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Dominant Role (dominant + role)
Selected AbstractsIn Situ Urbanization in Rural China: Case Studies from Fujian ProvinceDEVELOPMENT AND CHANGE, Issue 2 2000Yu Zhu In most parts of the developing world, the urbanization process has been dominated by rural,urban migration and the growth of existing cities. However, case-studies in China's Fujian Province suggest that this process can also be achieved mainly by in situ transformation in rural areas. Such in situ transformation of rural areas has been driven mainly by two forces, the development of township and village enterprises (TVEs) and the inflow of foreign investment; and facilitated by the relevant policies adopted by the Chinese government since 1978. The former has been very effective in the transformation of rural employment structure, while the latter has brought many physical changes to the previously rural landscape. Being mutually complementary, these two ways of rural transformation have not only benefited and urbanized the rural areas, but kept many farmers in their hometowns, replacing the dominant role of rural,urban migration and the growth of existing cities in the urbanization process. [source] Respiratory units of motor production and song imitation in the zebra finchDEVELOPMENTAL NEUROBIOLOGY, Issue 2 2002Michele Franz Abstract Juvenile male zebra finches (Taeniopygia guttata) learn a stereotyped song by imitating sounds from adult male tutors. Their song is composed of a series of syllables, which are separated by silent periods. How acoustic units of song are translated into respiratory and syringeal motor gestures during the song learning process is not well understood. To learn about the respiratory contribution to the imitation process, we recorded air sac pressure in 38 male zebra finches and compared the acoustic structures and air sac pressure patterns of similar syllables qualitatively and quantitatively. Acoustic syllables correspond to expiratory pressure pulses and most often (74%) entire syllables are copied using similar air sac pressure patterns. Even notes placed within different syllables are generated with similar air sac pressure patterns when only segments of syllables are copied (9%). A few of the similar syllables (17%) are generated with a modified pressure pattern, typically involving addition or deletion of an inspiration. The high similarity of pressure patterns for like syllables indicates that generation of particular sounds is constrained to a narrow range of air sac pressure conditions. Following presentation of stroboscope flashes, song was typically interrupted at the end of an expiratory pressure pulse, confirming that expirations and, therefore, syllables are the smallest unit of motor production of song. Silent periods, which separate syllables acoustically, are generated by switching from expiration to inspiration. Switching between respiratory phases, therefore, appears to play a dominant role in organizing the stereotyped motor program for song production. © 2002 Wiley Periodicals, Inc. J Neurobiol 51: 129,141, 2002 [source] The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptakeDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 1 2004Lucy H. Clerk Abstract Whether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of the data both supporting and questioning the role of insulin-mediated increases in limb blood flow in glucose metabolism. We advance the hypothesis that controversy has arisen, at least in part, from a failure to recognize that insulin exerts at least three separate actions on the peripheral vasculature, each with its own characteristic dose and time responsiveness. We summarize how, viewed in this manner, certain points of contention can be resolved. We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle. Copyright © 2003 John Wiley & Sons, Ltd. [source] The costs and benefits of fast livingECOLOGY LETTERS, Issue 12 2009Karen E. Rose Abstract Growth rates play a fundamental role in many areas of biology (Q. Rev. Biol., 67, 1992, 283; Life History Invariants. Some Explorations of Symmetry in Evolutionary Biology, 1993; Philos. Trans. R. Soc. Lond. B Biol. Sci., 351, 1996, 1341; Plant Strategies, Vegetation Processes, and Ecosystem Properties, 2002; Trends Ecol. Evol., 18, 2003, 471; Q. Rev. Biol., 78, 2003, 23; J. Ecol., 95, 2007, 926.) but the cost and benefits of different growth rates are notoriously difficult to quantify (Q. Rev. Biol., 72, 1997, 149; Funct. Ecol., 17, 2003, 328). This is because (1) growth rate typically declines with size and yet the most widely used growth measure , relative growth rate or RGR (conventionally measured as the log of the ratio of successive sizes divided by the time interval) , is not size-corrected and so confounds growth and size, (2) organisms have access to different amounts of resource and (3) it is essential to allow for the long-term benefits of larger size. Here we experimentally demonstrate delayed costs and benefits of rapid growth in seven plant species using a novel method to calculate size-corrected RGR. In control treatments, fast-growing plants benefited from increased reproduction the following year; however, fast-growing plants subjected to an experimental stress treatment (defoliation) showed strongly reduced survival and reproduction the following year. Importantly, when growth was estimated using the classical RGR measure, no costs or benefits were found. These results support the idea that life-history trade-offs have a dominant role in life-history and ecological theory and that the widespread failure to detect them is partly due to methodological shortcomings. Ecology Letters (2009) 12: 1379,1384 [source] Investment and Uncertainty: Precipitating the Great Depression in the United StatesECONOMICA, Issue 291 2006DAVID GREASLEY A severe collapse of fixed capital formation distinguished the onset of the Great Depression from other investment downturns between the world wars. Using a model estimated for the years 1890,2000, we show that the expected profitability of capital measured by Tobin's q, and the uncertainty surrounding expected profits indicated by share price volatility, were the chief influences on investment levels, and that heightened share price volatility played the dominant role in the crucial investment collapse in 1930. Investment did not simply follow the downward course of income at the onset of the depression: rather, its slump helped to propel the wider collapse. [source] Persistent or not persistent?ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2009Polychlorinated biphenyls are readily depurated by grizzly bears (Ursus arctos horribilis) Abstract Major pharmacokinetic processes influencing polychlorinated biphenyl (PCB) accumulation in mammals include uptake, biotransformation, respiration, and excretion. We characterized some of the factors underlying PCB accumulation/loss by evaluating PCB concentrations and patterns in pre- and posthibernation grizzly bears (Ursus arctos horribilis) and their prey. The PCB congeners with vicinal meta - and para -chlorine unsubstituted hydrogen positions consistently showed loss both before and during hibernation, supporting the idea of a dominant role for biotransformation. Retention of all other studied congeners relative to that of PCB 194 varied widely (from <1 to 100%) and was highly correlated with log octanol--water partition coefficient (p < 0.0001). A lack of loss for most of these other congeners during hibernation supports the notion that excretion (e.g., fecal or urinary) or lack of uptake during the feeding season underlies their lack of accumulation, because hibernating bears do not eat or excrete. We estimate that grizzly bears retain less than 10% of total PCBs taken up from their diet. Our results suggest that for grizzly bears, depuration of PCBs via biotransformation is important (explaining ,40% of loss), but that nonbiotransformation processes, such as excretion, may be more important (explaining ,60% of loss). These findings, together with the approximately 91% loss of the persistent PCB 153 congener relative to PCB 194 in grizzly bears, raise important questions about how one defines persistence of PCBs in wildlife and may have bearing on the interpretation of food-web biomagnification studies. [source] New insights into the regulation of iron homeostasisEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 5 2006R. Deicher Abstract Hepcidin evolves as a potent hepatocyte-derived regulator of the body's iron distribution piloting the flow of iron via, and directly binding, to the cellular iron exporter ferroportin. The hepcidin-ferroportin axis dominates the iron egress from all cellular compartments that are critical to iron homeostasis, namely placental syncytiotrophoblasts, duodenal enterocytes, hepatocytes and macrophages of the reticuloendothelial system. The gene that encodes hepcidin expression (HAMP) is subject to regulation by proinflammatory cytokines, such as IL-6 and IL-1; excessive hepcidin production explains the relative deficiency of iron during inflammatory states, eventually resulting in the anaemia of inflammation. The haemochromatosis genes HFE (the human leukocyte antigen-related gene), TfR2 (the transferrin receptor-2 gene) and HJV (the haemojuvelin gene) potentially facilitate the transcription of HAMP. Disruption of each of the four genes leads to a diminished hepatic release of hepcidin consistent with both a dominant role of hepcidin in hereditary haemochromatosis and an upstream regulatory role of HFE, TfR2 and HJV on HAMP expression. The engineered generation of hepcidin agonists, mimetics or antagonists could largely broaden current therapeutic strategies to redirect the flow of iron. [source] RESEARCH FOCUS ON COMPULSIVE BEHAVIOUR IN ANIMALS: An animal model of compulsive food-taking behaviourADDICTION BIOLOGY, Issue 4 2009Andrea Heyne ABSTRACT The increase in the incidence of obesity and eating disorders has promoted research aimed at understanding the aetiology of abnormal eating behaviours. Apart from metabolic factors, obesity is caused by overeating. Clinical reports have led to the suggestion that some individuals may develop addictive-like behaviours when consuming palatable foods, and compulsive eating plays a similar dominant role in obesity as compulsive drug taking does in drug addiction. The progress made in the development of treatment strategies for obesity is limited, in part, because the physiological and neurological causes and consequences of compulsive eating behaviour are not clearly understood and cannot readily be studied in human subjects. We have developed experimental approaches that reflect the functioning of the components of eating control, including compulsive food taking in rats. Rats that are given free choice between standard chow and a palatable, chocolate-containing ,Cafeteria Diet' (CD) develop distinct signs of compulsive food taking that appear at an early stage. These include the inability to adapt intake behaviour in periods of limited or bitter-tasting CD access, continued food intake during resting phases and changes in fine structure of feeding (duration, distribution and recurrence of feeding bouts). The model will help examine the neurobiological underpinnings of compulsive food seeking and food taking and provides a possibility to study the effects of novel anti-obesity compounds on compulsive eating and other components of food-taking behaviour in detail. For future use of genetic models, the possibility of a transfer to a mouse was discussed. [source] Right-hemisphere motor facilitation by self-descriptive personality-trait wordsEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 7 2005Istvan Molnar-Szakacs Abstract The emergent picture from the literature on the processing of self-related information suggests that in addition to the neural mechanisms involved in recognizing one's own face, there may also be neural representations of the self that are modality independent and favour the right hemisphere. We used focal, single-pulse transcranial magnetic stimulation in human subjects to assess cortical excitability during covert reading of self-descriptive personality-trait words. We hypothesized that the right hemisphere would show a greater overall facilitation to personality-trait words than the left hemisphere. Overall, personality-trait words led to significantly greater motor facilitation in the right hemisphere than in the left hemisphere. In addition, words rated as ,never' self-characteristic yielded significant right hemisphere facilitation, and words rated as ,always' self-characteristic showed a similar trend. The results are discussed in terms of the notion that the right hemisphere plays a dominant role in both self-relevant processing and the processing of affective stimuli. [source] The effect of socioeconomic factors on voter turnout in Finland: A register-based study of 2.9 million votersEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 5 2005PEKKA MARTIKAINEN The analyses are based on individual-level register data from electoral wards from the parliamentary elections of 1999 linked to population registration data on personal characteristics covering the whole 25 to 69 year-old Finnish electorate. The results show that income and housing tenure are more important determinants of turnout among older voters than among younger voters, whereas education has a dominant role in determining young people's turnout. Moreover, class has maintained its discriminatory power in determining turnout in all age groups even though working-class under-representation in participation can be partly attributable to previously obtained educational attainment. Furthermore, the lower turnout of younger voters remains unexplained even if socioeconomic factors are held constant. Lower turnout among lower social classes and among the young will affect the legitimacy of the prevalent model of party democracy. [source] Analyzing dynamic performance of stressed power systems in vicinity of instability by modal series methodEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 8 2009Ali H. Naghshbandy Abstract Highly stressed power systems exhibit complex dynamic behaviors such as inter-area oscillations when subjected to large disturbances. In such conditions, nonlinear effects have dominant role in determining dynamic response of the systems. In this paper by using modal series method, dynamic behaviors of the stressed power systems in severe conditions and near instability have been studied. Also two measures, mode dominance measure (MDM) and most perturbed machine factor (MPF) have been introduced. They determine the most dominant modes and identify the most perturbed generators when the system is subjected to a given fault. Contribution factors have been used to show the links between identified modes and machines from the analysis. Time domain simulation has been helped for validation of the results. By using similarity transformation, state variables have been represented in modal space and utilized to check the results. The studies are carried out on the IEEE 50-generator test system which demonstrates a wide range of dynamic characteristics at different loading levels and fault scenarios. Copyright © 2008 John Wiley & Sons, Ltd. [source] Variations in Hole Injection due to Fast and Slow Interfacial Traps in Polymer Light-Emitting Diodes with InterlayersADVANCED FUNCTIONAL MATERIALS, Issue 1 2010M. James Harding Abstract Detailed studies on the effect of placing a thin (10,nm) solution-processable interlayer between a light-emitting polymer (LEP) layer and a poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonic)-acid-coated indium tin oxide anode is reported; particular attention is directed at the effects on the hole injection into three different LEPs. All three different interlayer polymers have low ionization potentials, which are similar to those of the LEPs, so the observed changes in hole injection are not due to variations in injection barrier height. It is instead shown that changes are due to variations in hole trapping at the injecting interface, which is responsible for varying the hole current by up to two orders of magnitude. Transient measurements show the presence of very fast interfacial traps, which fill the moment charge is injected from the anode. These can be considered as injection pathway dead-ends, effectively reducing the active contact surface area. This is followed by slower interfacial traps, which fill on timescales longer than the carrier transit time across the device, further reducing the total current. The interlayers may increase or decrease the trap densities depending on the particular LEP involved, indicating the dominant role of interfacial chain morphology in injection. Penetration of the interlayer into the LEP layer can also occur, resulting in additional changes in the bulk LEP transport properties. [source] FLOX® Steam Reforming for PEM Fuel Cell Systems,FUEL CELLS, Issue 4 2004H.-P. Schmid Abstract Primary energy savings and CO2 reduction is one of the key motivations for the use of fuel cell systems in the energy sector. A benchmark of domestic cogeneration by PEMFC with existing large scale power production systems such as combined steam-gas turbine cycle, clearly reveals that only fuel cell systems optimising overall energy efficiency (>,85%) and electrical efficiencies (>,35%) show significant primary energy savings, about 10%, compared with the best competing technology. In this context, fuel processing technology plays a dominant role. A comparison of autothermal and steam reforming concepts in a PEMFC system shows inherent advantages in terms of efficiency at low complexity for the latter. The main reason for this is that steam reforming allows for the straightforward and effective use of the anode-off gas energy in the reformer burner. Consequently, practical electrical system efficiencies over 40% seem to be achievable, most likely by steam reformers. FLOX®-steam reforming technology has reached a high state of maturity, offering diverse advantages including: compact design, stable anode off-gas usage, high efficiency, as well as simple control behaviour. Scaling of the concept is straightforward and offers an opportunity for efficient adaptation to smaller (1,kW) and larger (50,kW) units. [source] Variability and divergence in Pongamia pinnata (L.) Pierre germplasm , a candidate tree for biodieselGCB BIOENERGY, Issue 6 2009N. SUNIL Abstract Three explorations were undertaken in South East Coastal zone of India covering parts of Andhra Pradesh (AP) and Orissa states to collect Pongamia pinnata (L.) Pierre germplasm during March,June 2007. A total of 123 accessions were collected and seed data recorded were analyzed for morphometric traits viz., seed length, seed width, seed thickness, 100-seed weight and oil content. Variation in the collected germplasm was analyzed using anova, simple measures of variation and D2 statistics. Significant genetic variability between seed traits and oil content and association among the seed traits was recorded. Phenotypic variance was higher than genotypic variance for all the characters indicating dominant role of environment. High heritability (broad sense) for 100-seed weight (97.6%) and oil content (86.7%) indicated the reliability of these characters as selection criteria for plus trees. Genetic gain was maximum for 100-seed weight (62.6%) followed by oil content (30.5%). D2 analysis grouped the accessions into 12 clusters. Cluster XII and cluster IX were the most diverse based on the intercluster distance. Based on the observed diversity, Chittoor, Srikakulam and Adilabad districts of AP are most suitable for collecting diverse germplasm lines and also for in situ conservation. [source] Wet and Dry Adhesion Properties of Self-Selective Nanowire ConnectorsADVANCED FUNCTIONAL MATERIALS, Issue 19 2009Hyunhyub Ko Abstract Here, the wet and dry adhesion properties of hybrid Ge/parylene nanowire (NW) connectors are examined. The ability of the NW connectors to bind strongly even under lubricating conditions, such as mineral oil, sheds light on the dominant role of van der Waals interactions in the observed adhesion. The superhydrophobic surface of the NW connectors enables the wet, self-cleaning of contaminant particles from the surface, similar to the lotus effect. In addition, the effect of NW length on the shear adhesion strength, repeated usability, and robustness of the connectors, all critical properties for applications that require reversible binding of components, is examined. [source] Quantifying the erosional impact of the Fennoscandian ice sheet in the Torneträsk,Narvik corridor, northern Sweden, based on cosmogenic radionuclide dataGEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 3-4 2002Arjen P. Stroeven Despite spectacular landform evidence of a dominant role for glacial action in shaping landscapes under former northern hemisphere ice sheets, there is little quantitative evidence for rates and patterns of erosion associated with specific glaciations. Here we use cosmogenic nuclide data to assess rates of subglacial erosion underneath the Fennoscandian ice sheet. By testing whether there are remnant nuclide concentrations in samples taken from sites that include both relict areas and features and landscapes typically associated with vigorous glacial erosion, we can constrain the level and pattern of modification that resulted from the last glaciation. Cosmogenic 10Be and 36Cl data from the Torneträsk region confirm the temporal and spatial variability of glacial erosion suggested by geomorphological mapping. At some sites, glacial erosion estimates in what appear to be heavily scoured areas indicate erosion of only c. 2 ± 0.4 m of bedrock, based on cosmogenic nuclide inheritance. This implies that the generation of severely scoured terrain in this study area required multiple glaciations. The overall modification produced by ice sheets along glacial corridors may be more restricted than previously thought, or may have occurred preferentially during earlier Quaternary glacial periods. [source] Evaporating characteristics of a microlayer under a bubbleHEAT TRANSFER - ASIAN RESEARCH (FORMERLY HEAT TRANSFER-JAPANESE RESEARCH), Issue 6 2002C.H. Li Abstract Using the Hallinan-Ervin model, the flow and evaporation in a bubble microlayer were theoretically analyzed, and the dryout characteristics and Staub's criterion were discussed in detail. It was revealed that the critical dryout radius is associated with the wettability of the heated surface, and that the dominant role for microlayer evaporation is disjoining pressure, not surface tension gradient. © 2002 Wiley Periodicals, Inc. Heat Trans Asian Res, 31(6): 456,462, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.10052 [source] Chinese Learning (kangaku) in Meiji Japan (1868,1912)HISTORY, Issue 277 2000Margaret Mehl Japan's development since the middle of the nineteenth century is usually summarized under the headings ,modernization' and ,westernization'. Such a perspective neglects the importance of indigenous traditions in the shaping of modern Japan, including Chinese learning (kangaku), which had been thoroughly assimilated and had formed the basis of the dominant ideology in the Tokugawa period (1600-1868). The leaders of the Meiji restoration of 1868 all had a kangaku education and their ideas were strongly influenced by it. Kangaku continued to play a dominant role in Japanese culture until well into the Meiji period and did not fall into decline until the mid-1890s. The main reason for this was not contempt for contemporary China in the wake of the Sino-Japanese war (1894-5), as has been argued, but the new national education system which stressed western knowledge. It was not a sign of waning interest in China, but of new forms this interest took. China became the object of new academic disciplines, including t,y,shi (East Asian history), which applied western methods and a new interpretative framework to the study of China. [source] The effect of soil type, meteorological forcing and slope gradient on the simulation of internal erosion processes at the local scaleHYDROLOGICAL PROCESSES, Issue 13 2010Guillaume Nord Abstract Numerical simulation experiments of water erosion at the local scale (20 × 5 m) using a process-based model [Plot Soil Erosion Model_2D (PSEM_2D)] were carried out to test the effects of various environmental factors (soil type, meteorological forcing and slope gradient) on the runoff and erosion response and to determine the dominant processes that control the sediment yield at various slope lengths. The selected environmental factors corresponded to conditions for which the model had been fully tested beforehand. The use of a Green and Ampt model for infiltration explained the dominant role played by rainfall intensity in the runoff response. Sediment yield at the outlet of the simulated area was correlated positively with rainfall intensity and slope gradient, but was less sensitive to soil type. The relationship between sediment yield (soil loss per unit area) and slope length was greatly influenced by all environmental factors, but there was a general tendency towards higher sediment yield when the slope was longer. Contribution of rainfall erosion to gross erosion was dominant for all surfaces with slope lengths ranging from 4 to 20 m. The highest sediment yields corresponded to cases where flow erosion was activated. An increase in slope gradient resulted in flow detachment starting upstream. Sediment exported at the outlet of the simulated area came predominantly from the zone located near the outlet. The microrelief helped in the development of a rill network that controlled both the ratio between rainfall and flow erosion and the relationship between sediment yield and slope length. Copyright © 2010 John Wiley & Sons, Ltd. [source] The geochemical characteristics of the Paraná River suspended sediment load: an initial assessmentHYDROLOGICAL PROCESSES, Issue 7 2003Pedro J. Depetris Abstract Most water in the Paraná River drainage basin is supplied by the tropical Upper Paraná (over 60% of the total annual water discharge, 550 km3). The total suspended solids (TSS) load (c. 80 × 106 t year,1), however, is essentially furnished (50,70%) by the mountainous, arid and mostly sediment-mantled upper Bermejo River drainage basin. This characteristic suggests that the Paraná River solid load (TSS, 600 km upstream from the mouth) is largely recycled sedimentary material, whose discharge-weighted mean chemical index of alteration is c. 71. The extended UCC-normalized multi-elemental diagrams are similar to those of other world rivers. Nevertheless, the detailed inspection of UCC-normalized rare earth element (REE) ,spidergrams' reveals a lithological source for the Paraná River TSS that might be compatible with either tholeiitic flood basalts (widespread in the upper drainage) or with young Andean intermediate volcanic rocks. In view of the Bermejo River's dominant role as a sediment contributor, we feel that the signature preserved in the Paraná's TSS is the latter. Conversely, the Uruguay River TSS REE signature is certainly determined by the extensive weathering products of Jurassic,Cretaceous tholeiitic basalts. Copyright © 2003 John Wiley & Sons, Ltd. [source] A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatantsIMMUNOLOGY, Issue 3 2006Shân L. Gyles Summary Human cultured mast cells, immunologically activated with immunoglobuin E (IgE)/anti-IgE, released a factor(s) that promoted chemotaxis of human CRTH2+ CD4+ T helper type 2 (Th2) lymphocytes. Mast cell supernatants collected at 20 min, 1 hr, 2 hr and 4 hr after activation caused a concentration-dependent increase in the migration of Th2 cells. The effect of submaximal dilutions of mast-cell-conditioned media was inhibited in a dose-dependent manner by ramatroban (IC50 = 96 nm), a dual antagonist of both the thromboxane-like prostanoid (TP) receptor and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), but not by the selective TP antagonist SQ29548, implicating CRTH2 in mediating the chemotactic response of these Th2 cells. The effect of mast-cell-conditioned media was mimicked by prostaglandin D2 (PGD2) and this eicosanoid was detected in the conditioned media from activated mast cells in concentrations sufficient to account for the activity of the mast cell supernatants. Treatment of the mast cells with the cyclo-oxygenase inhibitor diclofenac (10 ,m) inhibited both the production of PGD2 and the CRTH2+ CD4+ Th2-stimulatory activity, while addition of exogenous PGD2 to conditioned media from diclofenac-treated mast cells restored the ability of the supernatants to promote chemotaxis of these Th2 cells. The degree of inhibition caused by diclofenac treatment of the mast cells was concordant with the degree of inhibition of chemotactic responses afforded by CRTH2 blockade. These data suggest that PGD2, or closely related metabolites of arachidonic acid, produced from mast cells may play a central role in the activation of CRTH2+ CD4+ Th2 lymphocytes through a CRTH2-dependent mechanism. [source] Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responsesIMMUNOLOGY, Issue 2 2004Pallavur V. Sivakumar Summary Cytokines and their receptors represent key targets for therapeutic intervention. Ligands are being used to supplement cell numbers that become depleted as a result of disease (organ failure, infection) or subsequent disease treatments (i.e. chemotherapy). Conversely, the inhibition of target cell binding by cytokines is an established strategy for abrogating pathologic cellular activities common to many immunological diseases. Considerable effort in biomedical research is being focused on the cytokine families that play a dominant role in regulating immunity and then prioritizing each member for its therapeutic potential. Currently, the interleukin-2 (IL-2) family of cytokines is widely recognized for its central involvement in controlling lymphocyte function and is the most explored for medical utility. Collectively, these proteins (or their antagonists) are either marketed drugs or have received advanced testing for an impressive array of indications including cancer, infectious disease, transplantation, inflammation and allergic asthma. Here we review the current understanding of IL-21, the most recent member of this cytokine family to be discovered. As will be discussed, IL-21 shares many of the same attributes as its relatives in that it has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. Its ability to stimulate durable anti-tumour responses in mice defines one therapeutic indication that merits clinical development. [source] Wrapped input selection using multilayer perceptrons for repeat-purchase modeling in direct marketingINTELLIGENT SYSTEMS IN ACCOUNTING, FINANCE & MANAGEMENT, Issue 2 2001Stijn Viaene In this paper, we try to validate existing theory on and develop additional insight into repeat-purchase behavior in a direct marketing setting by means of an illuminating case study. The case involves the detection and qualification of the most relevant RFM (Recency, Frequency and Monetary) variables, using a neural network wrapper as our input pruning method. Results indicate that elimination of redundant and/or irrelevant inputs by means of the discussed input selection method allows us to significantly reduce model complexity without degrading the predictive generalization ability. It is precisely this issue that will enable us to infer some interesting marketing conclusions concerning the relative importance of the RFM predictor categories and their operationalizations. The empirical findings highlight the importance of a combined use of RFM variables in predicting repeat-purchase behavior. However, the study also reveals the dominant role of the frequency category. Results indicate that a model including only frequency variables still yields satisfactory classification accuracy compared to the optimally reduced model. Copyright © 2001 John Wiley & Sons, Ltd. [source] Financial Contagion in Five Small Open Economies: Does the Exchange Rate Regime Really Matter?INTERNATIONAL FINANCE, Issue 1 2000Zsolt Darvas This paper examines the spillover effects of the global financial crises of 1997,9 on five small open economies with different types of exchange rate regimes: the Czech Republic, Greece, Hungary, Israel and Poland. We found empirical evidence that the regional aspect played a dominant role in the intensity of the spillover effects. We found no empirical evidence that the pressures on exchange rates, interest rates and stock markets were primarily influenced by the exchange rate regime in place. Our findings do not support the commonly held view that flexible regimes are the best choice for small open emerging market economies exposed to volatile capital flows. [source] Effect of pressure on thermal aspects in the riser column of a pressurized circulating fluidized bedINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 3 2006A. V. S. S. K. S. Gupta Abstract In the present paper the effect of pressure on bed-to-wall heat transfer in the riser column of a pressurized circulating fluidized bed (PCFB) unit is estimated through a modified mechanistic model. Gas,solid flow structure and average cross-sectional solids concentration play a dominant role in better understanding of bed-to-wall heat transfer mechanism in the riser column of a PCFB. The effect of pressure on average solids concentration fraction ,c' in the riser column is analysed from the experimental investigations. The basic cluster renewal model of an atmospheric circulating fluidized bed has been modified to consider the effect of pressure on different model parameters such as cluster properties, gas layer thickness, cluster, particle, gas phase, radiation and bed-to-wall heat transfer coefficients, respectively. The cluster thermal conductivity increases with system pressure as well as with bed temperature due to higher cluster thermal properties. The increased operating pressure enhances the particle and dispersed phase heat transfer components. The bed-to-wall heat transfer coefficient increases with operating pressure, because of increased particle concentration. The predicted results from the model are compared with the experimentally measured values as well as with the published literature, and a good agreement has been observed. The bed-to-wall heat transfer coefficient variation along the riser height is also reported for different operating pressures. Copyright © 2005 John Wiley & Sons, Ltd. [source] On the effect of the local turbulence scales on the mixing rate of diffusion flames: assessment of two different combustion modelsINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 10 2002Jose Lopes Abstract A mathematical model for the prediction of the turbulent flow, diffusion combustion process, heat transfer including thermal radiation and pollutants formation inside combustion chambers is described. In order to validate the model the results are compared herein against experimental data available in the open literature. The model comprises differential transport equations governing the above-mentioned phenomena, resulting from the mathematical and physical modelling, which are solved by the control volume formulation technique. The results yielded by the two different turbulent-mixing physical models used for combustion, the simple chemical reacting system (SCRS) and the eddy break-up (EBU), are analysed so that the need to make recourse to local turbulent scales to evaluate the reactants' mixing rate is assessed. Predictions are performed for a gaseous-fuelled combustor fired with two different burners that induce different aerodynamic conditions inside the combustion chamber. One of the burners has a typical geometry of that used in gaseous fired boilers,fuel firing in the centre surrounded by concentric oxidant firing,while the other burner introduces the air into the combustor through two different swirling concentric streams. Generally, the results exhibit a good agreement with the experimental values. Also, NO predictions are performed by a prompt-NO formation model used as a post-processor together with a thermal-NO formation model, the results being generally in good agreement with the experimental values. The predictions revealed that the mixture between the reactants occurred very close to the burner and almost instantaneously, that is, immediately after the fuel-containing eddies came into contact with the oxidant-containing eddies. As a result, away from the burner, the SCRS model, that assumes an infinitely fast mixing rate, appeared to be as accurate as the EBU model for the present predictions. Closer to the burner, the EBU model, that establishes the reactants mixing rate as a function of the local turbulent scales, yielded slightly slower rates of mixture, the fuel and oxidant concentrations which are slightly higher than those obtained with the SCRS model. As a consequence, the NO concentration predictions with the EBU combustion model are generally higher than those obtained with the SCRS model. This is due to the existence of higher concentrations of fuel and oxygen closer to the burner when predictions were performed taking into account the local turbulent scales in the mixing process of the reactants. The SCRS, being faster and as accurate as the EBU model in the predictions of combustion properties appears to be more appropriate. However, should NO be a variable that is predicted, then the EBU model becomes more appropriate. This is due to the better results of oxygen concentration yielded by that model, since it solves a transport equation for the oxidant concentration, which plays a dominant role in the prompt-NO formation rate. Copyright © 2002 John Wiley & Sons, Ltd. [source] Effect of pressure and temperature on cluster and particle heat transfer in a pressurized circulating fluidized bedINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 14 2001B. V. Reddy Abstract The present work reports the influence of pressure and bed temperature on particle-to-wall heat transfer in a pressurized circulating fluidized bed (PCFB). The particle convection heat transfer plays a dominant role in determining the bed-to-wall heat transfer coefficient. So far, no information is reported on the effect of pressure and bed temperature on particle-to-wall heat transfer in a PCFB in the published literature. The present investigation reports some information in this direction. The effect of system pressure and bed temperature are investigated to study their influence on cluster and particle heat transfer. The particle convection heat transfer coefficient increases with system pressure and bed temperature due to higher cluster thermal conductivity. The increase in particle concentration (suspension density) results in greater cluster solid fraction and also the particle concentration near the wall is enhanced. This results in higher cluster and particle convection heat transfer between the bed and the wall. Higher particle convection heat transfer coefficient results in enhanced heat transfer between the bed and the wall. The results will also help to understand the bed-to-wall heat transfer mechanism in a better way in a PCFB. Copyright © 2001 John Wiley & Sons, Ltd. [source] A water heater using very high-temperature storage and variable thermal contact resistanceINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 10 2001C. K. Jotshi Abstract This paper describes the role of thermal contact resistance in a high-temperature sensible heat storage water heater using cast iron as a storage material. An experimental set-up consisting of a cast iron cylinder and a stainless-steel tube running through its centre was fabricated and tested. The experimental data were compared with a theoretical model. It was observed that the variation in thermal contact resistance between the cast-iron blocks and the tube with temperature plays a dominant role in extracting the heat at a reasonably constant temperature. The contact resistance between two contacting surfaces was modelled as the composite of two parallel resistances: one due to the points where two surfaces contact each other and the other due to a gap between the surfaces, which is often air filled. An approximate contact resistance prediction was obtained by assuming the resistance due to the air gap modulated by a correction factor which accounts for the contacting surface area. Based on the results from the experimental set-up and theoretical modelling, a prototype storage water heater using cast-iron blocks as the storage material was designed, fabricated and tested. Copyright © 2001 John Wiley & Sons, Ltd. [source] Improving geriatric mental health nursing care: Making a case for going beyond psychotropic medicationsINTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING, Issue 1 2003Philippe Voyer ABSTRACT Providing high-quality mental health nursing care should be an important and continuous preoccupation in the gerontological nursing field. As the proportion of elderly people in our society is growing, the emphasis on high-quality care will receive increasing attention from administrators, politicians, organized groups, researchers and clinical nurses. Recent findings illustrate unequivocally the important contribution of nurses to achieving the goal of high-quality geriatric care. However, the quality of care for the elderly with psychological difficulties has not been addressed. The objective of this article is to illustrate that while nurses can accomplish much to improve the well-being and mental health of the elderly, their skills are often underutilized. Psychotropic drugs are often the first-line interventions used by health-care professionals to treat mental health concerns of elderly persons. Alternative therapies that could be implemented and evaluated, such as psychological counselling, supportive counselling, education and life review, are infrequently used. Nevertheless, current scientific data suggest that it would be very advantageous if nurses were to play a dominant role in the care of elderly people who are depressed or experiencing sleep pattern disturbances. The same can be said about elderly chronic users of benzodiazepines, as well as those with cognitive impairment. Evidence for the use of psychotropic medications as a viable treatment option for the elderly both in the community and in the long-term care setting who are experiencing mental health challenges is examined. Alternative non-pharmacological approaches that nurses can use to augment care are also briefly discussed. [source] The World Bank's New Social Policies: PensionsINTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 170 2001François-Xavier Merrien Over the last 15 years, the world has become the scene of struggles between major inter-national stakeholders regarding the policies required for economic prosperity and social development. The World Bank plays a dominant role here. In this article, the author highlights the epistemic revolution the policy field has undergone under the aegis of the Bank. He analyses the basic aspects of the new orthodoxy regarding pensions and the effects on the policies of the governments concerned. He concludes with an examination of the theoretical and practical relevance of the recommendations and asks to what extent the Bank is able to learn from its own mistakes. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||