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Different Aspects (different + aspect)
Kinds of Different Aspects Terms modified by Different Aspects Selected AbstractsIs there a connection between weather at departure sites, onset of migration and timing of soaring-bird autumn migration in Israel?GLOBAL ECOLOGY, Issue 6 2006Judy Shamoun-Baranes ABSTRACT Aims, Different aspects of soaring-bird migration are influenced by weather. However, the relationship between weather and the onset of soaring-bird migration, particularly in autumn, is not clear. Although long-term migration counts are often unavailable near the breeding areas of many soaring birds in the western Palaearctic, soaring-bird migration has been systematically monitored in Israel, a region where populations from large geographical areas converge. This study tests several fundamental hypotheses regarding the onset of migration and explores the connection between weather, migration onset and arrival at a distant site. Location, Globally gridded meteorological data from the breeding areas in north-eastern Europe were used as predictive variables in relation to the arrival of soaring migrants in Israel. Methods, Inverse modelling was used to study the temporal and spatial influence of weather on initiation of migration based on autumn soaring-bird migration counts in Israel. Numerous combinations of migration duration and temporal influence of meteorological variables (temperature, sea-level pressure and precipitable water) were tested with different models for meteorological sensitivity. Results, The day of arrival in Israel of white storks, honey buzzards, Levant sparrowhawks and lesser spotted eagles was significantly and strongly related to meteorological conditions in the breeding area days or even weeks before arrival in Israel. The cumulative number of days or cumulative value above or below a meteorological threshold performed significantly better than other models tested. Models provided reliable estimates of migration duration for each species. Main conclusions, The meteorological triggers of migration at the breeding grounds differed between species and were related to deteriorating living conditions and deteriorating migratory flight conditions. Soaring birds are sensitive to meteorological triggers at the same period every year and their temporal response to weather appears to be constrained by their annual routine. [source] Imagining the Future: Children, Education and Intergenerational Transmission of Poverty in Urban BangladeshIDS BULLETIN, Issue 1 2009Naila Kabeer Failure to invest in children's education is widely recognised as a key mechanism for the intergenerational transmission of poverty. At the same time, rising levels of education among different socioeconomic groups in countries like Bangladesh suggest that poverty on its own is not an adequate explanation for this failure. This article uses survey data on low-income households in urban Bangladesh to explore what differentiates parents who have managed to send their children to school from those who have not. One factor is education: parents with no education are more likely to have children of school-going age who are not at school. Different aspects of household vulnerability, as captured by asset deficits, reliance on casual labour and female headship, also play an important role in determining whether children go to school or not. In addition, the article argues that contextual factors have an important influence on how parents imagine their children's future and how children themselves regard education. The hazards of daily life in slum environments, the limited range of job opportunities available and the absence of decent educational facilities all serve to undermine parental commitment and children's motivation with regard to education. The article suggests that the state and civil society should collaborate to promote educational and livelihood interventions which are responsive to the needs of the more vulnerable sections of the poor and to reshape how parents and children envisage the future. [source] Automated mechanism generation: From symbolic calculation to complex chemistryINTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 1 2006Artur Ratkiewicz Abstract Different aspects of the symbolic algebra computations for generating elementary reactions of complex systems are reviewed. Such calculations are the heart of each automated mechanism generator system and are employed extensively in different stages of mechanism generation. The range of symbolic calculation topics and basic ideas of these implementations, together with some specific examples, are given. Particular attention is devoted to the transition between the symbolic calculation and the real complex chemistry. © 2005 Wiley Periodicals, Inc. Int J Quantum Chem, 2006 [source] Applicant and Recruiter Reactions to New Technology in Selection: A Critical Review and Agenda for Future ResearchINTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT, Issue 2-3 2003Neil AndersonArticle first published online: 30 JUL 200 This paper presents a narrative review of recent research into applicant and recruiter reactions to new technology in employee selection. Different aspects of the use of new technology are noted including computer-based testing, Internet-based recruitment and candidate assessment, telephone-based and video-based interviews, video-based situational judgment tests, and virtual reality scenarios. It is argued that an appropriate way to conceptualize these advances is as ,technical innovations' as defined in the creativity and innovation research in Industrial, Work, and Organizational (IWO) psychology. Applicant reactions research is reviewed thematically, and studies into three main themes are discussed: Applicant preferences and reactions, equivalence, and adverse impact. Following Bartram (2001), an amphibian-monarchistic analogy is employed at several stages in the review. Four major criticisms of the extant applicant reactions research base are noted: its atheoretical orientation, a short-termist concentration upon reactions level outcomes, an over-reliance on students as surrogates, and a patchiness of coverage of crucial research questions. The second part of this paper explores neglected issues of recruiter adoption of new technology for employee selection. Again drawing from advances in the innovation and creativity literatures, this section explores likely antecedent factors at the individual and organizational levels of analysis. A general model of recruiter adoption of new technology is posited as a framework for future research in this area. For both applicant and recruiter reactions further research is called for and implications for practice are noted throughout. [source] Quality of life among long-term survivors of breast cancer: different types of antecedents predict different classes of outcomesPSYCHO-ONCOLOGY, Issue 9 2006Charles S. Carver Abstract Quality of life (QOL) has many aspects, both in the short-term and in the long-term. Different aspects of QOL may have different types of precursors: demographic, medical, and psychosocial. We examined this possibility in a group of long-term breast cancer survivors. Early-stage breast cancer patients (N=163) who had provided information about medical, demographic, and psychosocial variables during the year after surgery completed a multidimensional measure of QOL 5,13 years later. Initial chemotherapy and higher stage predicted greater financial problems and greater worry about appearance at follow-up. Being partnered at diagnosis predicted many psychosocial benefits at follow-up. Hispanic women reported greater distress and social avoidance at follow-up. Initial trait optimism predicted diverse aspects of better psychosocial QOL at follow-up, but not other aspects of QOL. Thus, different aspects of QOL at long-term follow-up had different antecedents. Overall, psychological outcomes were predicted by psychosocial variables, presence of a partner at diagnosis, and ethnicity. Financial outcomes, in contrast, were predicted by medical variables, which otherwise predicted little about long-term QOL. This divergence among aspects of QOL should receive closer attention in future work. Copyright © 2005 John Wiley & Sons, Ltd. [source] Fatigue in Parkinson's disease: a short updateACTA NEUROLOGICA SCANDINAVICA, Issue 2010A. G. Beiske Beiske AG, Svensson E. Fatigue in Parkinson's disease: a short update. Acta Neurol Scand: 2010: 122 (Suppl. 190): 78,81. © 2010 John Wiley & Sons A/S. This article provides a short update on fatigue in Parkinson's disease (PD), focusing on measurements, prevalence, associated factors, pathophysiology and treatment. As long as there is no universally accepted definition of fatigue the definition used has to be stated. Different aspects of fatigue, namely physical-, mental- and chronic fatigue will be discussed. The many questionnaires used to assess fatigue measure different aspects of fatigue, making comparisons between studies difficult. Examples of uni- and multidimensional self-report questionnaires are given. In PD patients, the wide range of prevalence of fatigue (37,56%) is largely because of varying definitions of fatigue and populations tested. Without understanding the pathophysiology of subjective fatigue, the development of effective therapies is a challenge. [source] Social Networks, Identification and Participation in an Environmental Movement: Low-medium Cost Activism within the British Columbia Wilderness Preservation Movement,CANADIAN REVIEW OF SOCIOLOGY/REVUE CANADIENNE DE SOCIOLOGIE, Issue 4 2002David B. Tindall Cet article examine comment la structure des réseaux personnels (ou égocentriques) est liée à la participation continue des individus dans un mouvement social (le British Columbia Wilderness Preservation Movement). Les résultats présentés dans ce texte suggèrent que la communication, le recrutement continu et l'identification influent sur le rapport entre la structure des réseaux et le niveau de participation dans le mouvement. Différents aspects de la structure du réseau personnel ont différents effets sur ces processus de médiation. Finalement, dans le contexte d'un activisme comportant des risques/coûts faibles ou moyens, les liens faibles sont plus importants pour faciliter la participation que ne le sont les liens forts. This article examines how the structure of egocentric (or personal) networks is related to the ongoing participation of individuals in a social movement (the British Columbia Wilderness Preservation Movement). The results presented in this paper suggest that: communication, ongoing recruitment, and identification mediate the relationship between ego-network structure and level of movement participation. Different aspects of personal network structure have differential effects on these intervening processes. Finally, under conditions of low-medium risk/cost activism, weak ties are more important to facilitating participation than are strong ties. [source] A Critical Review of Milk Fouling in Heat ExchangersCOMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, Issue 2 2006Bipan Bansal ABSTRACT Fouling of heat exchangers is a problem in the dairy industry and costs billions of dollars every year. It has been studied extensively by researchers around the world, and a large number of studies are reported in the literature. This review focuses on the mechanisms of milk fouling, investigating the role of protein denaturation and aggregation as well as mass transfer. We also endeavor to review the effect of a number of factors which have been classified into 5 categories: (1) milk quality, (2) operating conditions, (3) type and characteristics of heat exchangers, (4) presence of microorganisms, and (5) transfer of location where fouling takes place. Different aspects have been discussed with the view of possible industrial applications and future direction for research. It may not be possible to alter the properties of milk since they are dependent on the source, collection schedule, season, and many other factors. Lowering the surface temperature and increasing the flow velocity tend to reduce fouling. Reducing the heat transfer surface roughness and wettability is likely to lower the tendency of the proteins to adsorb onto the surface. The use of newer technologies like microwave heating and ohmic heating is gaining momentum because these result in lower fouling; however, further research is required to realize their full potential. The presence of microorganisms creates problem. The situation gets worse when the microorganisms get released into the process stream. The location where fouling takes place is of paramount importance because controlling fouling within the heat exchanger may yield little benefit in case fouling starts taking place elsewhere in the plant. [source] In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selectionEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 2 2005Shigekazu Takahashi Abstract Cytotoxic T,lymphocyte antigen-4 (CTLA-4) induces major inhibitory signals for T,cell activation. From analyses of TCR-transgenic (Tg) CTLA-4-deficient mice, it has been believed that CTLA-4 does not affect thymocyte development. To focus upon the in vivo function of CTLA-4 in thymocyte development from a different aspect, we have established Tg mice expressing either full-length CTLA-4 (FL-Tg) or a mutant CTLA-4 lacking the cytoplasmic region (truncated, TR-Tg), and analyzed thymocyte development. TR-T,cells express much higher CTLA-4 on the cell surface than FL-T,cells, in which most CTLA-4 was localized in intracellular vesicles. While CTLA-4,/, mice exhibit lymphoproliferative disease, neither of the Tg mice with CTLA-4,/, background developed the disorder. Although the development of thymocytes appeared normal in both Tg mice, in vivo depletion of double-positive thymocytes by injection of anti-CD3 Ab as well as the elimination of minor lymphocyte-stimulating antigen-reactive thymocytes were impaired in FL-Tg mice but not in TR-Tg mice. Functionally, cross-linking of CTLA-4 on thymocytes from FL-Tg mice, but not from TR-Tg mice, inhibited proliferation. These results reveal a potential role of CTLA-4, through its cytoplasmic domain, in the negative selection of thymocytes and in the prevention of lymphoproliferative disease. [source] DEFINED ORDER OF EVOLUTIONARY ADAPTATIONS: EXPERIMENTAL EVIDENCEEVOLUTION, Issue 7 2008Erez Oxman Organisms often adapt to new conditions by means of beneficial mutations that become fixed in the population. Often, full adaptation requires several different mutations in the same cell, each of which may affect a different aspect of the behavior. Can one predict order in which these mutations become fixed? To address this, we experimentally studied evolution of Escherichia coli in a growth medium in which the effects of different adaptations can be easily classified as affecting growth rate or the lag-phase duration. We find that adaptations are fixed in a defined and reproducible order: first reduction of lag phase, and then an increase of the exponential growth rate. A population genetics theory explains this order, and suggests growth conditions in which the order of adaptations is reversed. We experimentally find this order reversal under the predicted conditions. This study supports a view in which the evolutionary path to adaptation in a new environment can be captured by theory and experiment. [source] Production of a new model of slowly progressive Heymann nephritisINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 6 2003Arpad Z. Barabas Summary., A slowly progressive autoimmune kidney disease was induced in Sprague Dawley rats by subcutaneous injection of a chemically modified kidney antigen (rKF3), incorporated into Alum and Distemper complex vaccine, followed by subcutaneous injections of an aqueous preparation of the same antigen. Pathogenic autoantibodies developed, which reacted with fixed glomerular nephritogenic antigen. Subsequently, immunopathological events lead to chronic progressive immune complex glomerulonephritis and proteinuria. The slowly developing disease was morphologically and functionally similar to Heymann nephritis (HN). The damage observed in the kidneys of experimental animals at 8 weeks and at the end of the experiment was examined by direct fluorescent antibody test, histology and electron microscopy. The changes were similar to the typical lesions found in HN rat kidneys, but less severe. Animals became proteinuric from 17 weeks onward (instead of the usual 4,8 weeks). By the end of the experiment, at 8 months, 100% of the rats were proteinuric. This new experimental model of autoimmune kidney disease, which is not complicated by intraperitoneal deposition and retention of Freund's complete adjuvant and renal tubular antigens, allowed us to investigate the pathogenesis of the disease processes from a different aspect, and promises to be a useful and improved model for the investigation of future treatment options. [source] The Impact of Commercial Exploitation on the Preservation of Underwater Cultural HeritageMUSEUM INTERNATIONAL, Issue 4 2008Tatiana Villegas Zamora It is impossible to talk about underwater cultural heritage and not reflect upon the problem of the commercial exploitation of submerged archaeological sites. The romantic notion of the search for lost treasure embodied in books and popular movies such as the Indiana Jones series takes on a different aspect when we consider that treasure hunting has become one of the most dangerous and devastating threats to the preservation of underwater cultural heritage. Fishing communities, irresponsible sport divers collecting souvenirs or modern-day salvors often equipped with high technology are destroying this newly accessible and rich heritage. Their sole motivation is commercial profit without any concern for archaeological research, preservation of cultural and historical values or the potential for sustainable development involving cultural tourism for the benefit of coastal populations. This article will try to present an overview of the scope of site destruction by commercial exploitation, the loss of scientific information and the strategies used to convince governments and deceive public opinion. [source] Uncovering Symptom Progression History from Disease Registry Data with Application to Young Cystic Fibrosis PatientsBIOMETRICS, Issue 2 2010Jun Yan Summary The growing availability of various disease registry data has brought precious opportunities to epidemiologists to understand the natural history of the registered diseases. It also presents challenges to the traditional data analysis techniques because of complicated censoring/truncation schemes and temporal dynamics of covariate influences. In a case study of the Cystic Fibrosis Foundation Patient Registry data, we propose analyses of progressive symptoms using temporal process regressions, as an alternative to the commonly employed proportional hazards models. Two endpoints are considered, the prevalence of ever positive and currently positive for Pseudomonas aeruginosa (PA) infection in the lungs, which capture different aspect of the disease process. The analysis of ever PA positive via a time-varying coefficient model demonstrates the lack of fit, as well as the potential loss of information, in the standard proportional hazards analysis. The analysis of currently PA positive yields results that are clinically meaningful and have not previously been reported in the cystic fibrosis literature. Our analyses demonstrate that prenatal/neonatal screening results in lower prevalence of PA infection compared to traditional diagnosis via signs and symptoms, but this benefit attenuates with age. Calendar years of diagnosis also affect the risk of PA infection; patients diagnosed in more recent cohort show higher prevalence of ever PA positive but lower prevalence of currently PA positive. [source] A Shape Grammar for Developing Glyph-based VisualizationsCOMPUTER GRAPHICS FORUM, Issue 8 2009P. Karnick I.3.2 [Computer Graphics]: Graphics Systems; I.3.4 [Computer Graphics]: Graphics Utilities Abstract In this paper we address the question of how to quickly model glyph-based Geographic Information System visualizations. Our solution is based on using shape grammars to set up the different aspects of a visualization, including the geometric content of the visualization, methods for resolving layout conflicts and interaction methods. Our approach significantly increases modelling efficiency over similarly flexible systems currently in use. [source] Applied Geometry:Discrete Differential Calculus for GraphicsCOMPUTER GRAPHICS FORUM, Issue 3 2004Mathieu Desbrun Geometry has been extensively studied for centuries, almost exclusively from a differential point of view. However, with the advent of the digital age, the interest directed to smooth surfaces has now partially shifted due to the growing importance of discrete geometry. From 3D surfaces in graphics to higher dimensional manifolds in mechanics, computational sciences must deal with sampled geometric data on a daily basis-hence our interest in Applied Geometry. In this talk we cover different aspects of Applied Geometry. First, we discuss the problem of Shape Approximation, where an initial surface is accurately discretized (i.e., remeshed) using anisotropic elements through error minimization. Second, once we have a discrete geometry to work with, we briefly show how to develop a full- blown discrete calculus on such discrete manifolds, allowing us to manipulate functions, vector fields, or even tensors while preserving the fundamental structures and invariants of the differential case. We will emphasize the applicability of our discrete variational approach to geometry by showing results on surface parameterization, smoothing, and remeshing, as well as virtual actors and thin-shell simulation. Joint work with: Pierre Alliez (INRIA), David Cohen-Steiner (Duke U.), Eitan Grinspun (NYU), Anil Hirani (Caltech), Jerrold E. Marsden (Caltech), Mark Meyer (Pixar), Fred Pighin (USC), Peter Schröder (Caltech), Yiying Tong (USC). [source] Plasma Edge Physics with B2-EireneCONTRIBUTIONS TO PLASMA PHYSICS, Issue 1-2 2006R. Schneider Abstract The B2-Eirene code package was developed to give better insight into the physics in the scrape-off layer (SOL), which is defined as the region of open field-lines intersecting walls. The SOL is characterised by the competition of parallel and perpendicular transport defining by this a 2D system. The description of the plasma-wall interaction due to the existence of walls and atomic processes are necessary ingredients for an understanding of the scrape-off layer. This paper concentrates on understanding the basic physics by combining the results of the code with experiments and analytical models or estimates. This work will mainly focus on divertor tokamaks, but most of the arguments and principles can be easily adapted also to other concepts like island divertors in stellarators or limiter devices. The paper presents the basic equations for the plasma transport and the basic models for the neutral transport. This defines the basic ingredients for the SOLPS (Scrape-Off Layer Plasma Simulator) code package. A first level of understanding is approached for pure hydrogenic plasmas based both on simple models and simulations with B2-Eirene neglecting drifts and currents. The influence of neutral transport on the different operation regimes is here the main topic. This will finish with time-dependent phenomena for the pure plasma, so-called Edge Localised Modes (ELMs). Then, the influence of impurities on the SOL plasma is discussed. For the understanding of impurity physics in the SOL one needs a rather complex combination of different aspects. The impurity production process has to be understood, then the effects of impurities in terms of radiation losses have to be included and finally impurity transport is necessary. This will be introduced with rising complexity starting with simple estimates, analysing then the detailed parallel force balance and the flow pattern of impurities. Using this, impurity compression and radiation instabilities will be studied. This part ends, combining all the elements introduced before, with specific, detailed results from different machines. Then, the effect of drifts and currents is introduced and their consequences presented. Finally, some work on deriving scaling laws for the anomalous turbulent transport based on automatic edge transport code fitting procedures will be described. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Public policy and corporate environmental behaviour: a broader viewCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 5 2008Runa Sarkar Abstract Corporate strategies to manage the business,ecological environment interface have evolved against the backdrop of regulatory pressures and stakeholder activism. Despite its relevance with respect to sustainable development, a well developed theory encompassing all aspects of corporate environmental behaviour, especially incorporating incentive compatible public policy measures, is yet to be developed. This paper is a step in this direction, aiming to assimilate contributions related to different aspects of corporate environmental behaviour, capturing the transition from environmental management to environmental strategy. In the process we identify areas where there is a need for further research. We find that there is plenty of scope in developing more complex models to explain a manager's rationale for adopting sustainable strategies in the backdrop of the policy regime, and in conducting more empirical (both descriptive and quantitative) work to obtain clearer insights into managerial decisions. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment. [source] Intergenerational linkages in antisocial behaviourCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2009Terence P. Thornberry Background,A life-course perspective was used to examine whether a parent's adolescent antisocial behaviour increases the chances of his or her child being involved in antisocial behaviour and, if so, the extent to which different aspects of parenting mediate this relationship. Aim,It was hypothesised that there will be significant levels of intergenerational continuity in antisocial behaviour when parents have ongoing contact with the child, and that stress from parenting and ineffective parenting styles will mediate this relationship. Method,Longitudinal data from the Rochester Intergenerational Study were used to test these issues in structural equation models for fathers and for mothers. Results,Parental antisocial behaviour is significantly related to child antisocial behaviour for mothers and for fathers who have frequent contact with the child, but not for fathers with infrequent contact. For mothers, the impact of adolescent antisocial behaviour on the child's antisocial behaviour is primarily mediated through parenting stress and effective parenting. For high-contact fathers there are multiple mediating pathways that help explain the impact of their adolescent antisocial behaviour on their child's behaviour. Conclusions,The roots of antisocial behaviour extend back at least to the parent's adolescence, and parenting interventions need to consider these long-term processes. Copyright © 2009 John Wiley & Sons, Ltd. [source] Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanismDEVELOPMENTAL DYNAMICS, Issue 4 2004Gary R. Hime Abstract Mutations in the human homolog of the patched gene are associated with the developmental (and cancer predisposition) condition Nevoid Basal Cell Carcinoma Syndrome (NBCCS), as well as with sporadic basal cell carcinomas. Most mutations that have been identified in the germline of NBCCS patients are truncating or frameshift mutations, with amino acid substitutions rarely found. We show that a missense mutation in the sterol-sensing domain G509V acts as a dominant negative when assayed in vivo in Drosophila. Ectopic expression of a Drosophila patched transgene, carrying the analogous mutation to G509V, causes ectopic activation of Hedgehog target genes and ectopic membrane stabilisation of Smoothened. The G509V transgene behaves in a manner similar, except in its subcellular distribution, to a C-terminal truncation that has been characterised previously as a dominant-negative protein. G509V exhibits vesicular localisation identical to the wild-type protein, but the C-terminal truncated Patched molecule is localised predominantly to the plasma membrane. This finding suggests that dominant-negative function can be conferred by interruption of different aspects of Patched protein behaviour. Another mutation at the same residue, G509R, did not exhibit dominant-negative activity, suggesting that simple removal of the glycine at 509 is not sufficient to impart dominant-negative function. Developmental Dynamics 229:780,790, 2004. © 2004 Wiley-Liss, Inc. [source] Immediate effects of methylphenidate on cognitive attention skills of children with attention-deficit-hyperactivity disorderDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 6 2005Jane Hood MSc This study investigated the immediate effects of stimulant medication (methylphenidate) on cognitive attention processes in children with attention-deficit-hyperactivity disorder (ADHD). Thirteen males and two females (mean age 9y 5mo, SD 18.3mo) with a diagnosis of ADHD and who were to be prescribed methylphenidate were assessed twice on one day with the Test of Everyday Attention for Children, a neuropsychological battery designed to tap different aspects of cognitive attention. Between assessments, the children were administered methylphenidate (10mg). Each child had at least average intelligence (IQ 80 or over, as measured by the Wechsler Intelligence Scale for Children - III UK) and was on no other medication. A group of 16 children, who were matched for age, sex, and intelligence, also performed the cognitive tests twice on the same day to control for practice effects of testing. At the first assessment, children with ADHD demonstrated significant impairments in several aspects of cognitive attention in comparison with the control group, particularly sustained attention. After administration of methylphenidate for the children with ADHD, they showed significant improvements in their performance on measures of cognitive attention compared to controls. The immediate effects of methylphenidate and the significance of measuring cognitive aspects of attention as well as behavioural measures are discussed. [source] Health status of children with moderate to severe cerebral palsyDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 6 2001Gregory S Liptak MD MPH The aim of the study was to evaluate the health of children with cerebral palsy (CP) using a global assessment of quality of life, condition-specific measures, and assessments of health care use. A multicenter population-based cross-sectional survey of 235 children, aged 2 to 18 years, with moderate to severe impairment, was carried out using Gross Motor Function Classification System (GMFCS) levels III (n= 56), IV (n=55), and V (n=122). This study group scored significantly below the mean on the Child Health Questionnaire (CHQ) for Pain, General Health, Physical Functioning, and Impact on Parents. These children used more medications than children without CP from a national sample. Fifty-nine children used feeding tubes. Children in GMFCS level V who used a feeding tube had the lowest estimate of mental age, required the most health care resources, used the most medications, had the most respiratory problems, and had the lowest Global Health scores. Children with the most severe motor disability who have feeding tubes are an especially frail group who require numerous health-related resources and treatments. Also, there is a relationship among measures of health status such as the CHQ, functional abilities, use of resources, and mental age, but each appears to measure different aspects of health and well-being and should be used in combination to reflect children's overall health status. [source] Multiple sensitive periods in human visual development: Evidence from visually deprived childrenDEVELOPMENTAL PSYCHOBIOLOGY, Issue 3 2005Terri L. Lewis Abstract Psychophysical studies of children deprived of early visual experience by dense cataracts indicate that there are multiple sensitive periods during which experience can influence visual development. We note three sensitive periods within acuity, each with different developmental time courses: the period of visually-driven normal development, the sensitive period for damage, and the sensitive period for recovery. Moreover, there are different sensitive periods for different aspects of vision. Relative to the period of visually driven normal development, the sensitive period for damage is surprisingly long for acuity, peripheral vision, and asymmetry of optokinetic nystagmus, but surprisingly short for global motion. A comparison of results from unilaterally versus bilaterally deprived children provides insights into the complex nature of interactions between the eyes during normal visual development. © 2005 Wiley Periodicals, Inc. Dev Psychobiol 46: 163,183, 2005. [source] The origins and evolution of links between word learning and conceptual organization: new evidence from 11-month-oldsDEVELOPMENTAL SCIENCE, Issue 2 2003Sandra Waxman How do infants map words to their meaning? How do they discover that different types of words (e.g. noun, adjective) refer to different aspects of the same objects (e.g. category, property)? We have proposed that (1) infants begin with a broad expectation that novel open-class words (both nouns and adjectives) highlight commonalities (both category- and property-based) among objects, and that (2) this initial expectation is subsequently fine-tuned through linguistic experience. We examine the first part of this proposal, asking whether 11-month-old infants can construe the very same set of objects (e.g. four purple animals) either as members of an object category (e.g. animals) or as embodying a salient object property (e.g. four purple things), and whether naming (with count nouns vs. adjectives) differentially influences their construals. Results support the proposal. Infants treated novel nouns and adjectives identically, mapping both types of words to both category- and property-based commonalities among objects. [source] Insulin therapy and quality of life.DIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue S1 2009A review Abstract Three central goals in the treatment of diabetes mellitus are (1) the avoidance of hyperglycaemia to prevent the development or progression of diabetes complications over time, (2) the avoidance of hypoglycaemia and (3) the maintenance or achievement of good quality of life. Insulin is the most powerful agent that can be used to control blood glucose levels. This article reviews the studies that have investigated the effects of different types of insulin and insulin delivery techniques on quality of life of patients with type 1 or type 2 diabetes. First, the concept of ,quality of life' (QoL) is defined and different ways of measuring QoL are explained. Secondly, the effects of different aspects of insulin therapy on QoL are reviewed: (1) the phenomenon of ,psychological insulin resistance'; (2) the effects of different types of insulin: regular insulin versus short-acting insulin analogues, long-acting insulin analogues or biphasic mixtures; (3) multiple daily injections versus pump therapy. Having multiple complications of diabetes is clearly associated with decreased QoL. Results from large studies such as the Diabetes Control and Complications Trial (DCCT) and United Kingdom Prospective Diabetes Study (UKPDS) suggest that intensive treatment itself does not impair QoL. Recent findings further suggest that pump therapy, compared to multiple daily injections, has beneficial effects on QoL. The fact that multiple tools are used to assess QoL makes it difficult to draw conclusions regarding the effects of different types of insulin on QoL. More work on the standardization of the assessment of QoL in diabetes is urgently needed. Copyright © 2009 John Wiley & Sons, Ltd. [source] Stressful but rewarding: Norwegian personnel mobilised for the 2004 tsunami disasterDISASTERS, Issue 3 2009Siri Thoresen Adequate responses to disasters and emergency situations rely, among other factors, on coping abilities in disaster workers and emergency personnel. In this study, different aspects of disaster-related stressors and training/experience were investigated in Norwegian personnel (n = 581) mobilised for the 2004 tsunami disaster. The level of stress reactions, measured nine to ten months after the tsunami, was relatively low in this sample, indicating that the personnel coped well with the challenges of the disaster. The level of intrusive memories was higher in disaster-area personnel (n = 335) than in home-base personnel (n = 246). Stress reactions were significantly associated with witnessing experiences (disaster-area group) and with having to reject victims in need of help (both groups). Specific preparation for the mission was associated with a lower level of stress reactions in disaster-area personnel. Such factors may be considered in training and preparation programmes for disaster workers. [source] Risk assessment for nonindigenous pests: 2.DIVERSITY AND DISTRIBUTIONS, Issue 5 2001Accounting for interyear climate variability Abstract The paper firstly discusses the importance of accounting for interyear variability when assessing the likelihood of establishment of an alien pest. The potential establishment of Colorado beetle (Leptinotarsa decemlineata) is used as an illustration within the geographical context of England and Wales. An aggregate risk index is introduced as a probabilistic representation of the likelihood that a pest might complete a single generation over a 30-year period (1961,90). Data for individual years were used to compute, objectively, the interyear distribution of risk across the landscape. The standard deviation in area at risk (26 800 km2) was high relative to the average proportion of the landscape potentially at risk (95 700 km2). In 40% of years, the area at risk was estimated to be higher than ,average'. Secondly, the paper demonstrates multiple indices of risk that reflect different aspects of pest risk assessment. Viewing risk from a variety of perspectives provides a means of gauging the consistency and therefore reliability of the results. This contrasts with current practice, where a single mapped output is commonly presented to decision makers. Modelling using a daily time step allowed the use of indices to investigate the long-term probabilities of biotic and abiotic events of short duration. These indices include estimates of pest activity and flight potential. [source] Cover Picture: Electrophoresis 19'2009ELECTROPHORESIS, Issue 19 2009Article first published online: 2 OCT 200 Issue no. 19 is a special issue on "Electrochemistry in Microfluidics and Capillary Electrophoresis". It has 25 contributions providing an "actual overview on the different aspects of electrochemistry in general (not necessarily only electrochemical detection) involving principles, designs, and applications in microfluidics (not necessarily only in electrophoretic mode) and CE". [source] Cross-reactivity of antibodies to actin- depolymerizing factor/cofilin family proteins and identification of the major epitope recognized by a mammalian actin-depolymerizing factor/cofilin antibodyELECTROPHORESIS, Issue 15 2004Alisa E. Shaw Abstract Members of the actin-depolymerizing factor (ADF)/cofilin family of proteins are expressed in all eukaryotic cells. In higher vertebrates, cells often express as many as three different ADF/cofilin genes and each of these proteins may be phosphorylated on serine 3, giving rise to up to six different species. Also, many avian, amphibian, and invertebrate systems have been useful in studying different aspects of ADF/cofilin function. Antibodies have been prepared against different members of the ADF/cofilin family, but no systematic examination of their cross-reactivity has been reported. Although ADF and cofilins within a single vertebrate species have about a 70% sequence homology, antibodies often differentiate between these proteins. Here, Western blotting was used with chemiluminescence substrates of different sensitivities to determine the relative immunoreactivities of different polyclonal rabbit antibodies and a mouse monoclonal antibody to purified ADF/cofilins from plants, protists, nematodes, insects, echinoderms, birds, and mammals. From immunocross-reactivities and sequence alignments, the principal epitope in mammalian ADF and cofilin-1 recognized by an antibody raised against avian ADF was identified. The specificity of an antibody to the phosphopeptide epitope of metazoan ADF/cofilins was confirmed by two-dimensional (2-D) immunoblot analysis. Futhermore, this bank of antibodies was used to identify by Western blotting a putative member of the ADF/cofilin family in the sea slug, Aplysia californica. [source] Remodeling of extracellular matrix and epileptogenesisEPILEPSIA, Issue 2010Alexander Dityatev Summary Extracellular matrix (ECM) in the brain is composed of molecules synthesized and secreted by neurons and glial cells, which form stable aggregates of diverse composition in the extracellular space. In the mature brain, ECM undergoes a slow turnover and restrains structural plasticity while supporting multiple physiologic processes, including perisomatic ,-aminobutyric acid (GABA)ergic inhibition, synaptic plasticity, and homeostatic regulations. Seizures lead to striking remodeling of ECM, which may be essentially engaged in different aspects of epileptogenesis. This view is supported by human genetic studies linking ECM molecules and epilepsy, by data showing altered epileptogenesis in mice deficient in ECM molecules, and by evidence that ECM may shape seizure-induced sprouting of mossy fibers, granule cell dispersion, and astrogliosis. Therefore, restraining seizure-induced remodeling of ECM or suppressing the signaling triggered by the remodeled ECM might provide effective therapeutic strategies to antagonize the progression of epileptogenesis. [source] Quality of Life of People with Epilepsy in Iran, the Gulf, and Near EastEPILEPSIA, Issue 1 2005Gus A. Baker Summary:,Purpose: To study the impact of epilepsy and its treatment on the quality of life of people living in Iran and in countries in the Gulf and Near East. Methods: Clinical, demographic, and psychosocial details were collected through the use of a self-completed questionnaire distributed to patients attending hospital outpatient clinics. Results: Data were collected from 3,889 people with epilepsy from 10 countries. More than 40% of all respondents had frequent seizures, and reported levels of side effects from medication were high, the most commonly reported being nervousness, headaches, and tiredness. A significant number of respondents reported changing their medications because of side effects or poor seizure control. Respondents reported that epilepsy and its treatment had a significant impact on a number of different aspects of their daily lives. A significant number of respondents felt stigmatized by their epilepsy. Reported health status was reduced when compared with that of people without epilepsy, particularly for physical and social functioning and energy and vitality, as assessed by using a generic health status measure, the SF-36. Conclusions: This is the largest study to date documenting the impact of epilepsy and its treatment in Iran, the Gulf, and Near East regions. Differences were found between the quality-of-life profiles of respondents in this study and those who participated in an earlier parallel study in Europe. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||