Home About us Contact
|
Home About us Contact | ||
|
|
||
Ethnic Background (ethnic + background)
Kinds of Ethnic Background Selected AbstractsThe Shaping of San Livelihood Strategies: Government Policy and Popular ValuesDEVELOPMENT AND CHANGE, Issue 3 2002Michael Taylor The importance of understanding the livelihood strategies of poor people has received a fresh impetus over the last few years with the emphasis by many Western donors on poverty reduction. This article examines the livelihood strategies of San people in three villages on the northern peripheries of the Okavango Delta in Botswana. Their economic marginalization is compounded by their ethnic background; a stigma that also marginalizes them politically and socially. The analysis presented here not only challenges stereotypes commonly associated with San by demonstrating the interconnectedness of different means of ,looking for life', but it also brings to the fore the importance of considering institutional factors that regulate livelihood strategies. The article focuses on some of the unexpected consequences of the wider policy environment, and on how the values associated with different ways of life affect material subsistence strategies. These are particularly pronounced for people with a heritage of hunting and gathering living in a society that regards such practices as ,backward'. [source] Impaired glucose regulation and type 2 diabetes in children and adolescentsDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 6 2008Kerstin Kempf Abstract Diabetes mellitus in paediatric patients used to be almost exclusively type 1, but in recent years, case series as well as hospital-based and population-based studies indicated that the number of children and adolescents with type 2 diabetes (T2DM) has been increasing. This development is alarming since T2DM in youth is usually not an isolated condition, but accompanied by other cardiovascular risk factors such as obesity, dyslipidaemia, hypertension and low-grade inflammation. In adults, numerous studies provided detailed data on prevalence, incidence and risk factors for the development of T2DM, but for children and adolescents clinical and experimental data are still rather limited. This review provides an overview about the epidemiology and pathogenesis of T2DM in youth and about impaired glucose regulation as major risk factor for diabetes development with a special focus on the recent literature on clinical and lifestyle-related risk factors. Differences in incidence and prevalence across different populations indicate that ethnic background and genetic pre-disposition may be important risk determinants. In addition, epigenetic factors and foetal programming appear to confer additional risk before birth. Among the environmental and lifestyle-related risk factors there is evidence that obesity, hypercaloric diet, physical inactivity, socio-economic position (SEP), smoking, low-grade inflammation, psychosocial stress and sleeping patterns contribute to the risk for T2DM. However, the assessment of the relevance of risk factors and of incidence or prevalence estimates in youth is complicated by methodological issues that are also discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source] First-trimester fetal heart rate in mothers with opioid addictionADDICTION, Issue 7 2010Maximilian Schmid ABSTRACT Aim To investigate the difference in fetal heart rate of opioid-dependent mothers compared to non-dependent mothers in the first trimester of pregnancy. Design The data of 74 consecutive singleton pregnancies of mothers enrolled in a maintenance programme for opioid-dependent women was matched to 74 non-exposed singleton pregnancies by maternal age, crown,rump length, smoking status, ethnic background and mode of conception. Measurement Fetal heart rate measured as part of first-trimester screening by Doppler ultrasound between 11+0 and 13+6 gestational weeks was compared retrospectively. Findings The mean fetal heart rate in opioid-dependent mothers was 156.0 beats per minute (standard deviation 7.3) compared to 159.6 (6.5) in controls. The difference in fetal heart rate was significant (P = 0.02). There was a significant difference in mean maternal body mass index (P = 0.01) but not in mean nuchal translucency (P = 0.3), gestational age (0.5), fetal gender (P = 0.3) and parity (P = 0.3) between both groups. Fifty-five per cent (41 of 74) of cases were taking methadone, 30% (22 of 74) buprenorphine and 15% (11 of 74) were taking slow-release morphines throughout the pregnancy. Conclusions In fetuses of opioid-dependent mothers a decreased fetal heart rate can already be observed between 11+0 and 13+6 gestational weeks. The effect of opioid intake needs to be taken into consideration when interpreting fetal heart rate in opioid-dependent mothers at first-trimester screening. [source] A health inequalities perspective on violence against womenHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 2 2007Cathy Humphreys PhD BSocWk Abstract The present paper argues that the physical and mental health consequences of gender-based violence constitute a major public health problem in the UK and a source of significant health inequality. The concept of violence against women is explored alongside brief examples of the mental and physical health impact of this violence. While the impact on women's health is relatively uncontested, the extent to which social divisions such as poverty, class and minority ethnic status create specific vulnerabilities to violence are more controversial. A widely held view within the movement to support survivors within the UK has been that violence against women cuts across class and ethnicity, and is found in all communities and classes. A more nuanced discussion of the way in which poverty and ethnic background may create particular vulnerabilities is explored. Disentangling cause and consequence, and also the barriers to help-seeking for minority ethnic women are discussed. The role of social workers in addressing the way in which violence against women is both ubiquitous but marginal in their caseloads is discussed, and appropriate interventions to respond to health inequality issues are proposed. [source] Academics on Non-Standard Contracts in UK Universities: Portfolio Work, Choice and CompulsionHIGHER EDUCATION QUARTERLY, Issue 4 2007Donna Brown This paper analyses the profile and motivation of over 1,300 academics employed on part-time, fixed term or temporary contracts at 10 post-1992 UK universities, whom it categorises as ,non-standard academics'. Based on a questionnaire survey, it investigates their demographic background, including age, gender and ethnic background, as well as the factors behind acceptance of their current employment status. It reveals that six out of ten chose their status and correspond in some ways to the profile of ,portfolio worker' (high level of qualifications, multiple job holding and sense of independence). This tends to correct the perception of them as mainly ,casual'. However, commitment to their current employment status is less clear, with over one-third stating that they would accept a permanent job on their current hours. There are, therefore, signs of adaptation to certain forms of non-standard status (hours) but not to others (impermanence). Such uncertainty illustrates the hazy boundaries between casual and portfolio status. [source] Debt as a source of financial stress in Australian householdsINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 1 2006Andrew C. Worthington Abstract This paper examines the role of demographic, socio-economic and debt portfolio characteristics as contributors to financial stress in Australian households. The data are drawn from the most recent Household Expenditure Survey and relate to 3268 probability-weighted households. Financial stress is defined, among other things, in terms of financial reasons for being unable to have a holiday, to have meals with family and friends, to engage in hobbies and other leisure activities, and general money management. Characteristics examined include family structure and composition, source and level of household income, age, gender and marital status, ethnic background, housing value, debt repayment of various types and credit card usage. Binary logit models are used to identify the source and magnitude of factors associated with financial stress. The evidence provided suggests that financial stress is higher in families with more children and those from ethnic minorities, especially when reliant on government pensions and benefits, and lower in families with higher disposable incomes and housing values. There is weak evidence that Australia's historically high levels of household debt cause financial stress. [source] Studies of light scattering from ethnic hair fibersINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 4 2004K. Keis One of the most desirable hair attributes to consumers, irrespective of ethnic background, is hair shine. The light reflected from a fiber has two components, specular and diffuse. The specular fraction of reflected light from the front surface of the fiber is generally recognized as a contributor to high luster. The distinction between specular and diffuse reflection is, however, not always clearly defined. In this study an attempt has been made to differentiate between specular and diffuse reflectance by analyzing mathematically goniophotometric curves of light reflected from unaltered single hair fibers from European, African, and Asian ethnic groups. The effect of macroscopic characteristics of the hair fibers, such as fiber diameter, cross-sectional shape, and curvature on luster is demonstrated. Results indicate that broadening of the specular peak reduces luster values, and is related to these characteristics. Thus, specular peak broadening is one of the important features to take into account when evaluating luster. Therefore, a new method for luster evaluation from goniophotometric curves is proposed. Additionally, we present the general model for light scattering, showing how scattering by surface roughness of different origin and magnitudes, and the scattering and absorption processes by the hair's interior, affect the position of the specular reflectance peak and its broadening. [source] Retaining the mental health nursing workforce: Early indicators of retention and attritionINTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING, Issue 4 2005Sarah Robinson ABSTRACT:, In the UK, strategies to improve retention of the mental health workforce feature prominently in health policy. This paper reports on a longitudinal national study into the careers of mental health nurses in the UK. The findings reveal little attrition during the first 6 months after qualification. Investigation of career experiences showed that the main sources of job satisfaction were caregiving opportunities and supportive working relationships. The main sources of dissatisfaction were pay in relation to responsibility, paperwork, continuing education opportunities, and career guidance. Participants were asked whether they predicted being in nursing in the future. Gender and ethnicity were related to likelihood to remain in nursing in 5 years time. Age, having children, educational background, ethnic background, and time in first job were associated with likelihood of remaining in nursing at 10 years. Associations between elements of job satisfaction (quality of clinical supervision, ratio of qualified to unqualified staff, support from immediate line manager, and paperwork) and anticipated retention are complex and there are likely to be interaction effects because of the complexity of the issues. Sustaining positive experiences, remedying sources of dissatisfaction, and supporting diplomates from all backgrounds should be central to the development of retention strategies. [source] Psychometric properties of an interviewer-administered version of the Kessler Psychological Distress scale (K10) among Dutch, Moroccan and Turkish respondentsINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 3 2009T. Fassaert Abstract The Kessler Psychological Distress scale (K10) is an instrument that is widely used to screen for mental disorders, but information is lacking on its psychometric qualities in non-Western samples. This study used a population-based sample (N = 725) to assess the reliability and validity of the K10 across ethnic groups in an urban area. The results were generally supportive of the K10 as a reliable and valid instrument to screen for anxiety and depression in all three groups. Cronbach's alpha was high (0.93) and the results indicated the existence of a solid single factor structure. Item bias in relation to ethnic background was minor. In each group, there was good criterion validity with respect to one-month DSM-IV diagnosis for depressive and/or anxiety disorder. The results nevertheless highlight the importance of cross-cultural validation, as we found different cut-off values for ethnic subgroups to obtain optimal sensitivity and specificity for detecting depressive and/or anxiety disorders. Copyright © 2009 John Wiley & Sons, Ltd. [source] Oral health status in relation to ethnicity of children in the Municipality of Copenhagen, DenmarkINTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 3 2003A. Sundby Summary. Approximately 25% of children under the age of 18 in the Municipality of Copenhagen have a non-Danish ethnic background, and it is suspected that there may be major inequalities in oral health as a result. Objectives. The objectives of this study were to describe the occurrence of dental caries in different ethnic minorities, and to analyse whether the dental caries experience of the children may be affected by cultural and behavioural differences. Materials and methods. The study was conducted in Copenhagen as a cross-sectional investigation of 794 children, aged 3 and 5 years old (preschool), 7 years old (Grade 1) and 15 years old (Grade 9). Children of Danish, Turkish, Pakistani, Albanian, Somali and Arabian backgrounds were selected by convenience sampling. Epidemiological data were retrieved from the Danish Recording System for the Public Dental Health Services (SCOR) and sociological data were collected by postal questionnaires. Results. Marked differences in dental caries prevalence were observed when different ethnic minorities were compared to Danish children. These were most prominent for the primary dentition. At age 7, 53% of the Danish and 84% of the Albanian children were affected by dental caries, the mean caries experience was 3·5 dmfs (decayed, missed and filled surfaces) and 13·8 dmfs, respectively. Caries in incisors and/or smooth surfaces was observed in 10% of the Danish children and 48% of the Albanian children. There were cultural differences in dental attendance and self-care practices of children and parents. These socio-behavioural factors may help to explain the differences in dental caries prevalence and severity. Conclusions. Development of appropriate oral health promotion strategies is urgently needed to improve oral health behaviour and attitudes of parents and children of ethnic minorities. Preventive programs should be organized at local community level in close collaboration with key persons of ethnic minority societies. [source] Gender and Ethnic Differences in Marital Assimilation in the Early Twentieth Century,INTERNATIONAL MIGRATION REVIEW, Issue 3 2005Sharon Sassler Historical research on intermarriage has overlooked how distinctive patterns of ethnic settlement shape partner choice and assumed that the mate selection process operated the same way for men and women. This study utilizes a sample of youn married adults drawn from the 1910 Census IPUMS to examine 1) whether ethnic variation in partner choice was shaped by differences in group concentration and distribution and 2) if factors shaping outmarriage were gendered. About one fifth of young married Americans had spouses of a different ethnic background in 1910, though there was considerable ethnic variation in outmarriage propensities. Barriers to intermarriage fell at different rates, depending upon ethnic grou, sex, and region of settlement; they were weakest for first-and seconl eneration English men. Structural factors such as group size operatef differently for men and women; while larger group representation increased men's odds of outmarriage to both native stock and other white ethnic wives, women from the ethnic groups with the largest presence were significantly more likely to wed fellow ethnics than the native stock. Ultimately, even if they resided in the same location, the marriage market operated in different ways for ethnic women and men in search of mates. [source] Racist Events and Ethnic Identity in Low Income, African AmericansJOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 6 2006Alissa Sherry This study was designed to determine the relation between racist events and ethnic identity in a group of 100 low-income African Americans. Findings indicated that the more racist events one experienced, the more ethnic behaviors they endorsed and the more they had explored the meaning of their ethnic background. In addition, racist events were also indicative of feeling less close to individuals of other ethnic groups. Results suggest that experiencing racist events may contribute to an increased identification with one's own ethnic background and less affiliation with those of other ethnic backgrounds, with the cumulative effect of racist events over one's lifetime contributing the most to this finding. [source] A Study on Singaporeans' Perceptions of Sexual Harassment From a Cross-Cultural Perspective,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 4 2005Shu Li This paper addresses the question of whether culture and language in Singapore affect the interpretation of sexual harassment; that is, whether speakers from a different language and ethnic background will interpret the discourse domain of sexual harassment differently. Three studies constitute this research. The first study investigates whether certain cues relating to sexual harassment are judged equivalently across the ethnic groups. The second study examines how verbal space is conceptualized and ruled by the use of different languages used by different ethnic groups. The third study explores whether English, as a medium of communication, is a low-context language. Results show that different ethnic groups perceived the cues differently; that ethnicity affects the interpretation of a single English phrase; and that English as used by Singaporeans is a high-context language, which complicates the understanding of victims' coping responses. [source] Relationships among perceptions of parent involvement, time allocation, and demographic characteristics: Implication for policy formationJOURNAL OF COMMUNITY PSYCHOLOGY, Issue 5 2002Shulamit N. Ritblatt Variables that facilitate or hinder parent involvement (PI) in education and schools were explored, along with the amounts of time parents spent in various activities. A total of 506 participants from San Diego and Imperial Counties completed the first part of the study (1) designed to assess parents' beliefs about involvement with their child's school and education. Of these same participants, 357 self-selected parents also chose to complete a second part of the study (2) that assessed the amount of time parents spend in education-related activities. Factor analysis of the 506 participant responses revealed four school perception factors related to parent attitudes: (a) communication, (b) familiarity, (c) sensitivity, and (d) support. Factor analysis of the 357 participant responses to the time factors also revealed four involvement areas: (a) general school issues, (b) specific school issues, (c) extracurricular school activities, and (d) specific help. Significant relationships were found among three of the attitudinal factors (sensitivity, familiarity, and support) and various time factors, including total involvement time, general issues, specific problems, and extracurricular issues. Further, significant differences among means were found for both the school perception factors and the time factors based on ethnic background, income, and marital status. Recommendations for increasing parent involvement and formulating public policy are discussed. © 2002 Wiley Periodicals, Inc. [source] Y haplogroups and aggressive behavior in a Pakistani ethnic groupAGGRESSIVE BEHAVIOR, Issue 1 2009S. Shoaib Shah Abstract Studies show that personality dimensions such as aggression are influenced by genetic factors and that allelic variants located on the Y chromosome influence such behavior. We investigated polymorphisms on the male-specific region of the human Y chromosome in 156 unrelated males from the same ethnic background, who were administered the Punjabi translation of the Buss and Perry Aggression Questionnaire that measures four aspects that constitute aggressive behavior, i.e. physical aggression, verbal aggression, anger, and hostility. A value of .85 for Cronbach's coefficient , indicates considerable internal consistency and suggests that the psychometric properties of the aggression questionnaire can be adapted for the Pakistani population. A mean score±SD of 69.70±19.95 was obtained for the questionnaire. Each individual was genotyped following a phylogenetic hierarchical approach to define evolutionary Y haplogroups. Five Y haplogroups that are commonly found in Eurasia and Pakistan comprised 87% (n=136) of the population sample, with one haplogroup, R1a1, constituting 55% of the sampled population. A comparison of the total and four subscale mean scores across the five common Y haplogroups that were present at a frequency ,3% in this ethnic group revealed no overall significant differences. However, effect-size comparisons allowed us to detect an association of the haplogroups R2 (Cohen's d statistic=.448,.732) and R1a1 (d=.107,.448) with lower self-reported aggression mean scores in this population. Aggr. Behav. 35:68,74, 2009. © 2008 Wiley-Liss, Inc. [source] Removal of amateur blue-black tattoos in Arabic women of skin type (III,IV) with Q-switched alexandrite laserJOURNAL OF COSMETIC DERMATOLOGY, Issue 2 2005Iqbal A Bukhari Summary Background and Objectives, Tattoos in Arabic society used to have a cosmetic importance on the face of females. These were usually amateur tattoos done by non-professional women in the tribe. Because Islam as a religion prohibited its practice and its application, people became concerned about removing the old tattoos by any means. Nowadays, laser is considered an effective method of tattoo removal. Here, we report our experience in the removal of tattoos in Arabic women of skin type III,IV using the Q-switched alexandrite laser. Study Design/Materials and Methods, Twenty female subjects aged 35,50 years from similar racial and ethnic background with amateur tattoos were treated using the Q-switched alexandrite laser. Fluence threshold was determined and a spot test was made. Q-switched alexandrite laser with a fluence range 4.0,7.5 J/cm2 (mean 6.05) was used at 6,12-week intervals. Total treatment numbers ranged from three to six sessions (mean 4.15) with single-pulse technique application. Results, More than 95% lightening was achieved in five patients after three to six sessions at fluence range of 6,7.5 J/cm2 and > 75% lightening in 10 subjects after three to six sessions of treatment at fluence range of 4,7.5 J/cm2. Pinpoint bleeding was observed in one case but no pigmentary alteration or scarring was seen. Conclusion, Tattoo pigment removal by Q-switched alexandrite laser is an effective method in skin type (III,IV) with minimal side effects, which gives high patient satisfaction. [source] One therapist, four cultures: working with families in Greater ChinaJOURNAL OF FAMILY THERAPY, Issue 3 2002Yung Lee Rather than addressing ethnicity through a pre,set cultural lens, I discuss how my experiences as a family therapy trainer in Singapore, Hong Kong, Taiwan and Shanghai taught me to understand culture through the lens of the family. Similarities and differences among these cultural domains were reviewed. I also demonstrate how each encounter shaped my emotional responses and ways of intervention in the course of family interviews. Even though I belong to the same ethnic background, I had to interact differently in different arenas, despite my cultural values and theoretical orientation. [source] Underestimation and overestimation of personal weight status: associations with socio-demographic characteristics and weight maintenance intentionsJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 4 2006J. Brug Abstract Objective, Unwarranted underestimation and overestimation of personal weight status may prevent weight maintenance behaviour. The present study reports on correlates of under- and overestimation of personal weight status and the association with weight maintenance intentions and self-reported action. Design, Comparison of three cross-sectional surveys, representing different population groups. Subjects, Survey 1: 1694 adolescents 13,19 years of age; survey 2: 979 nonobese adults 25,35 years of age; survey 3: 617 adults 21,62 years of age. Measurements, Self-administered written questionnaires (surveys 1 and 3) and telephone-administered questionnaires (survey 2); self-reported BMI, self-rated weight status, intentions and self-reported actions to avoid weight gain or to lose weight, sex, age, education and ethnic background. Respondents were classified as people who are realistic about personal body weight status or people who under- and overestimate their body weight status, based on BMI and self-rated weight status. Results, Most respondents in the three survey populations were realistic about their weight status. Overestimation of weight status was consistently more likely among women, whereas underestimation was more likely among men, older respondents and respondents from ethnic minorities. Self-rated weight status was a stronger correlate of intentions and self-report actions to avoid weight gain than weight status based on Body Mass Index. Conclusions, Relevant proportions of the study populations underestimated or overestimated their bodyweight status. Overestimation of personal weight status may lead to unwarranted weight maintenance actions, whereas underestimation may result in lack of motivation to avoid further weight gain. [source] Implementing a postcolonial feminist perspective in nursing research related to non-Western populationsNURSING INQUIRY, Issue 2 2003Louise Racine Implementing a postcolonial feminist perspective in nursing research related to non-Western populations In this article, I argue that implementing a postcolonial feminist perspective in nursing research transcends the limitations of modern cultural theories in exploring the health problems of non-Western populations. Providing nursing care in pluralist countries like Canada remains a challenge for nurses. First, nurses must reflect on their ethnic background and stereotypes that may impinge on the understanding of cultural differences. Second, dominant health ideologies that underpin nurses' everyday practice and the structural barriers that may constrain the utilization of public healthcare services by non-Western populations must be further examined. Postcolonial feminism is aimed at addressing health inequities stemming from social discriminative practices. I will draw on extant literature and data of an ongoing ethnography exploring the Haitian caregivers' ways of caring for ageing relatives at home to unveil how the larger social and cultural world has an impact on caregivers' everyday lives. Marginalized locations represent privileged sites from which health problems, intersecting with power, race, gender, and social classes, can be addressed. Postcolonial feminism provides the analytic lens to look at the impact of these factors in shaping health experiences. It also suggests redirecting nursing cultural research and practice to achieve social justice in the healthcare system. [source] Spacing and crowding among African and Caucasian childrenORTHODONTICS & CRANIOFACIAL RESEARCH, Issue 2 2008EA Mugonzibwa Structured Abstract Authors,,, Mugonzibwa EA, Eskeli R, Laine-Alava MT, Kuijpers-Jagtman AM, Katsaros C Objective,,, To determine spacing and crowding according to ethnic group, gender and dental emergence stage among Tanzanian African and Caucasian children. Design,,, Cross-sectional epidemiological clinical study. Setting,,, A total of 869 African (428 boys, 441 girls) and 706 Caucasian (319 boys, 387 girls) school children, aged 3½,16 years. Main Outcome Measures,,, Comparison of spacing and crowding between African and Caucasian children according to gender and dental emergence stage. Results,,, Spacing was more often found in the maxilla, while crowding was more common in the mandible. Only during the transition of the maxillary permanent front teeth was there significantly more spacing in Caucasians. No gender differences were found. In both samples spacing decreased during later emergence stages. Crowding was more often found in Caucasian children than in African children. In Caucasian children the frequency of crowding increased with advanced emergence stages, while for Africans the trend was not consistent. Conclusion,,, When planning resources for orthodontic treatment for different populations as well as planning treatment for individuals, ethnic background and emergence stage of the dentition need to be considered. [source] Agreement between normative and perceived orthodontic need amongst deprived multiethnic school children in LondonORTHODONTICS & CRANIOFACIAL RESEARCH, Issue 2 2001Bilal Ahmed The Index of Orthodontic Treatment Need (IOTN) has been used in dental epidemiology and to prioritize orthodontic treatment. The aim of this paper was to use the aesthetic component (AC) of the IOTN to measure agreement between normative and perceived orthodontic need amongst school children. Three hundred and seventy-eight children aged 11,14 years, enrolled in London UK state schools participated in this survey. The study focused on three ethnic groups: white, black and South Asian. Townsend deprivation scores suggested that the children were from areas of high socio-economic deprivation. Logistic regression analysis was carried out for agreement between normative and perceived need at each threshold value. Perceived need for braces, ethnic background, social class and hours of television viewing were significant variables. Black pupils were significantly less likely to concur on normative and perceived need scores, tending to perceive less need for treatment than did the dentist. Subjects from lower social classes were significantly more likely to concur on normative and perceived need scores. In conclusion, the study showed that using the IOTN AC at various points along the scale, different influences play a significant role in agreement/disagreement between normative and perceived needs, indicating that patient,clinician agreement regards orthodontic treatment is sensitive to several cultural factors. [source] Infection of T lymphocytes in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children of non-Asian originPEDIATRIC BLOOD & CANCER, Issue 2 2009Karin Beutel MD Abstract Background Epstein-Barr virus (EBV) is one of the most frequent triggers of hemophagocytic lymphohistiocytosis (HLH). EBV-associated HLH (EBV-HLH) and ectopic infection of T cells has been particularly described in patients from Far East Asia. Procedure In a cohort of 12 children with EBV-HLH treated in Germany, the EB viral load was detected by real-time polymerase chain reaction in plasma and peripheral blood mononuclear cells (PBMC). Virological and clinical data were analyzed retrospectively. Results Among the 12 mainly German patients, children with underlying immunodeficiencies as well as otherwise healthy individuals were affected. The clinical course ranged from a steroid-responding to a fatal disease despite intensive treatment. Increased EBV copy numbers in plasma and/or PBMC were found in all patients. Serial measurements reflected the course of the disease. Cell-type specific viral load was determined in seven patients and revealed EBV-infection of T cells in all of them. In contrast to the reported Asian patients a significant viral load was also found in B cells. Conclusions T cell infection appears to be a typical feature of EBV-associated HLH irrespective of patients ethnic background and the clinical course. Evaluation of cell-type specific infection should be considered when targeted therapy is applied. Pediatr Blood Cancer 2009;53:184,190. © 2009 Wiley-Liss, Inc. [source] G protein ,3 subunit 825T genotype is not associated with differing outcome in pediatric renal transplant recipientsPEDIATRIC TRANSPLANTATION, Issue 2 2002Berthold Hocher Recent studies have identified a novel polymorphism (C825T) of the gene encoding the ,3 subunit of heterotrimeric G proteins (GNB3), associated with enhanced activation of G proteins, which appears to be more common in hypertensive patients. The donor GNB3 825TT genotype was associated with reduced kidney allograft survival in adults. We examined (in 100 Caucasian pediatric renal transplant recipients) whether the GNB3 (C825T) polymorphism was associated with disease progression and outcome after renal transplantation. The slope of 1/creatinine was determined by linear regression analysis of a median of 12 points before and after renal transplantation, and the population was divided into two groups of equal size, before and after transplantation, according to the slope. The observed frequencies were 57 for the CC, 33 for the CT, and 10 for the TT haplotype. For comparison, 738 consecutive newborn babies with the same ethnic background were typed in the same hospital. Allele frequencies were statistically not significantly different (chi-square test, p =,0.1327). When dividing the pediatric renal transplant recipients into two groups with regard to the slope of 1/creatinine, both before and after renal transplantation, the observed proportions were CC 26, CT 17, and TT 7 in the group with the poorer slope and CC 31, CT 16, and TT 3 in the group with the better slope before renal transplantation (not significant [NS], chi-square test, p =,0.1777). The observed proportions after renal transplantation were CC 26, CT 16, and TT 8 in the group with the poorer slope and CC 31, CT 15, and TT 4 in the group with the better slope, respectively (NS, chi-square test, p =,0.167). Allograft survival was not associated with the T allele. In conclusion, in a sizeable number of pediatric renal transplant recipients the GNB3 C825T polymorphism was found not to be a genetic risk factor for end-stage kidney disease. In addition, kidney graft function and survival was also found not to be associated with a recipient GNB3 C825T polymorphism. [source] Applicant Reactions to Selection Procedures: An Updated Model and Meta-AnalysisPERSONNEL PSYCHOLOGY, Issue 3 2004John P. Hausknecht An updated theoretical model of applicant reactions to selection procedures is proposed and tested using meta-analysis. Results from 86 independent samples (N= 48,750) indicated that applicants who hold positive perceptions about selection are more likely to view the organization favorably and report stronger intentions to accept job offers and recommend the employer to others. Applicant perceptions were positively correlated with actual and perceived performance on selection tools and with self-perceptions. The average correlation between applicant perceptions and gender, age, and ethnic background was near zero. Face validity and perceived predictive validity were strong predictors of many applicant perceptions including procedural justice, distributive justice, attitudes towards tests, and attitudes towards selection. Interviews and work samples were perceived more favorably than cognitive ability tests, which were perceived more favorably than personality inventories, honesty tests, biodata, and graphology. The discussion identifies remaining theoretical and methodological issues as well as directions for future research. [source] Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage populationAMERICAN JOURNAL OF HEMATOLOGY, Issue 4 2002Ramzi R. Finan Abstract Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies disputed such a link. The aim of this study was to determine the prevalence of prothrombin G20210A and factor V G1691A (R506Q, FV-Leiden) mutations in women with recurrent idiopathic abortions and to recommend management for high-risk mutation carriers. One hundred ten women with two or more consecutive unexplained first-trimester miscarriages (mean age ± SD, 32.3 ± 5.3) were compared to 67 parous women with uncomplicated pregnancies (mean age ± SD, 33.9 ±7.3) (P = 0.134) from the same ethnic background. The presence or absence of the prothrombin G20210A and FV-Leiden mutations was assessed by PCR and RFLP analysis, using HindIII and MnlI digestion, respectively. In women with primary habitual abortion, 45 (40.91%) carried the FV-Leiden mutation, of whom 7 were in the homozygote and 38 were in the heterozygote states, and 15 (13.64%) carried the prothrombin G20210A mutation all as heterozygotes, compared to 16.42% and 2.99% carrier rates among controls, respectively, all of whom were heterozygote carriers. Of the other risk factors analyzed, smoking (OR 1.76; 95% CI = 0.79,3.94) was more prevalent in habitual aborters compared to controls. Both FV-Leiden and factor II G20210A mutations are major inherited risk factor associated with primary recurrent miscarriages. Women with a family or personal history of thrombosis should be screened before or early in the pregnancy for FV-Leiden and factor II G20210A mutations. Am. J. Hematol. 71:300,305, 2002. © 2002 Wiley-Liss, Inc. [source] Genetic Admixture in Brazilians Exposed to Infection with Leishmania chagasiANNALS OF HUMAN GENETICS, Issue 3 2009Nicholas A. Ettinger Summary Visceral leishmaniasis (VL) in northeast Brazil is a disease caused by infection with the protozoan Leishmania chagasi. Infection leads to variable clinical outcomes ranging from asymptomatic infection to potentially fatal disease. Prior studies suggest the genetic background of the host contributes to the development of different outcomes after infection, although it is not known if ancestral background itself influences outcomes. VL is endemic in peri-urban areas around the city of Natal in northeast Brazil. The population of northeast Brazil is a mixture of distinct racial and ethnic groups. We hypothesized that some sub-populations may be more susceptible than others to develop different clinical outcomes after L. chagasi infection. Using microsatellite markers, we examined whether admixture of the population as a whole, or markers likely inherited from a distinct ethnic background, differed between individuals with VL, individuals with an asymptomatic infection, or individuals with no infection. There was no apparent significant difference in overall population admixture proportions among the three clinical phenotype groups. However, one marker on Chr. 22 displayed evidence of excess ancestry from putative ancestral populations among different clinical phenotypes, suggesting this region may contain genes determining the course of L. chagasi infection. [source] Association of ankylosing spondylitis with HLA,B*1403 in a West African populationARTHRITIS & RHEUMATISM, Issue 11 2002Carlos López-Larrea Objective To investigate the contribution of HLA class I alleles in the susceptibility to primary ankylosing spondylitis (AS) in West African patients living in Togo. Methods A large epidemiologic analysis of 9,065 West African rheumatology patients living in Togo was performed in order to identify those who had AS. Eight Togolese patients with AS were identified. HLA was typed by polymerase chain reaction using sequence-specific oligonucleotide probes. DNA typing was also performed on a control population of 85 healthy subjects matched for ethnic background. Results A significant association between AS and B*14 was identified. This allele was found in 62.5% of the AS patients (odds ratio 69), but was carried by only 2% of the healthy controls. Analysis for B14 subtypes showed that B*1403 was the predominant allele in AS patients (odds ratio 171), and that this allele was absent in healthy controls. B27 was virtually absent, being observed in only 1 AS patient (B*2705). Conclusion HLA,B*1403 shows the B27 "supertype" motif and may exert an effect on AS susceptibility according to the arthritogenic peptide model. The association of B*1403 with AS has not previously been reported in either population. [source] Explaining differences in birthweight between ethnic populations.BJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 12 2007The Generation R Study Objective, To examine whether differences in birthweight of various ethnic groups residing in the Netherlands can be explained by determinants of birthweight. Design, Population-based birth cohort study. Setting, Data of pregnant women and their partners in Rotterdam, the Netherlands. Population, We examined data of 6044 pregnant women with a Dutch, Moroccan, Turkish, Capeverdean, Antillean, Surinamese-Creole, Surinamese-Hindustani and Surinamese-other ethnic background. Methods, Regression analyses were used to assess the impact of biomedical, socio-demographic and lifestyle-related determinants on birthweight differences. Main outcome measure, Birthweight was established immediately after delivery in grams. Results, Compared with mean birthweight of offspring of Dutch women (3485 g, SD 555), the mean birthweight was lower in all non-Dutch populations, except in Moroccans. Differences ranged from an 88-g lower birthweight in offspring of the Turkish women to a 424-g lower birthweight in offspring of Surinamese-Hindustani women. Differences in gestational age, maternal and paternal height largely explained the lower birthweight in the Turkish, Antillean, Surinamese-Creole and Surinamese-other populations. Differences in birthweight between the Dutch and the Capeverdean and Surinamese-Hindustani populations could only partly be explained by the studied determinants. Conclusions, These results confirm significant differences in birthweight between ethnic populations that can only partly be understood from established determinants of birthweight. The part that is understood points to the importance of determinants that cannot easily be modified, such as parental height. Further study is necessary to obtain a fuller understanding. [source] Ethnicity and Image: Correlates of Crowd Affiliation Among Ethnic Minority YouthCHILD DEVELOPMENT, Issue 3 2008B. Bradford Brown Because ethnicity is a basis for defining peer crowds in ethnically diverse American high schools, some may question whether crowds foster discrimination and stereotyping or affirm minority youths' positive ties to their ethnic background. Through examination of both self- and peer ratings of crowd affiliation among 2,465 high school youth aged 14,19 years, this study assesses the likelihood that African American, Asian American, Latino, and multiethnic adolescents are associated with ethnically defined crowds. Crowd affiliations are related to friendship patterns among all groups, positive features of ethnic orientation for Asian and Latino youth, but also some aspects of stereotyping and discrimination for Latinos. Results emphasize ethnic diversity in the role that peer crowds play in minority adolescents' social experiences. [source] Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid formsCLINICAL & EXPERIMENTAL IMMUNOLOGY, Issue 3 2006L. N. Dornelles Summary Mannan-binding lectin (MBL) is an important component of the first-line defence against infections. Evidence has shown that MBL deficiency, reducing phagocytosis and internalization of intracellular pathogens may protect the host against intracellular infections such as leprosy. In this study, we speculated whether genetically determined low MBL serum levels confer protection against Mycobacterium leprae infection. One hundred and ninety-one patients with leprosy, presenting lepromatous (n = 118), tuberculoid (n = 31), dimorph (n = 30) and indeterminate (n = 12) clinical forms and 110 healthy controls matched with the patients according to sex, age and ethnic background were investigated. MBL concentrations were measured in a double-antibody enzyme immune assay and C-reactive protein (CRP) serum levels by nephelometry. A significant negative association of MBL low values (< 100 ng/ml) was observed with lepromatous patients when comparing with controls and tuberculoid patients [10/118, 8·47%versus 21/110, 19·09%P = 0·03 ,2 with Yates' correction, odds ratio (OR) 0·39, confidence interval (CI) 0·18,0·88 and 8/31, 25·81%, P = 0·02, OR 0·27, CI 0·09,0·75, respectively]. There was no significant difference in the distribution of MBL levels between patients and controls or among the clinical forms. The concentration of CRP was significantly increased in the patients (P = 0·0002) and in the lepromatous form (P = 0·0001) when compared to controls. A weak positive correlation between MBL and CRP levels was observed in the patients (P = 0·010, R = 0·255). These data suggest a protective role for MBL deficiency against the development of the most severe and multi-bacillary form of leprosy. [source] | ||||||||||||||||||||||||||||||||||