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Effective Control (effective + control)
Terms modified by Effective Control Selected AbstractsPatient preferences for managing asthma: results from a discrete choice experimentHEALTH ECONOMICS, Issue 7 2007Madeleine T. King Abstract Effective control of asthma requires regular preventive medication. Poor medication adherence suggests that patient preferences for medications may differ from the concerns of the prescribing clinicians. This study investigated patient preferences for preventive medications across symptom control, daily activities, medication side-effects, convenience and costs, using a discrete choice experiment embedded in a randomized clinical trial involving patients with mild,moderate persistent asthma. The present data were collected after patients had received 6 weeks' treatment with one of two drugs. Three choice options were presented, to continue with the current drug, to change to an alternative, hypothetical drug, or to take no preventive medication. Analysis used random parameter multinomial logit. Most respondents chose to continue with their current drug in most choice situations but this tendency differed depending on which medication they had been allocated. Respondents valued their ability to participate in usual daily activities and sport, preferred minimal symptoms, and were less likely to choose drugs with side-effects. Cost was also significant, but other convenience attributes were not. Demographic characteristics did not improve the model fit. This study illustrates how discrete choice experiments may be embedded in a clinical trial to provide insights into patient preferences. Copyright © 2007 John Wiley & Sons, Ltd. [source] Metabolism of PER.C6TM cells cultivated under fed-batch conditions at low glucose and glutamine levelsBIOTECHNOLOGY & BIOENGINEERING, Issue 1 2006Luis Maranga Abstract This is the first study to examine PER.C6TM cell glucose/energy and glutamine metabolism with fed-batch cultures at controlled low glutamine, low glucose, and simultaneous low glucose and low glutamine levels. PER.C6TM cell metabolism was investigated in serum-free suspension bioreactors at two-liter scale. Control of glucose and/or glutamine concentrations had a significant effect on cellular metabolism leading to an increased efficiency of nutrient utilization, altered byproduct synthesis, while having no effect on cell growth rate. Cultivating cells at a controlled glutamine concentration of 0.25 mM reduced qGln and q by approximately 30%, qAla 85%, and qNEAA 50%. The fed-batch control of glutamine also reduced the overall accumulation of ammonium ion by approximately 50% by minimizing the spontaneous chemical degradation of glutamine. No major impact upon glucose/energy metabolism was observed. Cultivating cells at a glucose concentration of 0.5 mM reduced qGlc about 50% and eliminated lactate accumulation. Cells exhibited a fully oxidative metabolism with Y of approximately 6 mol/mol. However, despite no increase in qGln, an increased ammonium ion accumulation and Y were also observed. Effective control of lactate and ammonium ion accumulation by PER.C6TM cells was achieved using fed-batch with simultaneously controlled glucose and glutamine. A fully oxidative glucose metabolism and a complete elimination of lactate production were obtained. The qGln value was again reduced and, despite an increased q compared with batch culture, ammonium ion levels were typically lower than corresponding ones in batch cultures, and the accumulation of non-essential amino acids (NEAA) was reduced about 50%. In conclusion, this study shows that PER.C6TM cell metabolism can be confined to a state with improved efficiencies of nutrient utilization by cultivating cells in fed-batch at millimolar controlled levels of glucose and glutamine. In addition, PER.C6TM cells fall into a minority category of mammalian cell lines for which glutamine plays a minor role in energy metabolism. © 2006 Wiley Periodicals, Inc. [source] Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replicationEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 10 2008Donatella Ciuffreda Abstract HCV infection has a severe course of disease in HIV/HCV co-infection and in liver transplant recipients. However, the mechanisms involved remain unclear. Here, we evaluated functional profiles of HCV-specific T-cell responses in 86 HCV mono-infected patients, 48 HIV/HCV co-infected patients and 42 liver transplant recipients. IFN-, and IL-2 production and ability of CD4 and CD8 T cells to proliferate were assessed after stimulation with HCV-derived peptides. We observed that HCV-specific T-cell responses were polyfunctional in HCV mono-infected patients, with presence of proliferating single IL-2-, dual IL-2/IFN-, and single IFN-,-producing CD4+ and dual IL-2/IFN-, and single IFN-,-producing CD8+ cells. In contrast, HCV-specific T-cell responses had an effector profile in HIV/HCV co-infected individuals and liver transplant recipients with absence of single IL-2-producing HCV-specific CD4+ and dual IL-2/IFN-,-producing CD8+ T cells. In addition, HCV-specific proliferation of CD4+ and CD8+ T cells was severely impaired in HIV/HCV co-infected patients and liver transplant recipients. Importantly, "only effector" T-cell responses were associated with significantly higher HCV viral load and more severe liver fibrosis scores. Therefore, the present results suggest that immune-based mechanisms may contribute to explain the accelerated course of HCV infection in conditions of HIV-1 co-infection and liver transplantation. [source] Towards evolution-proof malaria control with insecticidesEVOLUTIONARY APPLICATIONS (ELECTRONIC), Issue 4 2009Jacob C. Koella Abstract As many strategies to control malaria use insecticides against adult mosquitoes, control is undermined by the continual evolution of resistant mosquitoes. Here we suggest that using alternative insecticides, or conventional insecticides in alternative ways might enable effective control, but delay considerably or prevent the evolution of resistance. Our reasoning relies on an epidemiological and an evolutionary principle: (i) the epidemiology of malaria is strongly influenced by the life-span of mosquitoes, as most infected mosquitoes die before the malaria parasite has completed its development; and (ii) evolutionary pressure is strongest in young individuals, for selection on individuals that have completed most of their reproduction has little evolutionary effect. It follows from these principles, first, that insecticides that kill mosquitoes several days after exposure can delay considerably the evolution of resistance and, second, that the evolution of resistance against larvicides can actually benefit control, if it is associated with shorter life-span or reduced biting in adults. If a late-acting insecticide and a larvicide are combined, the evolution of resistance against larvicides can in some circumstances prevent the evolution of resistance against the more effective, late-acting insecticide, leading to sustainable, effective control. We discuss several potential options to create such insecticides, focussing on biopesticides. [source] Aptamer-Conjugated Nanoparticles Efficiently Control the Activity of ThrombinADVANCED FUNCTIONAL MATERIALS, Issue 18 2010Yen-Chun Shiang Abstract Thrombin-binding aptamer-conjugated gold nanoparticles (TBA-Au NPs) for highly effective control of thrombin activity towards fibrinogen are demonstrated. While a 29-base long oligonucleotide (TBA29) has known no enzymatic inhibitory functions for thrombin-mediated coagulation, the ultrahigh anticoagulant potency of TBA29 -Au NPs can be demonstrated via the steric blocking effect, at two orders of magnitude higher than that of free TBA29. The surface aptamer density on the Au NPs is important in determining their enzymatic inhibition of thrombin and their stability in the presence of nuclease. The practicality of 100TBA29 -Au NPs (100 TBA29 molecules per Au NP) for controlling thrombin-mediated coagulation in plasma is found, and the 100TBA29 -Au NPs has an ultra binding affinity towards thrombin (Kd = 2.7 × 10,11M) due to their high ligand density. The anticoagulant activity of TBA29 -Au NPs is found to be suppressed by TBA29 complementary sequence (cTBA29) modified Au NPs (cTBA29 -Au NPs), with a suppression rate 4.6-fold higher than that of cTBA29. The easily prepared and low-cost TBA29 -Au NPs and cTBA29 -Au NPs show their potential in biomedical applications for treating various diseases related to blood clotting disorders. In principle, this study opens the possibility of regulation of molecule binding, protein recognizing, and enzyme activity by using aptamer-functionalized nanomaterials. [source] Geochemical Factors Controlling Radium Activity in a Sandstone AquiferGROUND WATER, Issue 4 2006Tim Grundl Geochemical processes behind the occurrence of radium activities in excess of the U.S. EPA's drinking water limit of 5 pCi/L combined radium were investigated in a regional sandstone aquifer located in southeastern Wisconsin. Geochemical speciation modeling (PHREEQC 2.7) combined with a detailed understanding of the regional flow system provided by recent flow modeling efforts was used to determine that radium coprecipitation into barite controls radium activity in the unconfined portion of the aquifer. As the aquifer transitions from unconfined to confined conditions, radium levels rise and the water becomes more sulfate rich yet the aquifer remains at saturation with barite throughout. Calculations based on published distribution coefficients and the observed Ra:Ba atomic ratios indicate that barite contains ,12 ,g/kg coprecipitated radium. Confined portions of the aquifer have high concentrations of sulfate, and barium concentrations become too low to be an effective control on radium activity. Additional, as yet undefined, controls on radium are operative in the downgradient, confined portion of the aquifer. [source] Chronic viral hepatitis in hemodialysis patientsHEMODIALYSIS INTERNATIONAL, Issue 2 2005Sydney Tang Abstract Ever since the first outbreaks of hepatitis in hemodialysis units in the late 1960s, a number of hepatotropic viruses transmitted by blood and other body fluids have been identified. This review summarizes the current state of knowledge regarding these blood-borne agents from an epidemiologic and preventive perspective. Data source and study selection were obtained from research and review articles related to the epidemiology of viral hepatitis in hemodialysis and indexed on Medline and Embase from 1965 to 2004. Hepatitis B virus (HBV) was the first significant hepatotropic virus to be identified in hemodialysis centers. HBV infection has been effectively controlled by active vaccination, screening of blood donors, the use of erythropoietin, and segregation of HBV carriers. To date, HBV remains an important cause of morbidity in endemic areas. Hepatitis delta virus is a defective virus that can only infect HBV-positive individuals. Hepatitis C virus is the most significant cause of non-A, non-B hepatitis and is mainly transmitted by blood transfusion. The introduction in 1990 of routine screening of blood donors for HCV contributed significantly to the control of HCV transmission. An effective HCV vaccine remains an unsolved challenge, however. Pegylation of interferon-, has made it possible to treat HCV-positive dialysis patients. Unexplained sporadic outbreaks of hepatitis by the mid-1990s prompted the discovery of hepatitis G virus and hepatitis GB virus C in 1995 and the TT virus in 1997. Although epidemiologic analyses revealed high prevalence rates of both viruses in the hemodialysis population, their exact role in liver disease has yet to be determined. The vigilant observation of guidelines on universal precaution and regular virologic testing are the cornerstones of the effective control of chronic hepatitis in the setting of hemodialysis. [source] Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosisIMMUNOLOGY, Issue 4 2003Andre Kipnis Summary Chemokines play an important role in the development of immunity to tuberculosis. Chemokine ligand 2 (CCL2, JE, monocyte chemoattractant protein-1) is thought to be primarily responsible for recruiting monocytes, dendritic cells, natural killer cells and activated T cells, all of which play critical roles in the effective control of tuberculosis infection in mice. We show here that in mice in which the CCL2 gene was disrupted, low-dose aerosol infection with Mycobacterium tuberculosis resulted in fewer macrophages entering the lungs, but only a minor and transient increase in bacterial load in the lungs; these mice were still able to establish a state of chronic disease. Such animals showed similar numbers of activated T cells as wild-type mice, as determined by their expression of the CD44hi CD62lo phenotype, but a transient reduction in cells secreting interferon-,. These data indicate that the primary deficiency in mice unable to produce CCL2 is a transient failure to focus antigen-specific T lymphocytes into the infected lung, whereas other elements of the acquired host response are compensated for by different ligands interacting with the chemokine receptor CCR2. [source] Reassessment of treatments to retard browning of fresh-cut Russet potato with emphasis on controlled atmospheres and low concentrations of bisulphiteINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 7 2010Yurong Ma Summary The cultivar Pacific Russet with high browning susceptibility was used for most testing. Controlled atmospheres (0.3%, 3% and 21% O2 in combination with 0%, 6% or 12% CO2) and anti-browning chemicals were studied in relation to quality retention and wound-induced phenolic metabolism of fresh-cut slices for up to 16 days at 5 °C. The 3% O2+ 12% CO2 atmosphere was most effective among those tested, and retarded increases in phenolics and phenylalanine ammonia lyase activity, but had only slight benefit on visual quality. A 1.25% ascorbic acid +1.25% citric acid treatment was ineffective, but when combined with 3% O2+ 12% CO2, it was comparable with 0.025% sodium bisulphite. Bisulphite concentrations from 0.05% to 0.25% provided similar effective control of discolouration. Bisulphite as low as 0.025% with 3% O2+ 12% CO2 resulted in a visual quality score at the limit of marketability after 8 days at 5 °C. Chemical treatments did not retard increases in phenolic concentrations or phenolic enzyme activities. [source] The nature and influence of motivation within the MOA framework: implications for social marketingINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 4 2006Wayne Binney Social marketers acknowledge that to achieve optimum programme outcomes, identification and targeting of the non-conforming cohort is paramount. This article discusses the application of the social marketing framework, motivation, opportunity and ability (MOA) with a particular focus on the motivation aspect of the model. Motivation is considered from the perspectives of intrinsic and extrinsic motivation. Previously, the degree or level of motivation has been used in the operationalisation of the motivation construct, while in this paper the type of motivation is used as the basis for the construct. The construct is then applied to an environmental land management study, namely a rabbit control programme. Specifically, the aims of this paper were to further develop the MOA constructs, with a particular focus on motivation, including intrinsic and extrinsic motivation, to develop an understanding of the factors that are associated with ineffective behaviour and to develop a model to predict effective/ineffective control behaviour. Scales were developed to enable a study of the relationship between the MOA constructs, including intrinsic and extrinsic motivation, and the respondents control behaviour. Data were collected from a random sample of 566 respondents who were involved in the control programme. Using ANOVA and MANOVA techniques, significant differences were found between those landholders that exhibited effective control and ineffective control with regard to all MOA constructs. A multinomial logit (MNL) regression model was then developed to predict behaviour. This model showed that ability and intrinsic motivation were significant predictors of behaviour. The estimated model was able to predict recalcitrant landholders with 98% accuracy. The results of this study therefore provide a significant contribution to social marketing as it is the recalcitrant cohort that social marketers wish to understand and whose behaviour they frequently attempt to rectify in order to achieve stated social and/or environmental objectives. The implications for related social market theory, policy development and environmental management programmes are discussed. Copyright © 2006 John Wiley & Sons, Ltd. [source] The role of controlled drainage under drought conditions in an irrigated area in NWFP, Pakistan,IRRIGATION AND DRAINAGE, Issue 2 2003Gul Daraz Khan sécheresse; drainage commandé; eaux souterraines; efficacité d'utilisation de l'eau et rendement Abstract The River Swat is the source of irrigation for the entire irrigation system of Mardan, Nowshera and Charsadda districts. Reductions of water and overdrainage have influenced the yield of major crops. The impact of reduced supply at the inlet from the source, drought conditions and overdrainage from the area have lowered the groundwater to a disastrous level. Thus the present groundwater level cannot contribute to the crops. A subsurface collector at its exit in drainage unit 106 was controlled to raise the watertable. The study area was divided into 10 zones. Each zone was separately assessed to analyze the groundwater impact in response to the controlled technique adopted for mitigating drought in different strategies of the canal operation. The interaction of groundwater level with irrigation depth, crop yield, water use efficiency and water saving were also studied. During the rotational period of the canal, irrigations applied in section II raised the water level by nearly 1 m. The upslope area of section III also needed a large irrigation depth. The groundwater level on the downslopes of the lateral drains in sections I and V was at the design depth of 1.1 m during the rotational strategy, while it decreased only slightly on the upslopes of the lateral drains for the same positions. Because of effective control by the collector, the watertable on the downslopes of the laterals in sections II and III was affected less while in the respective upslope area of section III it dropped more than 2 m. The water levels in section IV (both in the upslope and downslope areas along the laterals) remained very close to the design level. A significant contribution of seepage in the upslope of the collector drain considerably reduced the irrigation depths. During the canal closure period, the watertables in the study area dropped to the limit from 2.3 to 3.25 m. After the reopening of the canal, the watertables in sections II, III and IV were raised from 2.55 to 0.70 m. During this period the water levels near the canal reached the design level. The maximum yield of 6.5 tons ha,1 on the downslopes of the lateral drains in section II was obtained, resulting in maximum water use efficiency of 0.93 kg m,3. However, the minimum yield of 3.5 tons ha,1 on the upslopes of the lateral drains in section I was obtained, resulting in the lowest water use efficiency of 0.35 kg m,3 near the deep surface drain (5 m). The impact of controlled subsurface drainage in zones 2, 3 and 7 resulted in the best maintenance of optimum groundwater level and moisture content. Therefore large amounts of extra irrigation water applied (ranging from 23 to 129% of that actually required) in different zones of the controlled area can be saved for drought conditions. Copyright © 2003 John Wiley & Sons, Ltd. RÉSUMÉ Le fleuve Swat est la source d'irrigation pour les systèmes d'irrigation entiers des zones de Mardan, de Nowshera et de Charsadda. Les réductions de drainage de l'eau et d'excédent ont influencé le rendement de récoltes principales. L'impact de l'approvisionnement réduit à l'admission de la source, des conditions de sécheresse et du drainage d'excédent du secteur ont laissé tomber les eaux souterraines à un niveau désastreux. Ainsi le niveau actuel d'eaux souterraines ne peut pas contribuer aux récoltes. Un collecteur à fleur de terre à sa sortie dans l'unité 106 de drainage a été commandé pour soulever le niveau hydrostatique. Le secteur d'étude a été divisé en dix zones. Chaque zone a été séparément évaluée pour analyser l'impact d'eaux souterraines en réponse à la technique commandée adoptée pour atténuer la sécheresse dans différentes stratégies de l'opération de canal. L'interaction du niveau d'eaux souterraines sur la profondeur d'irrigation, le rendement de récolte, l'efficacité d'utilisation de l'eau et l'économie de l'eau ont été également étudié. Pendant la période de rotation du canal, les irrigations appliquées dans la section II ont élevé le niveau d'eau de presque un mètre. Le secteur demontée de la section III avait besoin d'une grande profondeur d'irrigation. Le niveau d'eaux souterraines des déscentes de la vidange latérale dans les sections I et V était à la profondeur de conception de 1.1 m pendant la stratégie de rotation, tandis qu'il diminuait seulement légèrement aux montée des drains latéraux pour les mêmes positions. En raison de la commande efficace du collecteur, le niveau hydrostatique des déscentes des parties latérales dans les sections II et III a été affecté moins, tandis que dans le secteur respectif demontée de la section III il descentait à plus de deux mètres. Les niveaux d'eau dans la section IV (tous les deux dans les secteurs demontée etde déscentes le long des parties latérales) ont demeuré très près de la conception. La contribution significative de l'infiltration dans lamontee du drain de collecteur a considérablement réduit les profondeurs d'irrigation. Pendant la période de fermeture du canal, les niveaux hydrostatiques dans le secteur d'étude sont descendus la limite de 2.3 à 3.25 m. A la réouverture du canal, les niveaux hydrostatiques dans les sections II, III et IV augmenté de 2.55 à 0.70 m. Pendant cette période les niveaux d'eau près du canal ont atteint celui de la concept. Le rendement maximum de 6.5 tons ha,1 aux déscentes des drains latéraux dans la section II a été obtenu, ayant pour résultat l'efficacité maximum d'utilisation de l'eau de 0.93 kg m,3.Cependant le rendement minimum de 3.5 tons ha,1 aux montées des drains latéraux dans la section a été obtenu, ayant pour résultat la plus basse efficacité d'utilisation de l'eau de 0.35 kg m,3 près du drain extérieur profond (5 m). L'impact du drainage à fleur de terre commandé dans les zones 2, 3 et 7 a maintenu le meillear niveau d'eaux souterraines et le contenu d'humidité optimum. Par conséquent la grande quantité de l'eau supplémentaire d'irrigation celle appliquée (s'étendant de 23 à 129% deréellement requise) dans différentes zones de la zone de contrôle peut être sauvée pour les conditions de sécheresse. Copyright © 2003 John Wiley & Sons, Ltd. [source] Bacterial population dynamics and community structure in a pharmaceutical manufacturing water supply system determined by real-time PCR and PCR-denaturing gradient gel electrophoresisJOURNAL OF APPLIED MICROBIOLOGY, Issue 6 2004M. Kawai Abstract Aims:, To control bacteria in the pharmaceutical water supply system. Methods and Results:, Bacteria were enumerated by conventional culture method and fluorescent vital staining. Activated carbon treatment and storage in a tank provided favourable environments for bacterial growth. The bacterial population of the water in both the post-activated carbon treatment and the tank was analysed by denaturing gradient gel electrophoresis (DGGE) with PCR-amplified 16S rDNA fragments including V6, -7, and -8 regions. The bacterial community structure in activated carbon treated water was stable throughout the year. Several kinds of bacteria such as genus Aquaspirillum and Methylobacterium were found in the water after activated carbon treatment. The bacterial community structure was changed and other bacteria such as mycobacteria were detected after storage. Mycobacteria were quantified in water samples using real-time PCR targeting the 16S rDNA gene. Mycobacteria were also detected in tap water and their number was increased 103,104 -fold higher after storage. Conclusion:, These data suggest the importance of culture-independent methods for quality control of water used in pharmaceutical manufacturing. Significance and Impact of the Study:, Critical steps and specified bacteria that should be controlled in the water supply system were recognized by culture-independent methods. These data will enable effective control of water used in the pharmaceutical industry. [source] Evaluation of the effectiveness of an early peripheral burning strategy in controlling wild fires in north-western ZimbabweAFRICAN JOURNAL OF ECOLOGY, Issue 4 2009Isaac Mapaure Abstract A review of the occurrence of wild fires in Sengwa Wildlife Research Area (SWRA), Zimbabwe, is presented for the period 1965,1993. The effectiveness and desirability of early burning of peripheral areas introduced in 1979 are evaluated. More than 75% of wild fires occurred between July and October, 48.6% of which originated from communal lands. Early burning of peripheral areas led to significant reductions in extent of areas burnt, from annual mean areas of 115 km2 (1965,1978) to 11 km2 (1979,1993) because of effective control of fires, which originated from communal lands. Some areas did not burn at all after 1979, and the overall probability of burning dropped from 0.484 to 0.187. Whilst it may be desirable to keep fires out of SWRA in the short term, fuel build-ups increase the fire hazard resulting in negative consequences on biodiversity in the long term. Consideration should be given to combine peripheral burning with low-intensity prescribed burning of selected blocks to keep a semblance of natural fire regimes to ensure the maintenance of biodiversity while simultaneously reducing the fire-hazard. An integrated fire management plan should be put in place for SWRA. Résumé Ici est passée en revue l'occurrence de feux sauvages dans l'Aire de recherche sur la faune sauvage de Sengwa (SWRA), au Zimbabwe, pour la période 1965,1993. L'efficacité et l'opportunité des feux précoces des zones périphériques, introduits en 1979, sont aussi évaluées. Plus de 75% des feux sauvages avaient lieu entre juillet et octobre, dont 48,6% trouvaient leur origine dans des terres communales. Le brûlage précoce des zones périphériques a conduit à des réductions significatives des superficies brûlées, qui sont passées d'une moyenne annuelle de 115 km2 (1965,1978) à 11 km2 (1979,1993) grâce au contrôle efficace des feux qui commençaient dans les terres communales. Certaines zones n'avaient pas brûlé du tout depuis 1979, et la probabilité globale de brûler a chuté de 0,484 à 0,187. S'il est, à court terme, souhaitable de préserver la SWRA contre les feux, l'accumulation de matières combustibles augmente les risques de feux qui pourraient avoir, à long terme, des conséquences négatives sur la biodiversité. Il faudrait envisager de combiner les feux en périphérie avec des feux programmés, de faible intensité, de certains blocs sélectionnés, pour conserver un semblant de régime naturel de feux et ainsi garantir le maintien de la biodiversité tout en réduisant les risques de feux. Il faudrait instaurer un plan de gestion des feux pour la SWRA. [source] A step-wise incremented Fourier series model for chemical reactivity predictionJOURNAL OF CHEMOMETRICS, Issue 6-7 2006Saloua Saidane Abstract In this paper, chemical reactivity is modeled as a time series of events defined by a reactant's concentration decay measured at consecutive discrete time periods. Since traditional time series techniques such as ARIMA and current Artificial Neural Networks require large data sets that are typically not available for chemical reactions, we developed a Step Wise Incremented Fourier Series (SWIFS) algorithm to model and predict nonlinear short time series. The application of SWIFS to experimental data from first- and second-order reactions produced a significant improvement in prediction accuracy over traditional integrated rate laws. In forward-time prediction, SWIFS has achieved significantly higher prediction accuracy with first- and second-order chemical reactions data. SWIFS also proved more robust in terms of error propagation caused by the effect of the size of the estimation set. The proposed SWIFS model also outperformed rate law models in backwards-time prediction. The ability of SWIFS to provide high accuracy in predicting chemical reactions may have beneficial implications on the efficiency of industrial production of chemicals as well as on the effective control of hazardous materials degradation. Copyright © 2007 John Wiley & Sons, Ltd. [source] Long-term outcome of chronic hepatitis B based on histological grade and stageJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 3 2007Byung Kyu Park Abstract Background and Aim:, This study evaluated the long-term outcome and prognostic factors of chronic hepatitis B, based on histological grade and stage. Methods:, A total of 188 patients with chronic hepatitis B were followed for a mean 119.8 months. Ultrasonography and clinical assessment were performed regularly. In addition, liver biopsy specimens were re-evaluated based on histological grade and stage. Results:, During follow-up, cirrhosis developed in 62 patients, decompensation in 20 patients, and hepatocellular carcinoma (HCC) in 21 patients. The serum alanine aminotransferase (ALT) level at the time of liver biopsy was significantly correlated with the grades of lobular and porto-periportal activity. The development of cirrhosis correlated well with the grade of porto-periportal activity and stage of fibrosis. The probabilities of developing cirrhosis, decompensation and HCC were significantly higher in patients whose ALT levels were persistently elevated without flares or flared-up without normalization than in patients whose ALT levels flared-up then normalized or were normally sustained. By multivariate analysis, age and biochemical profile during follow-up were independent prognostic factors for chronic hepatitis B. Conclusions:, The results demonstrate that histological grade and stage, and biochemical profile during follow-up in patients with chronic hepatitis B are important prognostic factors. Therefore, effective control of hepatitis activity might improve the long-term outcome of chronic hepatitis B patients. [source] Process control and monitoring of reactive crystallization of L -glutamic acidAICHE JOURNAL, Issue 8 2010Hannu Alatalo Abstract The aim of the present study was to investigate feedback control of a reactive crystallization process. The present study built up a control structure needed to control the driving force of reactive crystallization using the feed rate of added acid. The concentration of the crystallizing compound and pH was used to compute feedback in the closed-loop control of semi-batch precipitation. The concentration of L -glutamic acid was determined from measured MID-IR ATR-FTIR spectra based on a multivariate model. Dynamic change of set value was based on the mass of added sulfuric acid and pH. The studied properties of the product crystals were polymorphism and crystal size. The polymorphic composition was analyzed with a Raman spectrometer and was expressed by mass fraction of the ,-polymorph. The obtained results showed that the developed feedback process control system allows effective control of forming of polymorphs. © 2009 American Institute of Chemical Engineers AIChE J, 2010 [source] Anastomosis between the hepatic artery and the extrahepatic collateral or between extrahepatic collaterals: Observation on angiographyJOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, Issue 3 2009S Miyayama Summary Transcatheter arterial chemoembolisation for hepatocellular carcinoma is widely carried out not only through the hepatic artery but also through the extrahepatic collateral pathways. Anatomically, there are many anastomoses between the hepatic artery and the extrahepatic collateral as well as among the extrahepatic collaterals. However, these anastomoses may not be shown on angiography because the anastomosing braches are too small. These anastomoses may not only interfere with effective control of hepatocellular carcinoma by transcatheter arterial chemoembolisation but also cause unexpected procedure-related complications. Therefore, radiologists should have sufficient knowledge of these underlying anastomoses. In this report, we present our angiographic images. [source] Polyamides nanocapsules: Modeling and wall thickness estimationAICHE JOURNAL, Issue 6 2006K. Bouchemal Abstract This work provides a better understanding for effective control of the nanocapsules wall thickness. Polyamides based nanocapsules are prepared by interfacial polymerization combined with spontaneous emulsification. A clear guideline of how factors such as monomer concentration, diffusion, interfacial reaction, or water swelling influence the capsule formation is very important to the control of capsule wall structure and release performance. In this goal, the macroscopic planar models of the interfacial polycondensation between diethylenetriamine and sebacoyle chloride are studied experimentally and theoretically. This planar model is developed to examine the kinetics of the reaction and to perform the estimation of parameters thanks to the experiment measurements. The effect of the operating conditions on the wall thickness is also studied. The model is shown to be consistent with the experimental data. Next, the spherical model is deduced from the first one. The results obtained with this model are in accordance with some observations of wall thickness. From this model, the increase of the wall thickness is predicted for several operating conditions. © 2006 American Institute of Chemical Engineers AIChE J, 2006 [source] Steady-state multiplicity, flashback, and control issues in CH4 radiant burnersAICHE JOURNAL, Issue 9 2004M. Bizzi Abstract Methane is widely employed as a source of energy in combustion systems. Among the currently available technologies, radiant heaters offer high thermal efficiency and low environmental impact in comparison with atmospheric burners. The present work deals with the modeling of methane combustion in a noncatalytic metal fiber burner, represented by means of one-dimensional transient equations. The model accounts for a detailed reaction mechanism, radiation within the porous medium, longitudinal heat and mass transfer. After its validation, the model was employed to analyze a typical stability problem that affects these systems: under given operating conditions (low specific power inputs and excess of air) the occurrence of flashback may in fact preclude the safe operation of the system. As a consequence of energy radiation in the upstream direction, the burner upstream surface and the plenum chamber might become hot enough to heat in turn the gas feedstock, thus eventually determining flashback. In this paper, the mechanism of flashback is numerically investigated as a function of the burner structure and operating conditions by means of a model analysis so as to single out regions of flashback occurrence and a criterion for safe operation. Finally, some guidelines are outlined for a cheap and effective control of the system, paving the way for possible improvement of currently adopted control systems. © 2004 American Institute of Chemical Engineers AIChE J, 50: 2276,2286, 2004 [source] Enhancement of biocontrol activity of yeasts by adding sodium bicarbonate or ammonium molybdate to control postharvest disease of jujube fruitsLETTERS IN APPLIED MICROBIOLOGY, Issue 3 2003Y.K. Wan Abstract Aims: To assess the potential of sodium bicarbonate and ammonium molybdate as additives in enhancing the biocontrol efficacy of Rhodotorula glutinis and Cryptococcus laurentii against blue mould in jujube fruits. Methods and Results: Two yeasts at a concentration of 107 CFU ml,1, in combination with 238 mmol l,1 sodium bicarbonate or 15 mmol l,1 ammonium molybdate, showed a significant inhibition effect on blue mould of jujube fruits stored at 20°C for 5 days. The colonizing ability of the yeasts in wounded sites was significantly decreased in the presence of ammonium molybdate. Conclusions: Combining R. glutinis or C. laurentii with sodium bicarbonate or ammonium molybdate provided a more effective control of postharvest disease than using the antagonistic yeasts or the chemicals alone. Significance and Impact of the Study: The addition of sodium bicarbonate or ammonium molybdate reduced the number of antagonists required to efficiently control disease of postharvest fruits, which could result in the reduction of costs. [source] Multiple paternity in a natural population of a wild tobacco fly, Bactrocera cacuminata (Diptera: Tephritidae), assessed by microsatellite DNA markersMOLECULAR ECOLOGY, Issue 11 2007SIMON D. SONG Abstract Mating frequency has important implications for patterns of sexual selection and sexual conflict and hence for issues such as speciation and the maintenance of genetic diversity. Knowledge of natural mating patterns can also lead to more effective control of pest tephritid species, in which suppression programmes, such as the sterile insect technique (SIT) are employed. Multiple mating by females may compromise the success of SIT. We investigated the level of polyandry and sperm utilization in a Brisbane field population of the tropical fruit fly, Bactrocera cacuminata (Hering), using seven polymorphic microsatellite loci. The offspring of 22 wild-caught gravid females were genotyped to determine the number of males siring each brood and paternity skew, using the programs gerud and scare. Our data showed that 22.7% of females produced offspring sired by at least two males. The mean number of mates per female was 1.72. Paternal contributions of double-sired broods were skewed with the most successful male having sired between 76.9% and 87.5% of the offspring. These results have implications for SIT, because the level of remating we have identified would indicate that wild females could mate with one or more resident fertile males. [source] Dopamine transporter: Basic aspects and neuroimagingMOVEMENT DISORDERS, Issue S7 2003Paola P. Piccini MD Abstract The plasma membrane dopamine transporter (DAT) is found exclusively in dopamine neurones and seems to be the defining molecule of the dopamine neurone. It provides effective control over the intensity of dopamine-mediated signalling by recapturing the neurotransmitter released by presynaptic neurones. Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) represent unique techniques for assessing in vivo DAT distribution in humans and offer reliable methods for studying nigrostriatal dopaminergic function in health and disease. The characteristics of different DAT radiotracers, the modifying influences of factors such as age, gender, smoking habit, and dopaminergic drugs on DAT transporters as well as their implication in evaluation of neuroimaging studies are discussed. © 2003 Movement Disorder Society [source] Trophic supplements to intraguild predationOIKOS, Issue 4 2007Matthew P. Daugherty Intraguild predation (IGP) is a dominant community module in terrestrial food webs that occurs when multiple consumers feed both on each other and on a shared prey. This specific form of omnivory is common in terrestrial communities and is of particular interest for conservation biology and biological control given its potential to disrupt management of threatened or pest species. Extensive theory exists to describe the dynamics of three-species IGP, but these models have largely overlooked the potential for other, exterior interactions, to alter the dynamics within the IGP module. We investigated how three forms of feeding outside of the IGP module by intraguild predators (i.e. trophic supplementation) affect the dynamics of the predators (both IG predator and IG prey) and their shared resource. Specifically, we examined how the provision of a constant donor-controlled resource, the availability of an alternative prey species, and predator plant-feeding affect the dynamics of IGP models. All three forms of trophic supplements modified the basic expectations of IGP theory in two important ways, and their effects were similar. First, coexistence was possible without the IG prey being a superior competitor for the original shared resource if the IG prey could effectively exploit one of the types of trophic supplements. However, supplements to the IG predator restricted the potential for coexistence. Second, supplements to the IG prey ameliorated the disruptive effects of the IG predator on the suppression of the shared resource, promoting effective control of the resource in the presence of both predators. Consideration of these three forms of trophic supplementation, all well documented in natural communities, adds substantial realism and predictive power to intraguild predation theory. [source] Regulation of immune responses to Strongyloides venezuelensis challenge after primary infection with different larvae dosesPARASITE IMMUNOLOGY, Issue 3 2010H. C. SCHILTER Summary Nematode infections are generally followed by high rates of reinfection, leading to elevated prevalence in endemic areas. Therefore, the effective control of nematode infections depends on understanding the induction and regulation of protective mechanisms. However, most experimental models for protective immune response against nematodes use high parasite exposure, not always reflecting what occurs naturally in human populations. In this study, we tested whether infecting mice with different Strongyloides venezuelensis larvae loads would affect protective responses against reinfection. Interestingly, we found that a previous infection with 10,500 larvae conferred high rate of protection against reinfection with S. venezuelensis in mice, by destroying large numbers of migrating larvae. However, low-dose priming did not abolish adult worm maturation, as detected in high-dose primed group. Results also indicated that a previous low-dose infection delayed the development of cellular infiltrate, while a high inoculum rapidly induced these inflammatory features. Cytokine production by splenocyte cultures of challenge infected mice demonstrated that low-dose priming had increased production of IL-4 and IFN-,, while high-dose induced IL-4 production but not IFN-,. Our data support the hypothesis that low-dose nematode infection does not induce a polarized type-2 immune response, allowing adult worm survival. [source] Lack of fitness costs associated with pyriproxyfen resistance in the B biotype of Bemisia tabaciPEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 3 2009David W Crowder Abstract BACKGROUND: The insect growth regulator pyriproxyfen has provided effective control of the whitefly Bemisia tabaci Gennadius in many countries. Here, whether or not fitness costs were associated with pyriproxyfen resistance in a laboratory-selected resistant strain (QC02-R) of the B biotype was determined. RESULTS: Mortality caused by pyriproxyfen and fitness traits over time were measured in unselected and selected hybrid strains, which were created by crossing individuals of the resistant strain with individuals of a susceptible strain. Fitness costs were not associated with resistance in QC02-R, as mortality caused by pyriproxyfen did not increase over time in unselected hybrid strains and fitness traits were similar in unselected and selected hybrid strains. Using a new method to examine the inheritance of resistance, based on data from fitness cost experiments, it was estimated that pyriproxyfen resistance is controlled by two loci in the QC02-R strain. CONCLUSION: The lack of fitness costs associated with pyriproxyfen resistance could promote the evolution of resistance in field populations with similar traits to QC02-R. Copyright © 2008 Society of Chemical Industry [source] Competitive Interactions among First-Year and Second-Year Plants of the Invasive, Biennial Garlic Mustard (Alliaria petiolata) and Native Ground Layer VegetationRESTORATION ECOLOGY, Issue 5 2010Jonathan T. Bauer We studied the effects of hand weeding of second-year plants of the biennial garlic mustard (Alliaria petiolata) on first-year plants (seedlings) and native ground layer vegetation. Garlic mustard is a Eurasian species that has invaded deciduous forest ground layers in eastern North America. Treatments consisted of a control and an early or late weeding of second-year garlic mustard. The early treatment (early March) was applied before garlic mustard seeds had germinated and when most native species were dormant. The late treatment (mid-May) occurred after plants had bolted, flowering was occurring, and most native species and new garlic mustard seedlings were actively growing. Pre-treatment data were obtained in 2004 and treated and control plots were sampled in 2005, 2006, and 2007. No significant treatment effects were observed in 2004 or 2005. In 2006, mean cover of first-year plants was higher in the early weeding treatment than in the late weeding treatment and control. In 2007, mean cover of first-year garlic mustard was higher in the control than in either of the two weeding treatments. There were no significant treatment effects in any year on native vegetation cover, bare ground, or the five most abundant native species. Our data indicate that (1) late weeding of garlic mustard provided more effective control than early weeding because late weeding allows second-year plants to compete with garlic mustard seedlings for a longer period of time and (2) competition between first- and second-year plants is responsible for alternating dominance of first-year and second-year garlic mustard plants. [source] Predator, prey and pathogen interactions in introduced snail populationsANIMAL CONSERVATION, Issue 3 2001J. Gerlach The introduction of the carnivorous snail Euglandina rosea to Pacific islands by biological control programmes has had a devastating effect on native snail populations. In most areas the target species, Achatina fulica, has not been affected, although some unsubstantiated reports have led to E. rosea being viewed as an effective control agent. Data from recent laboratory and field studies of E. rosea were combined into a simple model of the interactions between populations of E. rosea and A. fulica and a disease agent. Predictions from the model correspond closely with field data from a number of sites. The model suggests that apparent reductions in A. fulica numbers following E. rosea introduction are the result of a combination of predation and disease effects, and that although the maximum population levels are reduced the population is stabilized at a relatively high level. The model predicts that both A. fulica and E. rosea populations will persist. Partulidae will decline following E. rosea invasion although Samoana spp. may persist at reduced densities. More effective control of A. fulica can be achieved through manual collecting. Control of E. rosea requires the imposition of a significant novel mortality factor. [source] Uterine compression sutures for post-partum bleeding with atony; modification of the B-Lynch sutureAUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 1 2009Jeevan Prasanga MARASINGHE We have described a modification of the B-Lynch uterine compression suture which is simple and effective. This technique apposes the anterior and posterior uterine walls, obliterating the cavity and thereby provides effective control of post-partum haemorrhage as a result of uterine atony. It comprises of vertical compression sutures and is distinct from B-Lynch and Haymen's suture by having an additional firm puncture just below the uterine fundus. This means that the suture is transfixed at the uterine fundus, thus eliminating the risk of the sutures sliding off at the uterine fundus. [source] Potential to reduce the spatial density of attract and kill traps required for effective control of Carpophilus spp. (Coleoptera: Nitidulidae) in stone fruit in AustraliaAUSTRALIAN JOURNAL OF ENTOMOLOGY, Issue 2 2010Mofakhar S Hossain Abstract Attract and kill (A&K) is an effective control technique for Carpophilus spp. attacking stone fruit but high cost has limited its adoption by growers. Field experiments during two successive growing seasons evaluated the potential to reduce the spatial density of A&K traps from three traps per ha (3 A&K) to two traps per ha (2 A&K), against medium to low beetle populations. Fruit damage in 2 A&K and 3 A&K treated blocks was significantly lower than in pesticide-treated control blocks. However there were no significant differences in blocks treated with either 2 A&K or 3 A&K traps in either season. The results suggest that the number of traps per ha can be reduced without reducing the efficacy of the A&K treatment where Carpophilus population levels are medium to low. [source] Crisp, The Senate, And The ConstitutionAUSTRALIAN JOURNAL OF POLITICS AND HISTORY, Issue 4 2008Stanley Bach This essay explores the development of L.F. Crisp's understanding of the appropriate role of Australia's Senate in the national political system. A review of his widely-used textbook over three decades reveals that, to Crisp, the Senate was conceived primarily to protect state interests, but that role was nullified almost immediately by the emergence of disciplined parties. Thereafter, the Senate usually was an ineffectual irrelevancy until the introduction of proportional representation transformed it into a threat to the constitutional system as it should operate. Crisp also appreciated that disciplined parties undermined effective control of government by the House of Representatives, yet he consistently failed to recognize in the Senate an institution capable of doing what the House of Representatives cannot: enforcing accountability on the government of the day. [source] | |||||||||||||||||||||||||||||||||||||