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Distinct Combinations (distinct + combination)

Distribution by Scientific Domains
Medical Sciences50%

Selected Abstracts

Immunophenotypic discrepancies between granulocytic and erythroid lineages in peripheral blood of patients with paroxysmal nocturnal haemoglobinuria

EUROPEAN JOURNAL OF HAEMATOLOGY, Issue 1 2000
Kriangsak Pakdeesuwan
Abstract: In paroxysmal nocturnal haemoglobinuria (PNH), somatic mutation of the PIG-A gene is thought to result in altered expression of glycosylphosphatidylinositol (GPI)-anchored proteins. This study was performed to determine if there were any heterogeneities of cellular phenotypes between two major peripheral blood cells, erythrocytes and granulocytes. Using CD59-based immunocytometry, the patterns of CD59 expression were shown to be conserved in the circulating erythroid cells (reticulocytes and mature erythrocytes) in all 29 patients with PNH. Twenty-one patients had distinct combinations of PNH type I, II, and III cells in different lineages. Only eight patients exhibited similar patterns of CD59 expression between the two lineages. Approximately one third of the patients had PNH type II cells in either or both of the two lineages indicating variable lineage involvement. The proportion of abnormal granulocutes was higher than those of abnormal reticulocytes and erythrocytes. In patients with appropriate erythropoietic responses to haemolysis (RPI>2.0), shift reticulocytes display predominantly PNH phenotypes. These immature erythroid cells with altered expression of GPI-anchored proteins may dominate the peripheral blood during periods of increased marrow activity resulting in greater phenotypic mosaicism in such patients. Discrepancies in expression of GPI-anchored proteins in PNH which are highly variable between the two lineages may be the result of their different life spans and the influence of complement-mediated cytolysis. The phenomena also indicated the possible occurrence of more than one PNH clones with variable clonal dominance. [source]

Clonally expanded CD4+CD28null T,cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements

EUROPEAN JOURNAL OF IMMUNOLOGY, Issue 1 2003
Ulf Wagner
Abstract Clonally expanded, autoreactive CD4+CD28null cells can be found in the peripheral blood of patients with rheumatoid arthritis and have been shown to be associated with severeextra-articular disease manifestations. We investigated the size of the CD4+CD28null compartment and the TCR , chain repertoire of expanded CD4+ clonotypes in 94 rheumatoid arthritis patients by complementarity-determining region 3 (CDR3) length analysis (spectratyping) in the BV6 and BV14 TCR families, with primers specific for three arbitrarily chosen , chain joining elements (BJ1S2, BJ2S3 and BJ2S7). The spectratyping results showed a strong correlation of the size of the CD4+CD28null compartment with the detected number of BV14 clonotypes, whereas no association with BV6 oligoclonality was found. Only clones using the BV14,BJ1S2 and BV14,BJ2S3 combinations contributed to this correlation, however, whereas BV14,BJ2S7 clones did not. This preferential correlation implies a role for the TCR , chain in stimulating clonal outgrowth and argues against the previously suggested superantigenic stimulation of in-vivo -expanded clones. Instead, since no evidence for shared antigen specificity could be detected, clonal expansion of T cells in rheumatoid arthritis might be influenced by the BJ elements because of changes in the flexibility of the protein backbone of the ,-chain. [source]

Privatising social housing in Taiwan

INTERNATIONAL JOURNAL OF SOCIAL WELFARE, Issue 1 2007
William D.H. Li
This article first reviews how the concept of privatisation has been referred to in the current restructuring of the social housing system, especially in the case of the UK. The term ,privatisation' is then examined in greater detail and its wider meaning is discussed. By using the network approach, privatisation in relation to housing can be understood in terms of the changing combinations of agents involved in providing social housing, which gives rise to the commodified impact on the distribution of social housing. By using the privatisation process of social housing in Taiwan as an example, three distinct combinations in terms of providing social housing are identified. With an increasing number of social housing units being provided by the marketised social housing model where private agents control the process of providing social housing, along with more market rules being involved in the provision and the partial removal of means tests in relation to the distribution of social housing, the privatisation of social housing development in Taiwan is having a major impact on equity. [source]

Your new product development (NPD) is only as good as your process: an exploratory analysis of new NPD process design and implementation

R & D MANAGEMENT, Issue 5 2007
Nukhet Harmancioglu
Given industry competitiveness, how do firms' new product development (NPD) process designs differ when responding to an innovation mandate? How do NPD design elements differ across firms when implementing NPD processes? These design elements are strategic business unit (SBU) senior management involvement, business case content, customer interactions, and cross-functional integration. What are the consequences of different combinations of NPD process design elements for innovation productivity? We explore these questions via a collective case study of newly implemented NPD process designs at three different SBUs of a major US-based international conglomerate, 1 year after receiving the mandate to grow through innovation. Our analysis suggests that industry competitiveness and firm characteristics influence the NPD process design as SBUs employ distinct combinations of NPD design elements. The differential emphasis on design elements leads to variation in process design and divergence in innovation productivity. [source]