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Effective Techniques (effective + techniques)
Selected AbstractsCK19 mRNA expression in the bone marrow of patients with esophageal squamous cell carcinoma and its clinical significanceDISEASES OF THE ESOPHAGUS, Issue 5 2010X. Zhang SUMMARY The 5-year survival rate in resectable patients with esophageal cancer is only 20% to 36%. Regional relapse and distant metastasis are responsible for the failure of treatment and the majority of cancer-related deaths. Earlier detection of metastases, especially micrometastases, has the potential for more accurate risk stratification in subsequent therapy decisions. No effective techniques have yet been found to detect metastases in erroneously thought to have early stage disease. This study was designed to investigate the clinical significance of bone marrow micrometastases detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with esophageal cancer. Expression of CK19 mRNA in the bone marrow of 61 patients with esophageal squamous cell carcinoma (ESCC) and 15 benign pulmonary and esophageal disease patients was assessed via RT-PCR. Correlation of CK19 mRNA expression to the clinicopathologic features and prognosis of the 61 patients was analyzed: 21.3% (13/61) were positive for expression of CK19 mRNA in patients with ESCC. No CK19 mRNA was detected of the 15 benign pulmonary and esophageal disease patients. CK19 mRNA expression did not correlate with the clinicopathologic features of the patients with ESCC, but patients with CK19 mRNA-positive bone marrow had earlier recurrence and shorter survival after surgery. In multivariate analysis, CK19 mRNA was found to be an independent predictor of a poor outcome. CK19 mRNA may be used as a molecular maker to detect bone marrow micrometastases in patients with ESCC and may help to select the proper therapy and predict the prognosis. [source] Additional Resources for Medical Student Educators: An Annotated ReviewACADEMIC EMERGENCY MEDICINE, Issue 4 2005Tamara Howard MD There are numerous resources available to help educators of medical students improve their methods of instruction. For example, several Internet sites exist that describe specific ways to teach and reinforce concepts basic to emergency medicine. Some of these sites also allow users to share their own experiences and teaching techniques. There are professional associations and organizations that specifically cater to the needs of those involved in the education and training of medical students and resident physicians. Educators may wish to take advantage of distance learning programs that offer instruction in areas such as adult learning, curriculum and teaching methods, and medical education evaluation and research. Finally, educators may wish to participate in professional development opportunities such as fellowships and online modules that have been designed to offer instruction on teaching skills, provide an arena for exchange of effective techniques, and acclimate faculty to academic medicine. [source] Neural network ensembles: combining multiple models for enhanced performance using a multistage approachEXPERT SYSTEMS, Issue 5 2004Shuang Yang Abstract: Neural network ensembles (sometimes referred to as committees or classifier ensembles) are effective techniques to improve the generalization of a neural network system. Combining a set of neural network classifiers whose error distributions are diverse can generate better results than any single classifier. In this paper, some methods for creating ensembles are reviewed, including the following approaches: methods of selecting diverse training data from the original source data set, constructing different neural network models, selecting ensemble nets from ensemble candidates and combining ensemble members' results. In addition, new results on ensemble combination methods are reported. [source] An analytical solution of one-dimensional consolidation for soft sensitive soil groundINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 9 2004Yun-Min Chen Abstract An analytical solution of one-dimensional consolidation for soft sensitive soil ground is presented. The moving boundary is introduced to indicate the notable change of consolidation behaviour of sensitive soil with the increase of stress level. It is assumed that the soil structure of the upper subsoil gradually destroys downwards with the dissipation of pore pressure, and the coefficient of consolidation as well as the coefficient of permeability of the upper subsoil become small, which hinders the dissipation of pore pressure of the lower subsoil. The consolidation degree curve obtained from the present solution is found to lie between the two curves obtained from Terzaghi one-dimensional consolidation solution with the parameters of the undisturbed soil and the remolded soil. The calculated results provide a new explanation for a general phenomenon in the consolidation of soft sensitive soil ground, as that for high loadings the consolidation is longer than for small ones. It should be pointed out from this study that both the deep mixing method and the long vertical drains methods are effective techniques for improving deep sensitive soil ground. Copyright © 2004 John Wiley & Sons, Ltd. [source] Lasers for facial rejuvenation: a reviewINTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 6 2003Evangelia Papadavid MD Background Different types of laser are used for resurfacing and collagen remodeling in cutaneous laser surgery. Methods A systematic review was performed of the different types of laser currently employed for skin rejuvenation. These systems are either ablative [high-energy pulsed or scanned carbon dioxide (CO2) laser emitting at a wavelength of 10,600 nm, single- or variable-pulse or dual ablative/coagulative mode erbium:yttrium aluminum garnet (Er:YAG) laser emitting at a wavelength of 2940 nm, or systems combining both 10,600 nm and 2940 nm wavelengths] or nonablative [Q-switched neodymium:yttrium aluminum garnet (Nd:YAG) laser emitting at a wavelength of 1064 nm, Nd:YAG laser emitting at a wavelength of 1320 nm, or diode laser emitting at a wavelength of 1450 nm]. Different protocols, patient selection, treatment techniques, and complications are discussed for each system. Results New-generation CO2 resurfacing lasers have been successful in the treatment of photodamaged skin and scarring, with a postoperative morbidity dependent on the depth of thermal damage. Because of its minimal penetration, the pulsed Er:YAG laser, usually used in the treatment of more superficial rhytides, produces less postoperative morbidity. Novel ablative systems have been developed and a further understanding of laser,tissue interaction has led to the design of nonablative systems for the treatment of rhytides, scarring, and photodamaged skin, the efficacy and profile of which remain to be evaluated in the long term. Conclusions There are several effective techniques for scar revision and the treatment of aged skin, but all have their drawbacks due to a lack of precise depth control and unwanted damage to the lower layers of the dermis. The Er:YAG laser is the treatment of choice for fine lines and superficial scars, whereas the CO2 laser is better for deeper rhytides and scars. In the future, a combination of lasers may be used for facial rejuvenation. [source] Engaging men in family therapy: does the gender of the therapist make a difference?JOURNAL OF FAMILY THERAPY, Issue 1 2001Anna Dienhart The results of this exploratory Delphi study provide a beginning formulation of a gender-sensitive approach to working with men in the specialized field of couple and family therapy. The research specifically investigated what a panel of thirty-six ,expert' family therapists believed would be appropriate and effective techniques to engage men in therapy and in the process of family change. This report focuses on findings highlighting differences between what female and male therapists preferred as techniques to work with men in family therapy. [source] Effect of Feeding Frequency, Water Temperature, and Stocking Density on the Growth of Tiger Puffer, Takifugu rubripesJOURNAL OF THE WORLD AQUACULTURE SOCIETY, Issue 1 2006Kotaro Kikuchi Effects of daily feeding frequency, water temperature, and stocking density on the growth of tiger puffer, Takifugu rubripes, fry were examined to develop effective techniques to produce tiger puffer in a closed recirculation system. Fish of 4, 14, and 180 g in initial body weight were fed commercial pellet diets once to five times a day to apparent satiation each by hand for 8 or 12 wk at 20 C. Daily feeding frequency did not affect the growth of 14- and 180-g-size fish. However, the daily feed consumption and weight gain of the 4-g-size fish fed three and five times daily were significantly higher than those of fish fed once daily (P < 0.05). Fish of 4 and 50 g in initial body weight were reared with the pellet diet at 15,30 C for 8 wk. The weight gain of fish increased with increasing water temperature up to 25 C and decreased drastically at 30 C for both sizes. Similar trends were observed for feed efficiency, although 4-g fish had highest efficiency at 20 C. Effects of stocking density on growth were examined with fish of 8, 13, and 100 g in initial body weight. Fish were reared with the pellet diet for 8 or 16 wk at 20 C. Fish were placed in floating net cages in the culture tank, and the stocking density was determined based on the total weight of fish and volume of the net cage. Fish of 8 g in body weight grew up to 35,36 g during the 8-wk rearing period independent of the stocking density of 8, 15, and 31 kg/m3 at the end of rearing. Final biomass per cage reached 32, 60, and 115 kg/m3 for 13-g-size fish, and 10, 18, and 35 kg/m3 for 100-g-size fish, and the growth of the fish tended to decrease with increasing stocking density for both sizes. [source] The prospect of high-precision Pb isotopic dating of meteoritesMETEORITICS & PLANETARY SCIENCE, Issue 1 2006Yuri Amelin Pb isotopic dates can be used to link the dates obtained from extinct nuclide chronometers to the absolute time scale. The factors that control precision and accuracy of Pb isotopic dates of meteorites: instrumental mass fractionation in isotopic analysis, mass spectrometer sensitivity, removal of common Pb, multi-stage evolution of U-Pb systems, disturbances caused by diffusion, alteration, and shock metamorphism, and uncertainties in decay constants and the natural ratio of the U isotopes are reviewed. The precision of Pb isotopic dates of meteorites attained with currently available techniques and methodology is ±0.5,1.0 Myr in favorable cases. The accuracy of time interval measurements is approximately the same. The most serious limitation on precision and accuracy of Pb isotopic dates is placed by the presence of common Pb of uncertain and/or variable isotopic composition. Improvement in precision and accuracy of Pb isotopic dates would be possible through combined advancement of techniques of isotopic analysis (most importantly, better control over instrumental mass fractionation) and more effective techniques for the removal of common Pb, together with a better understanding of the effects of thermal metamorphism, shock metamorphism, and aqueous alteration on the U-Pb system in meteorites. [source] Innovative Techniques for Placement of Implantable Cardioverter-Defibrillator Leads in Patients with Limited Venous Access to the HeartPACING AND CLINICAL ELECTROPHYSIOLOGY, Issue 2 2006BRYAN C. CANNON Background: Because of venous occlusion, intracardiac shunting, previous surgery, or small size placement of implantable cardioverter-defibrillator (ICD) leads may not be possible using traditional methods. The purpose of this study was to evaluate and describe innovative methods of placing ICD leads. Methods: The records of all patients undergoing ICD implantation at our institution were reviewed to identify patients with nontraditional lead placement. Indications for ICD, method of lead and coil placement, defibrillation thresholds, complications, and follow-up results were reviewed retrospectively. Results: Eight patients (aged 11 months to 29 years) were identified. Six patients with limited venous access to the heart (four extracardiac Fontan, one bidirectional Glenn, one 8 kg 11-month-old) underwent surgical placement of an ICD coil directly into the pericardial sac. A second bipolar lead was placed on the ventricle for sensing and pacing. Two patients with difficult venous access had a standard transvenous ICD lead inserted directly into the right atrium (transatrial approach) and then positioned into the ventricle. All patients had a defibrillation threshold of <20 J, although one patient required placement of a second coil due to an elevated threshold. There have been no complications and two successful appropriate ICD discharges at follow-up (median 22 months, range 5,42 months). Conclusions: Many factors may prohibit transvenous ICD lead placement. Nontraditional surgical placement of subcutaneous ICD leads on the pericardium or the use of a transatrial approach can be effective techniques in these patients. These procedures can be performed at low risk to the patient with excellent defibrillation thresholds. [source] | |||||||||||||