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Defense
Kinds of Defense Terms modified by Defense Selected AbstractsA PRAGMATIST DEFENSE OF NON-RELATIVISTIC EXPLANATORY PLURALISM IN HISTORY AND SOCIAL SCIENCEHISTORY AND THEORY, Issue 2 2008JEROEN VAN BOUWEL ABSTRACT Explanatory pluralism has been defended by several philosophers of history and social science, recently, for example, by Tor Egil Førland in this journal. In this article, we provide a better argument for explanatory pluralism, based on the pragmatist idea of epistemic interests. Second, we show that there are three quite different senses in which one can be an explanatory pluralist: one can be a pluralist about questions, a pluralist about answers to questions, and a pluralist about both. We defend the last position. Finally, our third aim is to argue that pluralism should not be equated with "anything goes": we will argue for non-relativistic explanatory pluralism. This pluralism will be illustrated by examples from history and social science in which different forms of explanation (for example, structural, functional, and intentional explanations) are discussed, and the fruitfulness of our framework for understanding explanatory pluralism is shown. [source] THE IDEA OF DEFENSE IN HISTORICAL AND CONTEMPORARY THINKING ABOUT JUST WARJOURNAL OF RELIGIOUS ETHICS, Issue 4 2008James Turner Johnson ABSTRACT What is, or should be, the role of defense in thinking about the justification of use of armed force? Contemporary just war thinking prioritizes defense as the principal, and perhaps the only, just cause for resorting to armed force. By contrast, classic just war tradition, while recognizing defense as justification for use of force by private persons, did not reason from self-defense to the justification of the use of force on behalf of the political community, but instead rendered the idea of just cause for resort to force in terms of the sovereign's responsibility to maintain justice, vindicating those who had suffered from injustice and punishing evildoers. This paper moves through three major stages in the historical development of just war thinking, first examining a critical phase in the formation of the classical idea of just cause as the responsibility to maintain justice, then discussing the shift, characteristic of the modern period, to an idea of sovereignty as connected to the state and the prioritization of defense of the state as just cause for use of force, and lastly showing how this conception of the priority of defense became part of the recovery of just war thinking in the latter part of the twentieth century. The paper concludes by noting recent changes in thought on international law that tend to emphasize justice at the expense of the right of self-defense, suggesting that the roots of just war thinking imply the need for a similar rethinking of contemporary just war discourse. [source] THE HONG KONG CURRENCY BOARD'S DEFENSE AGAINST FINANCIAL MARKET PRESSURE: A BEHAVIORAL PERSPECTIVETHE DEVELOPING ECONOMIES, Issue 2 2002Miron MUSHKAT Exchange rate regimes do not operate in an institutional vacuum, even when the scope for exercising policy discretion is distinctly limited. The Hong Kong linked exchange rate system is no exception. An interesting feature of the institutional environment in this case, not highlighted previously, is the apparent divergence in the assumptions of policymakers and market players regarding the merits of this mechanism in particular and currency boards in general. The corollary is that the Hong Kong monetary authorities need to intensify their efforts to disseminate relevant information, focusing especially on targets in the financial sector. [source] THE FAILING FIRM DEFENSE,THE JOURNAL OF INDUSTRIAL ECONOMICS, Issue 2 2005Lars Persson This paper evaluates the welfare consequences of the failing firm defense (FFD) in the EU and U.S. merger laws. To this end, I combine an oligopoly model with an ,endogenous valuations' auction model. The FFD is shown to work reasonably well for consumers unless small firms are too small. The FFD may, however, lead to total surplus losses, due to a ,least danger to competition' (LDC) condition which favors small, and thus possibly inefficient, firms. It is also shown that, in a multi-firm setting, the FFD increases the incentive for predation only when the assets are industry-specific. [source] TAIL SHEDDING IN ISLAND LIZARDS [LACERTIDAE, REPTILIA]: DECLINE OF ANTIPREDATOR DEFENSES IN RELAXED PREDATION ENVIRONMENTSEVOLUTION, Issue 5 2009Panayiotis Pafilis The ability of an animal to shed its tail is a widespread antipredator strategy among lizards. The degree of expression of this defense is expected to be shaped by prevailing environmental conditions including local predation pressure. We test these hypotheses by comparing several aspects of caudal autotomy in 15 Mediterranean lizard taxa existing across a swath of mainland and island localities that differ in the number and identity of predator species present. Autotomic ease varied substantially among the study populations, in a pattern that is best explained by the presence of vipers. Neither insularity nor the presence of other types of predators explain the observed autotomy rates. Final concentration of accumulated tail muscle lactate and duration of movement of a shed tail, two traits that were previously thought to relate to predation pressure, are in general not shaped by either predator diversity or insularity. Under conditions of relaxed predation selection, an uncoupling of different aspects of caudal autotomy exists, with some elements (ease of autotomy) declining faster than others (duration of movement, lactate concentration). We compared rates of shed tails in the field against rates of laboratory autotomies conducted under standardized conditions and found very high correlation values (r > 0.96). This suggests that field autotomy rates, rather than being a metric of predatory attacks, merely reflect the innate predisposition of a taxon to shed its tail. [source] ASYMMETRY IN STRUCTURAL DEFENSES: INSIGHTS INTO SELECTIVE PREDATION IN THE WILDEVOLUTION, Issue 9 2003C. A. Bergstrom Abstract Assessment of geographical patterns in fluctuating asymmetry (small, random differences between sides of bilateral characters) among populations shows promise as a tool to resolve the relative biomechanical importance of traits, in addition to being a possible indicator of habitat quality. We used 115 endemic freshwater populations of threespine stickleback (Gasterosteus aculeatus) from Haida Gwaii (Queen Charlotte Islands), British Columbia, Canada, to explore the degree of concordance between geographical variation of asymmetry in a predator defense structure (bony lateral plates) and geographical variation in several indirect measures of predation regime as well as several abiotic habitat variables. We found a geographical cline in the population frequency of lateral plate asymmetries, with reduced asymmetry in the southern clear-water regions of the archipelago characterized by long reaction distances and greater chance of capture by predators, and elevated asymmetry in the northern stained-water regions with poor visibility and low chances of capture. Lateral plate asymmetry was strongly correlated with expression of several defensive armor traits, including total plate numbers among populations, mean cross-sectional diameter of stickleback with the dorsal and pelvic spines erect, and mean degree of overlap between the plates and spine supports. There were no significant correlations between frequency of asymmetric fish and any of our abiotic habitat variables. Stickleback with structural plate asymmetries had fewer trout-induced scars than symmetric fish in the significant majority of populations, and there was a decrease in structural plate asymmetry with age in stained-water habitats, suggesting that trout predators may be selectively removing asymmetric fish in some lakes. This study provides evidence that geographical variation in developmental stability of threespine stickleback, as seen in the frequencies of asymmetry, reflects differences among populations in the importance of structural defenses to fitness rather than differences in habitat quality, and that asymmetry may be a target of selection by predators in wild populations. [source] INDUCED DEFENSES IN MACROALGAE: THE HERBIVORE MAKES A DIFFERENCEJOURNAL OF PHYCOLOGY, Issue 3 2001Charles D. Amsler First page of article [source] Middleware for real-time distributed simulationsCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 15 2004Thom McLean Abstract Distributed simulation applications often rely on middleware to provide services to support their execution over distributed computing environments. Such middleware spans many levels, ranging from low-level support for data transmission through object request brokers to higher level, simulation specific functionality such as time management. We discuss design alternatives for realizing such middleware for hard real-time distributed simulations such as hardware-in-the-loop applications. We present the results from tests of a prototype implementation of real-time Run-Time Infrastructure middleware. Its performance is compared with a non-real-time implementation. The context for this work is the High Level Architecture standard that has been defined by the U.S. Department of Defense. Copyright © 2004 John Wiley & Sons, Ltd. [source] The Gold Battles within the Cold War: American Monetary Policy and the Defense of Europe, 1960,1963DIPLOMATIC HISTORY, Issue 1 2002Francis J. Gavin First page of article [source] Accelerating botulism therapeutic product development in the Department of Defense,DRUG DEVELOPMENT RESEARCH, Issue 4 2009Andrea M. Stahl Abstract Coordinated small-molecule drug discovery research efforts for the treatment of botulism by the public sector, especially the U.S. Department of Defense (DoD) and Department of Health and Human Services (DHHS), began in the 1990s and represent a significant resource investment. Organization of an effective botulism therapeutic drug program, however, presents formidable technical and logistical challenges. Seven distinct BoNT serotypes are known, each representing a different target. Moreover, BoNT exerts its action inside peripheral cholinergic neurons, and some serotypes may persist functionally within nerve cells for weeks or months. Clinical botulism occurs infrequently, and the effectiveness of prolonged mechanical ventilation to treat poisoning further limits experimental drug testing. The efficacy of experimental compounds must be extrapolated from disparate cell- or tissue-based or rodent models. Numerous compounds with moderate efficacy in experimental laboratory assays have been reported, but may not possess the necessary safety, efficacy, and pharmacokinetic profile to support therapeutic development. To mitigate these challenges, we propose product development tools to assist in management of the BoNT portfolio and to clearly define the desired therapeutic product. Establishing a target product profile (TPP) is proposed to guide public sector managers toward critical aspects of the desired therapeutic product. Additional product development tools to assist in shaping research portfolios and to inform decisions regarding lead candidates to pursue are also discussed. Product development tools that facilitate the characterization of the ideal therapeutic product, and assist in the maintenance of a robust portfolio, will ameliorate the inherent financial risk in drug development for treating BoNT intoxication. Drug Dev Res 70:303,326, 2009. Published 2009 Wiley-Liss, Inc. [source] A Defense of Puttenham's Arte of English PoesyENGLISH LITERARY RENAISSANCE, Issue 1 2009Julian Lamb Recent critical accounts of Puttenham's treatise have tended to focus on the political nature of its poetics, and have in turn read the text as an exercise in courtly dissembling, or in self-fashioning. My argument is that such readings misunderstand the pedagogical nature of Puttenham's text, which distinguishes it from Sidney's Defense of Poetry and Daniel's Defense of Rhyme (to which the Art has been compared unfavourably). In the first half of this article I provide a re-interpretation of Puttenham's conception of decorum, suggesting that it is not an inexplicable rule designed to keep poetry the property the courtly elite, but rather a appetite and an imperative motivating the writing of poetry. In the second half of the article I consider Puttenham's understanding of the nature of decorum in terms of the relationship between custom and the rule. I suggest that Puttenham conceptualises this relationship as one between the aural and visual properties of language; between the ear and the eye. [source] Vapor phase transport of unexploded ordnance compounds through soilsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 10 2002Raghunathan Ravikrishna Abstract Unexploded ordnance(UXO) is a source of concern at several U.S. Department of Defense(DOD) sites. Localization of munitions and fate and transport of the explosive compounds from these munitions are a major issue of concern. A set of laboratory experiments were conducted in specially designed flux chambers to measure the evaporative flux of three explosive compounds (2,4-dinitrotoluene, 2,6-dinitrotoluene, and 1,3-dinitrobenzene) from three different soils. The effect of different soil moisture contents, the relative humidity of air contacting the soil surface, and soil temperature on the chemical fluxes were evaluated. A diffusion model was used to describe the chemical transport mechanism in the soil pore air. The soil-air partition constant was treated as a fit parameter in the model because of the uncertainty in the a priori estimation. The model predicts the qualitative trends of the experimental fluxes satisfactorily. Under extremely dry conditions, the flux decreased more rapidly than that predicted by the model. The fluxes from soils at 24°C were higher than those at 14°C, indicating a larger volatilization driving force at the higher temperature. [source] Influence of Age and Prior Experience on Territorial Behavior and the Costs of Defense in Male Collared LizardsETHOLOGY, Issue 1 2007Andrew M. Schwartz In polygynous species where males maintain strong interseasonal philopatry to the same breeding territories, older individuals have prior experience defending their areas, whereas younger individuals are defending a territory for the first time. Theoretical and empirical studies predict that under such conditions the cumulative costs of defense may be lower for older experienced males as a consequence of familiarity with environmental and/or social conditions in their particular local habitats. We used quantitative data from focal observational studies and introduction experiments to test the hypothesis that older collared lizard males (Crotaphytus collaris) with prior territorial experience (3 yr+ males) acquire larger territories allowing them to court more, different females, with greater frequency without incurring higher defense costs. Consistent with this hypothesis, 3 yr+ males controlled significantly larger territories and courted more females, without having significantly higher rates of territory patrol, frequencies of advertisement display, or aggressive interactions with same-sex competitors. Moreover, the intensity of responses to size- and age/experience-matched tethered intruders by 3 yr+ males was lower than that by 2 yr males in their first season of territory defense. Our results support the hypothesis that age/prior occupancy of territories lowers defense costs allowing males to defend larger areas and increase opportunities to court females, perhaps increasing mating opportunities. By contrast, 2 yr males may need to respond more aggressively to intruders because their ownership of territories is tenuous as a consequence of shorter territory occupancy. [source] Context Dependent Territory Defense: The Importance of Habitat Structure in Anolis sagreiETHOLOGY, Issue 6 2006Ryan Calsbeek Territoriality is a potentially costly endeavor, and several mechanisms for mitigating the costs of territoriality have been investigated in the wild. For example, territory owners can reduce the costs of defending territory boundaries by prioritizing defense of the most valuable areas within territories, investing less energy in low quality areas. We staged pairwise encounters between adult male lizards on natural territories in the wild, to test whether male brown anoles, Anolis sagrei, would differentially defend certain regions of their territories over others. Based on our observations that male A. sagrei spend most of their time on elevated perches on tree trunks or branches compared with sites on the ground, we predicted that territory residents would respond more aggressively to territory invasions that took place on elevated perches than to invasions on the ground. We measured significant differences in the behavior of residents following invasion on the ground vs. on the elevated perches, and results partially supported our hypothesis. Males performed more displays and approached intruders more often when territory invasion took place on the ground, but were quicker to attack intruders that entered territories on elevated perches. Our hypothesis was only partially supported, potentially indicating that elevated perches are preferred as outposts to monitor valuable sites on the ground. Our study provides evidence that territory defense varies not just among individuals, but also within individuals at different locations in a territory. [source] Perceptions of Effectiveness of Responses to Sexual Harassment in the US Military, 1988 and 1995GENDER, WORK & ORGANISATION, Issue 1 2003Juanita M. Firestone This analysis compares patterns of response to the harassment experiences that had the greatest effect on the respondents to the ,1988 Department of Defense (DoD) Survey of Sex Roles in the Active-Duty Military' and Form A of the ,1995 Armed Forces Sexual Harassment Survey'. We analyse the respondents' perceptions about effectiveness of their responses, and respondents' opinions about the efforts of senior military leadership, and their own immediate supervisors' efforts to ,make honest and reasonable efforts to stop sexual harassment in the active-duty military' (DoD, 1988; Bastian et al., 1996). Results indicate that while the military has been somewhat successful in attempts to lower actual incidence of sexual harassment, the percentage of those experiencing such uninvited and unwanted behaviours remains high. Similar patterns of responses in both years, with most employing personal solutions and few filing complaints with officials, may reflect the fact that official DoD policy focuses on individual behaviour and does not address the masculine environmental context that promotes such behaviours (see also Harrell and Miller, 1997). Findings also suggest that the ,no tolerance' policies adopted by the military may concentrate on the military image but ignore the wishes of the complainants who fear reprisals. If the rights and wishes of all parties involved are not taken into account, policies are unlikely to be successful (see, for example, Rowe, 1996). [source] Treatment of a Chromate-Contaminated Soil Site by in situ Gaseous ReductionGROUND WATER MONITORING & REMEDIATION, Issue 1 2007E.C Thornton A proof-of-concept field test for the treatment of hexavalent chromium in the vadose zone using in situ gaseous reduction was successfully completed by the U.S. Department of Energy and U.S. Department of Defense in a joint demonstration conducted at White Sands Missile Range, New Mexico. The test involved injecting hydrogen sulfide, diluted in air, into contaminated vadose zone sediment to reduce Cr(VI) to Cr(III). The gaseous mixture was injected directly into the contaminated sediment through a central injection well and vacuum extracted through the flow field with six boreholes at the site periphery over a 76-d period. Comparison of soil samples taken before and after the test indicated 70% of the total mass of hexavalent chromium originally present at the site was reduced and immobilized. The zone of highest contamination was nearly completely treated, with average Cr(VI) concentrations decreasing in this interval from an average of 8.1 mg/kg before treatment to 1.1 mg/kg after treatment. Treatment was best in higher permeability clean gypsum sands and less effective in zones containing greater amounts of silt and clay and a slightly higher iron content. All hexavalent chromium concentrations measured in the posttest samples, however, were well below the remedial goal and regulatory limit of 30 mg/kg. In addition, the field test demonstrated that vadose zone treatment of contamination can be safely conducted using diluted hydrogen sulfide gas mixtures. Ongoing development of the technology is being directed toward addressing the limitations of gaseous treatment arising from variations in sediment permeability and iron content and assessing the relationship between hydrogen sulfide consumption and reaction kinetics. [source] A Defense of Stiffer Penalties for Hate CrimesHYPATIA, Issue 2 2006CHRISTOPHER HEATH WELLMAN After defining a hate crime as an offense in which the criminal selects the victim at least in part because of an animus toward members of the group to which the victim belongs, this essay surveys the standard justifications for state punishment en route to defending the permissibility of imposing stiffer penalties for hate crimes. It also argues that many standard instances of rape and domestic battery are hate crimes and may be punished as such. [source] Primitive immune systems: Are your ways my ways?IMMUNOLOGICAL REVIEWS, Issue 1 2004Baruch Rinkevich Summary:, Although vertebrate immune systems have been commonly conceived as exquisitely developed to combat pervasiveness by pathogens, they are not infallible. The enigmatic expression of histocompatibility in vertebrates, the manifestation of natural chimerism, autoimmunity, malignancy, and other puzzling outcomes hint that immunity did not arise in evolution to fight infections and that this capacity is a late evolutionary appendage, owing its appearance to the redeployment of a system developed for other reasons. Allorecognition in the colonial tunicate Botryllus schlosseri serves here as a platform for a contending paradigm, advocating that immunity has developed as a surveillance machinery against and for purging of nascent selfish cells (stemmed from a kin organism or from transformed cells within the organism of origin). Defense against pathogens (always representing xenogeneic aliens) appeared later, revealing the multiplicity of newly developed phenomena. Allorecognition events characteristic of the Botryllus primitive immune system, such as fusion versus rejection, the morphological resorption with its expressed hierarchy, and the somatic/germ-cell parasitic outcomes, provide clues to the evolutionary basis of allorecognition. Recent work on Botryllus immunity that highlights the cost of littering individuality by somatic variants/allogeneic cells is discussed. [source] The Right of National DefenseINTERNATIONAL STUDIES PERSPECTIVES, Issue 1 2007DAVID R. MAPEL This article argues that there are two justifications of the right of national defense. First, some states possess the right as a means of protecting legitimate domestic political institutions. Second, all states possess the right within a morally defensible form of international law. Critics have argued that the first justification does not explain why one legitimate state should have the right not to be attacked and conquered by another legitimate state. Critics have argued that the second justification does not recognize that current international law is too flawed to justify a right of national defense for all states. This article defends the right against both criticisms. It then considers the scope of the right, focusing on the issue of proportionality. The article also argues that the two justifications of the right express potentially conflicting principles of justice, which can sometimes lead to hard choices, as illustrated by the NATO intervention in Kosovo. [source] Unipolarity, Globalization, and the War on Terror: Why Security Studies Should Refocus on Comparative Defense,INTERNATIONAL STUDIES REVIEW, Issue 3 2007Damon Coletta Changes in the international environment such as the shift toward unipolarity, the rise of globalization, and the expansion of terrorist networks have redefined the sorts of problems confronted by policymakers and military practitioners in the arena of national security. With most of its fundamental concepts and frameworks rooted in the study of international relations (IR), the field of security studies has failed to keep up. Highly educated soldiers and diplomats sent to help rebuild failed or fragmented states are still poorly equipped to identify major obstacles or formulate solutions for accomplishing their missions. The safety of states and societies today depends less exclusively on blocking the military, economic, and ideological initiatives of a foreign power and more on supporting the integrity of members that can participate in an international system regulated by generally agreed-upon rules and conventions. The need to help various types of states under a variety of cultural and economic conditions build legitimate, durable political institutions and functioning societies should push security studies toward a broader examination of comparative politics. Beyond the balance of power and modalities of interstate competition, the new security studies should embrace fundamentals found outside of IR to make more robust intellectual contributions to the examination of comparative defense. [source] Understanding the Threat of Biological WeaponsINTERNATIONAL STUDIES REVIEW, Issue 1 2000Susan B. Martin Books reviewed: Lederberg, Joshua (ed.), Biological Weapons: Limiting the Threat Zilinskas, Raymond A. (ed.), Biological Warfare: Modern Offense and Defense [source] Guidelines Abstracted from the Department of Veterans Affairs/Department of Defense Clinical Practice Guideline for the Management of Stroke RehabilitationJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 1 2006Miriam Rodin MD OBJECTIVES: To assist facilities in identifying those evidence-based processes of poststroke care that enhance measurable patient outcomes. The guideline(s) should be used by facilities (hospitals, subacute-care units and providers of long-term care) to implement a structured approach to improve rehabilitative practices and by clinicians to determine best interventions to achieve improved patient outcomes. OPTIONS: The guideline considers five elements of poststroke rehabilitation care: interdisciplinary teams; use of standardized assessments; intensity, timing, and duration of therapy; involvement of patients' families and caregivers in decision-making; and educational interventions for patients, families, and caregivers. Evidence, benefits, harms, and recommendations for each of the five designated elements and specific annotated recommendations for poststroke managements are presented separately. OUTCOMES: The overall guideline considers improvement in functional status measures as the primary outcome. Achieving community-dwelling status and preventing complications, death, and rehospitalization are also important outcomes. Costs are not specifically addressed. PARTICIPANTS: The Department of Veterans Affairs/Department of Defense (VA/DoD) Stroke Rehabilitation Working Group consisted of 28, largely VA and military hospital, representatives of medical and allied professions concerned with stroke diagnosis, management, and rehabilitation. Nine additional members with similar credentials served as the editorial committee. Technical consultation was contracted from ACS Federal Health Care, Inc., and the Center for Evidence-Based Practice, State University of New York,Upstate Medical University, Department of Family Medicine conducted evidence appraisal. Consensus was achieved over several years of facilitated group discussion and iterative evaluation of draft documents and supporting evidence. SPONSOR: The guideline was prepared under the auspices of the VA/DoD. No other source of support was identified in the document, or supporting documents. [source] NGRI Revisited: Venirepersons' Attitudes Toward the Insanity Defense,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 8 2006Brooke Butler Three hundred venirepersons from the 12th Judicial Circuit in Sarasota, Florida completed the following booklet of stimulus materials: one question measuring participants' level of support for insanity defense; a 16-item measure assessing participants' attitudes toward the myths associated with the insanity defense, the legal definitions of insanity, and mental illness; a case scenario; verdict preference; and standard demographic questions. Level of support for the insanity defense was significantly related to participants' attitudes toward legal standards of insanity, mental illness, and the myths associated with the insanity defense. In addition, results indicated that level of support for the insanity defense, age, educational level, occupation, type of prior jury service, and political views were significantly related to verdict preference. Notably, three factors that have been found to impact verdict preference in previous research failed to do so in the current study: participants' experience with psychological disorders; participants' exposure to psychotropic medications; and participants' experience with psychologists or psychiatrists. The findings both replicate and extend earlier findings by suggesting that attitudes toward the insanity defense are more complex than previously imagined. [source] Stability profiles of drug products extended beyond labeled expiration datesJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 7 2006Robbe C. Lyon Abstract The American Medical Association has questioned whether expiration dating markedly underestimates the actual shelf life of drug products. Results from the shelf life extension program (SLEP) have been evaluated to provide extensive data to address this issue. The SLEP has been administered by the Food and Drug Administration for the United States Department of Defense (DOD) for 20 years. This program probably contains the most extensive source of pharmaceutical stability data extant. This report summarizes extended stability profiles for 122 different drug products (3005 different lots). The drug products were categorized into five groups based on incidence of initial extension failures and termination failures (extended lot eventually failed upon re-testing). Based on testing and stability assessment, 88% of the lots were extended at least 1 year beyond their original expiration date for an average extension of 66 months, but the additional stability period was highly variable. The SLEP data supports the assertion that many drug products, if properly stored, can be extended past the expiration date. Due to the lot-to-lot variability, the stability and quality of extended drug products can only be assured by periodic testing and systematic evaluation of each lot. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 95: 1549,1560, 2006 [source] A Recent Perspective on Alcohol, Immunity, and Host DefenseALCOHOLISM, Issue 2 2009Gyongyi Szabo Background:, Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system. Methods:, Medline and Pubmed databases were used to identify published reports with particular interest in the period of 2000,2008 in the subject of alcohol use, infection, inflammation, innate, and adaptive immunity. Results:, This review article summarizes recent findings relevant to acute or chronic alcohol use-induced immunomodulation and its consequences on host defense against microbial pathogens and tissue injury. Studies with in vivo and in vitro alcohol administration are both discussed. The effects of alcohol on lung infections, trauma and burn injury, liver, pancreas, and cardiovascular diseases are evaluated with respect to the role of immune cells. Specific changes in innate immune response and abnormalities in adaptive immunity caused by alcohol intake are detailed. Conclusion:, Altered inflammatory cell and adaptive immune responses after alcohol consumption result in increased incidence and poor outcome of infections and other organ-specific immune-mediated effects. [source] In Defense of "Dependence"ALCOHOLISM, Issue 1 2008Carlton K. Erickson No abstract is available for this article. [source] In Defense of Moderate NeutralismJOURNAL OF SOCIAL PHILOSOPHY, Issue 3 2002Michael Pendlebury First page of article [source] Acute Alcohol Intoxication During Hemorrhagic Shock: Impact on Host Defense From InfectionALCOHOLISM, Issue 4 2004K. L. Zambell Abstract: Background: Acute alcohol intoxication is a frequent underlying condition associated with traumatic injury. Our studies have demonstrated that acute alcohol intoxication significantly impairs the immediate hemodynamic, metabolic, and inflammatory responses to hemorrhagic shock. This study investigated whether acute alcohol intoxication during hemorrhagic shock would alter the outcome from an infectious challenge during the initial 24 hr recovery period. Methods: Chronically catheterized male Sprague Dawley® rats were randomized to acute alcohol intoxication (EtOH; 1.75 g/kg bolus followed by a constant 15 hr infusion at 250,300 mg/kg/hr) or isocaloric isovolemic dextrose infusion (dex; 3 ml + 0.375 ml/hr). EtOH and dex were assigned to either fixed-volume (50%) hemorrhagic shock followed by fluid resuscitation with Ringer's lactate (EtOH/hem, dex/hem) or sham hemorrhagic shock (EtOH/sham, dex/sham). Indexes of circulating neutrophil function (apoptosis, phagocytosis, oxidative burst) were obtained at baseline, at completion of hemorrhagic shock, and at the end of fluid resuscitation. Bacterial clearance, lung cytokine expression, and myeloperoxidase activity were determined at 6 and 18 hr after an intratracheal challenge with Klebsiella pneumoniae (107 colony-forming units). Results: Mean arterial blood pressure was significantly lower in acute alcohol intoxication-hemorrhagic shock animals throughout the hemorrhagic shock. In sham animals, acute alcohol intoxication alone did not produce significant changes in neutrophil apoptosis or phagocytic activity but significantly suppressed phorbol myristic acid (PMA)-stimulated oxidative burst. Hemorrhagic shock produced a modest increase in neutrophil apoptosis and suppression of neutrophil phagocytic capacity but significantly suppressed PMA-stimulated oxidative burst. Acute alcohol intoxication exacerbated the hemorrhagic shock-induced neutrophil apoptosis and the hemorrhagic shock-induced suppression of phagocytosis without further affecting PMA-stimulated oxidative burst. Fluid resuscitation did not restore neutrophil phagocytosis or oxidative burst. Acute alcohol intoxication decreased (,40%) 3-day survival from K. pneumoniae in hemorrhagic shock animals, impaired bacterial clearance during the first 18 hr postinfection, and prolonged lung proinflammatory cytokine expression. Conclusions: These results demonstrate that the early alterations in metabolic and inflammatory responses to hemorrhagic shock produced by acute alcohol intoxication are associated with neutrophil dysfunction and impaired host response to a secondary infectious challenge leading to increased morbidity and mortality. [source] In Defense of "Public Reason": Supreme Court Justice William JohnsonJOURNAL OF SUPREME COURT HISTORY, Issue 2 2007SANDRA F. VANBURKLEO For those of us who gravitate toward rebels and upstarts, Supreme Court Justice William Johnson has uncommon appeal, if only because he was the first member of the federal Bench to kick up his heels in a sustained, effective, and deliberate way. In 1954, Johnson's only biographer, Donald Morgan, proclaimed him "the first dissenter,"1 a force for democratization in the style of Thomas Jefferson and Andrew Jackson, the man who persuaded Chief Justice John Marshall to compromise on the question of unitary opinions and institutionalize (if not applaud) publication of concurring or dissenting departures from the majority's official reasoning. [source] Food Defense in an Aquaculture SettingJOURNAL OF THE WORLD AQUACULTURE SOCIETY, Issue 2 2010Barbara Rasco Developing an overall food protection program for aquaculture and its related food processing operations includes biosecurity and good aquaculture practices for husbandry operations, and good manufacturing practices, food safety (sanitation standard operating procedures, and hazard analysis critical control point) programs for processing. Because of recent intentional contamination incidents of food and feed, developing and implementing a food defense as part of an overall food safety and quality management system have become more critical. Recent developments in food defense, suitable preventive measures, mitigation strategies, and model implementation plans for an aquaculture operation are presented here. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||