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Efficient Synthetic Route (efficient + synthetic_route)
Selected AbstractsChemInform Abstract: An Efficient Synthetic Route for Pyrrolizinone Synthesis Through Functionalized C-Alkylpyrroles.CHEMINFORM, Issue 8 2010Canan Unaleroglu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: An Efficient Synthetic Route for Quinazolinyl 4-Thiazolidinones.CHEMINFORM, Issue 49 2009Jyotirling R. Mali Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: An Efficient Synthetic Route to Substituted Tetrahydropyrimidines by Cu(OTf)2 -Mediated Nucleophilic Ring-Opening Followed by the [4 + 2] Cycloaddition of N-Tosylazetidines with Nitriles.CHEMINFORM, Issue 25 2009Manas K. Ghorai Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] An Efficient Synthetic Route to New Imidazo[1,2-a]pyridines by Cross-Coupling Reactions in Aqueous Medium.CHEMINFORM, Issue 20 2006Caroline Castera Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Short and Efficient Synthesis of Alkyne-Modified Amino Glycoside Building BlocksEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 17 2009Claudine M. Klemm Abstract In the light of recent progress in RNA biology, the need for molecules that bind to RNA and thus may be suited to manipulating RNA-mediated processes is steadily increasing. We present a very short and efficient synthetic route to alkyne-modified neamine and 2-deoxystreptamine derivatives on a half-gram scale. These derivatives are suitable for constructing a library of potential divalent RNA binders by copper-catalysed 1,3-dipolar cycloaddition to diazides ("click chemistry"). The conjugate dimers thus formed inhibitedDicer-mediated micro-RNA maturation with IC50 values between 0.6 and 15 ,M.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] Cyclotrimerization of ,Oxabenzonorbornadiene': Synthesis of syn - and anti -5,6,11,12,17,18-Hexahydro-5,18:6,11:12,17-triepoxytrinaphthyleneHELVETICA CHIMICA ACTA, Issue 9 2004Lucchi, Ottorino De An efficient synthetic route to the concave-shaped, potentially ionophoric syn - and anti -isomers of 5,6,11,12,17,18-hexahydro-5,18:6,11:12,17-triepoxytrinaphthylene (4) was elaborated. Starting from ,oxabenzonorbornadiene' (5), the stannylated precursor 9 was prepared in three steps, followed by cyclotrimerization catalyzed by copper(I) thiophene-2-carboxylate (CuTC) , which afforded 4 in a syn/anti ratio of 5,:,4. [source] The First Example of Saccharin-Lithium Bromide Catalysis: Direct Synthesis of N -Tosylimines from AlcoholsADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 10 2010Rajesh Patel Abstract The first procedure to access N -tosylimines directly from alcohols under mild and neutral conditions is reported. The protocol involves saccharin-lithium bromide-catalyzed oxidation of alcohols to aldehydes/ketones with chloramine-T followed by their condensation with the in situ generated oxidation by-product p -toluenesulfonamide in the same reaction vessel to afford N -tosylimines in 40,90% overall yields. The present work opens up a new and efficient synthetic route to N -tosyimines directly from alcohols in a one-pot procedure. [source] Silver-Catalyzed One-Pot Cyclization Reaction of Electron- Deficient Alkynes and 2-Yn-1-ols: An Efficient Domino Process to Polysubstituted FuransADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 1 2010Hua Cao Abstract Transition metal-catalyzed domino reactions have been used as powerful tools for the preparation of polysubstituted furans in a one-pot manner. In this paper, an efficient synthetic method was developed for the construction of tri- or tetrasubstituted furans from electron-deficient alkynes and 2-yn-1-ols by a silver-catalyzed domino reaction. It is especially noteworthy that a 2,3,5-trisubstituted 4-ynyl-furan was formally obtained in an extremely direct manner without tedious stepwise synthesis. In addition, regio-isomeric furans were observed when substituted aryl alkynyl ketones were employed. This methodology represents a highly efficient synthetic route to electron-deficient furans for which catalytic approaches are scarce. The reaction proceeds efficiently under mild conditions with commercially available catalysts and materials. [source] An efficient synthetic route to well-defined theta-shaped copolymersJOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 10 2009Gang-Yin Shi Abstract A series of well-defined ,-shaped copolymers composed of polystyrene (PS) and poly(,-caprolactone) (PCL) with controlled molecular weight and narrow molecular weight distribution have been successfully synthesized without any purification procedure by the combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and the "click" chemistry. The synthetic process involves two steps: (1) synthesis of AB2 miktoarm star copolymers, which contain one PCL chain terminated with two acetylene groups and two PS chains with two azido groups at their one end, (,,,,-diacetylene-PCL) (,-azido-PS)2, by ROP, ATRP, and the terminal group transformation; (2) intramolecular cyclization of AB2 miktoarm star copolymers to produce well-defined pure ,-shaped copolymers using "click" chemistry under high dilution. The 1H NMR, FTIR, and gel permeation chromatography techniques were applied to characterize the chemical structures of the resultant intermediates and the target polymers. Their thermal behavior was investigated by DSC. The mobility decrease of PCL chain across PS ring in the theta-shaped copolymers restricts the crystallization ability of PCL segment. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2620,2630, 2009 [source] ChemInform Abstract: A New Route for the Synthesis of Ozagrel Hydrochloride.CHEMINFORM, Issue 38 2010Chenglong Yu Abstract Starting from p-tolualdehyde, a new cost efficient synthetic route to title compound (VI), a highly selective thromboxane A2 inhibitor, is described. [source] Gold- and Silver-Catalyzed Tandem Amination/Ring Expansion of Cyclopropyl Methanols with Sulfonamides as an Expedient Route to PyrrolidinesCHEMISTRY - A EUROPEAN JOURNAL, Issue 33 2008Weidong Rao Abstract An efficient synthetic route to pyrrolidines that relies on AuCl/AgOTf-catalyzed tandem amination/ring expansion of substituted cyclopropyl methanols with sulfonamides is reported herein. The reactions proceed rapidly at 100,°C with catalyst loadings as low as 2,mol,% and produce the pyrrolidine products in yields of 30,95,%. The method was shown to be applicable to a broad range of cyclopropyl methanols, including unactivated ones, and sulfonamide substrates containing electron-withdrawing, electron-donating, and sterically-demanding substituents. The mechanism is suggested to involve activation of the alcohol substrate by the AuCl/AgOTf catalyst, followed by ionization of the starting material, which causes ring opening of the cyclopropane moiety and trapping by the sulfonamide nucleophile. The resultant aminated acyclic intermediate undergoes subsequent intramolecular hydroamination to give the pyrrolidine. [source] A Convergent Approach to Biocompatible Polyglycerol "Click" Dendrons for the Synthesis of Modular Core,Shell Architectures and Their Transport BehaviorCHEMISTRY - A EUROPEAN JOURNAL, Issue 30 2008Monika Wyszogrodzka Dipl.-Ing. Abstract Dendrimers are an important class of polymeric materials for a broad range of applications in which monodispersity and multivalency are of interest. Here we report on a highly efficient synthetic route towards bifunctional polyglycerol dendrons on a multigram scale. Commercially available triglycerol (1), which is highly biocompatible, was used as starting material. By applying Williamson ether synthesis followed by an ozonolysis/reduction procedure, glycerol-based dendrons up to the fourth generation were prepared. The obtained products have a reactive core, which was further functionalized to the corresponding monoazido derivatives. By applying copper(I)-catalyzed 1,3-dipolar cycloaddition, so-called "click" coupling, a library of core,shell architectures was prepared. After removal of the 1,2-diol protecting groups, water-soluble core,shell architectures 24,27 of different generations were obtained in high yields. In the structure,transport relationship with Nile red we observe a clear dependence on core size and generation of the polyglycerol dendrons. [source] Amido-Functionalised Prodigiosenes: Synthesis and Anticancer PropertiesCHEMMEDCHEM, Issue 5 2009Abstract Prodigiosin: Amido-functionalised prodigiosin-derived compounds were synthesised via a robust and efficient synthetic route. These compounds were then evaluated against 60 human cell lines consisting of nine diverse tumour cell types and their anticancer activities were assessed. [source] | ||||||||||||||||||||||