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Direct C (direct + c)

Distribution by Scientific Domains
Chemistry88%

Selected Abstracts

,-Aminoadamantanecarboxylic Acids Through Direct C,H Bond Amidations

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 9 2007
Lukas Wanka
Abstract Utilizing bromine-free, direct C,H bond amidations we have synthesized a large variety of adamantane amides. Depending on the precursors used these amides directly yield pharmaceutically active aminoadamantanes or ,-aminoadamantanecarboxylic acids after hydrolytic cleavage. Theserigid analogues of ,-aminobutyric acid (GABA) were protected at the C- and N-termini and we synthesized a number of peptides incorporating ,-aminoadamantanecarboxylicacids in solution as well as via solid phase peptide synthesis. These peptides are promising scaffolds for applications in medicinal chemistry as well as in organocatalysis.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]

ChemInform Abstract: Nickel-Catalyzed Direct C,H Arylation and Alkenylation of Heteroarenes with Organosilicon Reagents.

CHEMINFORM, Issue 29 2010
Hitoshi Hachiya
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Switching the Regioselectivity of Direct C,H Arylation of 1,3-Dimethyluracil.

CHEMINFORM, Issue 50 2009
Miroslava Cernova
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-Coupling, N-Arylation, and Direct C,H Arylation Reactions.

CHEMINFORM, Issue 15 2009
Igor Cerna
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: Functionalizing Glycine Derivatives by Direct C,C Bond Formation.

CHEMINFORM, Issue 51 2008
Liang Zhao
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

,-Aminoadamantanecarboxylic Acids Through Direct C,H Bond Amidations.

CHEMINFORM, Issue 28 2007
Lukas Wanka
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

ChemInform Abstract: Steric Modulation of Chiral Biaryl Diamines via Pd-Catalyzed Directed C,H Arylation.

CHEMINFORM, Issue 31 2009
Christopher C. Scarborough
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Widespread known and novel phosphonate utilization pathways in marine bacteria revealed by functional screening and metagenomic analyses

ENVIRONMENTAL MICROBIOLOGY, Issue 1 2010
Asuncion Martinez
Summary Phosphonates (Pn), compounds with a direct C,P bond instead of the more common C,O,P ester bond, constitute a significant fraction of marine dissolved organic phosphorus and recent evidence suggests that they may be an alternative source of P for marine microorganisms. To further characterize the microorganisms and pathways involved in Pn utilization, we screened bacterioplankton genomic libraries for their ability to complement an Escherichia coli strain unable to use Pns as a P source. Using this approach we identified a phosphonatase pathway as well as a novel pair of genes that allowed utilization of 2-aminoethylphosphonate (2-AEPn) as the sole P source. These pathways are present in diverse bacteria common in marine plankton including representatives of Proteobacteria, Planctomycetes and Cyanobacteria. Analysis of metagenomic databases for Pn utilization genes revealed that they are widespread and abundant among marine bacteria, suggesting that Pn metabolism is likely to play an important role in P-depleted surface waters, as well as in the more P-rich deep-water column. [source]

,-Aminoadamantanecarboxylic Acids Through Direct C,H Bond Amidations

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 9 2007
Lukas Wanka
Abstract Utilizing bromine-free, direct C,H bond amidations we have synthesized a large variety of adamantane amides. Depending on the precursors used these amides directly yield pharmaceutically active aminoadamantanes or ,-aminoadamantanecarboxylic acids after hydrolytic cleavage. Theserigid analogues of ,-aminobutyric acid (GABA) were protected at the C- and N-termini and we synthesized a number of peptides incorporating ,-aminoadamantanecarboxylicacids in solution as well as via solid phase peptide synthesis. These peptides are promising scaffolds for applications in medicinal chemistry as well as in organocatalysis.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) [source]