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Dominant Model (dominant + model)
Selected AbstractsFrom ,Relief' to ,Justice and Protection': The Maintenance of Deserted Wives, British Masculinity and Imperial Citizenship, 1870,1920GENDER & HISTORY, Issue 2 2010Marjorie Levine-Clark In the early twentieth century, local British poor law guardians' concerns with the maintenance of deserted and neglected families were transformed into imperial, and later transnational, policy promoting justice for abandoned wives and children. Both local court cases concerning maintenance and policy debates at the national and imperial levels reveal the ways in which a breadwinner model of masculinity shaped maintenance policy and practice. Although the maintenance problem was framed differently by local welfare providers and imperial heads of state, concerns about welfare costs and human rights intersected in the figure of the irresponsible male citizen, who challenged the dominant model of British/imperial masculinity by refusing to maintain his wife. [source] Association between genetic variants of the metabotropic glutamate receptor 3 (GRM3) and cognitive set shifting in healthy individualsGENES, BRAIN AND BEHAVIOR, Issue 5 2010B. T. Baune Set-shifting and maintenance are complex cognitive processes, which are often impaired in schizophrenia. The genetic basis of these processes is poorly understood. We aimed to investigate the association between genetic variants of the metabotropic glutamate receptor 3 (GRM3) and cognitive set-shifting in healthy individuals. The relationship between 14 selected single nucleotide polymorphisms (SNPs) of the GRM3 gene and cognitive set-shifting as measured by perseverative errors using the modified card sorting test (MCST) was analysed in a sample of N = 98 young healthy individuals (mean age in years: 22.7 ± 0.19). Results show that SNP rs17676277 is related to the performance on the MCST. Subjects with the TT genotype showed significantly less perseverative errors as compared with the AA (P = 0.025) and AT (P = 0.0005) and combined AA/AT genotypes (P = 0.0005). Haplotype analyses suggest the involvement of various SNPs of the GRM3 gene in perseverative error processing in a dominant model of inheritance. The findings strongly suggest that the genetic variation (rs17676277 and three haplotypes) in the metabotropic GRM3 is related to cognitive set-shifting in healthy individuals independent of working memory. However, because of a relatively small sample size for a genetic association study, the present results are tentative and require replication. [source] Overcoming disciplinary solitude: The archaeology and geology of native copper in Eastern North AmericaGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 1 2007Mary Ann Levine Although native copper has attracted the scholarly attention of both geologists and archaeologists since the middle of the 19th century, it is only recently that native copper studies have benefited from interdisciplinary research. This history of disciplinary solitude can be traced to the professionalization of the two fields in the early 20th century, an era in which crossdisciplinary communication began to wane. The effects of this phenomena resulted in the development of a model of aboriginal native copper procurement by archaeologists that did not take into account the geological literature, which had long identified numerous,rather than a single,source of native copper in North America. In this article, the author discusses how this disciplinary solitude developed and how it resulted in the creation of a dominant model for native copper procurement that constrained our understanding of aboriginal lifeways for generations. The author also considers how increasing collaboration between geologists and archaeologists since the 1970s has led to the reevaluation of an old model of native copper procurement that has been uncritically accepted by most archaeologists for over a century and a half. © 2007 Wiley Periodicals, Inc. [source] Regulatory polymorphisms in the IL-10 gene promoter and HBV-related acute liver failure in the Chinese populationJOURNAL OF VIRAL HEPATITIS, Issue 11 2009Z. Yan Summary., Recent reports indicated that high levels of interleukin 10 (IL-10) contribute to the monocytes paralysis and poor clinical outcome in acute liver failure (ALF). Polymorphisms in the promoter region of IL-10 affect IL-10 production and confer susceptibility to inflammatory diseases. The aim of this study was to determine the possible association of the three polymorphisms (A-1082G, T-819C, A-592C) in the IL-10 gene promoter with the susceptibility to hepatitis B virus (HBV)-related ALF in a Chinese population. The IL-10 gene promoter polymorphisms were genotyped in 414 unrelated healthy blood donors, 367 asymptomatic HBV carriers and 345 HBV-related ALF patients. Functional analyses were conducted to verify the biological significances of the associated genetic variations. The allele frequencies of IL-10,592C and ,819C were significantly higher in HBV-related ALF patients than in blood donors and asymptomatic HBV carriers. Logistic regression analysis and stratification analysis with adjustment for age and sex indicated that the polymorphisms of A-592C and T-819C were associated with susceptibility to HBV-related ALF (P = 6.9 × 10,7), and the -1082A-819C-592C haplotype in the IL-10 gene promoter were associated with an increased susceptibility to ALF in HBV carriers (dominant model, P = 0.0002, odds ratio = 1.60, 95% CI 1.25,2.07). Functional analyses showed that the A-592C polymorphism is a nuclear proteins binding site, and the disease susceptible ,592C allele had a higher transcription activity compared with ,592A allele. This study emphasizes the importance of IL-10 in the pathophysiology of HBV-related ALF on the population level. [source] Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict responseALLERGY, Issue 5 2009H.-W. Park Background:, Recent findings have raised new interests about the use of anticholinergics, especially tiotropium, for the treatment of asthma. This study was performed to determine whether an additional improvement in lung function is obtained when tiotropium is administrated in addition to conventional therapies in severe asthmatics, and to identify factors capable of predicting the response to tiotropium, using a pharmacogenetic approach. Methods:, A total of 138 severe asthmatics on conventional medications and with decreased lung function were randomly recruited. Tiotropium 18 ,g was added once a day and lung functions were measured every 4 weeks. Responders were defined as those with an improvement of ,15% (or 200 ml) in the forced expiratory volume in 1 s (FEV1) that was maintained for at least 8 successive weeks. Eleven single nucleotide polymorphisms (SNPs) in CHRM1,3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding ,2 adrenoreceptor) were scored in 80 of the 138 asthmatics. Results:, Forty-six of the 138 asthmatics (33.3%) responded to tiotropium treatment. Logistic regression analyses (controlled for age, gender, and smoking status) showed that Arg16Gly in ADRB2 [P = 0.003, OR (95% CI) = 0.21 (0.07,0.59) in a minor allele,dominant model] was significantly associated with response to tiotropium. Conclusions:, As many as 30% of severe asthmatics on conventional medications with reduced lung function were found to respond to adjuvant tiotropium. The presence of Arg16Gly in ADRB2 may predict response to tiotropium. [source] LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease,MOVEMENT DISORDERS, Issue 7 2009Cyrus P. Zabetian MD Abstract Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic determinant of Parkinson's disease (PD) in European-derived populations, but far less is known about LRRK2 mutations and susceptibility alleles in Asians. To address this issue, we sequenced the LRRK2 coding region in 36 patients with familial PD, then genotyped variants of interest in an additional 595 PD cases and 1,641 controls who were all of Japanese ancestry. We also performed a meta-analysis of studies on G2385R, a polymorphism previously reported to associate with PD. One pathogenic (G2019S) and one putative pathogenic (R1067Q) mutation were each observed in two patients with sporadic PD. The overall mutation frequency among patients was 0.6%. G2385R was highly associated with PD under a dominant model in our dataset (adjusted OR, 1.83; 95% CI, 1.31,2.54; P = 3.3 × 10,4) and similar results were seen in the meta-analysis (summary OR assuming fixed effects, 2.55; 95% CI, 2.10,3.10). G2385R represents the first consistently replicated common PD susceptibility variant in a non-European population and its effect size is substantially greater than that reported for other well-validated genetic risk factors for the disease. However, LRRK2 mutations appear to be rare among Japanese patients with PD. © 2009 Movement Disorder Society [source] Evidence for the multigenic inheritance of schizophreniaAMERICAN JOURNAL OF MEDICAL GENETICS, Issue 8 2001Robert Freedman Abstract Schizophrenia is assumed to have complex inheritance because of its high prevalence and sporadic familial transmission. Findings of linkage on different chromosomes in various studies corroborate this assumption. It is not known whether these findings represent heterogeneous inheritance, in which various ethnic groups inherit illness through different major gene effects, or multigenic inheritance, in which affected individuals inherit several common genetic abnormalities. This study therefore examined inheritance of schizophrenia at different genetic loci in a nationally collected European American and African American sample. Seventy-seven families were previously genotyped at 458 markers for the NIMH Schizophrenia Genetics Initiative. Initial genetic analysis tested a dominant model, with schizophrenia and schizoaffective disorder, depressed type, as the affected phenotype. The families showed one genome-wide significant linkage (Z,=,3.97) at chromosome 15q14, which maps within 1 cM of a previous linkage at the ,7-nicotinic receptor gene. Chromosome 10p13 showed suggestive linkage (Z,=,2.40). Six others (6q21, 9q32, 13q32, 15q24, 17p12, 20q13) were positive, with few differences between the two ethnic groups. The probability of each family transmitting schizophrenia through two genes is greater than expected from the combination of the independent segregation of each gene. Two trait-locus linkage analysis supports a model in which genetic alleles associated with schizophrenia are relatively common in the general population and affected individuals inherit risk for illness through at least two different loci. © 2001 Wiley-Liss, Inc. [source] Are the Japanese Selfish, Altruistic or Dynastic?THE JAPANESE ECONOMIC REVIEW, Issue 1 2002Charles Yuji HoriokaArticle first published online: 18 DEC 200 I analyse a variety of evidence for Japan and, where available, for the United States on bequest practices, the importance and nature of bequest motives, bequest division, the willingness of individuals to help others, etc., in order to shed light on which model of household behaviour applies in the two countries. My results suggest that the selfish lifecycle model is the dominant model of household behaviour in both countries but that it is far more applicable in Japan; that the dynasty model is also more applicable in Japan but is not of dominant importance even there; and, conversely, that the altruism model is far more applicable in the USA. JEL Classification Numbers: D12, D64, D91, E21. [source] Linkage and Association Study of Late-Onset Alzheimer Disease Families Linked to 9p21.3ANNALS OF HUMAN GENETICS, Issue 6 2008S. Züchner Summary A chromosomal locus for late-onset Alzheimer disease (LOAD) has previously been mapped to 9p21.3. The most significant results were reported in a sample of autopsy-confirmed families. Linkage to this locus has been independently confirmed in AD families from a consanguineous Israeli-Arab community. In the present study we analyzed an expanded clinical sample of 674 late-onset AD families, independently ascertained by three different consortia. Sample subsets were stratified by site and autopsy-confirmation. Linkage analysis of a dense array of SNPs across the chromosomal locus revealed the most significant results in the 166 autopsy-confirmed families of the NIMH sample. Peak HLOD scores of 4.95 at D9S741 and 2.81 at the nearby SNP rs2772677 were obtained in a dominant model. The linked region included the cyclin-dependent kinase inhibitor 2A gene (CDKN2A), which has been suggested as an AD candidate gene. By re-sequencing all exons in the vicinity of CDKN2A in 48 AD cases, we identified and genotyped four novel SNPs, including a non-synonymous, a synonymous, and two variations located in untranslated RNA sequences. Family-based allelic and genotypic association analysis yielded significant results in CDKN2A (rs11515: PDT p = 0.003, genotype-PDT p = 0.014). We conclude that CDKN2A is a promising new candidate gene potentially contributing to AD susceptibility on chromosome 9p. [source] | |||||||||||||