurface low density body. Instead, the best fit is achieved for a bowl-shaped structure with a slight central rise as expected for an impact crater of this size in mainly sedimentary target. The structure can be either root-less (i.e., impact crater) or rooted with a narrow feeder dyke with relatively higher magnetic susceptibility and density (i.e., volcanic maar crater). The geophysical signature, the solitary appearance, the predominantly sedimentary setting, and the comparably large size of the Tsenkher structure favor the impact crater alternative. However, until mineralogical/geochemical evidence for an impact is presented, the maar alternative remains plausible although exceptional as it would make the Tsenkher structure one of the largest in the world in an unusual setting for maar craters. [source] Genetic monogamy despite social promiscuity in the pot-bellied seahorse (Hippocampus abdominalis)MOLECULAR ECOLOGY, Issue 11 2007A. B. WILSON Abstract Sexual selection theory predicts a positive correlation between relative parental investment and mate choice. In syngnathid fishes (seahorses and pipefish), males brood offspring in specialized brooding structures. While female-female mating competition has been demonstrated in some pipefishes, all seahorses (genus Hippocampus) studied to date have been found to have conventional sex roles with greater male,male competition for access to mates despite possessing the most complex brood structures in the family. Although multiple mating is common in pipefish, seahorses are again exceptional, exhibiting strict genetic monogamy. Both demographic and behavioural explanations have been offered to explain the lack of multiple mating in seahorse species, but these hypotheses have not yet been explicitly addressed. We investigated mating systems and brood parentage of the pot-bellied seahorse, Hippocampus abdominalis, a temperate-water species that is socially promiscuous with conventional sex roles in laboratory populations. We observed promiscuous courtship behaviour and sex-role reversal in high density, female-biased field populations of H. abdominalis. We hypothesize that sex roles are plastic in H. abdominalis, depending on local population density and sex ratio. Despite promiscuous courtship behaviour, all assayed male seahorses were genetically monogamous in both laboratory and wild populations. Physiological limitations associated with embryo incubation may explain the absence of multiple mating in seahorses and may have played an important role in the development of the unique reproductive behaviour typical in these species. [source] Characterization of nuclear DNA microsatellite markers in the ant Cataglyphis cursorMOLECULAR ECOLOGY RESOURCES, Issue 4 2004M. PEARCY Abstract The ant Cataglyphis cursor is exceptional in that unmated workers are potentially able to lay both male and female eggs. We characterized eight pairs of primers for microsatellite loci, developed from genomic DNA for this species. Variability was tested with DNA from 19 workers and all eight loci were highly polymorphic, displaying 5,10 alleles and a high level of heterozygosity. Cross-species amplifications indicate that these microsatellites might be useful in genetic studies of other species belonging to the genus Cataglyphis. [source] Onychomycosis is no longer a rare finding in childrenMYCOSES, Issue 1 2006M. Lange Summary Onychomycosis was considered uncommon in children. This survey was carried out to estimate the frequency of fungal nail infections in children and adolescents (0,18 years of age) attending our clinic in the last decade and gain more insight into the aetiology and clinics of this entity in the paediatric age group. This study is based on data obtained from 2320 children and adolescents suspected of superficial fungal infection. Onychomycosis was diagnosed in 99 cases, representing 19.8% of all mycologically confirmed superficial mycoses (500 cases) in our material. Fingernail onychomycosis was recognized in 52 (10.4%) cases; children under 3 years of age were predominantly involved. Candida albicans was the most common isolated pathogen. Toenail onychomycosis concerned 47 (9,4%) patients; the incidence increased steadily with increasing age. Trichophyton rubrum was the most common aetiological agent with respect to toenail infection followed by T. mentagrophytesvar. interdigitale and T. mentagrophytes var. granulosum. The majority of fungal nail infections were characterized clinically by distal and lateral subungual onychomycosis. The growing trend towards the frequency of toenail and fingernail onychomycosis in children and adolescents was found in the last decade in north Poland. The results of our study show that onychomycosis in prepubertal children is not exceptional and should be considered in differential diagnosis of nail plate disorders. [source] | ||||||||||||||||||||||||||||||||||||||||||||||