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Enantioselective Total Synthesis (enantioselective + total_synthesis)
Selected AbstractsEnantioselective Total Syntheses of the Cyclotryptamine Alkaloids Hodgkinsine (I) and Hodgkinsine B (II).CHEMINFORM, Issue 38 2003Jeremy J. Kodanko No abstract is available for this article. [source] Enantioselective Total Synthesis of the Marine Toxin (,)-Gymnodimine Employing a Barbier-Type Macrocyclization,ANGEWANDTE CHEMIE, Issue 40 2009Ke Kong Exoten des Meeres: tert -Butyllithium vermittelt bei Umgebungstemperatur eine Barbier-Makrocyclisierung in der ersten Totalsynthese von (,)-Gymnodimin (Ts: Toluol-4-sulfonyl; TBS: tert -Butyldimethylsilyl), einem marinen Toxin aus der Familie der spirocyclischen Imine. Die Synthese enthält außerdem eine vinyloge Mukaiyama-Aldolreaktion zur Kupplung der labilen Butenolidgruppe an eine makrocyclische Keton-Zwischenstufe. [source] ChemInform Abstract: The Pauson,Khand Reaction as a New Entry to the Synthesis of Bridged Bicyclic Heterocycles: Application to the Enantioselective Total Synthesis of (-)-Alstonerine (X).CHEMINFORM, Issue 7 2009Kenneth A. Miller Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Concise, Enantioselective Total Synthesis of (-)-Alstonerine.CHEMINFORM, Issue 31 2007Kenneth A. Miller Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Enantioselective Total Synthesis of (2R,3R,6R)-N-Methyl-6- (deca-1,,3,,5,-trienyl)-3-methoxy-2-methylpiperidine, an Insecticidal Alkaloid.CHEMINFORM, Issue 21 2006Yusuke Nakatani Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Enantioselective Total Synthesis of Isoedunol (I) and ,-Araneosene (II) Featuring Unconventional Strategy and Methodology.CHEMINFORM, Issue 9 2006Jason S. Kingsbury Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Exploiting the Pd- and Ru-Catalyzed Cycloisomerizations: Enantioselective Total Synthesis of (+)-Allocyathin B2.CHEMINFORM, Issue 48 2005Barry M. Trost Abstract For Abstract see ChemInform Abstract in Full Text. [source] An Intramolecular Diels,Alder Approach to the Eunicelins: Enantioselective Total Synthesis of Ophirin B.CHEMINFORM, Issue 51 2004Michael T. Crimmins No abstract is available for this article. [source] Enantioselective Total Synthesis of Erogorgiaene: Applications of Asymmetric Cu-Catalyzed Conjugate Additions of Alkylzincs to Acyclic Enones.CHEMINFORM, Issue 24 2004Richard R. III Cesati No abstract is available for this article. [source] First Enantioselective Total Synthesis of (-)-Heliannuol C.CHEMINFORM, Issue 9 2004Tomoyo Kamei Abstract For Abstract see ChemInform Abstract in Full Text. [source] Enantioselective Total Synthesis of Aspidophytine.CHEMINFORM, Issue 38 2003Shinjiro Sumi No abstract is available for this article. [source] Short, Enantioselective Total Synthesis of Okaramine N.CHEMINFORM, Issue 36 2003Phil S. Baran No abstract is available for this article. [source] ChemInform Abstract: First Enantioselective Total Synthesis of (-)-Tejedine.CHEMINFORM, Issue 49 2002You-Chu Wang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Stereoselective Synthesis of Substituted ,-Butyrolactones by the [3 + 2] Annulation of Allylic Silanes with Chlorosulfonyl Isocyanate: Enantioselective Total Synthesis of (+)-Blastmycinone.CHEMINFORM, Issue 27 2001Zhi-Hui Peng Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Enantioselective Total Synthesis of Brevetoxin A: Convergent Coupling Strategy and CompletionCHEMISTRY - A EUROPEAN JOURNAL, Issue 36 2009Michael Abstract A highly convergent, enantioselective total synthesis of brevetoxin A is reported. The development of a [X+2+X] Horner,Wadsworth,Emmons/cyclodehydration/reductive etherification convergent coupling strategy allowed a unified approach to the synthesis of two advanced tetracyclic fragments from four cyclic ether subunits. The Horner,Wittig coupling of the two tetracyclic fragments provided substrates that were explored for reductive etherification, the success of which delivered a late-stage tetraol intermediate. The tetraol was converted to the natural product through an expeditious selective oxidative process followed by methylenation. [source] Organocatalytic Approach to Benzofused Nitrogen-Containing Heterocycles: Enantioselective Total Synthesis of (+)-AngustureineCHEMISTRY - A EUROPEAN JOURNAL, Issue 32 2008Santos Fustero Prof. Simply selective: The organocatalytic intramolecular aza-Michael reaction (IMAMR) was employed as an enantioselective tool to generate enantiomerically enriched isoindolines, indolines, tetrahydroquinolines, and tetrahydroisoquinolines from o -substituted alkylidenes, anilines and benzylamines (see scheme). The methodology was applied to the synthesis of the natural product (+)-Angustureine. [source] Enantioselective Total Synthesis of Brevetoxin A: Convergent Coupling Strategy and CompletionCHEMISTRY - A EUROPEAN JOURNAL, Issue 36 2009Michael Abstract A highly convergent, enantioselective total synthesis of brevetoxin A is reported. The development of a [X+2+X] Horner,Wadsworth,Emmons/cyclodehydration/reductive etherification convergent coupling strategy allowed a unified approach to the synthesis of two advanced tetracyclic fragments from four cyclic ether subunits. The Horner,Wittig coupling of the two tetracyclic fragments provided substrates that were explored for reductive etherification, the success of which delivered a late-stage tetraol intermediate. The tetraol was converted to the natural product through an expeditious selective oxidative process followed by methylenation. [source] Total Synthesis of Potent Antitumor Agent (,)-Lasonolide,A: A Cycloaddition-Based StrategyCHEMISTRY - AN ASIAN JOURNAL, Issue 10 2008Abstract A detailed account of the enantioselective total synthesis of (,)-lasonolide,A is described. Our initial synthetic route to the top tetrahydropyran ring involved Evans asymmetric alkylation as the key step. Initially, we relied on the diastereoselective alkylation of an ,-alkoxyacetimide derivative containing an ,, stereogenic center and investigated such an asymmetric alkylation reaction. Although alkylation proceeded in good yield, the lack of diastereoselectivity prompted us to explore alternative routes. Our subsequent successful synthetic strategies involved highly diastereoselective cycloaddition routes to both tetrahydropyran rings of lasonolide,A. The top tetrahydropyran ring was constructed stereoselectively by an intramolecular 1,3-dipolar cycloaddition reaction. The overall process constructed a bicyclic isoxazoline, which was later unravelled to a functionalized tetrahydropyran ring as well as a quaternary stereocenter present in the molecule. The lower tetrahydropyran ring was assembled by a Jacobsen catalytic asymmetric hetero-Diels,Alder reaction as the key step. The synthesis also features a Lewis acid catalyzed epoxide opening to form a substituted ether stereoselectively. [source] |