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Terms modified by Daily Time Selected AbstractsShould levodopa dose be reduced when switched to stalevo?EUROPEAN JOURNAL OF NEUROLOGY, Issue 3 2008G. Linazasoro The addition of entacapone to levodopa-carbidopa (LC) or the switch from LC to a tablet containing levodopa,carbidopa,entacapone (LCE) improves the wearing-off phenomenon, increases the ,on' time and decreases the ,off' time, but the appearance or exacerbation of dyskinesias is the more frequent side-effect. Thus, a reduction of the total levodopa dosage would be recommended. However, this could result in a lack of efficacy against the wearing-off. We report on the results of a clinical trial conducted to determine the best way in terms of efficacy, tolerability and safety of switching from LC to LCE in patients with Parkinson's disease (PD) and end of dose wearing-off. 39 patients with PD and wearing-off without or with mild dyskinesias were randomly assigned to either a group receiving the same LC dosage or to a group in which the total LC amount was reduced by 15,25%. Four weeks after the change, both groups showed an increase in daily ,on' time and a reduction in the daily time spent in ,off'. Two patients in each group experienced an increase in basal dyskinesias. No differences in clinical assessment between groups were found. Tolerance was excellent. This study suggests that switching from LC to LCE in patients with mild-to-moderate wearing-off can be done safely with or without reducing the total LD amount, but in the clinical setting it would be more practical to keep the dosage of LC unchanged unless severe dyskinesias are present. [source] Changes in body mass and organ size during wing moult in non-breeding greylag geese Anser anserJOURNAL OF AVIAN BIOLOGY, Issue 6 2005Anthony D. Fox The "cost-benefit" hypothesis states that specific body organs show mass changes consistent with a trade-off between the importance of their function and cost of their maintenance. We tested four predictions from this hypothesis using data on non-breeding greylag geese Anser anser during the course of remigial moult: namely that (i) pectoral muscles and heart would atrophy followed by hypertrophy, (ii) leg muscles would hypertrophy followed by atrophy, (iii) that digestive organs and liver would atrophy followed by hypertrophy and (iv) fat depots be depleted. Dissection of geese captured on three different dates during wing moult on the Danish island of Saltholm provided data on locomotory muscles and digestive organ size that confirmed these predictions. Locomotory organs associated with flight showed initial atrophy (a maximum loss of 23% of the initial pectoral muscle mass and 37% heart tissue) followed by hypertrophy as birds regained the powers of flight. Locomotory organs associated with running (leg muscles, since geese habitually run to the safety of water from predator-type stimuli) showed initial hypertrophy (a maximum gain of 37% over initial mass) followed by atrophy. The intestines and liver showed initial atrophy (41% and 37% respectively), consistent with observed reductions in daily time spent feeding during moult, followed by hypertrophy. The majority of the 22% loss in overall body mass (mean 760 g) during the flightless period involved fat utilisation, apparently consumed to meet shortfalls between daily energetic needs and observed rates of exogenous intake. The results support the hypothesis that such phenotypic plasticity in size of fat stores, locomotor and digestive organs can be interpreted as an evolutionary adaptation to meet the conflicting needs of the wing moult. [source] Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response studyJOURNAL OF SLEEP RESEARCH, Issue 1 2003Gregory Belenky SUMMARY Daytime performance changes were examined during chronic sleep restriction or augmentation and following subsequent recovery sleep. Sixty-six normal volunteers spent either 3 (n = 18), 5 (n= 16), 7 (n = 16), or 9 h (n = 16) daily time in bed (TIB) for 7 days (restriction/augmentation) followed by 3 days with 8 h daily TIB (recovery). In the 3-h group, speed (mean and fastest 10% of responses) on the psychomotor vigilance task (PVT) declined, and PVT lapses (reaction times greater than 500 ms) increased steadily across the 7 days of sleep restriction. In the 7- and 5-h groups speed initially declined, then appeared to stabilize at a reduced level; lapses were increased only in the 5-h group. In the 9-h group, speed and lapses remained at baseline levels. During recovery, PVT speed in the 7- and 5-h groups (and lapses in the 5-h group) remained at the stable, but reduced levels seen during the last days of the experimental phase, with no evidence of recovery. Speed and lapses in the 3-h group recovered rapidly following the first night of recovery sleep; however, recovery was incomplete with speed and lapses stabilizing at a level comparable with the 7- and 5-h groups. Performance in the 9-h group remained at baseline levels during the recovery phase. These results suggest that the brain adapts to chronic sleep restriction. In mild to moderate sleep restriction this adaptation is sufficient to stabilize performance, although at a reduced level. These adaptive changes are hypothesized to restrict brain operational capacity and to persist for several days after normal sleep duration is restored, delaying recovery. [source] Parental education, time in paid work and time with children: an Australian time-diary analysisTHE BRITISH JOURNAL OF SOCIOLOGY, Issue 4 2006Lyn Craig Abstract How does parental education affect time in the paid workforce and time with children? Potentially, the effects are contradictory. An economic perspective suggests higher education means a pull to the market. Human capital theory predicts that, because higher education improves earning capacity, educated women face higher opportunity costs if they forego wages, so will allocate more time to market work and less to unpaid domestic labour. But education may also exercise a pull to the home. Attitudes to child rearing are subject to strong social norms, and parents with higher levels of education may be particularly receptive to the current social ideal of attentive, sustained and intensive nurturing. Using data from the Australian Bureau of Statistics Time-use Survey 1997, this study offers a snapshot of how these contradictory pulls play out in daily life. It finds that in Australia, households with university-educated parents spend more daily time with children than other households in physical care and in developmental activities. Sex inequality in care time persists, but fathers with university education do contribute more time to care of children, including time alone with them, than other fathers. Mothers with university education allocate more daily time than other mothers to both childcare and to paid work. [source] Participation in organized weekly physical exercise in obese adolescents reduced daily physical activityACTA PAEDIATRICA, Issue 2 2009Maria Hagströmer Abstract Aim: The aim of this study was to describe the impact of organized weekly exercise for 13 weeks on aerobic fitness, objectively assessed habitual physical activity and body weight in obese adolescents. Methods: After inclusion and diagnostic evaluation, the adolescents were randomized to either an exercise group or to a control group which lasted for 13 weeks and consisted of a variety of group exercise activities. Out of 47 adolescents 31 (66%) could be evaluated, 16 in the exercise group and 15 in the control group. Results: After the intervention, the exercise group had decreased the daily time spent in moderate activity by 17 (32) min/day (p < 0.05), and the average intensity by 60 (96) counts/min (p < 0.05). A tendency for increased time spent in inactivity was found (37 min/day). No differences were seen in the control group for any of the variables measured. Conclusion: The exercise group showed, in contrast to expectations, a reduction in total daily physical activity with organized physical exercise compared to the control group. This may partly explain the failure of many intervention trials. [source] | ||||||||||