Evolving Understanding (evolving + understanding)

Distribution by Scientific Domains

Selected Abstracts

Our evolving understanding of 22q.11 deletion syndrome

Fiona Connell
No abstract is available for this article. [source]

Role of Bcl-2 family of proteins in malignancy

Belinda C. Baliga
Abstract B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival and proapoptotic proteins. Bcl-2 itself is a prosurvival member of the family and its aberrant expression has been linked to a variety of different cancers, including several hematological malignancies. Although the exact mechanism of action of Bcl-2 family of proteins in regulating apoptosis is still a matter of some debate, these proteins appear to act upstream of caspase activation. Many recent studies have shown the therapeutic potential of targeting Bcl-2 family members for the treatment of cancer. This article summarizes what is currently known about Bcl-2-like proteins and how the evolving understanding of the biology of these proteins is paving way for the development of novel cancer therapeutics. Copyright 2001 John Wiley & Sons, Ltd. [source]

Introduction: Researching Democracy and Social Change with Violence in the Foreground

IDS BULLETIN, Issue 3 2009
Jenny Pearce
There are many studies of violence within specific fields of the social sciences, but the next stage in our evolving understanding of violence may lie with interdisciplinary approaches. By traversing traditional academic categories, violence as a variable may become more visible in its multiple modes. It is through our ability to see the linkages between interpersonal, cultural, collective, political, state, interstate and structural violences that we can gain a better understanding of its persistence in human interactions. Researchers for this IDS Bulletin set out not only to understand contemporary dynamics of violence, but also to work with people trapped in violent places, spaces and histories who were willing to talk about and act upon their situation. Researching violence in an interactive way with those living in the thick of it posed many ethical, safety, epistemological and methodological challenges. These are documented in this IDS Bulletin alongside findings on the dimensions and impact of violence in different contexts. [source]

Capacity and capacity development: Coping with complexity

Derick W. Brinkerhoff
This overview article introduces the topic of capacity and capacity development (CD), noting the vagueness and multiplicity of definitions and approaches. It presents the model of capacity developed by the European Centre for Development Policy Management (ECDPM) study, and reviews our evolving understanding of CD. Brief summaries of the contributions to the symposium highlight the main findings and key points. The contents of the symposium include four country cases,Pakistan, Tanzania, Brazil, and Papua New Guinea (PNG),and one conceptual piece on CD in fragile states. Several common themes emerge: the benefits of viewing capacity and CD through systems lenses, the salience of the politics of CD; and the need to change how donors and capacity builders approach the practice of CD. Copyright 2010 John Wiley & Sons, Ltd. [source]

How Can Research Organizations More Effectively Transfer Research Knowledge to Decision Makers?

Applied research organizations invest a great deal of time, and research funders invest a great deal of money generating and (one hopes) transferring research knowledge that could inform decisions about health and health care. Basing these knowledge-transfer activities on our evolving understanding of the most effective approaches to knowledge transfer will help us achieve value for money in our individual and collective investments in health services and health policy research. Research organizations and research funders can probably be excused for not basing their activities on research evidence until now, however, because the variety of relevant questions, target audiences, and disciplinary perspectives and methodological approaches used in empirical studies has made the identification of take-home messages from this field of research a very difficult task. We provide an organizing framework for a knowledge-transfer strategy and an overview of our understanding of the current knowledge for each of the five elements of the framework. The framework provides an overall approach to knowledge transfer that can be evaluated as a whole over long periods of time, as well as specific elements that can be evaluated and fine-tuned over shorter periods of time. [source]

The WikiID: An Alternative Approach to the Body of Knowledge

Hannah Rose Mendoza M.F.A.
ABSTRACT A discussion of the locus of design knowledge is currently underway as well as a search for clear boundaries defined by a formal Body of Knowledge (BoK). Most attempts to define a BoK involve the creation of "jurisdictional boundaries of knowledge" that "allow those who possess this knowledge to claim authority over its application" (Guerin & Thompson, 2004, p. 1). This claim is attractive but such control may no longer be an option in the Internet Age, when even the call for the discussion of the BoK definition process is on the Web. Marshall-Baker (2005) argued that "the moment knowledge is bordered it is no longer knowledge" (p. xiv). Whereas data and information are easily captured and generalized, knowledge is specific to users and their evolving understandings, implying purposeful application over time. This paper explores knowledge as process transcending boundaries and seeks to answer not "where" the locus lies but rather "what" that locus could be. Using a feminist framework, I argue that in conjunction with the work done thus far we should move toward the creation of an inclusive model for the BoK. In such a model, the value of the profession is felt as a result of inclusion in and interaction with the knowledge creation process. I propose that the BoK should not be a printed document, but a Web-based organizational system that supports change and innovation. Wikipedia provides this type of inclusive, mutable system, and the same framework could be applied to the creation of a systemic BoK. I call this creation the WikiID. [source]