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Effective Values (effective + value)

Distribution by Scientific Domains

Physics and Astronomy	50%

Selected Abstracts

Variability in non-nucleoside reverse transcriptase and protease inhibitor concentrations among HIV-infected adults in routine clinical practice

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Issue 5 2006
José Moltó
What is already known about this subject ,,The concentration of protease and non-nucleoside reverse transcriptase inhibtors in plasma has been related to both efficacy and toxicity. ,,Most antiretroviral concentration data come from selected populations of patients undergoing therapeutic drug monitoring programmes, which may overestimate interindividual variability. What this study adds ,,Our study has demonstrated the large interindividual variability in antiretroviral drug concentrations in an unselected population of patients during routine clinical practice. ,,These results may provide interesting information to clinicians for the management of antiretroviral therapy in HIV-infected patients. Aims The objective of this study was to assess interindividual variability in trough concentrations of plasma of non-nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) among HIV-infected adults in a routine outpatient setting. Methods One hundred and seventeen patients who attended our clinic for routine blood tests, and who were receiving antiretroviral therapy which included NNRTI or PI were studied. Patients were not informed that drug concentrations were going to be measured until blood sampling. The times of the last antiretroviral dose and of blood sampling were recorded. Drug concentrations were considered optimal if they were above the proposed minimum effective value. In addition, efavirenz, nevirapine and atazanavir concentrations were considered potentially toxic if they were >,4.0 mg l,1, >,6.0 mg l,1 and >,0.85 mg l,1, respectively. Results Overall, interindividual variability of NNRTI and PI concentrations in plasma was approximately 50%, and only 68.4% of the patients had drug concentrations within the proposed therapeutic range. Poor adherence explained only 35% of subtherapeutic drug concentrations. Conclusion Interindividual variability in trough concentrations of NNRTI and PI among HIV-infected adults is large in routine clinical practice, with drug concentrations being outside the therapeutic window in a significant proportion of patients. These findings provide further evidence that therapeutic drug monitoring may be useful to guide antiretroviral therapy in clinical practice. [source]

Semi-empirical model for site effects on acceleration time histories at soft-soil sites.

EARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 11 2004
Part 1: formulation, development
Abstract A criterion is developed for the simulation of realistic artificial ground motion histories at soft-soil sites, corresponding to a detailed ground motion record at a reference firm-ground site. A complex transfer function is defined as the Fourier transform of the ground acceleration time history at the soft-soil site divided by the Fourier transform of the acceleration record at the firm-ground site. Working with both the real and the imaginary components of the transfer function, and not only with its modulus, serves to keep the statistical information about the wave phases (and, therefore, about the time variation of amplitudes and frequencies) in the algorithm used to generate the artificial records. Samples of these transfer functions, associated with a given pair of soft-soil and firm-ground sites, are empirically determined from the corresponding pairs of simultaneous records. Each function included in a sample is represented as the superposition of the transfer functions of the responses of a number of oscillators. This formulation is intended to account for the contributions of trains of waves following different patterns in the vicinity of both sites. The properties of the oscillators play the role of parameters of the transfer functions. They vary from one seismic event to another. Part of the variation is systematic, and can be explained in terms of the influence of ground motion intensity on the effective values of stiffness and damping of the artificial oscillators. Another part has random nature; it reflects the random characteristics of the wave propagation patterns associated with the different events. The semi-empirical model proposed recognizes both types of variation. The influence of intensity is estimated by means of a conventional one-dimensional shear wave propagation model. This model is used to derive an intensity-dependent modification of the values of the empirically determined model parameters in those cases when the firm-ground earthquake intensity used to determine these parameters differs from that corresponding to the seismic event for which the simulated records are to be obtained. Copyright © 2004 John Wiley & Sons, Ltd. [source]

The fundamental difference between shear alpha viscosity and turbulent magnetorotational stresses

MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2008
Martin E. Pessah
ABSTRACT Numerical simulations of turbulent, magnetized, differentially rotating flows driven by the magnetorotational instability (MRI) are often used to calculate the effective values of alpha viscosity that is invoked in analytical models of accretion discs. In this paper, we use various dynamical models of turbulent magnetohydrodynamic stresses, as well as numerical simulations of shearing boxes, to show that angular momentum transport in MRI-driven accretion discs cannot be described by the standard model for shear viscosity. In particular, we demonstrate that turbulent magnetorotational stresses are not linearly proportional to the local shear and vanish identically for angular velocity profiles that increase outwards. [source]

The influence of substrate on the magnetic properties of MnZn ferrite thin film fabricated by alternate sputtering

PHYSICA STATUS SOLIDI (A) APPLICATIONS AND MATERIALS SCIENCE, Issue 10 2008
Lanxi Wang
Abstract Mn0.5Zn0.5Fe2O4 film which has the highest saturation magnetization among Mn1,xZnx Fe2O4 thin films was prepared by the alternate rf sputtering method from two targets with compositions of MnFe2O4 and ZnFe2O4, respectively. The films were deposited on single-crystal Si(100), MgO(100) and SiO2/Si(100) substrates. The as-deposited films were amorphous, and after annealing in a vacuum furnace at 550 °C, polycrystalline MnZn ferrite films with residual amorphous matrix were obtained. The coercivity of all films is low, and the film on the MgO(100) substrate shows a coercivity as low as 27 Oe. The grain size of all films is about 20 nm and is less than the ferromagnetic exchange length (160 nm), so magnetic anisotropies are averaged to lower effective values. Furthermore, the negative magnetostriction constant of crystalline MnZn ferrite and the positive magnetostriction constant of amorphous Fe-based matrix will cancel out and may lead to a low or vanishing saturation magnetostriction constant. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]