GENES, BRAIN AND BEHAVIOR, Issue 8 2005
D. I. Boomsma
For a large sample of twin pairs from the Netherlands Twins Register who were recruited at birth and followed through childhood, we obtained parental ratings of Anxious/Depression (A/D). Maternal ratings were obtained at ages 3 years (for 9025 twin pairs), 5 years (9222 pairs), 7 years (7331 pairs), 10 years (4430 pairs) and 12 years (2363 pairs). For 60,90% of the pairs, father ratings were also available. Multivariate genetic models were used to test for rater-independent and rater-specific assessments of A/D and to determine the genetic and environmental influences on individual differences in A/D at different ages. At all ages, monozygotic twins resembled each other more closely for A/D than dizygotic twins, implying genetic influences on variation in A/D. Opposite sex twin pairs resembled each other to same extent as same-sex dizygotic twins, suggesting that the same genes are expressed in boys and girls. Heritability estimates for rater-independent A/D were high in 3-year olds (76%) and decreased in size as children grew up [60% at age 5, 67% at age 7, 53% at age 10 (60% in boys) and 48% at age 12 years]. The decrease in genetic influences was accompanied by an increase in the influence of the shared family environment [absent at ages 3 and 7, 16% at age 5, 20% at age 10 (5% in boys) and 18% at age 12 years]. The agreement between parental A/D ratings was between 0.5 and 0.7, with somewhat higher correlations for the youngest group. Disagreement in ratings between the parents was not merely the result of unreliability or rater bias. Both the parents provided unique information from their own perspective on the behavior of their children. Significant influences of genetic and shared environmental factors were found for the unique parental views. At all ages, the contribution of shared environmental factors to variation in rater-specific views was higher for father ratings. Also, at all ages except age 12, the heritability estimates for the rater-specific phenotype were higher for mother ratings (59% at age 3 and decreasing to 27% at age 12 years) than for father ratings (between 14 and 29%). Differences between children, even as young as 3 years, in A/D are to a large extent due to genetic differences. As children grow up, the variation in A/D is due in equal parts to genetic and environmental influences. Anxious/Depression, unlike many other common childhood psychopathologies, is influenced by the shared family environment. These findings may provide support for why certain family therapeutic approaches are effective in the A/D spectrum of illnesses. [source]

BOOM BUST: HOUSE PRICES, BANKING AND THE DEPRESSION OF 2010

ECONOMIC AFFAIRS, Issue 4 2005
John Calverley
No abstract is available for this article. [source]

J -SHAPE OR LINEAR RELATIONSHIP BETWEEN ALCOHOL CONSUMPTION AND DEPRESSION: DOES IT MATTER?

ADDICTION, Issue 6 2005
BENJAMIN TAYLOR
No abstract is available for this article. [source]

IS INBREEDING DEPRESSION LOWER IN MALADAPTED POPULATIONS?

EVOLUTION, Issue 7 2009
A QUANTITATIVE GENETICS MODEL
Despite abundant empirical evidence that inbreeding depression varies with both the environment and the genotypic context, theoretical predictions about such effects are still rare. Using a quantitative genetics model, we predict amounts of inbreeding depression for fitness emerging from Gaussian stabilizing selection on some phenotypic trait, on which, for simplicity, genetic effects are strictly additive. Given the strength of stabilizing selection, inbreeding depression then varies simply with the genetic variance for the trait under selection and the distance between the mean breeding value and the optimal phenotype. This allows us to relate the expected inbreeding depression to the degree of maladaptation of the population to its environment. We confront analytical predictions with simulations, in well-adapted populations at equilibrium, as well as in maladapted populations undergoing either a transient environmental shift, or gene swamping in heterogeneous habitats. We predict minimal inbreeding depression in situations of extreme maladaptation. Our model provides a new basis for interpreting experiments that measure inbreeding depression for the same set of genotypes in different environments, by demonstrating that the history of adaptation, in addition to environmental harshness per se, may account for differences in inbreeding depression. [source]

THE EFFECT OF SELF-FERTILIZATION, INBREEDING DEPRESSION, AND POPULATION SIZE ON AUTOPOLYPLOID ESTABLISHMEN

EVOLUTION, Issue 9 2005
Joseph H. Rausch
Abstract The minority cytotype exclusion principle describes how random mating between diploid and autotetraploid cytotypes hinders establishment of the rare cytotype. We present deterministic and stochastic models to ascertain how selfing, inbreeding depression, unreduced gamete production, and finite population size affect minority cytotype exclusion and the establishment of autotetraploids. Results demonstrate that higher selfing rates and lower inbreeding depression in autotetraploids facilitate establishment of autotetraploid populations. Stochastic effects due to finite population size increase the probability of polyploid establishment and decrease the mean time to tetraploid fixation. Our results extend the minority cytotype exclusion principle to include important features of plant reproduction and demonstrate that variation in mating system parameters significantly influences the conditions necessary for polyploid establishment. [source]

ENVIRONMENTAL CONDITIONS AFFECT THE MAGNITUDE OF INBREEDING DEPRESSION IN SURVIVAL OF DARWIN'S FINCHES

EVOLUTION, Issue 6 2002
Lukas F. Keller
Abstract Understanding the fitness consequences of inbreeding (inbreeding depression) is of importance to evolutionary and conservation biology. There is ample evidence for inbreeding depression in captivity, and data from wild populations are accumulating. However, we still lack a good quantitative understanding of inbreeding depression and what influences its magnitude in natural populations. Specifically, the relationship between the magnitude of inbreeding depression and environmental severity is unclear. We quantified inbreeding depression in survival and reproduction in populations of cactus finches (Geospiza scandens) and medium ground finches (Geospiza fortis) living on Isla Daphne Major in the Galapagos Archipelago. Our analyses showed that inbreeding strongly reduced the recruitment probability (probability of breeding given that an adult is alive) in both species. Additionally, in G. scandens, first-year survival of an offspring withf= 0.25 was reduced by 21% and adults withf= 0.25 experienced a 45% reduction in their annual probability of survival. The magnitude of inbreeding depression in both adult and juvenile survival of this species was strongly modified by two environmental conditions, food availability and number of competitors. In juveniles, inbreeding depression was only present in years with low food availability, and in adults inbreeding depression was five times more severe in years with low food availability and large population sizes. The combination of relatively severe inbreeding depression in survival and the reduced recruitment probability led to the fact that very few inbred G. scandens ever succeeded in breeding. Other than recruitment probability, no other trait showed evidence of inbreeding depression in G. fortis, probably for two reasons: a relatively high rate of extrapair paternity (20%), which may lead to an underestimate of the apparent inbreeding depression, and low sample sizes of highly inbred G. fortis, which leads to low statistical power. Using data from juvenile survival, we estimated the number of lethal equivalents carried by G. scandens, G. fortis, and another congener, G. magnirostris. These results suggest that substantial inbreeding depression can exist in insular populations of birds, and that the magnitude of the inbreeding depression is a function of environmental conditions. [source]

HETEROSIS AND OUTBREEDING DEPRESSION IN DESCENDANTS OF NATURAL IMMIGRANTS TO AN INBRED POPULATION OF SONG SPARROWS (MELOSPIZA MELODIA)

EVOLUTION, Issue 1 2002
Amy B. Marr
Abstract We studied heterosis and outbreeding depression among immigrants and their descendants in a population of song sparrows on Mandarte Island, Canada. Using data spanning 19 generations, we compared survival, seasonal reproductive success, and lifetime reproductive success of immigrants, natives (birds with resident-hatched parents and grandparents), and their offspring (F1s, birds with an immigrant and a native parent, and F2s, birds with an immigrant grandparent and resident-hatched grandparent in each of their maternal and paternal lines). Lifetime reproductive success of immigrants was no worse than that of natives, but other measures of performance differed in several ways. Immigrant females laid later and showed a tendency to lay fewer clutches, but had relatively high success raising offspring per egg produced. The few immigrant males survived well but were less likely to breed than native males of the same age that were alive in the same year. Female F1s laid earlier than expected based on the average for immigrant and native females, and adult male F1s were more likely to breed than expected based on the average for immigrant and native males. The performance differences between immigrant and native females and between F1s and the average of immigrants and natives are consistent with the hypothesis that immigrants were disadvantaged by a lack of site experience and that immigrant offspring benefited from heterosis. However, we could not exclude the possibility that immigrants had a different strategy for optimizing reproductive success or that they experienced ecological compensation for life-history parameters. For example, the offspring of immigrants may have survived well because immigrants laid later and produced fewer clutches, thereby raising offspring during a period of milder climatic conditions. Although sample sizes were small, we found large performance differences between F1s and F2s, which suggested that either heterosis was associated with epistasis in F1s, that F2s experienced outbreeding depression, or that both phenomena occurred. These findings indicate that the performance of dispersers may be affected more by fine-scale genetic differentiation than previously assumed in this and comparable systems. [source]

MAINTENANCE OF ANDRODIOECY IN THE FRESHWATER SHRIMP, EULIMNADIA TEXANA: ESTIMATES OF INBREEDING DEPRESSION IN TWO POPULATIONS

EVOLUTION, Issue 3 2000
Stephen C. Weeks
Abstract., Androdioecy is an uncommon form of reproduction in which males coexist with hermaphrodites. Androdioecy is thought to be difficult to evolve in species that regularly inbreed. The freshwater shrimp Eulimnadia texana has recently been described as both androdioecious and highly selfing and is thus anomalous. Inbreeding depression is one factor that may maintain males in these populations. Here we examine the extent of "late" inbreeding depression (after sexual maturity) in these clam shrimp using two tests: (1) comparing the fitness of shrimp varying in their levels of individual heterozygosity from two natural populations that differ in overall genetic diversity; and (2) specifically outcrossing and selfing shrimp from these same populations and comparing fitness of the resulting offspring. The effects of inbreeding differed within each population. In the more genetically diverse population, fecundity, size, and mortality were significantly reduced in inbred shrimp. In the less genetically diverse population, none of the fitness measures was significantly lowered in selfed shrimp. Combining estimates of early inbreeding depression from a previous study with current estimates of late inbreeding depression suggests that inbreeding depression is substantial (,= 0.68) in the more diverse population and somewhat lower (,= 0.50) in the less diverse population. However, given that males have higher mortality rates than hermaphrodites, neither estimate of inbreeding depression is large enough to account for the maintenance of males in either population by inbreeding depression alone. Thus, the stability of androdioecy in this system is likely only if hermaphrodites are unable to self-fertilize many of their own eggs when not mated to a male or if male mating success is generally high (or at least high when males are rare). Patterns of fitness responses in the two populations were consistent with the hypothesis that inbreeding depression is caused by partially recessive deleterious alleles, although a formal test of this hypothesis still needs to be conducted. [source]

ASPIRIN USE, DEPRESSION, AND COGNITIVE IMPAIRMENT IN LATER LIFE: THE HEALTH IN MEN STUDY

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 5 2010
Osvaldo P. Almeida MD
No abstract is available for this article. [source]

EVIDENCE FOR THE VALIDITY OF THE AMERICAN MEDICAL ASSOCIATION'S CAREGIVER SELF-ASSESSMENT QUESTIONNAIRE AS A SCREENING MEASURE FOR DEPRESSION

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 2 2010
Gary Epstein-Lubow MD
No abstract is available for this article. [source]

DEPRESSION AND MEDICAL ILLNESS IN CHINESE NONAGENARIANS AND CENTENARIANS

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 12 2008
Huang Chang-Quan MD
No abstract is available for this article. [source]

DEPRESSION AFTER HIP FRACTURE

JOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 1 2007
Barbara Kamholz MD
No abstract is available for this article. [source]

THE LACUSTRINE LIANGJIALOU FAN IN THE DONGYING DEPRESSION, EASTERN CHINA: DEEP-WATER RESERVOIR SANDSTONES IN A NON-MARINE RIFT BASIN

JOURNAL OF PETROLEUM GEOLOGY, Issue 4 2005
Jin Qiang
A lacustrine fan covering an area of about 175sq. km has been identified in the Liangjialou area in the SW of the Dongying Depression, a Tertiary non-marine rift basin in eastern China. Fluvial and deltaic sandstones are established reservoir rocks in the basin, and the deep-water sandstones of the fan succession, which are assigned to Member 3 of the lower Tertiary Shahejie Formation, are also thought to have important reservoir potential. Available data for this study included some 800m of core from 16 wells, well-log data from 426 wells, and 220 sq.km of 3D surveys together with well-test and other production data. From geomorphological reconstructions of the fan, we distinguish first-order (major) fan channels from second-order branched and more distal tip channels. Crevasse splays and overbank shales occur between channels, and sandstone lobes were deposited at channel mouths. Conglomeratic sandstones deposited in major channels are probably the most promising reservoir facies (average porosity c. 20%; average permeability > 1D). Fan construction took place during a single complete cycle of lake level variation which was composed of several sub-cycles. During initial highstand conditions, the fan was dominated by small-scale branched and tip channels and intervening sandy lobes. Fan size increased rapidly during the following lowstand, and then decreased during the ensuing highstand. [source]

REPLENISHINGTHE SOILANDTHE SOULOF TEXAS: THE CIVILIAN CONSERVATION CORPSINTHE LONE STAR STATEASAN EXAMPLEOF STATE -FEDERAL WORK RELIEF DURINGTHE GREAT DEPRESSION

THE HISTORIAN, Issue 4 2003
KENNETH E. HENDRICKSON JR.
First page of article [source]

THE ROLE OF THE HIGH COURT IN FEDERAL ARBITRATION DURING THE GREAT DEPRESSION: PRESERVING A FUTURE FOR ,REASON AND MORAL SUASION'?

AUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 2 2008
Rohan Price
arbitration; Australia; depression; legal institutions; wage fixation Between 1929 and 1933 the Australian federal system of conciliation and arbitration came under economic and political strain. This article reveals that arbitration proved to be an adaptable industrial relations framework for dealing with economic depression. While the monetary entitlements of workers were reduced, the legal instrumentality that conferred the wage cuts, the Arbitration Court, itself defied abolition and evolved to be a protective body. There was a subtle and previously unremarked interaction in the regulatory functions of the High Court, the Arbitration Court, and the Commonwealth Parliament characterised by the purposeful abstention of the High Court and Scullin Government and the activism of the Arbitration Court. [source]

STATE-LEVEL BASIC WAGES IN AUSTRALIA DURING THE DEPRESSION, 1929,35: INSTITUTIONS AND POLITICS OVER MARKETS

AUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 3 2007
Peter Sheldon
Australia; basic wage; depression; institutions; state tribunal State wage-fixation tribunals developed quite particular patterns of basic wage fixation during the Depression. They declined to follow the Commonwealth Court's 10 per cent wage cut, thereby confining its effect to about half the workforce and creating distinctly different State and Commonwealth basic wage patterns in each capital city. Further, tribunals' uneven patterns of basic wage adjustment to deflation meant that in some states, the real State basic wage increased. Patterns of state institutional behaviour and state politics therefore help explain the stickiness of real average wage levels during the Depression. [source]

RECOVERY FROM DEPRESSION: AUSTRALIA IN AN ARGENTINE MIRROR 1895,1913

AUSTRALIAN ECONOMIC HISTORY REVIEW, Issue 3 2006
Article first published online: 20 OCT 200, Ian W. McLean
Argentina; Australia; debt crisis; recovery policies The recovery from the 1890s depression in Australia was prolonged, and economic growth from 1895 to 1913 was below that in the comparable settler economies of Argentina and Canada. Why? Australia's hesitant initial recovery is typically attributed to the imbalances in the economy resulting from the preceding boom, and its further delay to severe drought. Drawing on Argentine experience, it is suggested that additional factors need to be considered. Unlike Argentina, the unwillingness or inability of Australian governments to reschedule foreign debt or devalue the exchange rate exacerbated the slump. And the era of low-cost pioneer farming ended earlier than in Argentina (or Canada). [source]

Studying the incidence of depression: an ,interval' effect

INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 4 2000
Jane M. Murphy
Abstract A review of studies about the incidence of depression suggested that the length of the ,interval' of follow up may influence the findings. Exploration of these issues is carried out using data from the Stirling County Study, an investigation of psychiatric epidemiology in a general population. The study's customary method of diagnosis, DePression and AnXiety (DPAX), and the Diagnostic Interview Schedule (DIS) were used in an incidence investigation whose ,interval' was less than three years. Average annual incidence rates of depression for both DPAX and DIS were about 15 per 1000. Where longer intervals were used in the Stirling Study, rates were close to four per 1000. Projected lifetime risk based on the lower rates was more congruent with reported lifetime prevalence than that based on the higher rates. Irrespective of method, 90% or more of the incident cases gave an onset that predated the initial interview, suggesting poor reliability. This was often due to the fact that information given in the first interview met some but not all of the criteria for diagnosis. Being in the ,borderline' category at the beginning of the study significantly increased incidence. Thus, evidence from the Stirling County Study replicated findings that suggest an ,interval effect' and pointed to the need in incidence studies for distinguishing between the onset of the prodrome and the onset of diagnosable depression. Copyright © 2000 Whurr Publishers Ltd. [source]

Stress Resistance and Environmental Dependency of Inbreeding Depression in Drosophila melanogaster

CONSERVATION BIOLOGY, Issue 4 2000
Jesper Dahlgaard
Two important issues are whether stress and inbreeding effects are independent as opposed to synergistic, and whether inbreeding effects are general across stresses as opposed to stress-specific. We found that inbreeding reduced resistance to acetone and desiccation in adult Drosophila melanogaster, whereas resistance to knockdown heat stress was not affected. Inbred flies, however, experienced a greater proportional decrease in productivity than outbreds following heat stress. Correlations using line means indicated that all resistance traits were uncorrelated in the inbred as well as in the outbred flies. Recessive, deleterious alleles therefore did not appear to have any general deleterious effects on stress resistance. Inbreeding within a specific environment and selection for resistant genotypes may therefore purge a population of deleterious genes specific to only one environmental stress. Resumen: Tanto la endogamia como el estrés ambiental pueden tener efectos adversos sobre la adaptabilidad afectando la conservación de especies en peligro de extinción. Dos temas importantes son determinar si los efectos del estrés y la endogamia son independientes en lugar de ser sinérgicos, y determinar si los efectos de la endogamia son generales para distintos tipos de estrés o si son específicos para un tipo determinado de estrés. Encontramos que la endogamia reduce la resistencia a la acetona y la desecación en adultos de Drosophila melanogaster, mientras que la resistencia al efecto demoledor del estrés por calor no fue afectada. Sin embargo, las moscas endogámicas experimentaron una disminución proporcionalmente mayor en la productividad que aquellas moscas sin endogamia después de experimentar un estrés por calor. Las correlaciones obtenidas usando líneas medias indicaron que las características de resistencia no estuvieron correlacionadas ni en moscas con endogamia, ni en moscas sin ella. Aparentemente los alelos nocivos recesivos no tuvieron ningún efecto nocivo general en la resistencia al estrés. La endogamia dentro de un ambiente específico y la selección por genotipos resistentes podrían, por lo tanto, eliminar una población de genes nocivos específicos a un solo estrés ambiental. [source]

Delinquency and the profile of offences among depressed and non-depressed adolescents

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2006
MINNA RITAKALLIO
Background,Depression has previously been found to be closely connected to adolescent delinquency, but little is known about how depression is related to different types of delinquency. Aim,To investigate patterns of criminal behaviour according to depression among repeatedly delinquent adolescents. Method,The sample was 14- to 16-year-old repeatedly delinquent adolescents (n 3679) taking part in the Finnish School Health Promotion Study, surveyed for versatility and specialization of delinquency in relation to depression. Results,Patterns of criminal behaviour differed between depressed and non-depressed delinquent adolescents. The delinquent behaviour of depressed adolescents was more versatile than that of non-depressed adolescents who mainly specialized in one offence type. Non-depressed delinquent boys had most often specialized in violence. Most depressed delinquent boys had committed a variety of offences, but among those who did specialize the specialist category was violent offences. Non-depressed delinquent girls had specialized in shoplifting. Among depressed delinquent girls vandalism was the most typical offence. Conclusion,Differences in the delinquent behaviour of depressed and non-depressed delinquent adolescents suggest the value of including clinical assessment, and treatment for some, in an appropriately comprehensive pattern of management. Copyright © 2006 John Wiley & Sons, Ltd. [source]

Depression, hopelessness and suicide ideation among vulnerable prisoners

CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 3 2005
Emma J. Palmer PhD
Background Self-harm among prisoners is high, and suicide rates increasing. Assessment of depressive characteristics is easy. To what extent are these linked with previous self-harm? Aims To compare depressive characteristics of prisoners who report previous self-harm with those who do not. Methods Twenty-four new arrivals at an adult male category B local prison who reported previous episodes of suicidal behaviour (including self-harm and/or explicit attempted suicide) were assessed using the Beck Hopelessness Scale, the Beck Depression Inventory-II, and the Beck Scale for Suicide Ideation. A further 24 new arrivals were matched as closely as possible with them on sociodemographic and offending characteristics. Results Mean scores on the Beck Hopelessness Scale, the Beck Depression Inventory-II, and the Beck Scale for Suicide Ideation were significantly higher among the prisoners with a history of self-harm. Discussion Prisoners with a previous history of self-harm are more likely than those without to show a range of depressive symptoms than their imprisoned peers without such a history, suggesting a continued vulnerability to self-harm and perhaps suicide. Copyright © 2005 John Wiley & Sons, Ltd. [source]

A randomised controlled trial of cognitive behaviour therapy for psychosis in a routine clinical service

ACTA PSYCHIATRICA SCANDINAVICA, Issue 4 2010
E. Peters
Peters E, Landau S, McCrone P, Cooke M, Fisher P, Steel C, Evans R, Carswell K, Dawson K, Williams S, Howard A, Kuipers E. A randomised controlled trial of cognitive behaviour therapy for psychosis in a routine clinical service. Objective:, To evaluate cognitive behaviour therapy for psychosis (CBTp) delivered by non-expert therapists, using CBT relevant measures. Method:, Participants (N = 74) were randomised into immediate therapy or waiting list control groups. The therapy group was offered 6 months of therapy and followed up 3 months later. The waiting list group received therapy after waiting 9 months (becoming the delayed therapy group). Results:, Depression improved in the combined therapy group at both the end of therapy and follow-up. Other significant effects were found in only one of the two therapy groups (positive symptoms; cognitive flexibility; uncontrollability of thoughts) or one of the two time points (end of therapy: general symptoms, anxiety, suicidal ideation, social functioning, resistance to voices; follow-up: power beliefs about voices, negative symptoms). There was no difference in costs between the groups. Conclusion:, The only robust improvement was in depression. Nevertheless, there were further encouraging but modest improvements in both emotional and cognitive variables, in addition to psychotic symptoms. [source]

The evolution of depression and suicidality in first episode psychosis

ACTA PSYCHIATRICA SCANDINAVICA, Issue 3 2010
R. Upthegrove
Upthegrove R, Birchwood M, Ross K, Brunett K, McCollum R, Jones L. The evolution of depression and suicidality in first episode psychosis. Objective:, To have a clearer understanding of the ebb and flow of depression and suicidal thinking in the early phase of psychosis, whether these events are predictable and how they relate to the early course of psychotic symptoms. Method:, Ninety-two patients with first episode psychosis (FEP) completed measures of depression, including prodromal depression, self-harm and duration of untreated psychosis. Follow-up took place over 12 months. Results:, Depression occurred in 80% of patients at one or more phases of FEP; a combination of depression and suicidal thinking was present in 63%. Depression in the prodromal phase was the most significant predictor of future depression and acts of self-harm. Conclusion:, Depression early in the emergence of a psychosis is fundamental to the development of future depression and suicidal thinking. Efforts to predict and reduce depression and deliberate self-harm in psychosis may need to target this early phase to reduce later risk. [source]

Conceptual background, development, and preliminary data from the unified protocol for transdiagnostic treatment of emotional disorders,

DEPRESSION AND ANXIETY, Issue 10 2010
Zofia A. Wilamowska M.A.
Abstract Anxiety and mood disorders are common, chronic, costly, and characterized by high comorbidity. The development of cognitive behavioral approaches to treating anxiety and mood disorders has left us with highly efficacious treatments that are increasingly widely accepted. The proliferation of treatment manuals targeting single disorders, sometimes with trivial differences among them, leaves the mental health professional with no clear way to choose one manual over another and little chance of ever becoming familiar with most of them, let alone trained to competence in their delivery. Deepening understanding of the nature of emotional disorders reveals that commonalities in etiology and latent structures among these disorders supersedes differences. Based on empirical evidence from the domains of learning, emotional development and regulation, and cognitive science, we have distilled a set of psychological procedures that comprise a unified intervention for emotional disorders. The Unified Protocol (UP) is a transdiagnostic, emotion-focused cognitive behavioral treatment, which emphasizes the adaptive, functional nature of emotions, and seeks to identify and correct maladaptive attempts to regulate emotional experiences, thereby facilitating appropriate processing and extinction of excessive emotional responding to both internal (somatic) and external cues. The treatment components of the UP are briefly outlined. Theory and rationale supporting this new approach are described along with some preliminary evidence supporting its efficacy. Implications for the treatment of emotional disorders using the UP are discussed. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]

A review of empirically supported psychological therapies for mood disorders in adults

DEPRESSION AND ANXIETY, Issue 10 2010
Steven D. Hollon Ph.D.
Abstract Background: The mood disorders are prevalent and problematic. We review randomized controlled psychotherapy trials to find those that are empirically supported with respect to acute symptom reduction and the prevention of subsequent relapse and recurrence. Methods: We searched the PsycINFO and PubMed databases and the reference sections of chapters and journal articles to identify appropriate articles. Results: One hundred twenty-five studies were found evaluating treatment efficacy for the various mood disorders. With respect to the treatment of major depressive disorder (MDD), interpersonal psychotherapy (IPT), cognitive behavior therapy (CBT), and behavior therapy (BT) are efficacious and specific and brief dynamic therapy (BDT) and emotion-focused therapy (EFT) are possibly efficacious. CBT is efficacious and specific, mindfulness-based cognitive therapy (MBCT) efficacious, and BDT and EFT possibly efficacious in the prevention of relapse/recurrence following treatment termination and IPT and CBT are each possibly efficacious in the prevention of relapse/recurrence if continued or maintained. IPT is possibly efficacious in the treatment of dysthymic disorder. With respect to bipolar disorder (BD), CBT and family-focused therapy (FFT) are efficacious and interpersonal social rhythm therapy (IPSRT) possibly efficacious as adjuncts to medication in the treatment of depression. Psychoeducation (PE) is efficacious in the prevention of mania/hypomania (and possibly depression) and FFT is efficacious and IPSRT and CBT possibly efficacious in preventing bipolar episodes. Conclusions: The newer psychological interventions are as efficacious as and more enduring than medications in the treatment of MDD and may enhance the efficacy of medications in the treatment of BD. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]

The relationship between anxiety disorders and suicide attempts: findings from the National Epidemiologic Survey on Alcohol and Related Conditions

DEPRESSION AND ANXIETY, Issue 9 2010
Josh Nepon M.D.
Abstract Background: Previous work has suggested that anxiety disorders are associated with suicide attempts. However, many studies have been limited by lack of accounting for factors that could influence this relationship, notably personality disorders. This study aims to examine the relationship between anxiety disorders and suicide attempts, accounting for important comorbidities, in a large nationally representative sample. Methods: Data came from the National Epidemiologic Survey on Alcohol and Related Conditions Wave 2. Face-to-face interviews were conducted with 34,653 adults between 2004 and 2005 in the United States. The relationship between suicide attempts and anxiety disorders (panic disorder, agoraphobia, social phobia, specific phobia, generalized anxiety disorder, posttraumatic stress disorder (PTSD)) was explored using multivariate regression models controlling for sociodemographics, Axis I and Axis II disorders. Results: Among individuals reporting a lifetime history of suicide attempt, over 70% had an anxiety disorder. Even after adjusting for sociodemographic factors, Axis I and Axis II disorders, the presence of an anxiety disorder was significantly associated with having made a suicide attempt (AOR=1.70, 95% confidence interval (CI): 1.40,2.08). Panic disorder (AOR=1.31, 95% CI: 1.06,1.61) and PTSD (AOR=1.81, 95% CI: 1.45,2.26) were independently associated with suicide attempts in multivariate models. Comorbidity of personality disorders with panic disorder (AOR=5.76, 95% CI: 4.58,7.25) and with PTSD (AOR=6.90, 95% CI: 5.41,8.79) demonstrated much stronger associations with suicide attempts over either disorder alone. Conclusion: Anxiety disorders, especially panic disorder and PTSD, are independently associated with suicide attempts. Clinicians need to assess suicidal behavior among patients presenting with anxiety problems. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]

Depression and obesity: do shared genes explain the relationship?

DEPRESSION AND ANXIETY, Issue 9 2010
Niloofar Afari Ph.D.
Abstract Background: Studies have found a modest association between depression and obesity, especially in women. Given the substantial genetic contribution to both depression and obesity, we sought to determine whether shared genetic influences are responsible for the association between these two conditions. Methods: Data were obtained from 712 monozygotic and 281 dizygotic female twin pairs who are members of the community-based University of Washington Twin Registry. The presence of depression was determined by self-report of doctor-diagnosed depression. Obesity was defined as body mass index of ,30,kg/m2, based on self-reported height and weight. Generalized estimating regression models were used to assess the age-adjusted association between depression and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental influences. Results: We found a modest phenotypic association between depression and obesity (odds ratio=1.6, 95% confidence interval=1.2,2.1). Additive genetic effects contributed substantially to depression (57%) and obesity (81%). The best-fitting bivariate model indicated that 12% of the genetic component of depression is shared with obesity. Conclusions: The association between depression and obesity in women may be in part due to shared genetic risk for both conditions. Future studies should examine the genetic, environmental, social, and cultural mechanisms underlying the relationship between this association. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]

Previous experience of spontaneous or elective abortion and risk for posttraumatic stress and depression during subsequent pregnancy

DEPRESSION AND ANXIETY, Issue 8 2010
Lydia Hamama
Abstract Background: Few studies have considered whether elective and/or spontaneous abortion (EAB/SAB) may be risk factors for mental health sequelae in subsequent pregnancy. This paper examines the impact of EAB/SAB on mental health during subsequent pregnancy in a sample of women involved in a larger prospective study of posttraumatic stress disorder (PTSD) across the childbearing year (n=1,581). Methods: Women expecting their first baby completed standardized telephone assessments including demographics, trauma history, PTSD, depression, and pregnancy wantedness, and religiosity. Results: Fourteen percent (n=221) experienced a prior elective abortion (EAB), 13.1% (n=206) experienced a prior spontaneous abortion (SAB), and 1.4% (n=22) experienced both. Of those women who experienced either an EAB or SAB, 13.9% (n=220) appraised the EAB or SAB experience as having been "a hard time" (i.e., potentially traumatic) and 32.6% (n=132) rated it as their index trauma (i.e., their worst or second worst lifetime exposure). Among the subset of 405 women with prior EAB or SAB, the rate of PTSD during the subsequent pregnancy was 12.6% (n,51), the rate of depression was 16.8% (n=68), and 5.4% (n,22) met criteria for both disorders. Conclusions: History of sexual trauma predicted appraising the experience of EAB or SAB as "a hard time." Wanting to be pregnant sooner was predictive of appraising the experience of EAB or SAB as the worst or second worst (index) trauma. EAB or SAB was appraised as less traumatic than sexual or medical trauma exposures and conveyed relatively lower risk for PTSD. The patterns of predictors for depression were similar. Depression and Anxiety, 2010.© 2010 Wiley-Liss, Inc. [source]

Psychological resilience and neurocognitive performance in a traumatized community sample,

DEPRESSION AND ANXIETY, Issue 8 2010
Aliza P. Wingo M.D.
Abstract Background: Whether psychological resilience correlates with neurocognitive performance is largely unknown. Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure. Methods: In this cross-sectional study of 226 highly traumatized civilians, we assessed neurocognitive performance, history of childhood abuse and other trauma exposure, and current depressive and PTSD symptoms. Resilience was defined as having ,1 trauma and no current depressive or PTSD symptoms; non-resilience as having ,1 trauma and current moderate/severe depressive or PTSD symptoms. Results: The non-resilient group had a higher percentage of unemployment (P=.006) and previous suicide attempts (P<.0001) than the resilient group. Both groups had comparable education and performance on verbal reasoning, nonverbal reasoning, and verbal memory. However, the resilient group performed better on nonverbal memory (P=.016) with an effect size of .35. Additionally, more severe childhood abuse or other trauma exposure was significantly associated with non-resilience. Better nonverbal memory was significantly associated with resilience even after adjusting for severity of childhood abuse, other trauma exposure, sex, and race using multiple logistic regression (adjusted OR=1.2; P=.017). Conclusions: We examined resilience as absence of psychopathology despite trauma exposure in a highly traumatized, low socioeconomic, urban population. Resilience was significantly associated with better nonverbal memory, a measure of ability to code, store, and visually recognize concrete and abstract pictorial stimuli. Nonverbal memory may be a proxy for emotional learning, which is often dysregulated in stress-related psychopathology, and may contribute to our understanding of resilience. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]

The Attentional Resource Allocation Scale (ARAS): psychometric properties of a composite measure for dissociation and absorption,

DEPRESSION AND ANXIETY, Issue 8 2010
R. N. Carleton M.A.
Abstract Background: Differences in attentional processes have been linked to the development and maintenance of psychopathology. Shifts in such processes have been described by the constructs Dissociation and Absorption. Dissociation occurs when external and/or internal stimuli are excluded from consciousness due to discrepant, rather than unitary, manifestations of cognitive awareness [Erdelyi MH. 1994: Int J Clin Exp Hypnosis 42:379,390]. In contrast, absorption can be conceptualized by a focus on limited stimuli, to the exclusion of other stimuli, because of unifying, rather than discrepant, manifestations of cognitive awareness. The Dissociative Experiences Scale [DES; Bernstein EM, Putnam FW. 1986: J Nerv Ment Dis 174:727,735] and Tellegen Absorption Scale [TAS; Tellegen A, Atkinson G. 1974: J Abnorm Psychol 83:268,277] are common measures of each construct; however, no factor analyses are available for the TAS and despite accepted overlap, no one has assessed the DES and TAS items simultaneously. Previous research suggests the constructs and factor structures need clarification, possibly including more parsimonious item inclusion [Lyons LC, Crawford HJ. 1997: Person Individ Diff 23:1071,1084]. The purpose of this study was to evaluate the factor structure of the DES and TAS and create a psychometrically stable measure of Dissociation and Absorption. Methods: This study included data from an undergraduate (n=841; 76% women) and a community sample (n=233; 86% women) who each completed the DES and TAS. Results: Exploratory factor analyses [Osborne JW (ed). 2008: Best Practices in Quantitative Methods. Los Angeles: Sage Publications Inc.] with all DES and TAS items suggested a 15-item 3-factor solution (i.e., imaginative involvement, dissociative amnesia, attentional dissociation). Confirmatory factor analyses resulted in excellent fit indices for the same solution. Conclusions: The items and factors were conceptualized in line with precedent research as the Attentional Resource Allocation Scale (ARAS). Comprehensive results, implications, and future research directions are discussed. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [source]