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Disulfide Derivatives (disulfide + derivative)

Distribution by Scientific Domains

Chemistry	75%

Selected Abstracts

ChemInform Abstract: Novel Photoreaction Using Diphenyl Disulfide Derivatives: Photoinduced Oxidation of Allyl Alcohol.

CHEMINFORM, Issue 31 2008
Takaaki Tsuboi
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine ,-synthase (CBS) deficiency

AMERICAN JOURNAL OF MEDICAL GENETICS, Issue 1 2002
Reza Yaghmai
Abstract Cystathionine ,-synthase (CBS) deficiency, the most common form of homocystinuria, is an autosomal recessive inborn error of homocysteine metabolism. Treatment of B6-nonresponsive patients centers on lowering homocysteine and its disulfide derivatives (tHcy) by adherence to a methionine-restricted diet. However, lifelong dietary control is difficult. Betaine supplementation is used extensively in CBS-deficient patients to lower plasma tHcy. With betaine therapy, methionine levels increase over baseline, but usually remain below 1,500 ,mol/L, and these levels have not been associated with adverse affects. We report a child with B6-nonresponsive CBS deficiency and dietary noncompliance whose methionine levels reached 3,000 ,mol/L on betaine, and who subsequently developed massive cerebral edema without evidence of thrombosis. We investigated the etiology by determining methionine and betaine metabolites in our patient, and several possible mechanisms for her unusual response to betaine are discussed. We conclude that the cerebral edema was most likely precipitated by the betaine therapy, although the exact mechanism is uncertain. This case cautions physicians to monitor methionine levels in CBS-deficient patients on betaine and to consider betaine as an adjunct, not an alternative, to dietary control. © 2002 Wiley-Liss, Inc. [source]

A method for the identification of the double-bond position of isomeric linear tetradecenols and related compounds based on mass spectra of dimethyl disulfide derivatives

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 1 2002
Gu Yuan
A simple method is presented for calculation of the double-bond position in linear tetradecenols based on mass spectral data of dimethyl disulfide derivatives. In this approach, the m/z ratios of the molecular ion and of one (or both) of the two most abundant fragment ions were utilized to calculate the double-bond position, without the requirement to identify both fragment ions resulting from carbon-carbon cleavage across what was originally the double bond. The approach was tested with mass spectra of dimethyl disulfide derivatives of 12 isomeric tetradecenols, and the double-bond position in each isomer was successfully identified by this method. The method was shown to work also for the corresponding acetates. Copyright © 2001 John Wiley & Sons, Ltd. [source]