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Degradable Poly (degradable + poly)

Distribution by Scientific Domains

Polymers and Materials Science	100%

Selected Abstracts

Novel Amphiphilic Degradable Poly(, -caprolactone)- graft -poly(4-vinyl pyridine), Poly(, -caprolactone)- graft -poly(dimethylaminoethyl methacrylate) and Water-Soluble Derivatives

MACROMOLECULAR RAPID COMMUNICATIONS, Issue 9 2008
Benjamin Nottelet
Abstract New amphiphilic graft copolymers that have a poly(, -caprolactone) (PCL) biodegradable hydrophobic backbone and poly(4-vinylpyridine) (P4VP) or poly(2-(N,N- dimethylamino)ethyl methacrylate) (PDMAEMA) hydrophilic side chains have been prepared by anionic polymerization of the corresponding 4VP and DMAEMA monomers using a PCL-based macropolycarbanion as initiator. The water solubility of these amphiphilic copolymers is improved by quaternization, which leads to fully water-soluble cationic copolymers that give micellar aggregates in deionized water with diameters ranging from 65 to 125 nm. In addition, to improve the hydrophilicity of PCL- g -P4VP, grafting of poly(ethylene glycol) (PEG) segments has been carried out to give a water-soluble double grafted PCL- g -(P4VP;PEG) terpolymer. [source]

Electrospinning of degradable elastomeric nanofibers with various morphology and their interaction with human fibroblasts

JOURNAL OF APPLIED POLYMER SCIENCE, Issue 1 2008
Erik Borg
Abstract Artelon® (degradable poly(urethane urea) elastomer) was electrospun into scaffolds for tissue engineering. The diameter of the electrospun fibers, studied by scanning electron microscopy, ranged from 100 nm to a few ,m, with an average diameter of 750 nm. The molar mass of the polymer had a major influence on the morphology of the scaffold. Furthermore, aging of the polymer solution caused changes in viscosity, as measured by stress sweeps between 13.5,942 Pa that affected the morphology. The electrospun Artelon mats exhibited about the same elongations to break, both exceeding 200%, measured by tensile tests. The degradation study showed similar degradation behavior in electrospun mats and solids. In vitro study showed that human fibroblasts not only adhere to the surface but also migrate, proliferate, and produce components of an extracellular matrix. These results strongly support the use of electrospun Artelon as a scaffold in tissue engineering. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 [source]

Aliphatic poly(ester-carbonate)s bearing amino groups and its RGD peptide grafting

JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 21 2008
Xiuli Hu
Abstract This article deals with (1) synthesis of novel cyclic carbonate monomer (2-oxo [1,3]dioxan-5-yl)carbamic acid benzyl ester (CAB) containing protected amino groups; (2) ring-opening copolymerization of the cyclic monomer with L -lactide (LA) to provide novel degradable poly(ester-carbonate)s with functional groups; (3) removal of the protective benzyloxycarbonyl (Cbz) groups by catalytic hydrogenation to afford the corresponding poly(ester- co -carbonate)s with free amino groups; (4) grafting of oligopeptide Gly-Arg-Gly-Asp-Ser-Tyr (GRGDSY, abbreviated as RGD) onto the copolymer pendant amino groups in the presence of 1,1,-carbonyldiimidazole (CDI). The structures of P(LA- co -CA/RGD) and its precursor were confirmed by 1H NMR analysis. Cell experiments showed that P(LA- co -CA/RGD) had improved adhesion and proliferation behavior. Therefore, the novel RGD-grafted block copolymer is promising for cell or tissue engineering applications. © Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7022,7032, 2008 [source]

in vitro Evaluation of Biodegradable Poly(butylene succinate) as a Novel Biomaterial

MACROMOLECULAR BIOSCIENCE, Issue 5 2005
Haiyan Li
Abstract Summary: Poly(butylene succinate) (PBSU) can be easily synthesized by condensation polymerization of the starting materials of succinic acid and butan-1,4-diol. It has good degradability and possesses excellent processability. Due to these advantages, PBSU was first evaluated in the present study for its potential application as a novel biomaterial. The in vitro biocompatibility of the PBSU was evaluated by monitoring proliferation and differentiation of osteoblasts cultured on the PBSU film substrates for different periods. The results showed that the PBSU was biocompatible as the osteoblasts could proliferate and differentiate on the PBSU plates. In addition, the hydrolytic degradation behavior of the PBSU films in the phosphate-buffered saline (PBS) was also investigated and the results suggested that the PBSU degraded in the PBS solution with the same behavior as that of the degradable poly(, -hydroxyesters). In addition to the biocompatibility and hydrolytic degradation, some physical properties, including hydrophilicity, and mechanical and thermal properties of the PBSU substrates, were also determined and the results revealed that the PBSU was hydrophilic and ductile with excellent processability. The biocompatibility of the PBSU, together with the advantages of hydrolytic degradability, hydrophilicity, and excellent processability, indicated that PBSU has the potential to be used as a biomaterial for tissue repair. Alkaline phosphate activity of osteoblasts cultured on PBSU and TCPS substrates for different time periods. [source]

Lithocholic-acid-containing poly(ester,anhydride)s

POLYMERS FOR ADVANCED TECHNOLOGIES, Issue 11-12 2003
Michal Y. Krasko
Abstract New degradable poly(ester-anhydride)s were prepared by melt polycondensation of poly(sebacic acid) (PSA), transesterified by different amounts (30,90%) of lithocholic acid (LCA), a natural hydroxy bile acid. Transesterification of PSA is a one-pot reaction that starts with a high-molecular-weight polymer based on anhydride bonds and yields polymer based on random anhydride,ester bonds. A systematic study of the synthesis, characterization, degradation in vitro, drug release, and stability of these polymers was performed. Polymers with molecular weights (Mw) in the range of 12,000,115,000 and melting points in the range of 55,112,°C were obtained for 30,90% of lithocholic acid content. NMR and IR spectroscopic analyses indicate the formation of ester bonds in the polyanhydride backbone. The experimental results fit the calculated molecular weight, with the highest Mw obtained for a 4:6 PSA,LCA ratio. The study shows that some of these new degradable copolymers can be potentially used as carriers for the controlled release of drugs. Copyright © 2003 John Wiley & Sons, Ltd. [source]