Home  About us  Contact
 

Dog New Tricks (dog + new_trick)

Distribution by Scientific Domains
Medical Sciences80%

Kinds of Dog New Tricks

  • old dog new trick
    		•

    Selected Abstracts

    Vitamin K to reverse the anticoagulant effect of vitamin K antagonists: can you teach an old dog new tricks?

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 3 2010
    J. D. DOUKETIS
    To cite this article: Douketis JD, Spyropoulos AC. Vitamin K to reverse the anticoagulant effect of vitamin K antagonists: can you teach an old dog new tricks? J Thromb Haemost 2010; 8: 496,8. See also Steib A, Barre J, Mertes M, Morel MH, Nathan N, Ozier Y, Treger M, Samama CM. Can oral vitamin K before elective surgery substitute for preoperative heparin bridging in patients on vitamin K antagonists? This issue, pp 499,503. [source]

    Can oral vitamin K before elective surgery substitute for preoperative heparin bridging in patients on vitamin K antagonists?

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 3 2010
    A. STEIB
    See also Douketis JD, Spyropoulos AC. Vitamin K to reverse the anticoagulant effect of vitamin K antagonists: can you teach an old dog new tricks? This issue, pp 496,8. Summary.,Background: After a vitamin K antagonist (VKA) overdose, 1,2 mg of oral vitamin K can lower the International Normalized Ratio (INR) to the therapeutic range. Objective: To establish whether oral vitamin K can substitute for heparin bridging and decrease the INR to , 1.5 before elective surgery. Methods: Patients on long-term VKAs were randomized either to heparin bridging after the last VKA dose on day , 5 before surgery (group H) or to VKA treatment until day , 2, followed by 1 mg of oral vitamin K on the day before surgery (group K). Blood clotting variables were assessed on days ,5/,2, 1 and 0, and postoperatively. If the target INR was not achieved 2 h before incision, surgery was deferred or performed after injection of prothrombin complex concentrate (PCC). Results: In 30 of 94 included patients, baseline INR was outside the chosen range (18, INR < 2; 12, INR > 3.5), leaving 34 eligible patients in group H and 30 in group K. The groups were balanced in terms of body mass index, VKA treatment duration and indication, scheduled surgery, preoperative and postoperative hemoglobin, and blood loss. The INR was significantly higher in group K on days , 1 and 0 than in group H. An INR , 1.5 was not achieved in 20 group K patients (66%). Surgery was postponed or performed after PCC injection in 12 of these 20 patients. Conclusions: Oral vitamin K (1 mg) cannot substitute for heparin bridging before surgery. In addition, one-third of patients on VKAs were exposed to a risk of bleeding (overdose) or thrombosis (underdose), thus highlighting the need for new oral anticoagulants. [source]

    Gene therapy for hepatocellular carcinoma,teaching old dogs new tricks

    HEPATOLOGY, Issue 1 2001
    Simon C. Afford Ph.D.
    No abstract is available for this article. [source]

    Structural materials underpinning functional materials: teaching old dogs new tricks

    POLYMER INTERNATIONAL, Issue 5 2008
    William A MacDonald
    Abstract ,Structural' polymers are finding new applications underpinning new technology developments based on functional polymers. This paper discusses the use of polyester films as base substrates for flexible electronic applications based on conjugated polymers and low-temperature hydrogenated amorphous silica processing, and discusses the challenges involved in successfully developing substrates ,fit for purpose'. Copyright © 2008 Society of Chemical Industry [source]