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Distribution by Scientific Domains

Medical Sciences	33%
Life Sciences	19%
Business, Economics, Finance and Accounting	14%
Chemistry	13%
Humanities and Social Sciences	7%
Psychology	2%
Engineering	2%
7 Other Domains	10%

Kinds of Entry

computerized physician order entry

extracellular ca2+ entry

physician order entry

Terms modified by Entry

Selected Abstracts

TRIGGER-POINT MECHANISM AND CONDITIONAL COMMITMENT: IMPLICATIONS FOR ENTRY, COLLUSION, AND WELFARE

CONTEMPORARY ECONOMIC POLICY, Issue 2 2007
LARRY D. QIU
When fixed, sunk investment costs are high, firms may not have sufficient incentive to enter the market unless future entry is constrained. In this case, the government faces a dilemma between a full commitment and noncommitment of restricted future entry. A way out is to consider a commitment conditional on the realization of the uncertain parameters, such as the trigger-point mechanism (TPM) that sets conditions on current production level, excess capacity, and demand growth under which future entry will be allowed. This article shows that the TPM facilitates the incumbents' collusion but may improve social welfare under certain circumstances. (JEL L13, L43, L50, H10, H54) [source]

ENTRY AND EXIT OF LABOR AND CAPITAL IN A FISHERY

NATURAL RESOURCE MODELING, Issue 2 2005
ASGEIR DANIELSSON
ABSTRACT. Exit and entry of fishermen, as well as vessels, is modeled explicitly. If the speed of exit and entry of fishermen is less than instantaneous the wage rate varies with the fortunes of the fishing firms and affects the endogenous labor supply creating a second transmission mechanism from profits to effort. There are realistic cases where this mechanism has important effects on the stability of the dynamic system and on the effects of taxes (subsisdies) on the size of the fish stock. If labor supply depends negatively on the wage rate, the immediate effect of an increase in the tax rate is to increase effort and harvest. This condition makes it also more probable that the dynamic system is unstable. In those cases where the dynamic system is unstable the increase in the tax rate increases overexploitation not only in the short-term but also in the long-term. [source]

RAISING WAGES TO DETER ENTRY INTO UNIONIZED MARKETS,

THE JAPANESE ECONOMIC REVIEW, Issue 4 2009
SHINGO ISHIGURO
This paper investigates entry under a unionized oligopoly when entry and wage negotiations are sequential. We find the incumbent has incentives to raise the wage, which strengthens the bargaining position of the union relative to the entrant at subsequent negotiations and thus discourages entry. We show that entry is more likely to be deterred (accommodated) if the union is wage (employment) oriented and that raising unemployment compensation during recession not only reduces the burden of the unemployed but also induces new entry, creating more employment opportunities. However, during a business boom, reducing unemployment compensation is a better policy. [source]

DISTANCE, BANK HETEROGENEITY AND ENTRY IN LOCAL BANKING MARKETS,

THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 3 2008
ROBERTO FELICI
We examine the determinants of entry into Italian local banking markets during the period 1991,2002 and build a simple model in which the probability of branching in a new market depends on the features of both the local market and the potential entrant. Econometric findings show that banks are more likely to expand into those markets that are closest to their pre-entry locations. Large banks are also more able to cope with distance-related entry costs than small banks. Finally, banks have become increasingly able to open branches in distant markets, due to the advent of information and communication technologies. [source]

THE ROLE OF DIFFERENTIATION STRATEGY IN LOCAL TELECOMMUNICATION ENTRY AND MARKET EVOLUTION: 1999,2002,

THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 3 2006
SHANE GREENSTEIN
We examine the role of differentiation among competitive local exchange carriers (CLECs) in nearly 1,200 U.S. cities in 1999 and 2002, before and after a valuation crash affecting communications firms. We test and reject the null hypothesis of homogeneous competitors. We also find strong evidence that differentiated CLECs account for both potential market demand and the business strategies of competitors when making their entry decisions. Finally, product heterogeneity in markets in 1999 helps predict how the structure of markets evolved through 2002. We conclude that the policy debate for local telecommunications regulation should account for differentiated behavior. [source]

Creating Early Success in Financial Accounting: Improving Performance on Adjusting Journal Entries,

ACCOUNTING PERSPECTIVES, Issue 2 2010
FRED PHILLIPS
cognition; écritures comptables; formation; intervention Abstract Adjusting journal entries constitute a necessary component of accrual basis accounting and are critical to the accuracy of financial statements. However, accounting students often struggle to comprehend these accounting entries, which is a concern given that failure to understand early topics in accounting courses has been found to impact course performance and selection of undergraduate major. Perceiving accounting as a language, we utilize psycholinguistic theory to understand how an instructor may improve coherence of students' mental structures of accounting problems. We conduct an experiment to investigate the extent to which a simple instructor intervention, requiring that the initial deferral transaction be recorded, is able to improve student performance on the subsequent deferral adjustments, and whether this improvement is consistent across problem sets that differ in task difficulty. Consistent with our theoretical prediction, we find that this intervention results in improved performance. The beneficial effect of the intervention is found to differ across problem-set task difficulty. Implications for accounting education are discussed. Favoriser dès le départ la réussite en comptabilité générale en améliorant la qualité des écritures de régularisation Résumé Les écritures de régularisation font partie intégrante de la comptabilité d'exercice et sont indispensables à l'exactitude des états financiers. Or, les étudiants en comptabilitééprouvent souvent de la difficultéà comprendre ces écritures comptables, observation préoccupante puisque la méconnaissance de notions élémentaires des cours de comptabilité influe, a-t-on constaté, sur la réussite des cours et le choix d'une majeure au premier cycle. Envisageant la comptabilité comme un langage, les auteurs ont recours à la théorie de la psycholinguistique pour déterminer comment un enseignant peut améliorer la cohérence des structures mentales avec lesquelles les étudiants abordent des problèmes comptables. Ils se livrent à une expérience dans laquelle ils analysent dans quelle mesure la simple intervention de l'enseignant, exigeant la comptabilisation initiale d'une opération de report, peut améliorer la performance de l'étudiant en ce qui a trait aux ajustements de report subséquents, et si cette amélioration demeure constante dans des problématiques où la difficulté de la tâche diffère. Conformément à leur prévision théorique, les auteurs constatent que cette intervention entraîne une amélioration de la performance. Ils observent que l'effet bénéfique de cette intervention diffère selon la difficulté de la tâche associée à la problématique. Enfin, ils analysent les conséquences de ces observations pour la formation comptable. [source]

Welfare transitions in the 1990s: The economy, welfare policy, and the EITC

JOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 4 2004
Jeffrey GroggerArticle first published online: 25 AUG 200
The rapid decline in the welfare caseload remains a subject of keen interest to both policymakers and researchers. In this paper, I use data from the Survey of Income and Program Participation spanning the period from 1986 to 1999 to analyze how the economy, welfare reform, the earned income tax credit (EITC), and other factors influence welfare entries and exits, which in turn affect the caseload. I find that the decline in the welfare caseload resulted from both increases in exits and decreases in entries. Entries were most significantly affected by the economy, the decline in the real value of welfare benefits, and the expansion of the EITC. Exits were most significantly affected by the economy and federal welfare reform. Federal reform had its greatest effects on longer-term spells of the type generally experienced by more disadvantaged recipients. Some out-of-sample predictions help explain the otherwise puzzling observation that, despite substantial increases in the unemployment rate since 2000, caseloads have remained roughly constant. © 2004 by the Association for Public Policy Analysis and Management [source]

Entries in the Leiden Duchenne muscular dystrophy mutation database: An overview of mutation types and paradoxical cases that confirm the reading-frame rule

MUSCLE AND NERVE, Issue 2 2006
Annemieke Aartsma-Rus PhD
Abstract The severe Duchenne and milder Becker muscular dystrophy are both caused by mutations in the DMD gene. This gene codes for dystrophin, a protein important for maintaining the stability of muscle-fiber membranes. In 1988, Monaco and colleagues postulated an explanation for the phenotypic difference between Duchenne and Becker patients in the reading-frame rule: In Duchenne patients, mutations induce a shift in the reading frame leading to prematurely truncated, dysfunctional dystrophins. In Becker patients, in-frame mutations allow the synthesis of internally deleted, but largely functional dystrophins. Currently, over 4700 mutations have been reported in the Leiden DMD mutation database, of which 91% are in agreement with this rule. In this study we provide an update of the mutational variability in the DMD gene, particularly focusing on genotype,phenotype correlations and mutations that appear to be exceptions to the reading-frame rule. Muscle Nerve, 2006 [source]

Alphabetical Listing of All Yearbook Entries

POLICY STUDIES JOURNAL, Issue 2009
Article first published online: 23 FEB 200
First page of article [source]

Latest news and product developments

PRESCRIBER, Issue 17 2007
Article first published online: 6 NOV 200
Drug information stilllacking for mentally ill Half of people with mental illness still have no say in the medication they are prescribed and one-third are not informed about side-effects, according to the latest report by the Healthcare Commission and the Commission for Social Care Inspection (www.health-carecommission.org.uk). The annual national review of adult mental health services found overall improvement among local intervention teams in 2005/06 compared with the preceding year, though all could improve further and the performance of 46 per cent were rated as only fair or weak. A survey of 7446 people with schizophrenia also showed that only 46 per cent had access to psychological treatments. More incentives for shift of care in Scotland Scotland has made good progress on shifting NHS care into the community but joined-up thinking, better information and incentives are needed to overcome barriers to better management of long-term conditions in adults, says Audit Scotland (www.audit-scotland.gov.uk). Reviewing progress on the 2005 strategy document Delivering for Health, Audit Scotland found good progress on asthma and diabetes services , partly due to the effects of the GMS contract. Better information about clinical activity, costs and effectiveness is needed to help redesign services. Patients with more than one long-term condition do not receive co-ordinated care and many want greater involvement in their care, the report concluded. Acorn, QOF and Guy Rotherham awards Entries are invited for the 2007 annual Acorn, QOF and Guy Rotherham Awards. The awards are run in association with the NHS Alliance, Improvement Foundation, British Cardiac Society, British Cardiac Patients Society and Prescriber. The CHD QOF Award, sponsored by Schering-Plough, recognises the achievement of an individual practice that gains maximum points in the CHD and heart failure QOF domains, and a second award is given to the primary care organisation (PCO) that achieves the best average scores across its practices. The entry form can be found at www.escriber.com. The closing date is 12 October. Entries are also invited for the Guy Rotherham Award from PCOs that can demonstrate they have delivered a high-impact change resulting in better outcomes and services for patients. For online entry go to www.improvementfoundation.org/guy rotherhamaward. Closing date is 5 October. Award winners will receive free entry for three to the NHS Alliance conference and the conference dinner. The winner of the Guy Rotherham Award will also receive £3000. NICE scores five out of six NICE acted unreasonably in relying solely on the Mini-Mental State Examination (MMSE) to define severity of Alzheimer's disease in its updated technology appraisals, with the effect of discriminating against people with learning or language difficulties, the High Court has ruled. The five other claims by Eisai that NICE acted unreasonably and irrationally were not upheld. This was the first court action against NICE in its eight-year history. It has now promised to publish revised appraisals on its website on 7 September and is consulting with Eisai, Shire Pharmaceuticals and the Alzheimer's Society on the best approach. PPRS reform follows Office of Fair Trading report The Government is to renegotiate the Pharmaceutical Price Regulation Scheme (PPRS) following the critical report by the Office of Fair Trading (OFT). In February, the OFT recommended renegotiation of the PPRS to reward innovation and obtain better value for patients. In particular, it called for a pricing scheme based on value for patients, ie effectiveness, rather than profit controls. The DoH, acknowledging the report's complexity, says it will take four principles into account in its negotiations during the forthcoming months: value for money, promoting innovation, assisting the uptake of new cost-effective medicines and promoting market stability. MHRA launches e-bulletin The MHRA (www.mhra.gov.uk) has next issue can be downloaded. The launched an electronic bulletin to August bulletin includes items on provide health professionals with antidepressants and suicide, updates about the safe use of medi-adverse effects of dopamine ago-cines. Users need to sign up to nists and information about smokreceive an e-mail alert when the ing cessation and isotretinoin. DURG call for abstracts The Drug Utilisation Research Group is calling for abstracts for its 19th annual meeting ,Target-driven medicine , is this the end of prescribing freedom?' to be held on 7 February 2008 at the Royal Society of Medicine, London. Abstracts are requested on any aspects of drug utilisation research. A bursary of £500 will be awarded for the best abstract received. The closing date for receipt of abstracts is 26 November. Further information about abstract submission is available at www.durg.org.uk. GP prescribing up by half Prescription volume and costs in England increased by approximately half over the decade to 2006, according to data published by the Information Centre for Health and Social Care (www.ic.nhs.uk). The number of items dispensed per year increased by 55 per cent and the cost by 60 per cent in real terms. The average number of items per head of population was 10.0 in 1996 and 14.8 in 2006; older people received 21.2 items per head in 1996 but 40.8 in 2006. MR morphines similar Modified-release preparations of morphine are equivalent in the treatment of severe pain, according to a new review by Bandolier (www.jr2.ox.ac.uk). The analysis of 54 randomised trials, which reviewed the release mechanisms and clinical data for four brands, showed these preparations provide effective analgesia for malignant and nonmalignant pain; about 4 per cent of patients were unable to tolerate the adverse effects of morphine. NSAIDs compared in OA Etoricoxib (Arcoxia) and naproxen are equally effective in the long-term treatment of osteoarthritis (Ann Rheum Dis 2007;66:945,51). Extension studies for two one-year trials showed that, after a total of 138 weeks, the two drugs had almost identical effects on pain and function assessments. All treatments were generally well tolerated, but serious cardiovascular effects were more common with etoricoxib and serious GI effects more common with naproxen. CPN nystatin allowed Community practitioner nurses (CPNs) may now prescribe oral nystatin (Nystan) to treat oral thrush in neonates, following a special amendment to the regulations limiting their prescribing to licensed indications. CPNs may now prescribe oral nystatin at the dose recommended in the BNF for Children provided they are sure of the diagnosis. In doing so, they accept clinical and medicolegal responsibility for their actions. There are no other exceptions to the prohibition of off-label prescribing. Copyright © 2007 Wiley Interface Ltd [source]

Quality of clinical notes for vascular surgery admissions: A CRABEL score review

ANZ JOURNAL OF SURGERY, Issue 7-8 2009
Jun Suh
Abstract Aim:, To compare the quality of patient notes between acute and elective admissions in vascular surgery. Method:, Patient notes from the 50 most recent acute and elective admissions on a vascular surgical unit were reviewed using the CRABEL score. Points for quality of record keeping were awarded in four categories: Initial Clerking, Subsequent Entries, Consent and Discharge Summary. Total scores were calculated as a percentage. One hundred per cent represents the minimum quality standard expected. Overall CRABEL scores were compared for differences in the quality of note keeping between acute and elective admissions. Further analysis identified areas that need improvement. Results:, The mean CRABEL score for acute admissions was 79.2% (77.0,81.3, 95% C.I.) compared to 81.3% (78.8,83.8, 95% C.I.) for elective admissions (t -test P= n.s.). When the individual categories were analysed no statistically significant difference was observed between the two groups for ,Subsequent Entries' and ,Consent' sections (t -test p= n.s.). ,Initial Clerking' category scored significantly better for elective 16.3 out of 20 (15.7,16.9, 95% C.I.) admissions compared to acute admissions 14.6 out of 20 (13.9,15.3, 95% C.I.), (t -test P= 0.00063). ,Discharge Summary' section also scored significantly better for elective admissions 9.9 out of 10 (9.9,10.0, 95% C.I.) compared to acute admissions 9.6 out of 10 (9.3,9.9, 95% C.I.), (t -test P= 0.040). Conclusion:, There was no statistically significant difference in the overall quality of written patient notes between acute and elective admissions, however ,Initial Clerking' and ,Discharge Summary' were better documented for elective admissions. Both acute and elective admissions were observed to have substandard quality of record keeping. [source]

Making the Most of Theatre and Painting: The Power of Tableaux Vivants in Joyous Entries from the Southern Netherlands (1458,1635)

ART HISTORY, Issue 2 2010
Stijn Bussels
First page of article [source]

3-Bromopropenyl Esters in Organic Synthesis: Indium- and Zinc-Mediated Entries to Alk-1-ene-3,4-diols.

CHEMINFORM, Issue 25 2003
Marco Lombardo
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Quality of clinical notes for vascular surgery admissions: A CRABEL score review

Density-mediated responses of bark beetles to host allelochemicals: a link between individual behaviour and population dynamics

ECOLOGICAL ENTOMOLOGY, Issue 4 2002
Kimberly F. Wallin
Abstract ,1. Bark beetles (Coleoptera: Scolytidae) accept or reject host conifers based partly on concentrations of phloem monoterpenes. They colonise trees in aggregations, in response to pheromones that attract flying beetles to trees undergoing colonisation. A series of entry and gallery construction assays was conducted to determine whether responses by individual beetles to monoterpenes are altered by pheromones and/or the presence of other beetles. 2. Entry into the amended media by Ips pini and the length of time until entry were not influenced by the presence of aggregation pheromones. 3. Entry into amended media was influenced by the presence of other beetles on the surface of, or constructing galleries in, the substrate. The effects of alpha-pinene and limonene on host entry behaviour were mediated by the density of beetles on the surface of the assay arena, and by the density of beetles constructing galleries within the medium. 4. The percentage of beetles entering medium amended with higher concentrations of monoterpenes increased with increased density of beetles on the surface of the assay arena, until a threshold density of three or four beetles per assay arena, after which entrance rate declined. 5. The presence of other beetles constructing galleries elicited more rapid entry by the test beetles. 6. Gallery lengths were generally higher in the presence of aggregation pheromones. 7. Gallery lengths increased with increased density of beetles within the assay arena. 8. These results suggest a link between the density of bark beetles and responses of individuals. This linkage may partially explain behavioural changes observed during population eruptions. [source]

The Impact of Trade on Intra-Industry Reallocations and Aggregate Industry Productivity

ECONOMETRICA, Issue 6 2003
Marc J. Melitz
This paper develops a dynamic industry model with heterogeneous firms to analyze the intra-industry effects of international trade. The model shows how the exposure to trade will induce only the more productive firms to enter the export market (while some less productive firms continue to produce only for the domestic market) and will simultaneously force the least productive firms to exit. It then shows how further increases in the industry's exposure to trade lead to additional inter-firm reallocations towards more productive firms. The paper also shows how the aggregate industry productivity growth generated by the reallocations contributes to a welfare gain, thus highlighting a benefit from trade that has not been examined theoretically before. The paper adapts Hopenhayn's (1992a) dynamic industry model to monopolistic competition in a general equilibrium setting. In so doing, the paper provides an extension of Krugman's (1980) trade model that incorporates firm level productivity differences. Firms with different productivity levels coexist in an industry because each firm faces initial uncertainty concerning its productivity before making an irreversible investment to enter the industry. Entry into the export market is also costly, but the firm's decision to export occurs after it gains knowledge of its productivity. [source]

The Impact of Shocks on the UK Economy in and Out of EMU

ECONOMIC OUTLOOK, Issue 4 2002
Article first published online: 16 DEC 200
Entry to EMU at an inappropriate exchange rate could trigger a full-blown business cycle in the UK. Once inside EMU, the UK's response to a number of different economic shocks would change , partly because of the fixed exchange rate, and partly because of the common monetary policy. In particular, when an asymmetric shock occurs , one that hits the UK harder than other Eurozone economies , the UK response is generally likely to be more pronounced inside EMU than outside. We find that that result still applies even in a reformed EMU , one in which the ECB and the labour market are reformed to bring them closer to the Anglo,Saxon model. [source]

The Impact of Interorganizational Imitation on New Venture International Entry and Performance

ENTREPRENEURSHIP THEORY AND PRACTICE, Issue 1 2010
Stephanie A. Fernhaber
We examine the impact of interorganizational imitation on new venture international entry and subsequent performance. Using a sample of 150 U.S.-based publicly held new ventures, we find that new venture international entry is in part an imitative response to the internationalization of other firms in the venture's home country industry and/or subsets of firms with certain traits or outcomes. We also find that interorganizational imitation moderates the relationship between new venture international entry and profitability, but not the relationship between new venture international entry and sales growth. These findings contribute to the growing body of literature on new venture internationalization. [source]

Entrepreneurial Founder Teams: Factors Associated with Member Entry and Exit

ENTREPRENEURSHIP THEORY AND PRACTICE, Issue 2 2003
Deniz Ucbasaran
This exploratory study provides a review of the neglected area of entrepreneurial founder team turnover. A novel distinction is made between entrepreneurial founder team member entry and team member exit. Ninety owner-managed ventures were monitored between 1990 and 2000. Presented hypotheses relating to a team's human capital were explored using multivariate logistic regression analysis. Variables associated with entry were found not to be the same as those associated with exit. The size of the founding team was significantly negatively associated with subsequent team member entry. The link between team turnover and entrepreneurial team heterogeneity was mixed. Functional heterogeneity was weakly significantly positively associated with team member entry. Heterogeneity of prior entrepreneurial experience was significantly positively associated with team member exit. In addition, family firms were significantly negatively associated with team member exit. The average age of the team was not significantly associated with team member entry or exit. Additional insights in future research may be gathered if a broader definition of team turnover (i.e., considering team member entry and exit) is considered. Practitioner awareness of the different factors associated with team member entry and exit may encourage them to provide assistance, which facilitates the team building process over time in developing firms. Promising areas for additional research are highlighted. [source]

Mechanisms and consequences of bladder cell invasion by uropathogenic Escherichia coli

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 2008
B. K. Dhakal
ABSTRACT Strains of uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections worldwide. Multiple studies over the past decade have called into question the dogmatic view that UPEC strains act as strictly extracellular pathogens. Rather, bacterial expression of filamentous adhesive organelles known as type 1 pili and Afa/Dr fibrils enable UPEC to invade host epithelial cells within the urinary tract. Entry into bladder epithelial cells provides UPEC with a protected niche where the bacteria can persist quiescently for long periods, unperturbed by host defences and protected from many antibiotic treatments. Alternately, internalized UPEC can rapidly multiply, forming large intracellular inclusions that can contain several thousand bacteria. Initial work aimed at defining the host and bacterial factors that modulate the entry, intracellular trafficking, and eventual resurgence of UPEC suggests a high degree of host-pathogen crosstalk. Targeted disruption of these processes may provide a novel means to prevent and treat recurrent, relapsing and chronic infections within the urinary tract. [source]

Dental school admissions in Ireland: can current selection criteria predict success?

EUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 2 2006
C. D. Lynch
Introduction:, Entry into university education in Ireland, including dental school, is based solely on academic performance in the Leaving Certificate Examination, held at the end of formal school education. The aim of this investigation was to examine the suitability of this process for the selection of dental students in Ireland. Materials and methods:, Information for all dental students who entered the dental degree programme immediately following completion of the Leaving Certificate Examination at the National University of Ireland, Cork, during the years 1997,1999 was retrieved. Information was collected relating to gender, the number of times the student had attempted the Leaving Certificate Examination, their performance in this examination, the total number of marks awarded to each student at the end of the First and Final Dental Examinations, and their performance in individual modules. Results:, Whilst there was a significant relationship between performance in the Leaving Certificate Examination and the First Dental Examination (correlation coefficient = 0.22, P < 0.05), this relationship could only explain 12% of the variation within the performance of students in this examination. There was no relationship between performance in the Leaving Certificate and the Final Dental Examination (correlation coefficient = 0.09, P > 0.05). There was a significant correlation between performance in the Leaving Certificate Examination and performance in seven of the 55 programme modules, all of which were pre-clinical modules, and of which five were related to basic sciences. Conclusions:, Based on the limitations of this study, the current selection process for dental students in Ireland seems to be of limited value. [source]

Synthesis of 3-(Tosylalkyl)indazoles and their Desulfonylation Reactions , A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel,Crafts Process

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 19 2009
Silvia Campetella
Abstract Reaction of indazoles with aldehydes in the presence of p -toluenesulfinic acid affords the corresponding sulfonyl indazoles in satisfactory yields. The reported Friedel,Crafts process is rather unusual on indazoles because of the reduced electronic density of the heterocycle. The obtained sulfonyl indazoles can be desulfonylated under reductive conditions, finally leading to 3-alkylated indazoles.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]

Sequential 1,3-Dipolar Cycloaddition of Nitrones to ,-(2-Aminophenyl) ,,,-Ynones and Cyclocondensation: A New Entry to the Isoxazolino[4,5- c]quinoline Ring

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 7 2009
Giorgio Abbiati
Abstract The reaction of ,-(2-aminophenyl) ,,,-ynones with N -methyl nitrones provides a simple and efficient entry to the isoxazolino[4,5- c]quinoline ring system through a sequential 1,3-dipolar cycloaddition/annulation process. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]

Highly Stereoselective Metal-Mediated Entry to Functionalized Tetrahydrothiophenes by Barbier-Type Carbonyl-Addition Reactions

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 15 2008
Benito Alcaide
Abstract Reactions of tetrahydrothiophene-3-carbaldehydes with stabilized organometallic reagents were investigated in aqueous media. Tetrahydrothiophene-3-carbaldehydes and a variety of stabilized organic halides undergo stereocontrolled coupling under Barbier-type conditions in the presence of different metals (zinc, tin, indium) and additives [ammonium chloride, hydrobromic acid, hafnium(IV) chloride, bismuth(III) chloride]. The regiochemistry of the carbonyl addition processes, when applicable, was excellent.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

A New, Expeditious Entry to the Benzophenanthrofuran Framework by a Pd-Catalyzed C - and O -Arylation/PIFA-Mediated Oxidative Coupling Sequence

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 12 2005
Fátima Churruca
Abstract The synthesis of a series of 2,3-diarylbenzo[b]furans starting from 1,2-diarylethanones and 1,2-dibromoarenes proceeds by means of both homogeneous and polymer-anchored palladium catalysts. This tandem process can be effectively halted at the C -arylation step, thus providing key o -bromoarylated deoxybenzoin intermediates in good yields. The efficient oxidative coupling leading to benzo[b]phenanthro[9,10- d]furans is carried out using the safer hypervalent iodine reagent PIFA. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

Silylation-Mediated Transesterification of O -Phenyl H-Phosphonothioates , A New Entry to Nucleoside H-Phosphonothioate Monoesters

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 24 2004
Gaston Lavén
Abstract O -Phenyl H-phosphonothioate undergoes a facile transesterification with suitably protected nucleosides upon in situ silylation with tert -butyldiphenylsilyl chloride in pyridine/ toluene to produce the corresponding 3,-H-phosphonothioates in good yields. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]

A New Entry to Bis-Tröger's Bases

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 5 2004
Thierry Mas
Abstract This paper reports the use of p -phenylenediamine to prepare bis-Tröger's bases. The methyl,nitro-substituted bis-Tröger's base 5, already previously prepared by another procedure, was obtained in fewer steps, although with no improvement in the yield of the desired syn isomer. The symmetric dinitro-substituted bis-Tröger's base 17, which cannot be prepared by the older method, was then synthesized. Its structure was determined by mass spectrometry, 2D NMR spectroscopy, and, in the case of the syn isomer, by X-ray crystallography. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]

Records of Bursaphelenchus spp. intercepted in imported packaging wood at Ningbo, China

FOREST PATHOLOGY, Issue 5 2006
J. Gu
Summary From January 2003 to June 2005, samples from 3416 batches of wooden packaging material were inspected for the presence of nematodes in the Ningbo Entry,Exit Inspection and Quarantine Bureau, China. Bursaphelenchus spp. were detected in 202 batches from 25 different countries. The following species were identified on the basis of their morphology and their intergenic transcribed spacer-restriction fragment length polymorphism (ITS-RFLP) patterns: B. xylophilus, B. fungivorus, B. rainulfi, B. hylobianum, B. thailandae, B. mucronatus, B. aberrans, B. lini, B. singaporensis, B. doui, B. conicaudatus, B. vallesianus, B. pinasteri, B. hofmanni and B. arthuri. The most frequently found species were B. mucronatus (57 batches), B. xylophilus (40 batches), B. fungivorus (21 batches), B. rainulfi (19 batches) and B. thailandae (nine batches). The pine wood nematode B. xylophilus was not only found in packaging wood imported from areas where it is known to occur (i.e. The United States of America, Japan, Korea, Hong Kong and Taiwan), but also from countries considered to be free of this dangerous pest (i.e. Brazil, Thailand, Belgium, The Netherlands, Italy and Spain). The occurrence of B. xylophilus in packaging wood from countries regarded as being free of the nematode can most likely be explained by the global circulation of wooden packaging material among infested and non-infested countries. Our findings emphasize the need to fully implement international standards on phytosanitary treatment of packaging wood, in order to prevent further spread of the pine wood nematode, and the need for careful re-examination of the current heat treatment measures. Résumé De Janvier 2003 à Juin 2005, des échantillons de 3416 lots de matériel d'emballage en bois ont été inspectés pour rechercher la présence de nématodes au bureau de quarantaine de Ningbo, en Chine. Des Bursaphelenchus spp. ont été détectés dans 202 lots en provenance de 25 pays différents. Les espèces suivantes ont été identifiées sur la base de leur morphologie et des profils de restriction de l'ITS: B. xylophilus, B. fungivorus, B. rainulfi, B. hylobianum, B. thailandae, B. mucronatus, B. aberrans, B. lini, B. singaporensis, B. doui, B. conicaudatus, B. vallesianus, B. pinasteri, B. hofmanni, et B. arthuri. Les espèces les plus fréquemment trouvées sont B. mucronatus (57 lots), B. xylophilus (40 lots), B. fungivorus (21 lots), B. rainulfi (19 lots) et B. thailandae (9 lots). Le nématode du pin, B. xylophilus, a été trouvé dans du bois d'emballage en provenance non seulement de zones où sa présence est connue (Etats-Unis, Japon, République de Corée, Hongkong et Taïwan) mais aussi de pays considérés comme indemnes de ce redoutable pathogène (Brésil, Thaïlande, Belgique, Pays-Bas, Italie et Espagne). La présence de B. xylophilus dans du bois d'emballage de pays considérés comme indemnes s'explique probablement par la circulation généralisée de matériel d'emballage en bois entre pays infestés ou non. Nos résultats soulignent la nécessité d'appliquer pleinement les normes de traitement phytosanitaire du bois d'emballage, afin d'éviter une plus grande dissémination du nématode du pin, et de réexaminer de façon approfondie les mesures actuelles de traitement thermique. Zusammenfassung Von Januar 2003 bis Juni 2005 wurde im Quarantäne-Inspektionsbüro in Ningbo, China, das Verpackungsholz von 3416 Sendungen nematologisch untersucht. Bursaphelenchus spp. wurden in 202 Sendungen aus 25 verschiedenen Ländern festgestellt. Folgende Arten wurden morphologisch und mit Hilfe der ITS-RFLP-Methode identifiziert: B. xylophilus, B. fungivorus, B. rainulfi, B. hylobianum, B. thailandae, B. mucronatus, B. aberrans, B. lini, B. singaporensis, B. doui, B. conicaudatus, B. vallesianus, B. pinasteri, B. hofmanni, und B. arthuri. Die am häufigsten gefundenen Arten waren B. mucronatus (57 mal), B. xylophilus (40), B. fungivorus (21), B. rainulfi (19) and B. thailandae (9). Der Quarantäneschädling B. xylophilus wurde nicht nur in Verpackungsholz aus Gebieten mit bekannter Verbreitung des Nematoden (USA, Japan, Republik Korea, Hongkong, Taiwan) gefunden, sondern auch aus Ländern, die als frei vom Kiefernholznematoden gelten (Brasilien, Belgien, Niederlande, Italien, Spanien). Die Feststellung von B. xylophilus in Verpackungsholz aus Nichtbefallsländern kann nur durch Zirkulation des Verpackungsholzes zwischen Befalls- und Nichtbefallsländern erklärt werden. Der mittlere prozentuale Anteil der jegliche Nematoden enthaltenden Packholzproben lag im Zeitraum von Januar 2000 bis August 2005 bei 21,3 %; eine klare Tendenz zur Zu- oder Abnahme war während dieser Jahre nicht erkennbar. Die Befunde unterstreichen die Notwendigkeit der strikten Anwendung international erarbeiteter Standards der phytosanitären Behandlung von Verpackungsholz zur Verhinderung der Verschleppung des Kiefernholznematoden und der Überprüfung der Wirksamkeit der zur Zeit angewandten Maßnahmen. [source]

Delivery of Nucleic Acids through the Controlled Disassembly of Multifunctional Nanocomplexes

ADVANCED FUNCTIONAL MATERIALS, Issue 24 2009
Mahmoud Elsabahy
Abstract In this study, novel pH-responsive polyion complex micelles (PICMs) were developed for the efficient delivery of nucleic acid drugs, such as antisense oligonucleotide (AON) and short interfering RNA (siRNA). The PICMs consisted of a poly(amidoamine) (PAMAM) dendrimer,nucleic acid core and a detachable poly(ethylene glycol)- block -poly(propyl methacrylate- co -methacrylic acid) (PEG- b -P(PrMA- co -MAA)) shell. The micelles displayed a mean hydrodynamic diameter ranging from 50 to 70,nm, a narrow size distribution, and a nearly neutral surface charge. They could be lyophilized without any additives and stored in dried form. Upon redispersion in water, no change in complexation efficiency or colloidal properties was observed. Entry of the micelles into cancers cells was mediated by a monoclonal antibody fragment positioned at the extremity of the PEG segment via a disulfide linkage. Upon cellular uptake and protonation of the MAA units in the acidic endosomal environment, the micelles lost their corona, thereby exposing their positively charged endosomolytic PAMAM/nucleic acid core. When these pH-responsive targeted PICMs were loaded with AON or siRNAs that targeted the oncoprotein Bcl-2, they exhibited a greater transfection activity than nontargeted PICMs or commercial PAMAM dendrimers. Moreover, their nonspecific cytotoxicity was lower than that of PAMAM. The pH-responsive PICMs reported here appear as promising carriers for the delivery of nucleic acids. [source]

Trade Policies for Exporting Industries under Free Entry

GERMAN ECONOMIC REVIEW, Issue 4 2001
Roberto A. De Santis
This paper computes optimal export taxes and domestic production subsidies for exporting industries under free entry. We show that domestic welfare is not at maximum, as is typically believed, when the export price is a monopoly price, and the domestic price is a competitive price, because a market structure effect has to be taken into account. Furthermore, we show that the optimal tax/subsidy formulas for an oligopoly coincide with those under perfect competition, if foreign and domestic demand functions are both linear. We also discuss optimal trade policies when only one instrument is available, and we run numerical simulations to determine and compare optimal trade taxes under endogenous and exogenous market structures. [source]