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Different Determinants (different + determinant)

Distribution by Scientific Domains

Medical Sciences	40%
Business, Economics, Finance and Accounting	40%

Selected Abstracts

Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies

IMMUNOLOGY, Issue 4 2008
Tyler R. Hall
Summary Type 1 diabetes is caused by the autoimmune destruction of pancreatic beta cells. Here we show that administration of a human monoclonal antibody (b96·11) specific to the 65-kDa isoform of glutamate decarboxylase (GAD65) to prediabetic non-obese diabetic (NOD) mice significantly delays the onset of autoimmune diabetes. We found this effect to be epitope-specific, as only b96·11 showed this therapeutic property, while a GAD65-specific human monoclonal control antibody (b78) derived from the same patient, but specific to a different determinant of GAD65, had no significant effect on the progression of disease. Administration of b96·11 or b78 to NOD mice was accompanied by the generation of anti-idiotypic antibodies. Importantly, the induced anti-idiotypic antibodies were specific for the immunizing antibody and blocked the binding of GAD65 by the respective antibody. These findings suggest a potential role for the internal image of the GAD65 determinant recognized by b96·11 in the anti-idiotypic antibody, supporting an immunomodulatory role for GAD65-specific autoantibodies, as originally postulated by Jerne. [source]

Towards a More Rational IMF Quota Structure: Suggestions for the Creation of a New International Financial Architecture

DEVELOPMENT AND CHANGE, Issue 3 2000
Raghbendra Jha
The authors of this article argue that, in the absence of a well-founded quota formula, the very basis of the creation of the IMF as an institution at the centre of international financial arrangements was flawed; that there is no clear rationale for the determinants of quota structures and their weighting scheme; and that the quota allocation as an instrument seeks to target too many objectives. As a result, large and arbitrary cross-country variations exist in the relative impact of different determinants on the quota shares of different countries. The quota formulas therefore need to be reviewed and an alternative approach evolved, in which emphasis is placed on the size of the economy rather than its openness, along with efficiency parameters. The authors suggest some principles which might underpin redefined quota structures in support of a new financial architecture. They provide illustrative calculations using India as a case study, and trace the impact of the redefined quota structures against the backdrop of the impact of the Eleventh General Review on India's quota position. [source]

ORGANIZATIONAL CHANGE, SKILL FORMATION, HUMAN CAPITAL MEASUREMENT: EVIDENCE FROM ITALIAN MANUFACTURING FIRMS

JOURNAL OF ECONOMIC SURVEYS, Issue 2 2010
Gilberto Antonelli
Abstract This paper emphasizes the role of labour demand as a determinant of human capital formation. After a section in which the alternative conceptions on the functioning of labour markets are presented and different ways of measuring human capital are compared, an applied analysis is carried out in which we provide a labour-demand-oriented measure of human capital, as defined by the amount of specific skills firms generate through work-based training (WBT) activities. By merging three rich firm-level datasets, we estimate the impact of a set of variables supposed to affect both the propensity to invest in WBT and the intensity of training within the Italian manufacturing industry over the period 2001,2005. Special attention is devoted to the variables characterizing within-firm organization of knowledge, organizational change and the formation of competence pipelines: among them, innovation, internationalization commitment, out-sourcing and new hirings. The estimates show that the effect of innovation on WBT is higher when the introduction of new technologies is supported by organizational innovations. When looking at the nature of WBT, we investigate the different determinants of the firms' propensity to provide both in-house and outside training. We measure training intensity in terms, respectively, of the number of provided training activities, private and total training costs and share of trainees. [source]

Why Do Part-time Workers Invest Less in Human Capital than Full-timers?

LABOUR, Issue 2009
Annemarie Nelen
We analyse whether lower investments in human capital of part-time workers are due to workers' characteristics or human resource practices of the firm. We focus on investments in both formal training and informal learning. Using the Dutch Life-Long-Learning Survey 2007, we find that part-time workers have different determinants for formal training and informal learning from full-time workers. The latter benefit from firms' human resource practices such as performance interviews, personal development plans, and feedback. Part-time workers can only partly compensate the lack of firm support when they have a high learning motivation and imagination of their future development. [source]

Assessing Tribal Youth Physical Activity and Programming Using a Community-Based Participatory Research Approach

PUBLIC HEALTH NURSING, Issue 2 2010
Cynthia Perry
ABSTRACT Objective: American Indian youth experience a greater prevalence of obesity compared with the general U.S. population. One avenue to reverse the trend toward increasing obesity prevalence is through promoting physical activity. The goal of this project was to understand tribal youths' current patterns of physical activity behavior and their beliefs and preferences about physical activity. Design and Sample: This assessment used a community-based participatory research approach. Sample included 35 Native youth aged 8,18. Measures: A Community Advisory Board was created that specifically developed an exercise survey for this assessment to explore physical activity patterns, preferences, and determinants. Twenty-six youth completed the survey. Descriptive statistics were analyzed, exploring differences by age group. Nine youth participated in 2 focus groups. Qualitative data were analyzed with thematic analysis. Results: Youth distinguished between sports and exercise, with each possessing different determinants. Common motivators were friends, coach, and school, and barriers were lack of programs and school or work. None of the youth reported meeting the recommended 60 min of strenuous exercise daily. Conclusions: This tribal academic partnership responded to a tribal concern by developing an exercise survey and conducting focus groups that addressed tribal-specific questions. The results are informing program development. [source]