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Entry Point (entry + point)

Distribution by Scientific Domains

Life Sciences	26%
Humanities and Social Sciences	23%
Medical Sciences	20%
Chemistry	10%
Earth and Environmental Science	6%
4 Other Domains	15%

Selected Abstracts

Disaster Mitigation and Preparedness: The Case of NGOs in the Philippines

DISASTERS, Issue 3 2001
Emmanuel M. Luna
The Philippines is very vulnerable to natural disasters because of its natural setting, as well as its socio-economic, political and environmental context - especially its widespread poverty. The Philippines has a well-established institutional and legal framework for disaster management, including built-in mechanisms for participation of the people and NGOs in decision-making and programme implementation. The nature and extent of collaboration with government in disaster preparedness and mitigation issues varies greatly according to their roots, either in past confrontation and political struggles or traditional charity activities. The growing NGO involvement in disaster management has been influenced by this history. Some agencies work well with local government and there is an increasing trend for collaborative work in disaster mitigation and preparedness. Some NGOs, however, retain critical positions. These organisations tend to engage more in advocacy and legal support for communities facing increased risk because of development projects and environmental destruction. Entry points into disaster mitigation and preparedness vary as well. Development-oriented agencies are drawn into these issues when the community members with whom they work face disaster. Relief organisations, too, realise the need for community mobilisation, and are thus drawn towards development roles. [source]

Recreational Portage Trails as Corridors Facilitating Non-Native Plant Invasions of the Boundary Waters Canoe Area Wilderness (U.S.A.)

CONSERVATION BIOLOGY, Issue 5 2005
SARA JO M. DICKENS
corredores; invasiones; perturbación humana; recreación; senderos Abstract:,Wilderness areas are protected and valued in part for recreation; recreational use, however, can negatively impact these areas. In particular, recreational use can facilitate transport of non-native propagules and create open sites for establishment of non-native species. We examined the role of recreational portage trails in the introduction and establishment of non-native plants into the Boundary Waters Canoe Area Wilderness of northern Minnesota (U.S.A.). On 20 portages, we sampled non-native plant richness and cover at four distances (0, 10, 25, and 50 m) from trails. Non-native richness and cover were not related to distance from wilderness entry point. Non-native richness and cover were, however, negatively related to distance from trails. All six non-native species we observed were either directly on or within 1 m of trails. These results suggest that recreational trails act as corridors facilitating invasions of non-native plants into wilderness areas. It remains unclear, however, whether these effects are caused by dispersal of propagules, creation of bare ground, or changes in the native plant community. Resumen:,En parte, las áreas silvestres son protegidas y valoradas para recreación; sin embargo, el uso recreativo puede impactar a estas áreas negativamente. En particular, el uso recreativo puede facilitar el transporte de propágulos no nativos y crear áreas abiertas para el establecimiento de especies no nativas. Examinamos el papel de senderos recreativos en la introducción y establecimiento de plantas no nativas en el Boundary Waters Canoe Area Wilderness en el norte de Minnesota (E.U.A.). En 20 senderos, muestreamos la riqueza y cobertura de plantas no nativas a cuatro distancias (0, 10, 25 y 50 m) de los senderos. La riqueza y cobertura de no nativas no se relacionaron con la distancia al punto de entrada al área silvestre. Sin embargo, la riqueza y cobertura de no nativas se relacionaron negativamente con la distancia a los senderos. Las seis especies no nativas fueron observadas directamente sobre o a 1 m de los senderos. Estos resultados sugieren que los senderos recreativos fungen como corredores que facilitan la invasión de plantas no nativas a las áreas silvestres. Sin embargo, aún no es claro si estos efectos son causados por la dispersión de propágulos, la creación de suelo desnudo o por cambios en la comunidad de plantas nativas. [source]

Sector Approaches, Sustainable Livelihoods and Rural Poverty Reduction

DEVELOPMENT POLICY REVIEW, Issue 3 2001
Jim Gilling
This article examines the relationship between sector-wide approaches (SWAps), sustainable livelihoods approaches (SLAs) and rural poverty reduction. The authors suggest that SLAs provide one means by which SWAps can focus more effectively on poverty reduction, whilst SWAps provide an entry point via which government and donor initiatives can be made supportive of the livelihoods of the poor. The article puts forward guidelines indicating the core issues upon which donors should focus to enhance the poverty impact of sector-wide approaches. [source]

An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries

DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 7 2000
Roger D Freeman MD
We have established a multisite, international database of 3500 individuals diagnosed with Tourette syndrome (TS). The male:female ratio is 4.3:1 for the total sample, with wide variation among sites; the male excess occurs at every site. Anger control problems, sleep difficulties, coprolalia, and self-injurious behavior only reach impressive levels in individuals with comorbidity. Anger control problems are strongly correlated with comorbidity, regardless of site, region, or whether assessed by neurologists or psychiatrists. The mean age at onset of tics is 6.4 years. At all ages, about 12% of individuals with TS have no reported comorbidity. The most common reported comorbidity is attention-deficit-hyperactivity disorder. Males are more likely to have comorbid disorders than females. The earlier the age at onset, the greater the likelihood of a positive family history of tics. An understanding of the factors producing these and other variations might assist in better subtyping of TS. Because behavioral problems are associated with comorbidity, their presence should dictate a high index of suspicion of the latter, whose treatment may be at least as important as tic reduction. The established database can be used as the entry point for further research when large samples are studied and generalizability of results is important. [source]

Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase

FEBS JOURNAL, Issue 2 2005
Oliver-M.
In recent studies on heme-copper oxidases a particular glutamate residue in subunit II has been suggested to constitute the entry point of the so-called K pathway. In contrast, mutations of this residue (E78II) in the Paracoccus denitrificans cytochrome c oxidase do not affect its catalytic activity at all (E78IIQ) or reduce it to about 50% (E78IIA); in the latter case, the mutation causes no drastic decrease in heme a3 reduction kinetics under anaerobic conditions, when compared to typical K pathway mutants. Moreover, both mutant enzymes retain full proton-pumping competence. While oxidized-minus-reduced Fourier-transform infrared difference spectroscopy demonstrates that E78II is indeed addressed by the redox state of the enzyme, absence of variations in the spectral range characteristic for protonated aspartic and glutamic acids at ,,1760 to 1710 cm,1 excludes the protonation of E78II in the course of the redox reaction in the studied pH range, although shifts of vibrational modes at 1570 and 1400 cm,1 reflect the reorganization of its deprotonated side chain at pH values greater than 4.8. We therefore conclude that protons do not enter the K channel via E78II in the Paracoccus enzyme. [source]

Social Citizenship in the European Union: Nested Membership

JCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2001
Thomas Faist
The ,European social dimension' offers a strategic entry point for analysing the development of citizenship in the European Union (EU). The first part of this contribution discusses the functions of social citizenship in this emerging multi-level governance network. Second, the analysis deals with two prominent and stylized paradigms that have sought to grasp the new multiple-level quality of social citizenship in the EU: residual and post-national concepts of membership in liberal democracies and advanced welfare states. Although each of these approaches captures selected elements of social citizenship, they are unable to deal with rights and duties in multiple governance levels in a satisfactory way. Therefore, the discussion moves to an alternative concept,nested citizenship. This means that European citizenship is nested in various sites: regional, state and supra-state forms of citizenship function in complementary ways,while the associated norms, rules and institutions are subject to constant revision and further development on all governance levels. Third, the analysis shows that the concept of nested citizenship can help to overcome the fruitless dichotomy of Euro-optimism and Euro-pessimism concerning social policy and citizenship. This discussion suggests a conception of European social citizenship as a common project, evolving towards common present- and future-oriented understandings of substantial rights and democratic principles in the EU. [source]

QSAR model for alignment-free prediction of human breast cancer biomarkers based on electrostatic potentials of protein pseudofolding HP-lattice networks

JOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 16 2008
Santiago Vilar
Abstract Network theory allows relationships to be established between numerical parameters that describe the molecular structure of genes and proteins and their biological properties. These models can be considered as quantitative structure,activity relationships (QSAR) for biopolymers. The work described here concerns the first QSAR model for 122 proteins that are associated with human breast cancer (HBC), as identified experimentally by Sjöblom et al. (Science 2006, 314, 268) from over 10,000 human proteins. In this study, the 122 proteins related to HBC (HBCp) and a control group of 200 proteins that are not related to HBC (non-HBCp) were forced to fold in an HP lattice network. From these networks a series of electrostatic potential parameters (,k) was calculated to describe each protein numerically. The use of ,k as an entry point to linear discriminant analysis led to a QSAR model to discriminate between HBCp and non-HBCp, and this model could help to predict the involvement of a certain gene and/or protein in HBC. In addition, validation procedures were carried out on the model and these included an external prediction series and evaluation of an additional series of 1000 non-HBCp. In all cases good levels of classification were obtained with values above 80%. This study represents the first example of a QSAR model for the computational chemistry inspired search of potential HBC protein biomarkers. © 2008 Wiley Periodicals, Inc. J Comput Chem 2008 [source]

Precise landmarking in computer assisted total knee arthroplasty is critical to final alignment

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 10 2010
Yaron S. Brin
Abstract Image-free computer navigation systems build a frame of reference of a patient's knee from anatomical landmarks entered by the surgeon during the initial stage of total knee arthroplasty. We performed tibial cuts on 70 sawbones using computer navigation. All landmarks were marked identically except for the tibial mechanical entry point, which was marked correctly in 10 bones and with offsets of 5, 10, and 15,mm medially and laterally in the others. The actual coronal angle of the tibial cuts was measured directly and compared to the final angle given by the navigation system. Significant deviations of the coronal angle were observed in the trial groups. Landmarking errors during navigated TKA can lead to inaccurate tibial bone cuts. This navigation system did not have an iterative software method to verify landmarking errors that can lead to inaccurate tibia bone cuts. Published by Wiley Periodicals, Inc. J Orthop Res 28:1355,1359, 2010 [source]

Creating Peer Sexual Harassment: Mobilizing Schools to Throw the Book at Themselves

LAW & POLICY, Issue 1 2006
JODI L. SHORT
This paper describes how peer-to-peer sexual harassment rapidly was transformed from an unremarkable reality of secondary school life into a serious social and legal problem. First, it shows how organizations and professionals served as an entry point for social change and legal mobilization. I argue that schools were quick to address peer sexual harassment because activists framed it as a moral and pedagogical issue that resonated with educators' deeply held professional values. Second, the paper shows how law and organizations developed endogenously. Without any legal mandate, schools created and institutionalized harassment policies. Courts then looked to these organizational practices to determine the content and scope of Title IX. In this way, schools literally "enacted" the law through their practices. This finding goes beyond previous work on endogeneity in that school policies influenced law at the level of doctrine, not simply at the level of meaning, enforcement, or application. [source]

On Recognition, Caring, and Dementia

MEDICAL ANTHROPOLOGY QUARTERLY, Issue 4 2008
Janelle S. Taylor
The onset of dementia raises troubling questions. Does the person with dementia still recognize you? If someone cannot recognize you, can they still care about you? This essay takes such questions as the entry point for a broader inquiry into recognition, its linkages to care, and how claims to social and political "recognition" are linked to, or premised on, the demonstrated capacity to "recognize" people and things. In the words and actions of her severely impaired mother, the author finds guidance toward a better, more compassionate question to ask about dementia: how can we best strive to "keep the cares together"? [source]

Patterns of Innervation of the Anterior Maxilla: A Cadaver Study with Relevance to Canine Fossa Puncture of the Maxillary Sinus,

THE LARYNGOSCOPE, Issue 10 2005
Simon Robinson FRACS
Abstract Objectives/Hypothesis: Complications from canine fossa puncture of the maxillary sinus are caused by damage to the anterior superior alveolar nerve (ASAN) and the middle superior alveolar nerve (MSAN). The aim of this study was to elucidate the pattern of ASAN and MSAN within the anterior maxilla and to secondly determine suitable surgical landmarks to aid in accurately localizing the area of the canine fossa least likely to produce complications when a trocar is passed into the maxillary sinus. Methods: Anatomic dissection of the anterior face of the maxilla from 20 cadaver heads was performed. The pattern and presence of the ASAN and MSAN was identified on each side and tabulated. Landmarks for the safest entry point for canine fossa puncture were determined, and each side had a puncture placed using these landmarks. Any disruption of nerves was noted. Results: Multiple differing patterns of ASAN were identified. The ASAN emerged from its foramen as a single trunk in 30 (75%) sides and in a double trunk in 10 (25%). In 24 (60%), single or multiple branches from the ASAN trunks were identified. A MSAN was identified in 9 (23%) maxillae. The safest entry point for a canine fossa puncture was where a vertical line drawn through the mid-pupillary line was bisected by a horizontal line drawn through the floor of the pyriform aperture. Conclusions: There is significant variation in the pattern of ASAN and MSAN within the anterior face of the maxilla. By using the newly described landmarks when performing a canine fossa puncture, there is reduced risk of damage to these nerves and provides a reliable point to enter the maxillary sinus. [source]

ORIGINAL ARTICLE: Accuracy of surface landmark identification for cannula cricothyroidotomy

ANAESTHESIA, Issue 9 2010
D. S. J. Elliott
Summary Cannula cricothyroidotomy is recommended for emergency transtracheal ventilation by all current airway guidelines. Success with this technique depends on the accurate and rapid identification of percutaneous anatomical landmarks. Six healthy subjects underwent neck ultrasound to delineate the borders of the cricothyroid membrane. The midline and bisecting transverse planes through the membrane were marked with an invisible ink pen which could be revealed with an ultraviolet light. Eighteen anaesthetists were then invited to mark an entry point for cricothyroid membrane puncture. Only 32 (30%) attempts by anaesthetists accurately marked the skin area over the cricothyroid membrane. Of these only 11 (10%) marked over the centre point of the membrane. Entry point accuracy was not significantly affected by subjects' weight, height, body mass index, neck circumference or cricothyroid dimensions. Consultant and registrar anaesthetists were significantly more accurate than senior house officers at correctly identifying the cricothyroid membrane. Accuracy of percutaneously identifying the cricothyroid membrane was poor. Ultrasound may assist in identifying anatomical landmarks for cricothyroidotomy. [source]

Uneven Developments: From The,Grundrisse To,Capital

ANTIPODE, Issue 5 2008
Joel Wainwright
Abstract:, Since its publication, Marxists have debated the relation between the,Grundrisse and the first volume of,Capital. This paper offers one entry point into this debate by comparing the way each text frames its "problematic of uneven development", that is, the way that capitalism's inherently uneven development is thematized as a problem for explanation. In the,Grundrisse the uneven nature of capitalism as development is explained by the emergence of capitalism from precapitalist relations. While this analysis is not entirely absent from,Capital (cf the discussion of primitive accumulation), precapitalist formations are not treated as systematically in,Capital. By contrast, uneven development enters,Capital in the final section, particularly where Marx criticizes Wakefield. Reading these two texts together, I argue that the problematic of uneven development shifts from,Grundrisse to,Capital in a way that underscores Marx's growing stress on capital's imperial character. This shift has its roots in political events of the period when Marx rewrote,Grundrisse into,Capital. [source]

Single-port laparoscopic splenectomy: The first three cases

ASIAN JOURNAL OF ENDOSCOPIC SURGERY, Issue 1 2010
Y.K. You
Abstract In the past two decades, laparoscopic surgery has replaced open surgery in most abdominal surgeries, including splenectomies for which it has become the standard. Single-port laparoscopic surgery is a newly emerging surgical technique that decreases postoperative scarring and parietal trauma. Herein we report on three cases of splenectomy in which single-port laparoscopic surgery technique was applied. Between October 2008 and January 2009, a 13-year-old male suffering from grade-III splenic trauma and two females, aged 33 and 61, respectively, and both diagnosed with immune thrombocytopenic purpura, underwent single-port laparoscopic splenectomies. Preoperative and postoperative management, including vaccination, was performed in a routine manner. A 3.5 cm transverse incision at the anterior axillary line at umbilicus level was used as a single-port entry point. The entire procedure took 195, 125 and 133 minutes, respectively. All patients recovered and were discharged without any complications. [source]

The Thanksgiving Turkey Tap: A New and Simple Model for Teaching Ultrasound-guided Thoracentesis

ACADEMIC EMERGENCY MEDICINE, Issue 2009
Derek Richardson
Thoracentesis is a critical procedure that every emergency physician must be able to perform comfortably. By introducing ultrasound technology to the procedure, we have the potential to redefine the standard of care for emergency department thoracentesis by effectively decreasing complication rates of this procedure. Ultrasound-guided thoracentesis has been shown to lead to fewer incidents of pneumothorax than the traditional technique; however, due to the complicated anatomy of the chest wall, this skill is difficult to teach without using living patient models. The NewYork-Presbyterian Emergency Medicine Residency Program has developed an effective model for teaching and practicing ultrasound-guided thoracentesis. The Presbyterian model uses a whole turkey with the cavity lined with a water-retaining plastic sheet, containing water and an air-filled balloon. Ultrasound can then be used to visualize the ribs, the underlying fluid, and the balloon representing lung space. By using a standard thoracentesis kit with our model, the complete procedure can be performed and techniques of positioning, entry point, and fluid collection can be demonstrated and practiced. This was performed for 50 medical students, residents, and attending physicians in late November 2008 for under $100. This simple model may be used to introduce new practitioners to thoracentesis, or to update experienced physicians on new techniques to decrease complication rates during procedures with an effective and inexpensive model. [source]

How to kill a mocking bug?

CELLULAR MICROBIOLOGY, Issue 4 2006
Vitor B. Pinheiro
Summary All metazoans have evolved means to protect themselves from threats present in the environment: injuries, viruses, fungi, bacteria and other parasites. Insect protection includes innate physical barriers and both cellular and humoral responses. The insect innate immune response, best characterized in Drosophila melanogaster, is a rapid broad response, triggered by pathogen-associated molecular patterns (PAMPs) recognition, which produces a limited range of effectors that does not alter upon continued pathogen exposure and lacks immunological memory. The Drosophila response, particularly its humoral response, has been investigated by both low and high-throughput methods. Three signalling pathways conserved between insects and mammals have been implicated in this response: Toll (equivalent to mammalian TLR), Imd (equivalent to TNF,) and Hop (equivalent to JAK/STAT). This review provides an entry point to the insect immune system literature outlining the main themes in D. melanogaster bacterial pathogen detection and humoral and cellular immune responses. The Drosophila immune response is compared with other insects and the mammalian immune system. [source]

Cyclostreptin and Microtubules: Is a Low-Affinity Binding Site Required?

CHEMBIOCHEM, Issue 1 2010
Andrew J. Prussia Dr.
Abstract Cyclostreptin (CS) is a recently discovered natural product with cytotoxic activity caused by microtubule stabilization. It is the only known microtubule-stabilizing agent (MSA) that covalently binds to tubulin. It also exhibits the fast-binding kinetics seen for other MSAs. Through careful peptide digestion and mass spectrometry analysis, Buey et al. found that two amino acids are labeled by CS: Asn228, near the known taxane-binding site, and Thr220, in the type I microtubule pore. This led Buey et al. to propose Thr220 resides at the site previously predicted to be a way station or low-affinity site. By using molecular dynamics simulations and structural considerations of the microtubule pore and tubulin dimer, we conclude that postulation of a low-affinity site is unnecessary to explain the available experimental data. An alternative explanation views the microtubule pore as a structural entity that presents a substantial kinetic barrier to ligand passage to the known taxane-binding site,an entry point to the microtubule lumen that becomes completely blocked if cyclostreptin is bound at Thr220. Simulations of the free dimer also suggest a common mechanism of microtubule stabilization for taxane site MSAs through their conformational effect on the M-loop. Such an effect explains the low tubulin polymerization caused by cyclostreptin in vitro despite its covalent attachment. [source]

Schools: Central to Providing Comprehensive CAMH Services in the Future?

CHILD AND ADOLESCENT MENTAL HEALTH, Issue 3 2008
Gill Salmon
It is now widely agreed that meeting the mental health needs of children and young people is a task only possible if all children's services work together. Recent epidemiological data indicate that schools are a key entry point to mental health services for children and young people, and have an important role in the assessment and management of children with neurodevelopmental disorders. This paper explores the rationale for collaborative working between health and educational professionals, examines some examples of good practice, explores factors contributing to their success or failure and considers future developments. [source]

Soft tissue anatomy around the hip and its implications for choice of entry point in antegrade femoral nailing

CLINICAL ANATOMY, Issue 6 2008
C.M. Ansari Moein
Abstract Antegrade intramedullary nailing is an accepted method of treatment for femoral shaft fractures. Entrance of the nail through the trochanteric fossa is currently recommended by some surgeons. This approach results in some cases, however, in loss of abduction strength and persistent pain. Nail insertion at the tip of the greater trochanter may be more favorable. In this study the anatomical relationships of the trochanteric fossa and of the tip of the greater trochanter were explored. Dissection was carried out in 10 fresh human cadaver femurs. The risks and safety of the two entry points with respect to the adjacent soft tissues were assessed. Abductor muscles and tendons, branches of the medial circumflex femoral artery and the hip joint capsule were at risk during nail insertion through the trochanteric fossa. These structures were not endangered during insertion through the trochanteric tip. The reported clinical morbidity after nailing through the trochanteric fossa may result from direct soft tissue injury and may be reduced by choosing the route through the greater trochanter. Clin. Anat. 21:568,574, 2008. © 2008 Wiley-Liss, Inc. [source]

Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome,

DEVELOPMENTAL DYNAMICS, Issue 2 2007
Maia L. Green
Abstract Fetal Alcohol Spectrum Disorders (FASD) are birth defects that result from maternal alcohol use. We used a non a priori approach to prioritize candidate pathways during alcohol-induced teratogenicity in early mouse embryos. Two C57BL/6 substrains (B6J, B6N) served as the basis for study. Dosing pregnant dams with alcohol (2× 2.9 g/kg ethanol spaced 4 hr on day 8) induced FASD in B6J at a higher incidence than B6N embryos. Counter-exposure to PK11195 (4 mg/kg) significantly protected B6J embryos but slightly promoted FASD in B6N embryos. Microarray transcript profiling was performed on the embryonic headfold 3 hr after the first maternal alcohol injection (GEO data series accession GSE1074). This analysis revealed metabolic and cellular reprogramming that was substrain-specific and/or PK11195-dependent. Mapping ethanol-responsive KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways revealed down-regulation of ribosomal proteins and proteasome, and up-regulation of glycolysis and pentose phosphate pathway in B6N embryos; and significant up-regulation of tight junction, focal adhesion, adherens junction, and regulation of the actin cytoskeleton (and near-significant up-regulation of Wnt signaling and apoptosis) pathways in both substrains. Expression networks constructed computationally from these altered genes identified entry points for EtOH at several hubs (MAPK1, ALDH3A2, CD14, PFKM, TNFRSF1A, RPS6, IGF1, EGFR, PTEN) and for PK11195 at AKT1. Our findings are consistent with the growing view that developmental exposure to alcohol alters common signaling pathways linking receptor activation to cytoskeletal reorganization. The programmatic shift in cell motility and metabolic capacity further implies cell signals and responses that are integrated by the mitochondrial recognition site for PK11195. Developmental Dynamics 236:613,631, 2007. © 2007 Wiley-Liss, Inc. [source]

Segment-specific expression of connexin31 in the embryonic hindbrain is regulated by Krox20

DEVELOPMENTAL DYNAMICS, Issue 4 2002
Stefan Jungbluth
Abstract Communication and interaction between cells has been shown to be important during the embryonic development of the vertebrate hindbrain, which becomes transiently subdivided into segments called rhombomeres (r). One gene family allowing intercellular communication and possibly being involved in the control of hindbrain development is the connexin family encoding gap junction channels. Here, we have characterized in detail the previously observed (Dahl et al., 1997) expression of one particular connexin gene, connexin31 (Cx31), in the mouse embryonic hindbrain and compared it with that of Cx43 and Cx36. We found transient Cx31 expression from approximately embryonic day (E) E8,E11 in two small lateral/dorsal subgroups of cells in the hindbrain. We could show that these spots of expression corresponded to r3 and r5 and that Cx31 expression in r3 and r5 was controlled by the transcription factor Krox20. In contrast, expression of Cx43 and Cx36 started later (from E9.5 and E10.5, respectively) and was confined to longitudinal stripes of expression. In addition, from E10.5,E11.5, Cx31 was expressed by a column of cells in ventral r4, most likely representing contralateral vestibulo-acoustic efferent neurons, immediately anterior to a ventral column expressing Cx36 at the same stage. From E11.5 onward, another site of Cx31 expression was detected in the boundary cap cells in the entry/exit points of all mixed sensory/motor and in the entry points of pure sensory nerves. This expression was not present in the boundary cap cells of the exit points of pure motor nerves. So far, our analysis of the hindbrain area of Cx31 -deficient embryos in terms of projections of sensory or motor neurons or in the generation or migration of neurons has not yet revealed any obvious defects. © 2002 Wiley-Liss, Inc. [source]

Networked identities: understanding relationships between strong and weak ties in networked environments

JOURNAL OF COMPUTER ASSISTED LEARNING, Issue 2 2008
T. Ryberg
Abstract In this paper we take up a critique of the concept of Communities of Practice (CoP) voiced by several authors, who suggest that networks may provide a better metaphor to understand social forms of organization and learning. Through a discussion of the notion of networked learning and the critique of CoPs we shall argue that the metaphor or theory of networked learning is itself confronted with some central tensions and challenges that need to be addressed. We then explore these theoretical and analytic challenges to the network metaphor, through an analysis of a Danish social networking site. We argue that understanding meaning making and ,networked identities' may be relevant analytic entry points in navigating the challenges. [source]

The efficiency of mitochondrial electron transport chain is increased in the long-lived mrg19 Saccharomyces cerevisiae

AGING CELL, Issue 6 2009
Nitish Mittal
Summary Integrity of mitochondrial functionality is a key determinant of longevity in several organisms. In particular, reduced mitochondrial ROS (mtROS) production leading to decreased mtDNA damage is believed to be a crucial aspect of longevity. The generation of low mtROS was thought to be due to low mitochondrial oxygen consumption. However, recent studies have shown that higher mitochondrial oxygen consumption could still result in low mtROS and contribute to longevity. This increased mitochondrial efficiency (i.e. low mtROS generated despite high oxygen consumption) was explained as a result of mitochondrial biogenesis, which provides more entry points for the electrons to the electron transport chain (ETC), thereby resulting in low mtROS production. In this study, we provide evidence for the existence of an alternative pathway to explain the observed higher mitochondrial efficiency in the long-lived mrg19 mutant of Saccharomyces cerevisiae. Although we observe similar amounts of mitochondria in mrg19 and wild-type (wt) yeast, we find that mrg19 mitochondria have higher expression of ETC components per mitochondria in comparison with the wt. These findings demonstrate that more efficient mitochondria because of increased ETC per mitochondria can also produce less mtROS. Taken together, our findings provide evidence for an alternative explanation for the involvement of higher mitochondrial activity in prolonging lifespan. We anticipate that similar mechanisms might also exist in eukaryotes including human. [source]

Gender and collective action: motivations, effectiveness and impact

JOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 1 2008
Lauren Pandolfelli
Abstract Gender is often a key determinant of people's abilities to participate in collective action, yet there has been relatively little research on the links between gender and collective action. This article, and the ones that follow in this special issue, explore the intersection of these two fields. We present three entry points for a gendered analysis of collective action: motivations to engage in collective action; effectiveness of collective action (as defined by group objectives and the process by which the group works to meet those objectives); and impact of collective action on gender equity. We discuss each of these themes by highlighting key issues presented in the articles in this special issue. Copyright © 2008 John Wiley & Sons, Ltd. [source]

Water Resources Modeling of the Ganges-Brahmaputra-Meghna River Basins Using Satellite Remote Sensing Data,

JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 6 2009
Bushra Nishat
Nishat, Bushra and S.M. Mahbubur Rahman, 2009. Water Resources Modeling of the Ganges-Brahmaputra-Meghna River Basins Using Satellite Remote Sensing Data. Journal of the American Water Resources Association (JAWRA) 45(6):1313-1327. Abstract:, Large-scale water resources modeling can provide useful insights on future water availability scenarios for downstream nations in anticipation of proposed upstream water resources projects in large international river basins (IRBs). However, model set up can be challenging due to the large amounts of data requirement on both static states (soils, vegetation, topography, drainage network, etc.) and dynamic variables (rainfall, streamflow, soil moisture, evapotranspiration, etc.) over the basin from multiple nations and data collection agencies. Under such circumstances, satellite remote sensing provides a more pragmatic and convenient alternative because of the vantage of space and easy availability from a single data platform. In this paper, we demonstrate a modeling effort to set up a water resources management model, MIKE BASIN, over the Ganges, Brahmaputra, and Meghna (GBM) river basins. The model is set up with the objective of providing Bangladesh, the lowermost riparian nation in the GBM basins, a framework for assessing proposed water diversion scenarios in the upstream transboundary regions of India and deriving quantitative impacts on water availability. Using an array of satellite remote sensing data on topography, vegetation, and rainfall from the transboundary regions, we demonstrate that it is possible to calibrate MIKE BASIN to a satisfactory level and predict streamflow in the Ganges and Brahmaputra rivers at the entry points of Bangladesh at relevant scales of water resources management. Simulated runoff for the Ganges and Brahmaputra rivers follow the trends in the rated discharge for the calibration period. However, monthly flow volume differs from the actual rated flow by (,) 8% to (+) 20% in the Ganges basin, by (,) 15 to (+) 12% in the Brahmaputra basin, and by (,) 15 to (+) 19% in the Meghna basin. Our large-scale modeling initiative is generic enough for other downstream nations in IRBs to adopt for their own modeling needs. [source]

Experience of Severe Acute Respiratory Syndrome in Singapore: Importation of Cases, and Defense Strategies at the Airport

JOURNAL OF TRAVEL MEDICINE, Issue 5 2003
Annelies Wilder-Smith
Background The importation of SARS was responsible for the outbreaks in Singapore, Hong Kong, Vietnam and Canada at a time when this new disease had not been identified. We report the incidence and impact of cases of SARS imported to Singapore between 25 February and 31 May 2003, and describe national measures to prevent further importation. Methods Information on imported cases of SARS and measures taken at entry points to Singapore was retrieved from the Ministry of Health and the Civil Aviation Authority of Singapore. Results Of the 6 imported cases, which all occurred before screening measures were implemented at the airport, only the first resulted in extensive secondary transmission. Of 442,973 air passengers screened after measures were implemented, 136 were sent to a designated hospital for further SARS screening; none was diagnosed as having SARS. Conclusions The SARS outbreak in Singapore can be traced to the first imported case. The absence of transmission from the other imported cases was probably a result of relatively prompt identification and isolation of cases, together with a low potential for transmission. New imported SARS cases therefore need not lead to major outbreaks if systems are in place to identify and isolate them early. Screening at entry points is costly, has a low yield and is not sufficient in itself, but may be justified in light of the major economic, social and international impact which even a single imported SARS case may have. [source]

Nutrient losses from rain-fed bench terraced cultivation systems in high rainfall areas of the mid-hills of Nepal

LAND DEGRADATION AND DEVELOPMENT, Issue 5 2007
G. P. Acharya
Abstract Between the elevations of 1000 and 2000,m in the mid-hills of Nepal, over 12 million people subsist on land-holdings of less than 0·5,ha. These farmers have limited access to commercial inputs such as fertilisers and are reliant on organic manures for soil fertility maintenance. Participatory research was conducted with farmers on bari land (upper slope rain-fed crop terraces) in the hill community of Landruk (bench terraces 0,5° slope, 3000,3500,mm annual rainfall, which aimed to develop soil and water management interventions that controlled erosion without resulting in high leaching, and so were effective in minimising total nutrient losses. Interventions tested were the control of water movement through diversion of run-on and planting fodder grasses on terrace risers on bench terraces. The interventions were effective in reducing soil loss from the bari land in comparison with existing farmer practices, but no effect was observed on nutrient losses in solution form through runoff and leaching. Losses of NO3 -N in leachate ranged from 17·3 to 99·7,kg,ha,1,yr,1, but only 0·7 to 5·6,kg,ha,1,yr,1 in runoff. The overall nutrient balance suggests that the system is not sustainable. Fertility is heavily dependent on livestock inputs and if the current trends of declining livestock numbers due to labour constraints continue, further losses in productivity can be expected. However, farmers are interested in interventions that tie ecosystem services with productivity enhancement and farmers' priorities should be used as entry points for promoting interventions that are system compatible and harness niche opportunities. Copyright © 2007 John Wiley & Sons, Ltd. [source]

Research and Moral Law: Ethics and the Social Science Research Relation

POLAR: POLITICAL AND LEGAL ANTHROPOLOGY REVIEW, Issue 2 2007
Amy Swiffen
This paper explores the ethics of social science research by taking the Canadian context as a case study of the increasing formalization of ethics review procedures in North America. Based on a biomedical model of harm prevention, all university research involving humans in Canada, regardless of discipline, must pass through an ethics board review. I read the official ethics policy document governing review procedures for human research in Canada and use two examples of criticism of such policy as entry points to identify and explore a limit in understandings of social research ethics. This limit is reached when ethics policy is criticized on the basis of the incompatibility of a general rule applied to a particular research situation. Using concepts from the ethical philosophies of Kant and Lacan, I move beyond the question of the application of general rules to particular research situations and push research ethics into different territory, where neither general rules nor the notion of particularity can be relied on to ground ethical action. In this other terrain, radical responsibility and unguaranteed decision are the only signposts. [source]

Investigating the surface process response to fault interaction and linkage using a numerical modelling approach

BASIN RESEARCH, Issue 3 2006
P.A. Cowie
ABSTRACT In order to better understand the evolution of rift-related topography and sedimentation, we present the results of a numerical modelling study in which elevation changes generated by extensional fault propagation, interaction and linkage are used to drive a landscape evolution model. Drainage network development, landsliding and sediment accumulation in response to faulting are calculated using CASCADE, a numerical model developed by Braun and Sambridge, and the results are compared with field examples. We first show theoretically how the ,fluvial length scale', Lf, in the fluvial incision algorithm can be related to the erodibility of the substrate and can be varied to mimic a range of river behaviour between detachment-limited (DL) and transport-limited (TL) end-member models for river incision. We also present new hydraulic geometry data from an extensional setting which show that channel width does not scale with drainage area where a channel incises through an area of active footwall uplift. We include this information in the coupled model, initially for a single value of Lf, and use it to demonstrate how fault interaction controls the location of the main drainage divide and thus the size of the footwall catchments that develop along an evolving basin-bounding normal fault. We show how erosion by landsliding and fluvial incision varies as the footwall area grows and quantify the volume, source area, and timing of sediment input to the hanging-wall basin through time. We also demonstrate how fault growth imposes a geometrical control on the scaling of river discharge with downstream distance within the footwall catchments, thus influencing the incision rate of rivers that drain into the hanging-wall basin. Whether these rivers continue to flow into the basin after the basin-bounding fault becomes fully linked strongly depends on the value of Lf. We show that such rivers are more likely to maintain their course if they are close to the TL end member (small Lf); as a river becomes progressively more under supplied, i.e. the DL end member (large Lf), it is more likely to be deflected or dammed by the growing fault. These model results are compared quantitatively with real drainage networks from mainland Greece, the Italian Apennines and eastern California. Finally, we infer the calibre of sediments entering the hanging-wall basin by integrating measurements of erosion rate across the growing footwall with the variation in surface processes in space and time. Combining this information with the observed structural control of sediment entry points into individual hanging-wall depocentres we develop a greater understanding of facies changes associated with the rift-initiation to rift-climax transition previously recognised in syn-rift stratigraphy. [source]