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Aggregation Mechanism (aggregation + mechanism)
Selected AbstractsTartatric Acid and L -Cysteine Synergistic-Assisted Synthesis of Antimony Trisulfide Hierarchical Structures in Aqueous SolutionEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 35 2009Jun Pan Abstract Alveolate amorphous Sb2S3 microspheres about 2 ,m in diameter were hydrothermally synthesized in aqueous solution without the use of a surfactant at 180 °C by using SbCl3, L -cysteine, and tartaric acid as starting materials. After annealing at 250 °C for 3 h under a nitrogen atmosphere, polycrystalline Sb2S3 hollow spheres were obtained. The morphology, structure, and phase composition of alveolate Sb2S3 microspheres were characterized by X-ray diffraction, field-emission scanning electron microscopy, energy dispersive X-ray analysis, and X-ray photoelectron spectroscopy. It was demonstrated that tartaric acid and L -cysteine play a key role in the formation of such hierarchical structures. In addition, the possible aggregation mechanism was proposed to illustrate the formation of Sb2S3 microspheres on the basis of the experimental results and analyses.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Increasing the throughput of HomePNAINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 7 2008Aurelio Amodei Jr Abstract In this paper we propose a new medium access mechanism for HomePNAv2 and HomePNAv3 standards. This mechanism uses a priority aggregation mechanism to avoid collisions, increasing these protocols throughput. Furthermore, this mechanism does not require modifying standards, since it can be implemented over their actual MAC sublayers. Simulation results show that the proposed mechanism is able to increase the throughput up to 44% for HomePNAv2 and 36% for HomePNAv3. Moreover, we also show how this mechanism affects network delay, analyzing average delay and jitter for all protocols presented. Copyright © 2008 John Wiley & Sons, Ltd. [source] Empirical assessment of a collaborative filtering algorithm based on OWA operatorsINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 12 2008Miguel-Angel Sicilia Classical collaborative filtering algorithms generate recommendations on the basis of ratings provided by users that express their subjective preference on concrete items. The correlation of ratings is used in such schemes as an implicit measure of common interest between users, that is used to predict ratings, so that these ratings determine recommendations. The common formulae used for the computation of predicted ratings use standard weighted averaging schemes as the fixed aggregation mechanism that determines the result of the prediction. Nonetheless, the surrounding context of these rating systems suggest that an approach considering a degree of group consensus in the aggregation process may better capture the essence of the "word,of,mouth" philosophy of such systems. This paper reports on the empirical evaluation of such an alternative approach in which OWA operators with different properties are tested against a dataset to search for the better empirical adjustment. The resulting algorithm can be considered as a generalization of the original Pearson formula based algorithm that allows for the fitting of the aggregation behavior to concrete databases of ratings. The results show that for the particular context studied, higher orness degrees reduce overall error measures, especially for high ratings, which are more relevant in recommendation settings. The adjustment procedure can be used as a general-purpose method for the empirical fit of the behavior of collaborative filtering systems. © 2008 Wiley Periodicals, Inc. [source] Synthesis of pathological and nonpathological human exon 1 huntingtinJOURNAL OF PEPTIDE SCIENCE, Issue 7 2010David Singer Abstract Huntington's disease (HD) is a neurodegenerative disorder that affects approximately 1 in 10 000 individuals. The underlying gene mutation was identified as a CAG-triplet repeat expansion in the gene huntingtin. The CAG sequence codes for glutamine, and in HD, an expansion of the polyglutamine (poly-Q) stretch above 35 glutamine residues results in pathogenicity. It has been demonstrated in various animal models that only the expression of exon 1 huntingtin, a 67-amino acid-long polypeptide plus a variable poly-Q stretch, is sufficient to cause full HD-like pathology. Therefore, a deeper understanding of exon 1 huntingtin, its structure, aggregation mechanism and interaction with other proteins is crucial for a better understanding of the disease. Here, we describe the synthesis of a 109-amino acid-long exon 1 huntingtin peptide including a poly-Q stretch of 42 glutamines. This microwave-assisted solid phase peptide synthesis resulted in milligram amounts of peptide with high purity. We also synthesized a nonpathogenic version of exon 1 huntingtin (90-amino acid long including a poly-Q stretch of 23 glutamine residues) using the same strategy. In circular dichroism spectroscopy, both polypeptides showed weak alpha-helical properties with the longer peptide showing a higher helical degree. These model peptides have great potential for further biomedical analyses, e.g. for large-scale pre-screenings for aggregation inhibitors, further structural analyses as well as protein,protein interaction studies. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd. [source] Advection of anchovy (Engraulis encrasicolus) larvae along the Catalan continental slope (NW Mediterranean)FISHERIES OCEANOGRAPHY, Issue 2 2007A. SABATÉS Abstract The Gulf of Lions is one of the main anchovy (Engraulis encrasicolus) spawning areas in the NW Mediterranean. During the spring, low-salinity surface water from the outflow of the Rhône is advected by the shelf-slope current along the continental slope off the Catalan coast. In June 2000, a Lagrangian experiment tracking these low-salinity surface waters was conducted to assess the importance of this transport mechanism for anchovy larvae and to determine the suitability of the tracked surface waters for survival of anchovy larvae. The experiment consisted of sampling the tracked water parcel for 10 days with three drifters launched at the core of the shelf-slope current where low-salinity surface waters were detected. The survey was completed by sampling the surrounding waters. Anchovy larvae from the spawning area in the Gulf of Lions were advected towards the south in the low-salinity waters. The size increase of anchovy larvae throughout the Lagrangian tracking closely followed the general growth rate calculated by otolith analysis (0.65 mm day,1). However, advection by the current was not the only mechanism of anchovy larval transport. A series of anticyclonic eddies, originated in the Gulf of Lions and advected southwards, seemed to play a complementary role in the transport of larvae from the spawning ground towards the nursery areas. These eddies not only contributed to larval transport but also prevented their dispersion. These transport and aggregation mechanisms may be important for anchovy populations along the Catalan coast and require further study. [source] Self-assembling properties of ionic-complementary peptides,JOURNAL OF PEPTIDE SCIENCE, Issue 3 2009Gabriella D'Auria Abstract Self-complementary synthetic peptides, composed by 8 and 16 residues, were analyzed by CD, NMR and small angle neutron scattering (SANS) techniques in order to investigate the relevance of charge and hydrophobic interactions in determining their self-assembling properties. All the sequences are potentially able to form fibrils and membranes as they share, with the prototype EAK16, a strictly alternating arrangement of polar and nonpolar residues. We find that 16-mer peptides show higher self-assembling propensities than the 8-mer analogs and that the aggregation processes are favored by salts and neutral pH. Peptide hydrophobic character appears as the most relevant factor in determining self-assembling. Solution conformational analysis, diffusion and SANS measurements all together show that the sequences with a higher self-assemble propensity are distributed, in mild conditions, between light and heavy forms. For some of the systems, the light form is mostly constituted by monomers in a random conformation, while the heavy one is constituted by ,-aggregates. In our study we also verified that sequences designed to adopt extended conformation, when dissolved in alcohol-water mixtures, can easily fold in helix structures. In that media, the prototype of the series appears distributed between helical monomers and ,-aggregates. It is worth noticing that the structural conversion from helical monomer to ,-aggregates, mimics ,-amyloid peptide aggregation mechanisms. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd. [source] Taking Others into Account: Self-Interest and Fairness in Majority Decision MakingAMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 3 2010Jan Sauermann Research on the formal properties of democratic aggregation mechanisms has a long tradition in political science. Recent theoretical developments, however, show that in the discussion of normative contents of democratic decisions, the actual shape of preferences deserves just as much attention. However, our knowledge about the concrete motivations of individual behavior in democratic decisions is incomplete. Using laboratory experiments, this article examines the existence of social preferences in majority decisions. Contrary to earlier experiments of committee decision making, we develop a design that controls for the conditions of communication and the level of information between subjects. This allows us to comparatively test the predictive power of several theories. We find strong evidence that self-interest and fairness motivate human behavior in majority decisions. [source] Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta-amyloidBIOTECHNOLOGY PROGRESS, Issue 4 2010Min S. Wang Abstract Although Alzheimer's disease (AD) is characterized by the extracellular deposition of fibrillar aggregates of beta-amyloid (A,), transient oligomeric species of A, are increasingly implicated in the pathogenesis of AD. Natively unfolded monomeric A, can misfold and progressively assemble into fibrillar aggregates, following a well-established "on pathway" seeded-nucleation mechanism. Here, we show that three simple saccharides, mannose, sucrose, and raffinose, alter A, aggregation kinetics and morphology. The saccharides inhibit formation of A, fibrils but promote formation of various oligomeric aggregate species through different "off pathway" aggregation mechanisms at 37°C but not at 60°C. The various oligomeric A, aggregates formed when coincubated with the different saccharides are morphologically distinct but all are toxic toward SH-SY5Y human neuroblastoma cells, increasing the level of toxicity and greatly prolonging toxicity compared with A, alone. As a wide variety of anti-A, aggregation strategies are being actively pursued as potential therapeutics for AD, these studies suggest that care must be taken to ensure that the therapeutic agents also block toxic oligomeric A, assembly as well as inhibit fibril formation. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010 [source] | ||||||||||