Differential

Distribution by Scientific Domains
Distribution within Business, Economics, Finance and Accounting

Kinds of Differential

  • cell differential
  • cost differential
  • earning differential
  • gender differential
  • gender wage differential
  • interest differential
  • interest rate differential
  • ito differential
  • pay differential
  • power differential
  • pressure differential
  • price differential
  • rate differential
  • selection differential
  • wage differential

  • Terms modified by Differential

  • differential ability
  • differential access
  • differential action
  • differential activation
  • differential activity
  • differential adaptation
  • differential admixture
  • differential allocation
  • differential amplifier
  • differential analysis
  • differential approach
  • differential association
  • differential binding
  • differential cell count
  • differential centrifugation
  • differential change
  • differential characteristic
  • differential contribution
  • differential control
  • differential count
  • differential diagnosis
  • differential display
  • differential display method
  • differential distribution
  • differential effect
  • differential effects
  • differential equation
  • differential equation approach
  • differential equation solver
  • differential equation system
  • differential evolution
  • differential evolution algorithm
  • differential exposure
  • differential expression
  • differential expression level
  • differential expression pattern
  • differential expression profile
  • differential form
  • differential function
  • differential gene expression
  • differential gene expression profile
  • differential growth
  • differential growth rate
  • differential impact
  • differential inclusion
  • differential induction
  • differential influence
  • differential inhibitory effects
  • differential interaction
  • differential interference contrast
  • differential interference contrast microscopy
  • differential involvement
  • differential item
  • differential item functioning
  • differential leucocyte count
  • differential level
  • differential localization
  • differential mechanism
  • differential method
  • differential migration
  • differential misclassification
  • differential modulation
  • differential mortality
  • differential operator
  • differential operators
  • differential outcome
  • differential pattern
  • differential performance
  • differential persistence
  • differential prediction
  • differential pressure
  • differential processing
  • differential production
  • differential protein expression
  • differential pulse voltammetry
  • differential quadrature
  • differential quadrature method
  • differential rate
  • differential recognition
  • differential regulation
  • differential relationships
  • differential reporting
  • differential requirement
  • differential resistance
  • differential response
  • differential responsiveness
  • differential risk
  • differential role
  • differential rotation
  • differential scanning calorimeter
  • differential scanning calorimetry
  • differential scanning calorimetry analysis
  • differential scanning calorimetry experiment
  • differential scanning calorimetry measurement
  • differential scanning calorimetry result
  • differential scanning calorimetry studies
  • differential screening
  • differential selection
  • differential sensitivity
  • differential splicing
  • differential stability
  • differential subcellular localization
  • differential success
  • differential survival
  • differential susceptibility
  • differential system
  • differential targeting
  • differential thermal analysis
  • differential tolerance
  • differential treatment
  • differential use
  • differential utilization
  • differential vulnerability

  • Selected Abstracts


    PRODUCT MARKET AND THE SIZE,WAGE DIFFERENTIAL*

    INTERNATIONAL ECONOMIC REVIEW, Issue 1 2002
    SHOUYONG SHI
    Using directed search to model the product market and the labor market, I show that large plants can pay higher wages to homogeneous workers and earn higher expected profit per worker than small plants, although plants are identical except size. A large plant charges a higher price for its product and compensates buyers with a higher service probability. To capture this size- related benefit, large plants try to become larger by recruiting at high wages. This size,wage differential survives labor market competition because a high wage is harder to get than a low wage. Moreover, the size,wage differential increases with the product demand when demand is initially low and falls when demand is already high. [source]


    TIEBOUT DYNAMICS: NEIGHBORHOOD RESPONSE TO A CENTRAL-CITY/SUBURBAN HOUSE-PRICE DIFFERENTIAL,

    JOURNAL OF REGIONAL SCIENCE, Issue 4 2007
    Paul Thorsnes
    ABSTRACT We take advantage of an unusual natural experiment,a high-quality 1920s subdivision split neatly in half by a central-city/suburban boundary,to study the response over 30 years to the relative decline in the quality of central-city services since the 1960s. As expected, a large sale price differential opens in the 1960s. Demographic characteristics are nevertheless similar across the boundary. Survey data indicate Tiebout sorting: the central city side attracts households who prefer alternatives to suburban public schools. Children attend parochial and public "magnet" schools. A neighborhood association supplements municipal services. Rigid service district boundaries inhibit closure of the house-price differential. [source]


    EXPORT SUBSIDIES, COST DIFFERENTIAL AND PRODUCT QUALITY

    PACIFIC ECONOMIC REVIEW, Issue 1 2010
    Hong Hwang
    This paper presents a vertical product differentiation model to examine the relationship between optimal trade policies and product qualities for different export countries under Cournot quantity competition as well as Bertrand price competition. We can also use this quality model to explain why Japan as a high production-cost country may have incentives to offer high subsidies. This is a case that cannot be explained by the strategic trade theory models à la Brander and Spencer (1985) or Eaton and Grossman (1986). [source]


    MALE MARITAL WAGE DIFFERENTIALS: TRAINING, PERSONAL CHARACTERISTICS, AND FIXED EFFECTS

    ECONOMIC INQUIRY, Issue 3 2010
    WILLIAM M. RODGERS III
    Using the National Longitudinal Survey of Youth 1979, we replicate previous estimates of the marital wage differential for white men, extend the analysis to African American men, then explain the within and between race differentials. We first control for formal job training, then for cognitive skills, parental background, and self-esteem with little effect. By contrast, the white differential but not the black differential disappears in fixed-effects estimation. We reconcile the cross-section/panel differentials by focusing on the distinct identification conditions employed by each technique. Men who never change marital status play a significant role in white cross-sectional estimates. (JEL J31, J12) [source]


    CAN THE HUMAN CAPITAL APPROACH EXPLAIN LIFE-CYCLE WAGE DIFFERENTIALS BETWEEN RACES AND SEXES?

    ECONOMIC INQUIRY, Issue 1 2007
    HUOYING WU
    Using data from the National Longitudinal Survey of Youth,1979 cohort (NLSY79), this paper shows the importance of postschool human capital investment in describing both gender and racial wage gaps. The empirical results suggest that male-female wage gaps, regardless of race, are mainly caused by gender differences in the human capital production process; generally, men gain more work experience and therefore have lower marginal costs of human capital production. Black-white lifetime wage differentials could partly result from higher implicit interest rates for blacks, while the deterioration of black males' relative economic status as they age can be attributed to higher depreciation rates of their human capital stock. (JEL J24, J30, C61) [source]


    INTERCITY RENT DIFFERENTIALS IN THE U.S. HOUSING MARKET 2000: UNDERSTANDING RENT VARIATIONS AS A SOCIOLOGICAL PHENOMENON

    JOURNAL OF URBAN AFFAIRS, Issue 4 2009
    JOHN I. GILDERBLOOM
    ABSTRACT:,This study extends the intercity rent differentials investigation by Gilderbloom and Appelbaum (1988) in relatively independent housing markets to see how it can be replicated using U.S. census data from the year 2000 against the 1970 and 1980 models with the addition of several new variables to measure its impact on intercity rents. We find that region, race, and climate no longer explain rent differentials in 2000 as it did in the 1980 research, while affirming that a large percentage of old houses and small mom-and-pop landlords causes rents to fall. We find that both the cost of homeownership and the level of household income remain critical factors in explaining the level of median rent across cities. We also find a strong correlation between cities with extensive anti-war activity in the late 1960s and same sex households having higher rents, although more research needs to be done before we argue a causal relationship. We contend that sociology needs to be put back into the equation in order to understand how rents vary from city to city. Our explanation of rent variations adds a social dimension that most other researches miss. We also show how the amount of explanatory power is increased significantly by adding in a sociological dimension. [source]


    THE PATTERN AND EVOLUTION OF GEOGRAPHICAL WAGE DIFFERENTIALS IN THE PUBLIC AND PRIVATE SECTORS IN GREAT BRITAIN,

    THE MANCHESTER SCHOOL, Issue 4 2007
    DAVID BELL
    Government policy on the nature of wage bargaining in the public sector can have important implications for the provision of public services. Using the New Earnings Survey, the Labour Force Survey and the British Household Panel Survey, we examine the size and evolution of public,private sector wage differentials across geographical areas within the UK and over time. Public sector bargaining structures have led to historically high wage premia, although these premia are declining over time. In high-cost low-amenity areas, such as the south-east of England, the public sector underpays relative to the private sector, therefore creating problems in recruitment to and provision of public services. Public sector labour markets are around 40 per cent as responsive to area differences in amenities and costs as are private sector labour markets. Differences in the degree of spatial variation between sectors are likely to remain, leading to persistent problems for the delivery of public services in some parts of the UK. Reform of public sector pay structures is likely to be costly, and so other non-pay policies need to be considered to increase the attractiveness of public sector jobs. [source]


    Differential age-related changes in motor unit properties between elbow flexors and extensors

    ACTA PHYSIOLOGICA, Issue 1 2010
    B. H. Dalton
    Abstract Aim:, Healthy adult ageing of the human neuromuscular system is comprised of changes that include atrophy, weakness and slowed movements with reduced spinal motor neurone output expressed by lower motor unit discharge rates (MUDRs). The latter observation has been obtained mostly from hand and lower limb muscles. The purpose was to determine the extent to which elbow flexor and extensor contractile properties, and MUDRs in six old (83 ± 4 years) and six young (24 ± 1 years) men were affected by age, and whether any adaptations were similar for both muscle groups. Methods:, Maximal isometric voluntary contraction (MVC), voluntary activation, twitch contractile properties, force,frequency relationship and MUDRs from sub-maximal to maximal intensities were assessed in the elbow flexors and extensors. Results:, Both flexor and extensor MVCs were significantly (P < 0.05) less (,42% and ,46% respectively) in the old than in the young. Contractile speeds and the force,frequency relationship did not show any age-related differences (P > 0.05). For the elbow flexors contraction duration was ,139 ms and for the extensors it was ,127 ms for both age groups (P > 0.05). The mean MUDRs from 25% MVC to maximum were lower (,10% to ,36%) in the old than in the young (P < 0.01). These age-related differences were larger for biceps (Cohen's d = 8.25) than triceps (Cohen's d = 4.79) brachii. Conclusion:, Thus, at least for proximal upper limb muscles, mean maximal MUDR reductions with healthy adult ageing are muscle specific and not strongly related to contractile speed. [source]


    Differential sustained changes in ,-opioid receptor availability following acupuncture and sham acupuncture therapy in fibromyalgia

    FOCUS ON ALTERNATIVE AND COMPLEMENTARY THERAPIES AN EVIDENCE-BASED APPROACH, Issue 2007
    RE Harris
    [source]


    Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype,phenotype correlations,

    HUMAN MUTATION, Issue 7 2009
    Jordan P. Lerner-Ellis
    Abstract Methylmalonic aciduria and homocystinuria, cblC type, is a rare disorder of intracellular vitamin B12 (cobalamin [Cbl]) metabolism caused by mutations in the MMACHC gene. MMACHC was sequenced from the gDNA of 118 cblC individuals. Eleven novel mutations were identified, as well as 23 mutations that were observed previously. Six sequence variants capture haplotype diversity in individuals across the MMACHC interval. Genotype,phenotype correlations of common mutations were apparent; individuals with c.394C>T tend to present with late-onset disease whereas patients with c.331C>T and c.271dupA tend to present in infancy. Other missense variants were also associated with late- or early-onset disease. Allelic expression analysis was carried out on human cblC fibroblasts compound heterozygous for different combinations of mutations including c.271dupA, c.331C>T, c.394C>T, and c.482G>A. The early-onset c.271dupA mutation was consistently underexpressed when compared to control alleles and the late-onset c.394C>T and c.482G>A mutations. The early-onset c.331C>T mutation was also underexpressed when compared to control alleles and the c.394C>T mutation. Levels of MMACHC mRNA transcript in cell lines homozygous for c.271dupA, c.331C>T, and c.394C>T were assessed using quantitative real-time RT-PCR. Cell lines homozygous for the late onset c.394C>T mutation had significantly higher levels of transcript when compared to cell lines homozygous for the early-onset mutations. Differential or preferential MMACHC transcript levels may provide a clue as to why individuals carrying c.394C>T generally present later in life. Hum Mutat 30:1,10, 2009. © 2009 Wiley-Liss, Inc. [source]


    The Role of Job Attributes in Understanding the Public-Private Wage Differential

    INDUSTRIAL RELATIONS, Issue 3 2002
    Keith A. Bender
    This study uses a unique data set for Great Britain to investigate the impact of differences in job attributes on the public-private wage differential. The study reveals that (1) there are substantial differences in wage structure between the two sectors, particularly finding that the public-sector wage structure is less sensitive to differences in the attributes of jobs, and (2) differences in job attributes play in a major role in accounting for pay differences across sectors. [source]


    Differential age-related change of prose memory in older Hong Kong Chinese of higher and lower education

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 3 2004
    T. M. C. Lee
    Abstract Background Memory difficulty is one of the most common complaints of older people, with or without psychiatric conditions. It is therefore of utmost important to understand how normal ageing process impacts upon prose memory so as to gain insight into ways to differentiate pathological vs normal age-related changes of the recall of prose observed among older people. Objectives To understand the differential age-related change of prose memory in older Hong Kong Chinese of higher and lower education. Method Forty-eight normal, healthy Cantonese-speaking Chinese were recruited. Seventeen of them were younger, highly educated participants. Among the 31 older people recruited, 19 of them received education comparable with the younger participants and 12 were older people of low education. A prose passage was constructed to measure the different processes of prose memory, including learning efficiency, rate of forgetting, recall accuracy, accuracy of temporal sequence of information recalled, distortions, and recognition memory. Results As expected, ageing affected all the processes of prose memory measured, except the rate of forgetting. Apart from learning efficiency and rate of forgetting, education was observed to modify the effect of ageing on all the processes studied. Conclusions Changes of prose memory associated with ageing and the differential effect of education on prose recall among older people were discussed. The findings seem to suggest that prose memory is a multifaceted construct. Copyright © 2004 John Wiley & Sons, Ltd. [source]


    Differential correlates of diet and phylogeny on the shape of the premaxilla and anterior tooth in sparid fishes (Perciformes: Sparidae)

    JOURNAL OF EVOLUTIONARY BIOLOGY, Issue 5 2004
    M. Linde
    Abstract We explore the correlational patterns of diet and phylogeny on the shape of the premaxilla and anterior tooth in sparid fishes (Perciformes: Sparidae) from the western Mediterranean Sea. The premaxilla is less variable, and in spite of the presence of species-specific features, a common structural pattern is easily recognizable in all species (i.e. the ascending and the articular processes are fused in a single branch, as in many percoid fishes). In contrast, tooth shape is more variable, and different structural types can be recognized (e.g. canine-like or incisive). Coupling geometric morphometric and comparative methods we found that the relationship between shape, diet and phylogeny also differs between premaxilla and tooth. Thus, the shape of the premaxilla is significantly correlated with food type, whereas the shape of the teeth is not correlated with diet, and probably reflects the species phylogenetic relationships. Two biological roles, resistance against compressive forces generated in the buccal cavity and the size of the oral gape, would explain the ecomorphological patterns of the premaxilla. The premaxilla and anterior tooth appear to evolve at different rates (mosaic evolution) and represent an example of morphological traits belonging to the same functional unit but following uncoupled evolutionary pathways. [source]


    Differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in colorectal cancer

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 6 2003
    TAE SOOK HWANG
    Abstract Background: The presence of hypoxic cells in solid tumors has been suggested to contribute to the malignant progression of various tumors. Recently, we reported an activation of heat shock transcription factor (HSF) and expression of heat shock proteins (Hsp) in murine tumor cells by hypoxia. Methods: To search for a possible role of Hsp in the malignant progression of human tumors, we analyzed the expression profiles of Hsp family proteins in weakly and highly metastatic human colorectal cancer (CRC) cell lines. We also analyzed the expression profiles of Bcl-2 family proteins because the altered expression of these proteins has been demonstrated in various solid tumors. Results: In the present paper we showed among various Hsp and Bcl-2 family proteins that the expression of Hsp70 and Hsp110 was elevated in highly metastatic CX-1 and HT-29 cells, while the expression of Bcl-2 was elevated in weakly metastatic MIP-101 and Clone A cells. Subsequent immunohistochemical analysis of 81 primary human CRC tissues demonstrated that the expression of Hsp70 and Hsp110 was highly correlated with the advanced clinical stages and positive lymph node involvement. The expression of Bcl-2, in contrast, was correlated to the early clinical stage and negative lymphovascular invasion. Conclusion: Taken together, our study demonstrated for the first time a differential, stage-dependent expression of Hsp70, Hsp110 and Bcl-2 in CRC. We suggest that the molecular mechanisms underlying the differential expression of Hsp and Bcl-2 family members deserves a more rigorous future study, the results of which might offer novel modes of rationale and strategy to predict and manipulate the malignant progression of colorectal cancers. [source]


    Differential stimulation-induced receptor localization in lipid rafts for interleukin-6 family cytokines signaling through the gp130/leukemia inhibitory factor receptor complex

    JOURNAL OF NEUROCHEMISTRY, Issue 3 2007
    Martha D. Port
    Abstract Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) are cytokines which signal through receptor complexes that include the receptor subunits glycoprotein 130 (gp130) and the LIF receptor (LIFR), but CNTF also requires the non-signal transducing CNTF receptor (CNTFR) for binding. We show here that in IMR-32 neuronal cells endogenously expressing the receptor subunits for LIF and CNTF, CNTFR, but not gp130 or LIFR, is found in detergent-resistant lipid rafts. In addition, stimulation of these cells with CNTF resulted in a rapid translocation of a portion of gp130 and LIFR into detergent-resistant lipid rafts while an equivalent stimulation with LIF did not. Disruption of lipid rafts by cholesterol depletion of cell membranes blocked the CNTF-induced translocation of LIFR and gp130. Interestingly, while cholesterol-depletion did not inhibit signal transducer and activator of transcription 3 phosphorylation by either CNTF or LIF stimulation, it strongly inhibited both CNTF- and LIF-mediated phosphorylation of extracellular signal-regulated kinases 1 and 2 and Akt. LIF and CNTF generally appear to have redundant effects in cells responsive to both cytokines. Intriguingly, the data presented here suggest a possible mechanism whereby CNTF or other cytokines that signal through CNTFR could generate signals distinct from those elicited by cytokines such as LIF which utilize a LIFR/gp130 heterodimer, via association with or exclusion from lipid rafts. [source]


    Differential and Age-Dependent Effects of Maternal Deprivation on the Hypothalamic-Pituitary-Adrenal Axis of Brown Norway Rats from Youth to Senescence

    JOURNAL OF NEUROENDOCRINOLOGY, Issue 7 2001
    J. O. Workel
    Abstract In this study, the hypothesis was tested that infants deprived from maternal care show persistent changes in hypothalamic-pituitary-adrenal activity. For this purpose, we studied the effect of maternal deprivation in one cohort of the healthy ageing Brown Norway rat strain showing still more than 80% survival rate at 32 months of age. Three-day-old male Brown Norway rats were either maternally deprived for 24 h or remained with the dam. In 3, 12 and 30,32 months (young, adult, senescent) deprived rats and their nondeprived littermates (controls), we determined basal resting and stress-induced plasma adrenocorticotropic hormone (ACTH) and corticosterone as well as corticotropin releasing hormone (CRH) mRNA expression in the paraventricular nucleus (PVN) of the hypothalamus. Mineralocorticoid (MR) and glucocorticoid receptors (GR) in hippocampus and PVN were also assessed using in vitro cytosol binding and in situ hybridization. The effect of ageing per se showed that in the control nondeprived Brown Norway rats, basal corticosterone and ACTH concentrations did not change during life. However, with age, the corticosterone response to novelty stress became progressively attenuated, but prolonged, while there was an age-related increase in the ACTH response. CRH mRNA expression in PVN decreased with age. Hippocampal MR binding and MR mRNA expression in the dentate gyrus were reduced at senescence, as were the GR binding capacities in hippocampus and hypothalamus. Maternal deprivation did not affect survival rate, body weight, nor adrenal weight of the ageing Brown Norway rats. Basal corticosterone and ACTH levels were not affected by deprivation, except for a rise in basal corticosterone concentrations at 3 months. At this age, the corticosterone output in response to novelty was attenuated in the deprived rats. In contrast, a striking surge in novelty stress-induced corticosterone output occurred at midlife while, at senescence, the corticosterone and ACTH responses were attenuated again in the deprived animals, particularly after the more severe restraint stressor. CRH mRNA expression was reduced only during adulthood in the deprived animals. After maternal deprivation, the MR mRNA in dentate gyrus showed a transient midlife rise. GR binding in hypothalamus and hippocampus GR binding was reduced in young rats while, in the senescent deprived animals, a reduced GRmRNA expression was observed in PVN and hippocampal CA1. In conclusion, in the Brown Norway rat, ageing causes a progressive decline in corticosterone output after stress, which is paralleled at senescence by decreased MR and GR mRNA expression in hippocampus and hypothalamus. The long-term effects of maternal deprivation become manifest differently at different ages and depend on test conditions. The deprivation effect culminates in a midlife corticosterone surge and results at senescence in a strongly reduced corticosterone output. [source]


    1H chemical shifts in NMR: Part 22,,Prediction of the 1H chemical shifts of alcohols, diols and inositols in solution, a conformational and solvation investigation

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 8 2005
    Raymond J. Abraham
    Abstract The 1H NMR spectra of a number of alcohols, diols and inositols are reported and assigned in CDCl3, D2O and DMSO- d6 (henceforth DMSO) solutions. These data were used to investigate the effects of the OH group on the 1H chemical shifts in these molecules and also the effect of changing the solvent. Inspection of the 1H chemical shifts of those alcohols which were soluble in both CDCl3 and D2O shows that there is no difference in the chemical shifts in the two solvents, provided that the molecules exist in the same conformation in the two solvents. In contrast, DMSO gives rise to significant and specific solvation shifts. The 1H chemical shifts of these compounds in the three solvents were analysed using the CHARGE model. This model incorporates the electric field, magnetic anisotropy and steric effects of the functional group for long-range protons together with functions for the calculation of the two- and three-bond effects. The long-range effect of the OH group was quantitatively explained without the inclusion of either the CO bond anisotropy or the COH electric field. Differential , and , effects for the 1,2-diol group needed to be included to obtain accurate chemical shift predictions. For DMSO solution the differential solvent shifts were calculated in CHARGE on the basis of a similar model, incorporating two-bond, three-bond and long-range effects. The analyses of the 1H spectra of the inositols and their derivatives in D2O and DMSO solution also gave the ring 1H,1H coupling constants and for DMSO solution the CHOH couplings and OH chemical shifts. The 1H,1H coupling constants were calculated in the CHARGE program by an extension of the cos2, equation to include the orientation effects of electronegative atoms and the CHOH couplings by a simple cos2, equation. Comparison of the observed and calculated couplings confirmed the proposed conformations of myo -inositol, chiro -inositol, quebrachitol and allo -inositol. The OH chemical shifts were also calculated in the CHARGE program. Comparison of the observed and calculated OH chemical shifts and CH. OH couplings suggested the existence of intramolecular hydrogen bonding in a myo -inositol derivative. Copyright © 2005 John Wiley & Sons, Ltd. [source]


    Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat

    NEUROGASTROENTEROLOGY & MOTILITY, Issue 3 2010
    D. O'malley
    Abstract Background, A growing body of data implicates increased life stresses with the initiation, persistence and severity of symptoms associated with functional gut disorders such as irritable bowel syndrome (IBS). Activation of central and peripheral corticotropin-releasing factor (CRF) receptors is key to stress-induced changes in gastrointestinal (GI) function. Methods, This study utilised immunofluorescent and Western blotting techniques to investigate colonic expression of CRF receptors in stress-sensitive Wistar Kyoto (WKY) and control Sprague Dawley (SD) rats. Key Results, No intra-strain differences were observed in the numbers of colonic CRFR1 and CRFR2 positive cells. Protein expression of functional CRFR1 was found to be comparable in control proximal and distal colon samples. Sham levels of CRFR1 were also similar in the proximal colon but significantly higher in WKY distal colons (SD: 0.38 ± 0.14, WKY: 2.06 ± 0.52, P < 0.01). Control levels of functional CRFR2 were similar between strains but sham WKYs samples had increased CRFR2 in both the proximal (SD: 0.88 ± 0.21, WKY: 1.8 ± 0.18, P < 0.001) and distal (SD: 0.18 ± 0.08, WKY: 0.94 ± 0.32, P < 0.05) regions. Exposure to open field (OF) and colorectal distension (CRD) stressors induced decreased protein expression of CRFR1 in SD proximal colons, an effect that was blunted in WKYs. CRD stimulated decreased expression of CRFR2 in WKY rats alone. Distally, CRFR1 is decreased in WKY rats following CRD but not OF stress without any apparent changes in SD rats. Conclusions & Inferences, This study demonstrates that psychological and physical stressors alter colonic CRF receptor expression and further support a role for local colonic CRF signalling in stress-induced changes in GI function. [source]


    Differential in vitro CD4+/CD8+ T-cell response to live vs. killed Leishmania major

    PARASITE IMMUNOLOGY, Issue 2 2010
    M. NATEGHI ROSTAMI
    Summary Clinical trials of killed Leishmania vaccines showed a limited efficacy compared with leishmanization (LZ). The reason for this difference in protection against cutaneous leishmaniasis (CL) is not known and in vivo studies on T-cell function may provide valuable information. Nevertheless, there are limited studies on the nature of the stimulatory effects of live vs. killed parasites on human T cells in vitro. A total of nine Leishmanin Skin Test+ volunteers with a history of self-healing CL (HCL) and seven healthy volunteers were included in this study. 5,6-carboxyfluroescein diacetate succinimidyl ester-labelled CD4+/CD8+ lymphocytes were cultured with killed Leishmania Lysate (Killed LL) or live Leishmania major (Live LM) and analysed for proliferation using flow cytometry. Culture supernatants were used for cytokine titration. In HCL volunteers, upon stimulation with killed LL, the number of proliferated CD4+/CD8+ cells was significantly more than that of unstimulated (P < 0·001) or live LM stimulated (P < 0·05) cells, or cells from controls (CD4+/CD8+: P < 0·05/P < 0·001). Stimulation of CD4+ cells with Live LM (P < 0·001) or Killed LL (P < 0·05) induced a significantly higher IFN-, production compared with that of controls, but Live LM induced significantly (P < 0·05) more IFN-, than Killed LL. A significantly (P < 0·05) higher IFN-, production was observed when CD8+ cells were stimulated with Live LM. Cells from HCL volunteers showed significantly more IL-10 production to Live LM stimulation compared with that of controls (CD4+: P < 0·05 /CD8+: P < 0·001) or cells stimulated with Killed LL (CD4+/CD8+: P < 0·001/P < 0·0005). Whereas Killed LL induced more proliferation response in purified T cells, Live LM induced cytokine production without significant induction of proliferation. The results from healed CL volunteers in this study could be implicated in further studies on T-cell response in vaccinated individuals. [source]


    Differential and reversible responses of common fen meadow species to abandonment

    APPLIED VEGETATION SCIENCE, Issue 1 2003
    Regula Billeter
    Binz & Heitz (1990) Abstract. We studied the effects of abandonment on two common fen plant species. In mown and a chronosequence of abandoned fen meadows spanning 35 yr, we measured fitness traits of the sedge Carex davalliana and the forb Succisa pratensis. Cessation of mowing had little effect on fitness traits and seed production of C. davalliana, but seedling density decreased more than threefold. Population density of S. pratensis decreased with increasing community biomass, but was not affected by the cessation of mowing. However, flowering frequency increased threefold and seed production was 20% higher in fallow meadows. Consequently, seedling density of S. pratensis increased nearly threefold after abandonment. However, these changes were not dependent on the age of the fallow. In a common garden and germination experiment, we found no differences in either species between plants from fallows and mown fen meadows, except for the height of the flowering stalk of S. pratensis. The combined results from the common garden experiment and the field studies indicate that changes in fitness traits observed in fallows were mostly phenotypic and likely to be reversible. If other species react in similar ways, there is a high potential for re-establishing traditional fen meadow communities from fallows by mowing. [source]


    Differential correlates to self-report and parent-report of callous,unemotional traits in a sample of juvenile sexual offenders

    BEHAVIORAL SCIENCES & THE LAW, Issue 6 2009
    Stuart F. White M.A.
    The association of callous,unemotional (CU) traits with violence and severe antisocial behavior has led to a recent focus on the association between CU traits and sexual offending behavior. When assessing juveniles with sexual offenses, practice standards recommend that multiple sources of data are considered. However, the differential correlates of parent-report versus self-report of CU traits in juvenile sex offenders have not been investigated. A sample of 94 detained male youth (mean age,=,15.22, SD,=,1.48) was administered both youth and parent versions of the Inventory of Callous,Unemotional Traits (ICU), a general delinquency risk assessment tool (YLS), and a sexual offending risk assessment tool (J-SOAP-II) to investigate concordance between self-report and parent-report of CU traits as well as association with general and sex-specific risk factors. Both parent-report and self-report of CU traits were significantly related to higher general delinquency risk scores, with parent-report showing stronger correlations than self-report. Both parent-report and self-report were related to sex-specific risk factors. However, only parent-report significantly predicted static sexual risk, while self-report significantly predicted dynamic sexual risk scores. Evidence supports the importance of including both parent- and self-report of CU traits in the comprehensive assessment of sexually offending youth. Copyright © 2009 John Wiley & Sons, Ltd. [source]


    The perceived credibility of older adults as witnesses and its relation to ageism,

    BEHAVIORAL SCIENCES & THE LAW, Issue 3 2007
    Katrin Mueller-Johnson Ph.D.
    In experiment 1, 267 undergraduates read a case summary and witness statement. Sex and age of the witness (49, 69, 79 or 89 years) were varied. Participants rated the witness's perceived convincingness, confidence, quality of observation, accuracy, honesty, competence, memory, suggestibility, and cognitive functioning. As well as an age effect for honesty, age by sex interactions were observed for several characteristics, particularly for comparisons of the 79-year-olds versus the 49-year-olds, and 89-year-olds versus the 49-year-olds. In experiment 2, 94 undergraduates read the same testimony given by a 79-year-old male or female witness, and completed the Fraboni Scale of Ageism and the Aging Semantic Differential. Participants who evidenced stronger aging stereotypes on these measures rated the witness less favorably than did participants who were less prejudiced. This experiment is the first to show a link between perceived credibility of older adults and ageist attitudes. Practical applications regarding how older witnesses are viewed by jurors, and the criminal justice system more generally, are discussed. Copyright © 2007 John Wiley & Sons, Ltd. [source]


    Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis

    BIPOLAR DISORDERS, Issue 2 2006
    David C Glahn
    Background:, Although bipolar disorder and schizophrenia have long been viewed as distinct illnesses, there is growing evidence that these two complex diseases share some common genes, which may manifest as overlapping neuropsychological impairments. Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder. Method:, We applied measures of working memory to patients with schizophrenia (n = 15), patients with schizoaffective disorder (n = 15), patients with psychotic (n = 11) and non-psychotic (n = 15) bipolar disorder, and demographically matched healthy subjects (n = 32), in order to determine the extent to which these groups show common or unique impairments. Results:, While patients with bipolar disorder (with and without psychotic features) and those with schizophrenia/schizoaffective disorder were impaired on backward digit span, only patients with a lifetime history of psychotic features, regardless of diagnosis, were impaired on spatial delayed response task. Conclusions:, Backward digit span performance is comparable in bipolar disorder and schizophrenia, and may be an appropriate endophenotypic marker that cuts across diagnostic categories. In contrast, spatial working memory performance clearly distinguishes non-psychotic bipolar disorder patients from patients with functional psychosis. [source]


    Elder Abuse: Keeping the Unthinkable in the Differential

    ACADEMIC EMERGENCY MEDICINE, Issue 6 2007
    Ryan D. Heyborne MD
    No abstract is available for this article. [source]


    Differential in vitro activity of anidulafungin, caspofungin and micafungin against Candida parapsilosis isolates recovered from a burn unit

    CLINICAL MICROBIOLOGY AND INFECTION, Issue 3 2009
    M. A. Ghannoum
    Abstract Recent studies suggest that differences in antifungal activity among echinocandins may exist. In this study, the activities of three echinocandins (anidulafungin, caspofungin, and micafungin) against Candida parapsilosis isolates from burn unit patients, healthcare workers and the hospital environment were determined. Additionally, the effect of these echinocandins on the cell morphology of caspofungin-susceptible and caspofungin-non-susceptible isolates was assessed using scanning electron microscopy (SEM). The C. parapsilosis isolates obtained from patients were susceptible to anidulafungin, but were less so to caspofungin and micafungin. Isolates obtained from healthcare workers or environmental sources were susceptible to all antifungals. SEM data demonstrated that although anidulafungin and caspofungin were equally active against a caspofungin-susceptible C. parapsilosis strain, they differed in their ability to damage a caspofungin-non-susceptible strain, for which lower concentrations of anidulafungin (1 mg/L) than of caspofungin (16 mg/L) were needed to induce cellular damage and distortion of the cellular morphology. To determine whether the difference in the antifungal susceptibility of C. parapsilosis isolates to anidulafungin as compared to the other two echinocandins could be due to different mutations in the FKS1 gene, the sequences of the 493-bp region of this gene associated with echinocandin resistance were compared. No differences in the corresponding amino acid sequences were observed, indicating that differences in activity between anidulafungin and the other echinocandins are not related to mutations in this region. The results of this study provide evidence that differences exist between the activities of anidulafungin and the other echinocandins. [source]


    Price Differentials between Dual-class Stocks: Voting Premium or Liquidity Discount?

    EUROPEAN FINANCIAL MANAGEMENT, Issue 3 2003
    Robert Neumann
    G32; G34 Abstract A series of papers suggest that private benefits can explain the price differentials between stock classes carrying different voting rights. However, in Denmark the premium is negative for several firms over long periods. This indicates that in the absence of takeover contests, where the voting right becomes crucial in a transfer of corporate control, the price differential in stock classes with identical dividend rights is more likely to reflect investors' liquidity risks. Whereas the existing literature tends to focus primarily on corporate control-related explanations, this paper documents the impact of liquidity on price spreads between dual-class shares. [source]


    Are Union Wage Differentials in the United States Falling?

    INDUSTRIAL RELATIONS, Issue 3 2008
    Article first published online: 21 MAY 200, MCKINLEY L. BLACKBURN
    This paper addresses several estimation and specification issues in estimating union wage differentials in the United States over the last two decades. Estimates provide strong evidence of a decline in the differential for women. For men, the differential appears to have declined for a person with overall average characteristics, but not for a male with characteristics of the average unionized male. [source]


    Gender Earnings Differentials Among College Administrators

    INDUSTRIAL RELATIONS, Issue 4 2004
    James Monks
    This analysis examines gender pay gap among the top five salaried individuals at private higher education institutions. We find a 13.0 percent average pay disadvantage for women versus men. This pay gap can be decomposed into a 10.4 percent differential owing to differences in the types of institutions and occupations that women hold relative to men and a 2.6 percent unexplained earnings differential. [source]


    Child Mortality and Socioeconomic Status: An Examination of Differentials by Migration Status in South Africa1

    INTERNATIONAL MIGRATION REVIEW, Issue 1 2007
    Kevin J. A. Thomas
    This study examines child mortality and socioeconomic status among migrants and nonmigrants. It also examines child mortality by migration status in all quintiles of socioeconomic status, comparing immigrants to the native-born and internal migrants to nonmigrants. The results show that among migrants, child mortality decreased faster as socioeconomic status increased than among nonmigrants. The results also show a cross-over in the likelihood of child mortality by immigration status as socioeconomic status increased. In the poorest socioeconomic quintiles immigrants had a greater likelihood of child mortality than the native-born while in the wealthiest quintiles child mortality was greater among the native-born. [source]


    Why the Rich Are Nastier Than the Poor , A Note on the Distribution of Wealth When Individuals Care for Payoff Differentials

    KYKLOS INTERNATIONAL REVIEW OF SOCIAL SCIENCES, Issue 2 2000
    Steffen Huck
    First page of article [source]