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Database Development (database + development)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

Euroethics,a database network on biomedical ethics

HEALTH INFORMATION & LIBRARIES JOURNAL, Issue 3 2006
Ylva Gavel
Background:,euroethics is a database covering European literature on ethics in medicine. It is produced within Eurethnet, a European information network on ethics in medicine and biotechnology. Objectives:, The aim of Euroethics is to disseminate information on European bioethical literature that may otherwise be difficult to find. Methods:, A collaboration model for pooling data from different centres was developed. The policy was to accomplish data uniformity, while still allowing for local differences in terms of software, indexing practices and resources. Records contributed to the database follow common standards in terms of data fields and indexing terms. The indexing terms derive from two thesauri, Thesaurus Ethics in the Life Sciences (TELS) and Medical Subject Headings (MeSH). Combining elements from search tools developed previously, the developers sought to find a technical solution optimized for this data model. An approach relying on a thesaurus database that is loaded along with the bibliographic database is described. Results and conclusions:, The present case study offers examples of possible approaches to several tasks often encountered in database development, such as: merging data from diverse sources, getting the most out of indexing terms used in a database, and handling more than one thesaurus in the same system. [source]

The Use of Coroners'/Medical Examiners' Data by Forensic Nurses

JOURNAL OF FORENSIC NURSING, Issue 1 2005
Steven A. Koehler MPH
The role of the forensic nurse clinician is a critically important component of database development. Information that forensic nurses collect and chart may play a role in future research projects. [source]

A comparison of flavonoids, carotenoids and vitamin C in commercial organic and conventional marinara pasta sauce

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 2 2008
Eunmi Koh
Abstract BACKGROUND: Characterising the levels of key phytochemicals in foods commonly consumed in the Western diet is critical for database development, estimating intake and assessing the potential health benefits associated with the consumption of these products. This paper describes a market-basket evaluation of the key flavonoids, carotenoids and vitamin C in commercial organic (five brands) and conventional (five brands) marinara pasta sauces. RESULTS: Levels of ascorbic acid ranged from undetected up to 6.87 mg per 100 g fresh weight. The levels of total vitamin C in six of the ten samples were significantly lower than the amount listed on the Nutrition Facts Panel (P < 0.001 or P < 0.01). The contents of total vitamin C, flavonoids and lycopene were not statistically different between organic and conventional samples. Conventional pasta sauces demonstrated a significantly higher level of all- trans -,-carotene (P < 0.05). CONCLUSION: This suggests that any beneficial differences in levels of flavonoids, carotenoids and vitamin C gained through cultivation practices are not measurable at the consumer level in processed tomato products. Additionally, the results point to a large disparity between the actual vitamin C content of these products and the content listed on the Nutrition Facts Panel. Copyright © 2007 Society of Chemical Industry [source]

Landslide Research at the British Geological Survey: Capture, Storage and Interpretation on a National and Site-Specific Scale

ACTA GEOLOGICA SINICA (ENGLISH EDITION), Issue 5 2009
Catherine PENNINGTON
Abstract: Landslide research at the British Geological Survey (BGS) is carried out through a number of activities, including surveying, database development and real-time monitoring of landslides. Landslide mapping across the UK has been carried out since BGS started geological mapping in 1835. Today, BGS geologists use a combination of remote sensing and ground-based investigations to survey landslides. The development of waterproof tablet computers (BGS·SIGMAmobile), with inbuilt GPS and GIS for field data capture provides an accurate and rapid mapping methodology for field surveys. Regional and national mapping of landslides is carried out in conjunction with site-specific monitoring, using terrestrial LiDAR and differential GPS technologies, which BGS has successfully developed for this application. In addition to surface monitoring, BGS is currently developing geophysical ground-imaging systems for landslide monitoring, which provide real-time information on subsurface changes prior to failure events. BGS's mapping and monitoring activities directly feed into the BGS National Landslide Database, the most extensive source of information on landslides in Great Britain. It currently holds over 14 000 records of landslide events. By combining BGS's corporate datasets with expert knowledge, BGS has developed a landslide hazard assessment tool, GeoSure, which provides information on the relative landslide hazard susceptibility at national scale. [source]

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database,,

HUMAN MUTATION, Issue 6 2007
Audrey Petitjean
Abstract The tumor suppressor gene TP53 is frequently mutated in human cancers. More than 75% of all mutations are missense substitutions that have been extensively analyzed in various yeast and human cell assays. The International Agency for Research on Cancer (IARC) TP53 database (www-p53.iarc.fr) compiles all genetic variations that have been reported in TP53. Here, we present recent database developments that include new annotations on the functional properties of mutant proteins, and we perform a systematic analysis of the database to determine the functional properties that contribute to the occurrence of mutational "hotspots" in different cancer types and to the phenotype of tumors. This analysis showed that loss of transactivation capacity is a key factor for the selection of missense mutations, and that difference in mutation frequencies is closely related to nucleotide substitution rates along TP53 coding sequence. An interesting new finding is that in patients with an inherited missense mutation, the age at onset of tumors was related to the functional severity of the mutation, mutations with total loss of transactivation activity being associated with earlier cancer onset compared to mutations that retain partial transactivation capacity. Furthermore, 80% of the most common mutants show a capacity to exert dominant-negative effect (DNE) over wild-type p53, compared to only 45% of the less frequent mutants studied, suggesting that DNE may play a role in shaping mutation patterns. These results provide new insights into the factors that shape mutation patterns and influence mutation phenotype, which may have clinical interest. Hum Mutat 28(6), 622,629, 2007. Published 2007 Wiley-Liss, Inc. [source]