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Depression Research (depression + research)

Distribution by Scientific Domains

Psychology	50%
Medical Sciences	50%

Selected Abstracts

No Influence of 5-HTTLPR Gene Polymorphism on Migraine Symptomatology, Comorbid Depression, and Chronification

HEADACHE, Issue 3 2010
Thomas Wieser MD
(Headache 2010;50:420-430) Background., The serotonergic system is thought to play an important role for mediating susceptibility to migraine and depression, which is frequently found comorbid in migraine. The functional polymorphism in the serotonin transporter gene linked polymorphic region (5-HTTLPR/SLC6A4) was previously associated with attack frequency and, thus, possibly with chronification. Objective., We hypothesized that patients with the "s" allele have higher attack frequency and, paralleling results in depression research, higher scores of depression. Methods., Genetic analysis of the SLC6A4 44 bp insertion/deletion polymorphism (5-HTTLPR) was performed in 293 patients with migraine with and without aura. Self-rating questionnaires were used for assessment of depression. Results., Multinomial logistic regression analysis found no evidence for association of the 5-HTTLPR polymorphism with either depression or migraine attack frequency. Conclusion., We were not able to demonstrate any influence of the serotonin transporter 5-HTTLPR polymorphism on migraine phenomenology (attack frequency or comorbid depression), thereby excluding this variant to be a common genetic denominator for chronic migraine and depression. [source]

Past expectations, present disappointments, future hopes or psychopathology as the rate-limiting step of progress in psychopharmacology

HUMAN PSYCHOPHARMACOLOGY: CLINICAL AND EXPERIMENTAL, Issue 1 2001
H. M Van Praag
Abstract In 1974 I published a paper in which we predicted that biological depression research would lead to new, innovative antidepressants, to more sophisticated prescription of antidepressants and ultimately to ,functional psychopharmacology'. These expectations have not materialized. The reasons why are discussed and the conclusion is reached that there are reasons to believe that, belated, they will come true. I consider it no bold venture to uphold them. Copyright © 2001 John Wiley & sons, Ltd. [source]

Stress generation in depression: Reflections on origins, research, and future directions

JOURNAL OF CLINICAL PSYCHOLOGY, Issue 9 2006
Constance Hammen
Depressed individuals report higher rates of stressful life events, especially those that have occurred in part because of the person's characteristics and behaviors affecting interpersonal interactions. Termed stress generation, this phenomenon draws attention to the role of the individual as an active contributor rather than passive player in his or her environment, and is therefore an example of action theory. In this article, the author speculates about the intellectual origins of her stress generation perspective, and notes somewhat similar transactional approaches to the stress-disorder link outside of depression research. The literature on stress generation in depression is reviewed, including studies that attempt to explore its correlates and predictors, covering clinical, contextual, family, genetic, cognitive, interpersonal, and personality variables. Empirical and conceptual gaps in our understanding of processes contributing to stressors in the lives of depressed people remain. The author concludes with suggestions for further research, with the goal of furthering understanding both of mechanisms of depression and of dysfunctional interpersonal processes, as well as development of effective interventions to help break the stress-recurrence cycle of depression. © 2006 Wiley Periodicals, Inc. J Clin Psychol 62: 1065,1082, 2006. [source]

Gender and Depression in Men: Extending Beyond Depression and Extending Beyond Gender

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 3 2008
Scott M. Safford
The study of gender issues in men is an interesting, relatively new, area of focus in depression research. It is exciting to anticipate the continued development of the gender frameworks described by Addis (2008), as they are more thoroughly investigated. Given the high comorbidity rates in depression and the wealth of research on risk factors for depression, it is important that researchers who enter this arena remember (a) not to limit their exploration of gender in men to only depression nor (b) to focus their study of risk factors for depression in men too exclusively on gender issues. [source]