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Drug Administration System (drug + administration_system)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

MMPI Profile as an Outcome "Predictor" in the Treatment of Noncancer Pain Patients Utilizing Intraspinal Opioid Therapy

NEUROMODULATION, Issue 3 2001
Daniel M. Doleys PhD
Objective. To evaluate changes in Minnesota Multiphasic Personality Inventory (MMPI) profiles pre- and post-treatment involving intrathecal opioid therapy. Patients and Methods. This study reports on 30 patients that were evaluated pre- and post-intraspinal opioid therapy. Treatment duration was slightly more than four years. Each patient experienced chronic non-cancer pain deemed suitable for trialing and subsequent implantation of a drug administration system (DAS). On average the patients had experienced pain for 8.4 years and had a mean of 3.2 pain-related surgeries. Results. The patients could be divided into "positive change group" and "negative change group" based upon pre- and post-treatment MMPI profiles. Those patients in the negative change group had more "normal profiles" pretreatment. This group evidenced less reduction in pain and was found to be using slightly higher levels of intraspinal opioids. Conclusions. These results would suggest that the MMPI profile may not be a good "predictor" of long-term outcome utilizing intraspinal opioid therapy. Indeed, patients with the more normal profile pretreatment did not fare as well as those with the more elevated profile. A positive change in MMPI profile from pre- to post-treatment was associated with a higher level of pain reduction. Patient selection therefore should be based not on a single test such as the MMPI, but on consistency across multiple sources of information including physical examination, complaints of pain and disability, behavioral observations, and psychological testing. [source]

Clinical assessment of a new anaesthetic drug administration system: a prospective, controlled, longitudinal incident monitoring study,

ANAESTHESIA, Issue 5 2010
C. S. Webster
Summary A safety-orientated system of delivering parenteral anaesthetic drugs was assessed in a prospective incident monitoring study at two hospitals. Anaesthetists completed an incident form for every anaesthetic, indicating if an incident occurred. Case mix data were collected and the number of drug administrations made during procedures estimated. From February 1998 at Hospital A and from June 1999 at Hospital B, until November 2003, 74 478 anaesthetics were included, for which 59 273 incident forms were returned (a 79.6% response rate). Fewer parenteral drug errors occurred with the new system than with conventional methods (58 errors in an estimated 183 852 drug administrations (0.032%, 95% CI 0.024,0.041%) vs 268 in 550 105 (0.049%, 95% CI 0.043,0.055%) respectively, p = 0.002), a relative reduction of 35% (difference 0.017%, 95% CI 0.006,0.028%). No major adverse outcomes from these errors were reported with the new system while 11 (0.002%) were reported with conventional methods (p = 0.055). We conclude that targeted system re-design can reduce medical error. [source]

A prospective, randomised clinical evaluation of a new safety-orientated injectable drug administration system in comparison with conventional methods,

ANAESTHESIA, Issue 1 2004
C. S. Webster
Summary Fifteen anaesthetists were observed while providing anaesthesia for 15 pairs of adult cardiac surgical operations, using conventional methods for one of each pair and a new drug administration system designed to reduce error for the other. Aspects of each method were rated by users on 10-cm visual analogue scales (10 being best). The new system was rated more favourably than conventional methods in terms of safety (median [range] = 8.1 [6.8,9.7] vs. 7.1 [2.6,9.3] cm; p = 0.001) and usability (8.5 [5.9,9.4] vs. 7.5 [3.2,9.8] cm; p = 0.027). The new system saved preparation time both before anaesthesia (median [range] = 180 [32,480] vs. 360 [120,600] s; p = 0.013) and during anaesthesia (10 [2,38] vs. 12 [10,60] s; p = 0.009). Prefilled syringes for the new system increased costs by ,23.00 per anaesthetic (p = 0.041), but this increase is likely to be offset by the potential of the new system to decrease costly iatrogenic harm by preventing drug error. [source]