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Ethanol Solvate (ethanol + solvate)
Selected AbstractsClindamycin hydrochloride monohydrate and its ethanol solvateACTA CRYSTALLOGRAPHICA SECTION C, Issue 2 2010Krishnan Ravikumar Clindamycin hydrochloride, an antibiotic of the lincomycin family, was crystallized as the monohydrate, namely (2S,4R)-2-(N -{(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)perhydropyran-2-yl]propyl}aminocarbonyl)-4-propylpyrrolidinium chloride monohydrate, C18H34ClN2O5S+·Cl,·H2O, (I), and as the monohydrate ethanol solvate, C18H34ClN2O5S+·Cl,·H2O·C2H6O, (II). The conformation of the clindamycin molecule in both crystal structures is the same and is found to be similar to that in enzyme-bound clindamycin. The simultaneous presence of free chloride ions and water molecules in (I) and of additional ethanol molecules in (II) provides an interesting network of hydrogen bonds. The significance of this study lies in the interactions in these structures and the aggregations occurring via hydrogen bonds in the hydrated and solvated crystalline forms of the title compound. [source] Dimeric (isoquinoline)(N -salicylidene- d,l -glutamato)copper(II) ethanol solvateACTA CRYSTALLOGRAPHICA SECTION C, Issue 5 2009Vratislav Langer The title racemic complex, bis[,- N -(2-oxidobenzylidene)- d,l -glutamato(2,)]bis[(isoquinoline)copper(II)] ethanol disolvate, [Cu2(C12H11NO5)2(C9H7N)2]·2C2H6O, adopts a square-pyramidal CuII coordination mode with a tridentate N -salicylideneglutamato Schiff base dianion and an isoquinoline ligand bound in the basal plane. The apex of the pyramid is occupied by a phenolic O atom from the adjacent chelate molecule at an apical distance of 2.487,(3),Å, building a dimer located on the crystallographic inversion center. The Cu...Cu spacing within the dimers is 3.3264,(12),Å. The ethanol solvent molecules are hydrogen bonded to the dimeric complex molecules, forming infinite chains in the a direction. The biological activity of the title complex has been studied. [source] Octasubstituted biphenylenes: is there a favoured conformation?ACTA CRYSTALLOGRAPHICA SECTION C, Issue 7 2007Peter J. Steel Octakis(pyrazol-1-ylmethyl)biphenylene ethanol solvate, C44H40N16·C2H6O, has two independent centrosymmetric molecules, one of which is hydrogen bonded to the solvent molecule. One molecule adopts an arrangement with three arms up and one down in each benzene ring, whilst the other molecule has a conformation with two adjacent arms on the same side of the ring. In neither case is the expected fully alternating form observed. [source] Order-disorder enantiotropy, monotropy, and isostructurality in a tetroxoprim-sulfametrole 1:1 molecular complex: Crystallographic and thermal studiesJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 11 2003Mino R. Caira Abstract Two enantiotropic polymorphs of a tetroxoprim (TXP)-sulfametrole (SMTR) 1:1 molecular complex monohydrate and two isostructural TXP-SMTR 1:1 molecular complex solvates with methanol and ethanol were grown and studied by X-ray diffraction and thermal methods (thermogravimetric analysis and differential scanning calorimetry). Interconversion of the polymorphic hydrates is essentially an order/disorder transition involving a substituent on the TXP molecule. These hydrated phases may be described as "nearly isostructural" with the methanol and ethanol solvates. Thermal data for decomposition of the solvates were rationalized on the basis of the location and topologies of solvent crystallographic sites. Solid-state properties of two monotropic polymorphs of the unsolvated TXP-SMTR 1:1 molecular complex were also investigated and the theoretical and experimental phase diagrams of the individual components were assessed. The existence of polymorphic and pseudopolymorphic forms is determined by conformational flexibility of the TXP-SMTR bimolecular complex components, a tendency for molecular disorder in TXP, the ability of the drug complex to form intricate, highly stabilized hydrogen-bonded frameworks, and the competition between nonspecific van der Waals and specific hydrogen bond interactions. © 2003 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 92:2164,2176, 2003 [source] | ||||||||||